Clarity Control Module KONTRON 460/465

Importance of the topic

The ability to integrate and control an autosampler directly from chromatography software enhances analytical reproducibility, maximizes laboratory throughput and reduces manual intervention. Proper configuration of the Kontron 460/465 autosampler within the Clarity environment streamlines sample handling and ensures that acquisition parameters are embedded in the recorded chromatograms.

Objectives and overview of the module

This document outlines the setup and operation of the Kontron 460/465 Control Module in the Clarity chromatography station. Key goals include establishing reliable serial communication, configuring device parameters, enabling remote or local operation modes, and incorporating autosampler settings into both methods and reports.

Methodology and used instrumentation

A stepwise installation and configuration process is followed:

• Physical setup: connection via RS-232 using a DB9F-DIN5M cable (p/n SK09) to an available COM port or through a MultiCOM adapter for multiple devices.
• Software integration: installing the AS Control module (p/n A26) within Clarity, adding the Kontron 460/465 driver in System Configuration, and assigning digital inputs/outputs for synchronization.
• Parameter loading: employing the DataApex UNI Setup dialog to select the correct Ruby driver script (KONTRON460_465AS.RB), set communication port, syringe volume, and instrument name, and verify communication with AutoDetect.

Main results and discussion

Successful integration results in new tabs in the Method Setup dialog for autosampler control and a dedicated Device Monitor pane showing real-time status, vial position, wash and reset commands, and mode switching between Local and Remote. Method parameters such as wash before/after injection are stored alongside acquisition data and included automatically in method reports.

Benefits and practical applications

• Fully automated sample injection reduces operator workload and variability.
• Synchronized digital triggering ensures precise coordination with detectors.
• Embedded method parameters improve traceability and audit readiness in QA/QC environments.
• Customizable instrument naming and reporting enhances laboratory documentation standards.

Future trends and potential applications

Emerging developments may include network-based autosampler control over Ethernet or USB, enhanced scripting capabilities for user-defined workflows, cloud-enabled data logging, and integration with laboratory information management systems (LIMS) for end-to-end sample tracking. Increased automation, remote monitoring via web interfaces, and advanced error diagnostics will further boost productivity in high-throughput laboratories.

Conclusion

The Kontron 460/465 Control Module for Clarity provides a robust and flexible solution for automating sample injection in chromatographic analyses. Detailed configuration steps, from physical cabling to software setup and troubleshooting, ensure reliable operation and consistent data reporting, making it suitable for a wide range of analytical chemistry applications.