In-depth Peptide Mapping with Iterative MS/MS Acquisition on the Agilent 6545XT AdvanceBio LC/Q‑TOFApplications | 2020 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
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Application NoteBiotherapeutics andBiosimilarsLC/MS/MS Peptide MappingComparison of Innovator andBiosimilars of RituximabAuthorSuresh Babu C.V.Agilent Technologies, Inc.AbstractThe development and manufacturing of biosimilars require comparabilitystudies with innovator biotherapeutic products. This Application Note presentsa peptide mapping analysis of monoclonal antibody (mAb) biologics to assessthe similarities...
Key words
innovator, innovatorpeptide, peptidecounts, countsmapping, mappingchain, chainbiosimilar, biosimilarcharge, chargeunmodified, unmodifiedptms, ptmsheavy, heavyassaymap, assaymapmabs, mabsbravo, bravobiosimilars, biosimilarsttppvldsdgsfflyskl
An Integrated Workflow for PeptideMapping of Monoclonal AntibodiesApplication NoteBiotherapeutics and BiosimilarsAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) represent one of the fastest growing classes of drugsin the pharmaceutical industry. As a protein drug, the manufacturing of an mAb frominitial expression to commercialization...
Key words
peptide, peptidemab, mabmapping, mappingcounts, countsassaymap, assaymapsgtasvvcllnnfypr, sgtasvvcllnnfypracquisition, acquisitionworkflow, workflowcharge, chargedigestion, digestionsequence, sequencewere, weredigested, digestednist, nistdiqmtqspstlsasvgdrvtitcsassr
Making Peptide Mapping Routinewith the Agilent 6545XT AdvanceBioLC/Q-TOFApplication NoteAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) comprise a rapidly growing group of protein-basedbiomolecules being researched. Due to the heterogeneous nature of protein drugs,extensive analytical characterization is required.Agilent Technologies, Inc.Santa Clara, CA, USAJing ChenAgilent...
Key words
peptide, peptidemapping, mappingpeptides, peptidesadvancebio, advancebioassaymap, assaymapagilent, agilentbravo, bravocharge, chargenqvsltclvk, nqvsltclvknative, nativecounts, countsmonoclonal, monoclonalantibody, antibodymass, massprocessing
Enhancing The Quality Of PeptideMapping Separation For TheAnalysis Of PTMApplication NoteBiotherapeutics and BiosimilarsAuthorIntroductionSuresh Babu C.V.Post-translational modifications (PTMs) on proteins such as monoclonal antibodies(mAbs) are critical quality attributes (CQAs) that define the drug efficacy andsafety. Characterization of PTMs is a difficult...
Key words
peptide, peptidecounts, countsntaylqmnslr, ntaylqmnslradvancebio, advancebiomab, mabdltmisr, dltmisrptms, ptmseeeqynstr, eeeqynstrdeamidated, deamidatedplus, plusdigest, digestmapping, mappingseparation, separationtryptic, trypticnonoxidized

In-depth Peptide Mapping with Iterative MS/MS Acquisition on the Agilent 6545XT AdvanceBio LC/Q‑TOFApplications | 2020 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words

 

Similar PDF

Toggle
Application NoteBiotherapeutics andBiosimilarsLC/MS/MS Peptide MappingComparison of Innovator andBiosimilars of RituximabAuthorSuresh Babu C.V.Agilent Technologies, Inc.AbstractThe development and manufacturing of biosimilars require comparabilitystudies with innovator biotherapeutic products. This Application Note presentsa peptide mapping analysis of monoclonal antibody (mAb) biologics to assessthe similarities...
Key words
innovator, innovatorpeptide, peptidecounts, countsmapping, mappingchain, chainbiosimilar, biosimilarcharge, chargeunmodified, unmodifiedptms, ptmsheavy, heavyassaymap, assaymapmabs, mabsbravo, bravobiosimilars, biosimilarsttppvldsdgsfflyskl
An Integrated Workflow for PeptideMapping of Monoclonal AntibodiesApplication NoteBiotherapeutics and BiosimilarsAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) represent one of the fastest growing classes of drugsin the pharmaceutical industry. As a protein drug, the manufacturing of an mAb frominitial expression to commercialization...
Key words
peptide, peptidemab, mabmapping, mappingcounts, countsassaymap, assaymapsgtasvvcllnnfypr, sgtasvvcllnnfypracquisition, acquisitionworkflow, workflowcharge, chargedigestion, digestionsequence, sequencewere, weredigested, digestednist, nistdiqmtqspstlsasvgdrvtitcsassr
Making Peptide Mapping Routinewith the Agilent 6545XT AdvanceBioLC/Q-TOFApplication NoteAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) comprise a rapidly growing group of protein-basedbiomolecules being researched. Due to the heterogeneous nature of protein drugs,extensive analytical characterization is required.Agilent Technologies, Inc.Santa Clara, CA, USAJing ChenAgilent...
Key words
peptide, peptidemapping, mappingpeptides, peptidesadvancebio, advancebioassaymap, assaymapagilent, agilentbravo, bravocharge, chargenqvsltclvk, nqvsltclvknative, nativecounts, countsmonoclonal, monoclonalantibody, antibodymass, massprocessing
Enhancing The Quality Of PeptideMapping Separation For TheAnalysis Of PTMApplication NoteBiotherapeutics and BiosimilarsAuthorIntroductionSuresh Babu C.V.Post-translational modifications (PTMs) on proteins such as monoclonal antibodies(mAbs) are critical quality attributes (CQAs) that define the drug efficacy andsafety. Characterization of PTMs is a difficult...
Key words
peptide, peptidecounts, countsntaylqmnslr, ntaylqmnslradvancebio, advancebiomab, mabdltmisr, dltmisrptms, ptmseeeqynstr, eeeqynstrdeamidated, deamidatedplus, plusdigest, digestmapping, mappingseparation, separationtryptic, trypticnonoxidized
 

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