In-depth Peptide Mapping with Iterative MS/MS Acquisition on the Agilent 6545XT AdvanceBio LC/Q‑TOFApplications | 2020 | Agilent TechnologiesInstrumentationLC/TOF, LC/HRMS, LC/MS, LC/MS/MSIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordsntaylqmnslr, iterative, peptide, mapping, counts, auto, acquisition, assaymap, charge, precursors, eccs, bravo, mass, depth, isoasp, agilent, advancebio, peptides, workflow, rolling, native, protein, ptm, asp, min, excluded, biotherapeutic, trypsin, translational, characterization, overlaid, integrated, manufacture, forms, mab, time, tkpreeqynstyr, sheath, yes, linfeng, sample, fragment, data, temperature, identification, column, representative, conventional, acquired, aspartate
LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab
Application NoteBiotherapeutics andBiosimilarsLC/MS/MS Peptide MappingComparison of Innovator andBiosimilars of RituximabAuthorSuresh Babu C.V.Agilent Technologies, Inc.AbstractThe development and manufacturing of biosimilars require comparabilitystudies with innovator biotherapeutic products. This Application Note presentsa peptide mapping analysis of monoclonal antibody (mAb) biologics to assessthe similarities...
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An Integrated Workflow for Peptide Mapping of Monoclonal Antibodies
An Integrated Workflow for PeptideMapping of Monoclonal AntibodiesApplication NoteBiotherapeutics and BiosimilarsAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) represent one of the fastest growing classes of drugsin the pharmaceutical industry. As a protein drug, the manufacturing of an mAb frominitial expression to commercialization...
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Making Peptide Mapping Routine with the Agilent 6545XT AdvanceBio LC/Q-TOF
Making Peptide Mapping Routinewith the Agilent 6545XT AdvanceBioLC/Q-TOFApplication NoteAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) comprise a rapidly growing group of protein-basedbiomolecules being researched. Due to the heterogeneous nature of protein drugs,extensive analytical characterization is required.Agilent Technologies, Inc.Santa Clara, CA, USAJing ChenAgilent...
peptide, peptidemapping, mappingpeptides, peptidesadvancebio, advancebioassaymap, assaymapagilent, agilentbravo, bravonqvsltclvk, nqvsltclvkcharge, chargecounts, countsnative, nativemonoclonal, monoclonalantibody, antibodymass, massbioconfirm
Enhancing The Quality Of Peptide Mapping Separation For The Analysis Of PTM
Enhancing The Quality Of PeptideMapping Separation For TheAnalysis Of PTMApplication NoteBiotherapeutics and BiosimilarsAuthorIntroductionSuresh Babu C.V.Post-translational modifications (PTMs) on proteins such as monoclonal antibodies(mAbs) are critical quality attributes (CQAs) that define the drug efficacy andsafety. Characterization of PTMs is a difficult...
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