In-depth Peptide Mapping with Iterative MS/MS Acquisition on the Agilent 6545XT AdvanceBio LC/Q‑TOF | LabRulez LCMS_EN
 

Similar PDF

Toggle
Application NoteBiotherapeutics andBiosimilarsLC/MS/MS Peptide MappingComparison of Innovator andBiosimilars of RituximabAuthorSuresh Babu C.V.Agilent Technologies, Inc.AbstractThe development and manufacturing of biosimilars require comparabilitystudies with innovator biotherapeutic products. This Application Note presentsa peptide mapping analysis of monoclonal antibody (mAb) biologics to assessthe similarities...
Key words
innovator, innovatorpeptide, peptidecounts, countsmapping, mappingchain, chainbiosimilar, biosimilarcharge, chargeunmodified, unmodifiedptms, ptmsheavy, heavyassaymap, assaymapbravo, bravomabs, mabsbiosimilars, biosimilarsttppvldsdgsfflyskl
An Integrated Workflow for PeptideMapping of Monoclonal AntibodiesApplication NoteBiotherapeutics and BiosimilarsAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) represent one of the fastest growing classes of drugsin the pharmaceutical industry. As a protein drug, the manufacturing of an mAb frominitial expression to commercialization...
Key words
peptide, peptidemab, mabmapping, mappingcounts, countsassaymap, assaymapsgtasvvcllnnfypr, sgtasvvcllnnfypracquisition, acquisitionworkflow, workflowdigestion, digestioncharge, chargesequence, sequencewere, werenist, nistdigested, digesteddiqmtqspstlsasvgdrvtitcsassr
Making Peptide Mapping Routinewith the Agilent 6545XT AdvanceBioLC/Q-TOFApplication NoteAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) comprise a rapidly growing group of protein-basedbiomolecules being researched. Due to the heterogeneous nature of protein drugs,extensive analytical characterization is required.Agilent Technologies, Inc.Santa Clara, CA, USAJing ChenAgilent...
Key words
peptide, peptidemapping, mappingpeptides, peptidesadvancebio, advancebioassaymap, assaymapagilent, agilentbravo, bravonqvsltclvk, nqvsltclvkcharge, chargecounts, countsnative, nativemonoclonal, monoclonalantibody, antibodymass, massbioconfirm
Enhancing The Quality Of PeptideMapping Separation For TheAnalysis Of PTMApplication NoteBiotherapeutics and BiosimilarsAuthorIntroductionSuresh Babu C.V.Post-translational modifications (PTMs) on proteins such as monoclonal antibodies(mAbs) are critical quality attributes (CQAs) that define the drug efficacy andsafety. Characterization of PTMs is a difficult...
Key words
peptide, peptidecounts, countsntaylqmnslr, ntaylqmnslradvancebio, advancebiodltmisr, dltmisrmab, mabeeeqynstr, eeeqynstrptms, ptmsdeamidated, deamidatedplus, plusdigest, digestmapping, mappingtryptic, trypticseparation, separationnonoxidized
 

Similar PDF

Toggle
Application NoteBiotherapeutics andBiosimilarsLC/MS/MS Peptide MappingComparison of Innovator andBiosimilars of RituximabAuthorSuresh Babu C.V.Agilent Technologies, Inc.AbstractThe development and manufacturing of biosimilars require comparabilitystudies with innovator biotherapeutic products. This Application Note presentsa peptide mapping analysis of monoclonal antibody (mAb) biologics to assessthe similarities...
Key words
innovator, innovatorpeptide, peptidecounts, countsmapping, mappingchain, chainbiosimilar, biosimilarcharge, chargeunmodified, unmodifiedptms, ptmsheavy, heavyassaymap, assaymapbravo, bravomabs, mabsbiosimilars, biosimilarsttppvldsdgsfflyskl
An Integrated Workflow for PeptideMapping of Monoclonal AntibodiesApplication NoteBiotherapeutics and BiosimilarsAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) represent one of the fastest growing classes of drugsin the pharmaceutical industry. As a protein drug, the manufacturing of an mAb frominitial expression to commercialization...
Key words
peptide, peptidemab, mabmapping, mappingcounts, countsassaymap, assaymapsgtasvvcllnnfypr, sgtasvvcllnnfypracquisition, acquisitionworkflow, workflowdigestion, digestioncharge, chargesequence, sequencewere, werenist, nistdigested, digesteddiqmtqspstlsasvgdrvtitcsassr
Making Peptide Mapping Routinewith the Agilent 6545XT AdvanceBioLC/Q-TOFApplication NoteAuthorsIntroductionDavid L. WongMonoclonal antibodies (mAbs) comprise a rapidly growing group of protein-basedbiomolecules being researched. Due to the heterogeneous nature of protein drugs,extensive analytical characterization is required.Agilent Technologies, Inc.Santa Clara, CA, USAJing ChenAgilent...
Key words
peptide, peptidemapping, mappingpeptides, peptidesadvancebio, advancebioassaymap, assaymapagilent, agilentbravo, bravonqvsltclvk, nqvsltclvkcharge, chargecounts, countsnative, nativemonoclonal, monoclonalantibody, antibodymass, massbioconfirm
Enhancing The Quality Of PeptideMapping Separation For TheAnalysis Of PTMApplication NoteBiotherapeutics and BiosimilarsAuthorIntroductionSuresh Babu C.V.Post-translational modifications (PTMs) on proteins such as monoclonal antibodies(mAbs) are critical quality attributes (CQAs) that define the drug efficacy andsafety. Characterization of PTMs is a difficult...
Key words
peptide, peptidecounts, countsntaylqmnslr, ntaylqmnslradvancebio, advancebiodltmisr, dltmisrmab, mabeeeqynstr, eeeqynstrptms, ptmsdeamidated, deamidatedplus, plusdigest, digestmapping, mappingtryptic, trypticseparation, separationnonoxidized
 

Related content

Overcoming the challenges of liquid chromatography method transfer: A CDMO perspective

Technical notes
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
---

Method for the determination of 431 Residual Pesticides in Honey using LCMS-8050 and GCMS-TQ8040 NX

Applications
| 2022 | Shimadzu
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

ASMS: IMPROVEMENTS IN SENSITIVITY, QUANTITATIVE LINEARITY, AND ROBUSTNESS USING A MODIFIED BENCH-TOP QUADRUPOLE ORTHOGONAL TIME-OF-FLIGHT MASS SPECTROMETER (Q-TOF MS)

Posters
| 2022 | Waters
Instrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Manufacturer
Waters
Industries
---

Determination of Per and Polyfluoroalkyl Substances in Soils Using Carbon S SPE by LC/MS/MS

Applications
| 2022 | Agilent Technologies
Instrumentation
Sample Preparation, Consumables, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

ASTM D4327-03 Compliant Analysis of Anions in Wastewater

Applications
| 2022 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Environmental
 

Related content

Overcoming the challenges of liquid chromatography method transfer: A CDMO perspective

Technical notes
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
---

Method for the determination of 431 Residual Pesticides in Honey using LCMS-8050 and GCMS-TQ8040 NX

Applications
| 2022 | Shimadzu
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

ASMS: IMPROVEMENTS IN SENSITIVITY, QUANTITATIVE LINEARITY, AND ROBUSTNESS USING A MODIFIED BENCH-TOP QUADRUPOLE ORTHOGONAL TIME-OF-FLIGHT MASS SPECTROMETER (Q-TOF MS)

Posters
| 2022 | Waters
Instrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Manufacturer
Waters
Industries
---

Determination of Per and Polyfluoroalkyl Substances in Soils Using Carbon S SPE by LC/MS/MS

Applications
| 2022 | Agilent Technologies
Instrumentation
Sample Preparation, Consumables, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

ASTM D4327-03 Compliant Analysis of Anions in Wastewater

Applications
| 2022 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Environmental
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use

LabRulez s.r.o., all rights reserved.