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USING TRAVELING WAVE ION MOBILITY MASS SPECTROMETRY TO INVESTIGATE NATIVE AND DEUTERATED PROTEINS AND PEPTIDES – NEW CAPABILITIES FOR CORE LABS

 

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APPLICATION OF CYCLIC ION MOBILITY MASS SPECTROMETRY FOR HIGH PEAK CAPACITY SEPARATIONS OF NATIVE AND DEUTERATED PEPTIDE MIXTURES Martin Palmer1, Dale A. Cooper-Shepherd1, Malcolm Anderson1, James I. Langridge1, Robert Tonge1, John R. Engen2 1 Waters Corporation, Wilmslow, Cheshire, UK, SK9…
Key words
cim, cimsidechain, sidechaincyclic, cyclicims, imsdeuteriums, deuteriumsexchange, exchangeback, backmobility, mobilitydeuteration, deuterationundeuterated, undeuterateddeuterated, deuteratedpeptide, peptideinfusion, infusionamide, amidepass
INVESTIGATING PRIMARY AND HIGHER-ORDER PROTEIN STRUCTURE ANALYSIS USING A NOVEL CYCLIC ION MOBILITY ENABLED QTOF PLATFORM Scott J. Berger1, Dale A. Cooper-Shepherd2 , Martin Palmer2, LeRoy B Martin1, Henry Shion1, and James I. Langridge2, 1 Waters Corporation, Milford, MA, 01757…
Key words
ims, imscycles, cyclescyclic, cyclictiime, tiimeintensity, intensitypanel, panelmobility, mobilityarrival, arrivalpeptide, peptideenabled, enablednovel, novelcycle, cycleunfolding, unfoldingqtof, qtofprotein
TANDEM ION MOBILITY COUPLED WITH MASS SPECTROMETRY FOR GAS PHASE UNFOLDING STUDIES Dale A. Cooper-Shepherd1, LeRoy B. Martin2, Martin Palmer1, James I. Langridge1 1 Waters Corporation, Wilmslow, Cheshire, UK, SK9 4 AX, 2Waters Corporation, Beverly, MA OVERVIEW  The cyclic…
Key words
unfolding, unfoldingmobility, mobilityims, imsttr, ttrarrival, arrivalcyclic, cyclicprotein, proteinarray, arrayround, roundunfolded, unfoldedenabled, enabledcim, cimrounds, roundsejected, ejectedion
HIGHER SENSITIVITY, DATA QUALITY AND THROUGHPUT FOR HYDROGEN DEUTERIUM EXCHANGE EXPERIMENTS WITH EXTENDED ION MOBILITY SEPARATION Alexandre F. Gomes[1], Lindsay Morrison[1], Malcolm Anderson[2], Colette Quinn[1] [1] Waters Corporation, 34 Maple St., Milford, MA, 01757, USA [2] Waters Corporation, Stamford Avenue,…
Key words
hdx, hdxcyclic, cyclicpeptides, peptidesdeuterium, deuteriumims, imspeptide, peptidesynapt, synaptcoverage, coveragepepsin, pepsinphosb, phosbadc, adcsequence, sequenceexperiments, experimentsleap, leapmobility
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