Determination of Nitrosamines in Active Pharmaceutical IngredientsApplications | 2020 | Agilent TechnologiesInstrumentation
LC/MS, LC/MS/MS, LC/QQQ
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words

 

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Application NotePharmaceuticalsDetermination of NitrosamineImpurities Using the Ultivo TripleQuadrupole LC/MSDetection of regulated genotoxic impurities from thedrug manufacturing processAuthorsChander Mani andSaikat BanerjeeAgilent Technologies, Inc.AbstractRecent findings show that some Angiotensin II receptor blocker (ARB) drugproducts contain carcinogenic nitrosamine impurities.1 As a result, many...
Key words
nmipa, nmipanmpha, nmphanmba, nmbaethylnitrosamine, ethylnitrosamineneipa, neipandipa, ndipandba, ndbandea, ndeanmea, nmeanpyr, npyrnpip, npipndma, ndmaultivo, ultivonitrosamine, nitrosamineaverage
APPLICATION NOTE73814HRAM LC-MS method for the determinationof nitrosamine impurities in drugsAuthors: Hao Yang, Thermo Fisher Scientific,San Jose, CA, USJon Bardsley, Thermo Fisher Scientific,Hemel Hempstead, UKMin Du, Thermo Fisher Scientific,Boston, MA, USOlaf Scheibner, Thermo Fisher Scientific,Dreieich, GermanyKeywords: Nitrosamines, NDMA, APCI, highresolution...
Key words
positive, positivenitrosamine, nitrosaminenitrosamines, nitrosaminesndma, ndmaranitidine, ranitidinedrug, drugtsim, tsimexcipient, excipientndipa, ndipaimpurities, impuritiesnmea, nmeanpyr, npyrnpip, npipndpa, ndpatms
Rapid Analysis of Genotoxic Nitrosamines by HPLC-MS/MSSensitive, Robust Assay Using a SCIEX Triple Quad™ 4500 System and the ExionLC™ SystemLihai Guo, Zhimin Long, Xiangyang LengAPAC Applications Support Center, ChinaIntroductionGenotoxic impurities (GTI’s) are intermediate, reactive productsor degradants formed during drug synthesis,...
Key words
ndela, ndelanmor, nmornpyr, npyrnpip, npipndpa, ndpandba, ndbandea, ndeandma, ndmaexionlc, exionlcrecovery, recoverynitrosodi, nitrosodigenotoxic, genotoxicnitrosamines, nitrosaminesquantitaiton, quantitaitonsultan

Determination of Nitrosamines in Active Pharmaceutical IngredientsApplications | 2020 | Agilent TechnologiesInstrumentation
LC/MS, LC/MS/MS, LC/QQQ
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words

 

Similar PDF

Toggle
Application NotePharmaceuticalsDetermination of NitrosamineImpurities Using the Ultivo TripleQuadrupole LC/MSDetection of regulated genotoxic impurities from thedrug manufacturing processAuthorsChander Mani andSaikat BanerjeeAgilent Technologies, Inc.AbstractRecent findings show that some Angiotensin II receptor blocker (ARB) drugproducts contain carcinogenic nitrosamine impurities.1 As a result, many...
Key words
nmipa, nmipanmpha, nmphanmba, nmbaethylnitrosamine, ethylnitrosamineneipa, neipandipa, ndipandba, ndbandea, ndeanmea, nmeanpyr, npyrnpip, npipndma, ndmaultivo, ultivonitrosamine, nitrosamineaverage
APPLICATION NOTE73814HRAM LC-MS method for the determinationof nitrosamine impurities in drugsAuthors: Hao Yang, Thermo Fisher Scientific,San Jose, CA, USJon Bardsley, Thermo Fisher Scientific,Hemel Hempstead, UKMin Du, Thermo Fisher Scientific,Boston, MA, USOlaf Scheibner, Thermo Fisher Scientific,Dreieich, GermanyKeywords: Nitrosamines, NDMA, APCI, highresolution...
Key words
positive, positivenitrosamine, nitrosaminenitrosamines, nitrosaminesndma, ndmaranitidine, ranitidinedrug, drugtsim, tsimexcipient, excipientndipa, ndipaimpurities, impuritiesnmea, nmeanpyr, npyrnpip, npipndpa, ndpatms
Rapid Analysis of Genotoxic Nitrosamines by HPLC-MS/MSSensitive, Robust Assay Using a SCIEX Triple Quad™ 4500 System and the ExionLC™ SystemLihai Guo, Zhimin Long, Xiangyang LengAPAC Applications Support Center, ChinaIntroductionGenotoxic impurities (GTI’s) are intermediate, reactive productsor degradants formed during drug synthesis,...
Key words
ndela, ndelanmor, nmornpyr, npyrnpip, npipndpa, ndpandba, ndbandea, ndeandma, ndmaexionlc, exionlcrecovery, recoverynitrosodi, nitrosodigenotoxic, genotoxicnitrosamines, nitrosaminesquantitaiton, quantitaitonsultan
 

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