Tailored high-throughput low-flow LC-MS methods for large sample cohort analysis

Applications | 2019 | Thermo Fischer ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Clinical Research
Manufacturer
Thermo Fischer Scientific
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POSTER NOTE 65060Novel capillary-flow LC HRAM MS platform for fastNovelcapillary-flowtargeted analysis androbust profilingof complex LCAlexander Boychenko1, Peter Bults2, Martin Ruehsamples1Thermo Fisher Scientific, Germering. Germany, 2UAuthorsCABSTRACTAlexander Boychenko,1 Peter Bults,2Martin Ruehl,1 Christopher Pynn,1 MikeBaynham,3 Wim Decrop,1 AlexanderHarder,4 Nico van de Merbel,2 RainerBischoff,2...
Key words
caplc, caplcdigest, digestlysate, lysateprotein, proteinhela, helapeptide, peptidecell, cellflow, flowplasma, plasmacytc, cytcexactive, exactivetargeted, targetedproteome, proteomesensitivity, sensitivityyptngytr
TECHNICAL NOTE 72777High-throughput capillary-flow LC-MS proteomicswith maximum MS utilizationAuthorsContentsAlexander Boychenko1, ChristopherPynn1, Bart van den Berg1,Tabiwang N. Arrey2, Mike Baynham 3,Wim Decrop1, Martin Ruehl11. Introduction.............................................................................................. 2Thermo Fisher Scientific,Germering, Germany2. Experimental............................................................................................. 2Thermo Fisher Scientific,Bremen, Germany2.2 Samples........................................................................................... 2Thermo Fisher Scientific,Runcorn, United Kingdom2.4 MS...
Key words
proteomics, proteomicsflow, flowthroughput, throughputtrap, trapthermo, thermodigest, digestscientific, scientificcolumn, columnhela, helawash, washhigh, highproteome, proteomecapillary, capillaryequilibration, equilibrationloading
TECHNICAL NOTE 73291Online 2D-nanoLC hyphenated with high-resolutionaccurate-mass Orbitrap mass spectrometry forcomprehensive and robust proteome profilingAuthors: Runsheng Zheng1, AlexanderBoychenko1, Tabiwang N. Arrey2, ChristopherPynn1, Wim Decrop1, Peter Jehle1Thermo Fisher Scientific, Germering,Germany; 2Thermo Fisher Scientific,Bremen, Germany1Keywords: Deep dive proteomics, UltiMate3000 RSLCnano, Orbitrap Exploris...
Key words
peptide, peptidehela, helagroups, groupspsm, psmproteome, proteomedigest, digestconfidential, confidentialprotein, proteindimension, dimensionfractions, fractionsprofiling, profilinggravy, gravyserum, serumncs, ncsdistribution
Ultra-Fast Capillary-Flow LC-MS Profiling of Complex Biological Matrices: Applicable to Large Sample CohortsOleksandr Boychenko1; Jenny Ho2; Christopher Pynn11Thermo Fisher Scientific, Germering, Germany; 2Thermo Fisher Scientific, Hemel Hempstead, UKABSTRACTOPTIMIZED HIGH-THROUGHPUT LC-MS METHODSLOW-FLOW LC-MS ANALYSIS OF HELA PROTEIN DIGESTROBUST ANALYSIS OF CRUDE...
Key words
protein, proteindigest, digestpsms, psmsmethods, methodscount, countoptimized, optimizedplasma, plasmafast, fastflow, flowexactive, exactivehela, helansi, nsihigh, highlow, lowmin