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Simple Approach for the Removal of Phospholipids in Small MoleculeQuantitative Bioanalysis Using Ostro Sample Preparation PlatesBilly J Molloy,1 and Robert Plumb 21Waters Corporation, Wilmslow, UK2Waters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTION■Rapid simple sample preparationQuantitative bioanalysis provides accurate and precise systemic drug■Phospholipid...
Key words
ostro, ostrophospholipids, phospholipidsplates, platesbioanalysis, bioanalysisremoval, removalmolecule, moleculepreparation, preparationsample, samplephospholipid, phospholipidquantitative, quantitativeapproach, approachsimple, simplesmall, smallpass, passplasma
Application NoteRapid Identification of Major Metabolites ofGefitinib Using Ion Mobility Enabled MS(HDMSE) with the SYNAPT XSRobert S. Plumb, Lauren Mullin, Adam King, Ian D. WilsonWaters Corporation, Computational and Systems Medicine, Imperial College AbstractThis application note demonstrates the use of the SYNAPT...
Key words
synapt, synaptgefitinib, gefitinibunifi, unifienabled, enabledmobility, mobilityhdmse, hdmsemetabolite, metaboliteidentification, identificationresolution, resolutionccs, ccsmetabolites, metabolitesims, imsspectrometer, spectrometerrelated, relateddrug
CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIBAND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACHLee A. Gethings1, Martin Palmer1, Adam King1, Lauren Mullin1, Ian D. Wilson2, Robert S. Plumb31Waters Corp., Wilmslow, UK; 2Imperial College, London,...
Key words
gefitinib, gefitiniburine, urineims, imscorrelation, correlationpathways, pathwaysmetabolites, metabolitesendogenous, endogenousdosed, dosedpearson, pearsoncorrelating, correlatingranked, rankedmetabolite, metabolitemice, miceoral, oraldose
Application NoteImproving Drug Metabolite Identification in Biofluidswith the ACQUITY PREMIER and Hybrid OrganicSurface Technology: Increased Sensitivity andReproducibilityLauren Mullin, Adam King, Lee A. Gethings, Robert S. PlumbWaters Corporation AbstractLiquid chromatography coupled with electrospray tandem mass spectrometry is the primaryplatform for drug metabolite...
Key words
premier, premieracquity, acquitymetabolites, metaboliteshybrid, hybriddrug, drugchromatography, chromatographypresent, presentincreased, increasedsystem, systemorganic, organicgefitinib, gefitinibpolymer, polymerelectrospray, electrosprayhormonal, hormonalcolumns
 

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Simple Approach for the Removal of Phospholipids in Small MoleculeQuantitative Bioanalysis Using Ostro Sample Preparation PlatesBilly J Molloy,1 and Robert Plumb 21Waters Corporation, Wilmslow, UK2Waters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTION■Rapid simple sample preparationQuantitative bioanalysis provides accurate and precise systemic drug■Phospholipid...
Key words
ostro, ostrophospholipids, phospholipidsplates, platesbioanalysis, bioanalysisremoval, removalmolecule, moleculepreparation, preparationsample, samplephospholipid, phospholipidquantitative, quantitativeapproach, approachsimple, simplesmall, smallpass, passplasma
Application NoteRapid Identification of Major Metabolites ofGefitinib Using Ion Mobility Enabled MS(HDMSE) with the SYNAPT XSRobert S. Plumb, Lauren Mullin, Adam King, Ian D. WilsonWaters Corporation, Computational and Systems Medicine, Imperial College AbstractThis application note demonstrates the use of the SYNAPT...
Key words
synapt, synaptgefitinib, gefitinibunifi, unifienabled, enabledmobility, mobilityhdmse, hdmsemetabolite, metaboliteidentification, identificationresolution, resolutionccs, ccsmetabolites, metabolitesims, imsspectrometer, spectrometerrelated, relateddrug
CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIBAND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACHLee A. Gethings1, Martin Palmer1, Adam King1, Lauren Mullin1, Ian D. Wilson2, Robert S. Plumb31Waters Corp., Wilmslow, UK; 2Imperial College, London,...
Key words
gefitinib, gefitiniburine, urineims, imscorrelation, correlationpathways, pathwaysmetabolites, metabolitesendogenous, endogenousdosed, dosedpearson, pearsoncorrelating, correlatingranked, rankedmetabolite, metabolitemice, miceoral, oraldose
Application NoteImproving Drug Metabolite Identification in Biofluidswith the ACQUITY PREMIER and Hybrid OrganicSurface Technology: Increased Sensitivity andReproducibilityLauren Mullin, Adam King, Lee A. Gethings, Robert S. PlumbWaters Corporation AbstractLiquid chromatography coupled with electrospray tandem mass spectrometry is the primaryplatform for drug metabolite...
Key words
premier, premieracquity, acquitymetabolites, metaboliteshybrid, hybriddrug, drugchromatography, chromatographypresent, presentincreased, increasedsystem, systemorganic, organicgefitinib, gefitinibpolymer, polymerelectrospray, electrosprayhormonal, hormonalcolumns
 

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