A Rapid UPLC-MS/MS Discovery Bioanalytical Method for the Quantification of Gefitinib and Four of Its Major Metabolites in Mouse Plasma
Applications | 2020 | WatersInstrumentation
LC/MS, LC/MS/MS, LC/QQQ
IndustriesMetabolomics, Clinical Research
ManufacturerWaters
Key wordsgefitinib, iressa, desmethyl, discovery, bioanalytical, uplc, metabolites, rapid, metabolite, major, four, pharmacokinetics, dose, drug, epidermal, quantification, mouse, orally, its, xevo, note, methodology, mins, application, micro, response, concentration, hour, showed, method, growth, conc, nominal, vss, regimen, early, quadrupole, lipophilicity, after, acquity, plus, truview, plasma, evaluation, clearance, triple, active, class, trials, waters
Similar PDF
LipidQuan™: A Robust LC-MS/MS Methodology for Rapidly Profiling the Lipidome of Liver Tissue Following Metabolism of the Drug Gefitinib
2022|Waters|Applications
Application Note LipidQuan™: A Robust LC-MS/MS Methodology for Rapidly Profiling the Lipidome of Liver Tissue Following Metabolism of the Drug Gefitinib Nyasha Munjoma, I.D. Wilson, Lee A. Gethings, Robert S. Plumb Waters Corporation For research use only. Not for use…
Key words
gefitinib, gefitinibmetabolism, metabolismdrug, druglipidomix, lipidomixtyrosine, tyrosineepidermal, epidermalliver, liverkinase, kinasenegative, negativegefitnib, gefitnibmultivatiate, multivatiategrowth, growthtkis, tkiscompetes, competescommencement
Rapid Identification of Major Metabolites of Gefitinib Using Ion Mobility Enabled MS (HDMSE) with the SYNAPT XS
2020|Waters|Applications
Application Note Rapid Identification of Major Metabolites of Gefitinib Using Ion Mobility Enabled MS (HDMSE) with the SYNAPT XS Robert S. Plumb, Lauren Mullin, Adam King, Ian D. Wilson Waters Corporation, Computational and Systems Medicine, Imperial College Abstract This application…
Key words
synapt, synaptgefitinib, gefitinibunifi, unifienabled, enabledmobility, mobilityhdmse, hdmsemetabolite, metaboliteidentification, identificationresolution, resolutionccs, ccsmetabolites, metabolitesims, imsspectrometer, spectrometerquinazoline, quinazolinerelated
Metabolomics: LIPIDOMIC AND DESI IMAGING STUDY OF MOUSE LIVER DOSED WITH A TYROSINE KINASE INHIBITING DRUG
2022|Waters|Posters
LIPIDOMIC AND DESI IMAGING STUDY OF MOUSE LIVER DOSED WITH A TYROSINE KINASE INHIBITING DRUG Nyasha Munjoma 1 , Giorgis Isaac 2 , Mark Towers 1 , Emmanuelle Claude 1 , Ian D Wilson 3 , Lee A. Gethings 1…
Key words
desi, desiimaging, imaginguntargeted, untargetedgefitinib, gefitiniblipidomics, lipidomicstissue, tissueccs, ccslipid, lipidkinase, kinasegefitnib, gefitnibpremier, premiertreated, treatedstatistical, statisticalomics, omicstyrosine
CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIB AND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACH
2020|Waters|Posters
CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIB AND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACH Lee A. Gethings1, Martin Palmer1, Adam King1, Lauren Mullin1, Ian D. Wilson2, Robert S. Plumb3 1 Waters Corp., Wilmslow,…
Key words
gefitinib, gefitiniburine, urineims, imscorrelation, correlationmetabolites, metabolitespathways, pathwaysendogenous, endogenouspearson, pearsondosed, dosedcorrelating, correlatingmetabolite, metaboliteranked, rankedmice, micestatistically, statisticallydose