A Rapid UPLC-MS/MS Discovery Bioanalytical Method for the Quantification of Gefitinib and Four of Its Major Metabolites in Mouse PlasmaApplications | 2020 | WatersInstrumentationLC/MS, LC/MS/MS, LC/QQQIndustriesMetabolomics, Clinical ResearchManufacturerWatersKey wordsgefitinib, iressa, desmethyl, discovery, bioanalytical, uplc, metabolites, rapid, metabolite, major, four, pharmacokinetics, dose, drug, epidermal, quantification, mouse, its, orally, xevo, methodology, note, application, mins, micro, response, concentration, showed, hour, method, growth, conc, nominal, vss, regimen, early, quadrupole, lipophilicity, after, plasma, plus, acquity, evaluation, truview, clearance, trials, triple, waters, predicting, class
Simple Approach for the Removal of Phospholipids in Small Molecule Quantitative Bioanalysis Using Ostro Sample Preparation Plates
Simple Approach for the Removal of Phospholipids in Small MoleculeQuantitative Bioanalysis Using Ostro Sample Preparation PlatesBilly J Molloy,1 and Robert Plumb 21Waters Corporation, Wilmslow, UK2Waters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTION■Rapid simple sample preparationQuantitative bioanalysis provides accurate and precise systemic drug■Phospholipid...
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Rapid Identification of Major Metabolites of Gefitinib Using Ion Mobility Enabled MS (HDMSE) with the SYNAPT XS
Application NoteRapid Identification of Major Metabolites ofGefitinib Using Ion Mobility Enabled MS(HDMSE) with the SYNAPT XSRobert S. Plumb, Lauren Mullin, Adam King, Ian D. WilsonWaters Corporation, Computational and Systems Medicine, Imperial CollegeAbstractThis application note demonstrates the use of the SYNAPT...
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CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIB AND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACH
CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIBAND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACHLee A. Gethings1, Martin Palmer1, Adam King1, Lauren Mullin1, Ian D. Wilson2, Robert S. Plumb31Waters Corp., Wilmslow, UK; 2Imperial College, London,...
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Improving Drug Metabolite Identification in Biofluids with the ACQUITY PREMIER and Hybrid Organic Surface Technology: Increased Sensitivity and Reproducibility
Application NoteImproving Drug Metabolite Identification in Biofluidswith the ACQUITY PREMIER and Hybrid OrganicSurface Technology: Increased Sensitivity andReproducibilityLauren Mullin, Adam King, Lee A. Gethings, Robert S. PlumbWaters CorporationAbstractLiquid chromatography coupled with electrospray tandem mass spectrometry is the primaryplatform for drug metabolite...
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