Developing a Quantitative Surrogate Peptide Assay – Peptide mapping through MRM Optimization for Measuring Dulaglutide in a Rat PK StudyApplications | 2020 | WatersInstrumentationLC/TOF, LC/HRMS, LC/MS, LC/MS/MS, LC/QQQIndustriesProteomics , Clinical ResearchManufacturerWatersKey wordsdulaglutide, skyline, masslynx, peptide, peptides, mrm, rat, optimization, mapping, via, digested, identification, proteinworks, surrogate, protein, quantitative, preparation, interface, step, workflow, assay, rapidly, workflows, transitions, plus, uplc, acquity, express, unifi, exported, class, digestion, judiciously, xevo, catabolite, develop, auto, optimize, platform, pursued, includes, experiments, refine, quanrecovery, here, injected, msi, precursor, interest, software
How to Maximize Bioanalytical Performance of Fc-Fusion Proteins: Practical Sample Preparation and LC-MS/MS Workflows for Dulaglutide Quantification from Plasma
How to Maximize Bioanalytical Performance of Fc-Fusion Proteins:Practical Sample Preparation and LC-MS/MS Workflows forDulaglutide Quantification from PlasmaCaitlin M. Dunning and Mark D. WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■ProteinWorks™ Auto-eXpress Low DigestGlucagon-like peptide-1 (GLP-1) receptor agonists, such as the GLP-1Kits for...
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Automating Sample Preparation Workflows for Hybrid LC-MS/MS Bioanalysis of Protein Therapeutics: Quantification of Etanercept Using Affinity Purification and Digestion
Automating Sample Preparation Workflows for Hybrid LC-MS/MSBioanalysis of Protein Therapeutics: Quantification of EtanerceptUsing Affinity Purification and DigestionPaula Orens and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTIONAutomating a hybrid LC-MS/MS sampleAutomated liquid handlers in bioanalytical laboratories are routinely usedpreparation approach for...
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Quantification of Human Papillomavirus (HPV) Antigens in the Nonavalent Vaccine GARDASIL 9
Application NoteQuantification of Human Papillomavirus(HPV) Antigens in the Nonavalent VaccineGARDASIL 9Caitlin Dunning, Mark WronaWaters CorporationAbstractQuantification and identity testing are an important part of vaccine substance and product batchrelease. Traditional methods can be non-selective, time consuming to develop, and may have...
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PEPTIDE AND PROTEIN BIOANALYSIS
[ APPLICATION NOTEBOOK ]PEPTIDE AND PROTEINBIOANALYSIS[ OUR SCIENTISTS ]Yun Alelyunas, PhDBefore coming to Waters in 2012, YunAlelyunas was a principal scientist and teamleader at AstraZeneca for 20 years whereshe was involved in industrial chemicalanalysis, in vitro ADME screening, andproject core...
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