How to Maximize Bioanalytical Performance of Fc-Fusion Proteins: Practical Sample Preparation and LC-MS/MS Workflows for Dulaglutide Quantification from PlasmaApplications | 2020 | WatersInstrumentationSample Preparation, Consumables, LC/MS, LC/MS/MS, LC/QQQIndustriesClinical ResearchManufacturerWatersKey wordshgegtftsdvssyleeqaak, glpssiek, dulaglutide, proteinworks, peptide, accuracy, lqc, hgeg, digestion, lloq, hqc, rsd, statistics, uplc, express, affinity, peptides, hmqc, superblock, digest, lmqc, acquity, glps, note, spe, capture, protein, application, auto, biotinylated, quanrecovery, surrogate, xevo, mqc, mcx, quantification, curve, plus, beads, rat, optimization, preparation, oasis, blanks, kit, pore, anti, dpevqfnwyvdgvevhnaktkpreeqfnstyr, gsfflysrltvdksrwqegnvfscsvmhealhn, hgegtftsdvssyleeqaakefiawlvkggggg
Developing a Quantitative Surrogate Peptide Assay – Peptide mapping through MRM Optimization for Measuring Dulaglutide in a Rat PK Study
Application NoteDeveloping a Quantitative Surrogate PeptideAssay – Peptide mapping through MRMOptimization for Measuring Dulaglutide in aRat PK StudyCaitlin Dunning, Mark WronaWaters CorporationAbstractDevelopment of fusion protein therapeutics, such as dulaglutide (TRULICITYTM), is rising and thereis a need for universal workflows which...
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Automating Sample Preparation Workflows for Hybrid LC-MS/MS Bioanalysis of Protein Therapeutics: Quantification of Etanercept Using Affinity Purification and Digestion
Automating Sample Preparation Workflows for Hybrid LC-MS/MSBioanalysis of Protein Therapeutics: Quantification of EtanerceptUsing Affinity Purification and DigestionPaula Orens and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTIONAutomating a hybrid LC-MS/MS sampleAutomated liquid handlers in bioanalytical laboratories are routinely usedpreparation approach for...
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Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for the Quantification of Monoclonal Antibody Light Chains in Plasma
Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for theQuantification of Monoclonal Antibody Light Chains in PlasmaCaitlin M. Dunning, Mary Lame, and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■Fast, reproducible, and simple sampleThe increasing complexity of biotherapeutics is driving the need forpreparation...
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Accurate and Sensitive LC-MS/MS Quantification of Adalimumab in Serum/Plasma: Impact of Sample Preparation on Method Performance
Accurate and Sensitive LC-MS/MS Quantification of Adalimumab inSerum/Plasma: Impact of Sample Preparation on Method PerformanceCaitlin Dunning, Mary Lame, Steven Calciano, and Kelly DoeringWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Speed and reproducibility of a generic kit-Adalimumab (HUMIRA®) is a humanized monoclonal antibody...
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