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Application NoteDeveloping a Quantitative Surrogate PeptideAssay – Peptide mapping through MRMOptimization for Measuring Dulaglutide in aRat PK StudyCaitlin Dunning, Mark WronaWaters Corporation AbstractDevelopment of fusion protein therapeutics, such as dulaglutide (TRULICITYTM), is rising and thereis a need for universal workflows which...
Key words
dulaglutide, dulaglutideskyline, skylinemasslynx, masslynxpeptide, peptidepeptides, peptidesmrm, mrmrat, ratoptimization, optimizationmapping, mappingvia, viadigested, digestedidentification, identificationproteinworks, proteinworkssurrogate, surrogateprotein
Automating Sample Preparation Workflows for Hybrid LC-MS/MSBioanalysis of Protein Therapeutics: Quantification of EtanerceptUsing Affinity Purification and DigestionPaula Orens and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTIONAutomating a hybrid LC-MS/MS sampleAutomated liquid handlers in bioanalytical laboratories are routinely usedpreparation approach for...
Key words
protein, proteinautomating, automatingtherapeutics, therapeuticshybrid, hybridbioanalysis, bioanalysisautomated, automatedworkflows, workflowsictcrpgwycalsk, ictcrpgwycalskimmunoaffinity, immunoaffinitypreparation, preparationpurification, purificationetanercept, etanerceptmanual, manualraw, rawnormalized
Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for theQuantification of Monoclonal Antibody Light Chains in PlasmaCaitlin M. Dunning, Mary Lame, and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■Fast, reproducible, and simple sampleThe increasing complexity of biotherapeutics is driving the need forpreparation...
Key words
chains, chainslight, lightquantification, quantificationadalimumab, adalimumabmab, mabmonoclonal, monoclonalxevo, xevotriple, tripleantibody, antibodypolyphenyl, polyphenylsubunit, subunitquadrupole, quadrupolebioresolve, bioresolveplasma, plasmaalkylation
Accurate and Sensitive LC-MS/MS Quantification of Adalimumab inSerum/Plasma: Impact of Sample Preparation on Method PerformanceCaitlin Dunning, Mary Lame, Steven Calciano, and Kelly DoeringWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Speed and reproducibility of a generic kit-Adalimumab (HUMIRA®) is a humanized monoclonal antibody...
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adalimumab, adalimumabserum, serumglewvsaitwnsghidyadsvegr, glewvsaitwnsghidyadsvegrquantification, quantificationnylawyqqkpgk, nylawyqqkpgkapytfgqgtk, apytfgqgtkproteinworks, proteinworksplasma, plasmaprotein, proteinspe, spepeptide, peptidedigestion, digestionaccurate, accuratedigest, digestsensitive
 

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Application NoteDeveloping a Quantitative Surrogate PeptideAssay – Peptide mapping through MRMOptimization for Measuring Dulaglutide in aRat PK StudyCaitlin Dunning, Mark WronaWaters Corporation AbstractDevelopment of fusion protein therapeutics, such as dulaglutide (TRULICITYTM), is rising and thereis a need for universal workflows which...
Key words
dulaglutide, dulaglutideskyline, skylinemasslynx, masslynxpeptide, peptidepeptides, peptidesmrm, mrmrat, ratoptimization, optimizationmapping, mappingvia, viadigested, digestedidentification, identificationproteinworks, proteinworkssurrogate, surrogateprotein
Automating Sample Preparation Workflows for Hybrid LC-MS/MSBioanalysis of Protein Therapeutics: Quantification of EtanerceptUsing Affinity Purification and DigestionPaula Orens and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTIONAutomating a hybrid LC-MS/MS sampleAutomated liquid handlers in bioanalytical laboratories are routinely usedpreparation approach for...
Key words
protein, proteinautomating, automatingtherapeutics, therapeuticshybrid, hybridbioanalysis, bioanalysisautomated, automatedworkflows, workflowsictcrpgwycalsk, ictcrpgwycalskimmunoaffinity, immunoaffinitypreparation, preparationpurification, purificationetanercept, etanerceptmanual, manualraw, rawnormalized
Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for theQuantification of Monoclonal Antibody Light Chains in PlasmaCaitlin M. Dunning, Mary Lame, and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■Fast, reproducible, and simple sampleThe increasing complexity of biotherapeutics is driving the need forpreparation...
Key words
chains, chainslight, lightquantification, quantificationadalimumab, adalimumabmab, mabmonoclonal, monoclonalxevo, xevotriple, tripleantibody, antibodypolyphenyl, polyphenylsubunit, subunitquadrupole, quadrupolebioresolve, bioresolveplasma, plasmaalkylation
Accurate and Sensitive LC-MS/MS Quantification of Adalimumab inSerum/Plasma: Impact of Sample Preparation on Method PerformanceCaitlin Dunning, Mary Lame, Steven Calciano, and Kelly DoeringWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Speed and reproducibility of a generic kit-Adalimumab (HUMIRA®) is a humanized monoclonal antibody...
Key words
adalimumab, adalimumabserum, serumglewvsaitwnsghidyadsvegr, glewvsaitwnsghidyadsvegrquantification, quantificationnylawyqqkpgk, nylawyqqkpgkapytfgqgtk, apytfgqgtkproteinworks, proteinworksplasma, plasmaprotein, proteinspe, spepeptide, peptidedigestion, digestionaccurate, accuratedigest, digestsensitive
 

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