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TANDEM QUADRUPOLE MS FOR THE QUANTIFICATION OF MONOCLONAL ANTIBODY SUBUNIT LIGHT CHAINS IN PLASMA Caitlin M. Dunning, Mary E. Lame, and Mark D. Wrona Waters Corporation, Milford, MA, USA INTRODUCTION CHROMATOGRAPHY MASS SPECTROMETRY 5 µg/mL Adalimumab - 10µL - Rep…
Key words
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[ TECHNOLOGY BRIEF ] Tackling Non-Specific Binding of Biotherapeutics Using LC-MS Compatible QuanRecovery Sample Plates with MaxPeak High Performance Surfaces Caitlin Dunning, Mary Lame, Mark Wrona, and Kim Haynes Waters Corporation, Milford, MA, USA Large, hydrophobic biomolecules are prone to…
Key words
quanrecovery, quanrecoverynsb, nsbmitigate, mitigatebiotherapeutics, biotherapeuticsplate, platebinding, bindingmaxpeak, maxpeakplates, platessurfaces, surfacesbrief, briefstored, storedhps, hpsnon, nonspecific, specifictechnology
[ APPLICATION NOTE ] Accurate and Sensitive LC-MS/MS Quantification of Adalimumab in Serum/Plasma: Impact of Sample Preparation on Method Performance Caitlin Dunning, Mary Lame, Steven Calciano, and Kelly Doering Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Speed and…
Key words
adalimumab, adalimumabserum, serumglewvsaitwnsghidyadsvegr, glewvsaitwnsghidyadsvegrquantification, quantificationnylawyqqkpgk, nylawyqqkpgkapytfgqgtk, apytfgqgtkproteinworks, proteinworksplasma, plasmaprotein, proteinspe, spepeptide, peptideaccurate, accuratedigestion, digestiondigest, digestsensitive
[ APPLICATION NOTE ] Development of a Hybrid Immunoaffinity-LC-MS/MS Method for the Quantification of Active Biotherapeutics Targeting TNF-α in Serum Caitlin Dunning and Mary Lame Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ High analytical sensitivity Tumor Necrosis Factor…
Key words
infliximab, infliximabimmunoaffinity, immunoaffinitynylawyqqkpgk, nylawyqqkpgkadalimumab, adalimumabbiotherapeutics, biotherapeuticssinsathyaesvk, sinsathyaesvketanercept, etanercepttnf, tnfictcrpgwycalsk, ictcrpgwycalskquantification, quantificationserum, serumhybrid, hybridapytfgqgtk, apytfgqgtkactive, activedilltqspailsvspger
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