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[ TECHNOLOGY BRIEF ]Tackling Non-Specific Binding of Biotherapeutics Using LC-MS CompatibleQuanRecovery Sample Plates with MaxPeak High Performance SurfacesCaitlin Dunning, Mary Lame, Mark Wrona, and Kim HaynesWaters Corporation, Milford, MA, USALarge, hydrophobic biomolecules are prone to nonspecific binding (NSB). Ensuring labware...
Key words
quanrecovery, quanrecoverynsb, nsbmitigate, mitigatebiotherapeutics, biotherapeuticsplate, platebinding, bindingmaxpeak, maxpeakplates, platessurfaces, surfacesbrief, briefhps, hpsstored, storednon, nonspecific, specifictechnology
Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for theQuantification of Monoclonal Antibody Light Chains in PlasmaCaitlin M. Dunning, Mary Lame, and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■Fast, reproducible, and simple sampleThe increasing complexity of biotherapeutics is driving the need forpreparation...
Key words
chains, chainslight, lightquantification, quantificationadalimumab, adalimumabmab, mabmonoclonal, monoclonalxevo, xevotriple, tripleantibody, antibodypolyphenyl, polyphenylsubunit, subunitquadrupole, quadrupolebioresolve, bioresolveplasma, plasmaalkylation
Accurate and Sensitive LC-MS/MS Quantification of Adalimumab inSerum/Plasma: Impact of Sample Preparation on Method PerformanceCaitlin Dunning, Mary Lame, Steven Calciano, and Kelly DoeringWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Speed and reproducibility of a generic kit-Adalimumab (HUMIRA®) is a humanized monoclonal antibody...
Key words
adalimumab, adalimumabserum, serumglewvsaitwnsghidyadsvegr, glewvsaitwnsghidyadsvegrquantification, quantificationnylawyqqkpgk, nylawyqqkpgkapytfgqgtk, apytfgqgtkproteinworks, proteinworksplasma, plasmaprotein, proteinspe, spepeptide, peptidedigestion, digestionaccurate, accuratedigest, digestsensitive
Development of a Hybrid Immunoaffinity-LC-MS/MS Method for theQuantification of Active Biotherapeutics Targeting TNF-α in SerumCaitlin Dunning and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■High analytical sensitivityTumor Necrosis Factor (TNF) is a vital protein that plays a key role in theLC-MS/MS...
Key words
infliximab, infliximabimmunoaffinity, immunoaffinitynylawyqqkpgk, nylawyqqkpgkadalimumab, adalimumabbiotherapeutics, biotherapeuticssinsathyaesvk, sinsathyaesvketanercept, etanercepttnf, tnfictcrpgwycalsk, ictcrpgwycalskquantification, quantificationserum, serumhybrid, hybridapytfgqgtk, apytfgqgtkactive, activedilltqspailsvspger
 

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[ TECHNOLOGY BRIEF ]Tackling Non-Specific Binding of Biotherapeutics Using LC-MS CompatibleQuanRecovery Sample Plates with MaxPeak High Performance SurfacesCaitlin Dunning, Mary Lame, Mark Wrona, and Kim HaynesWaters Corporation, Milford, MA, USALarge, hydrophobic biomolecules are prone to nonspecific binding (NSB). Ensuring labware...
Key words
quanrecovery, quanrecoverynsb, nsbmitigate, mitigatebiotherapeutics, biotherapeuticsplate, platebinding, bindingmaxpeak, maxpeakplates, platessurfaces, surfacesbrief, briefhps, hpsstored, storednon, nonspecific, specifictechnology
Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for theQuantification of Monoclonal Antibody Light Chains in PlasmaCaitlin M. Dunning, Mary Lame, and Mark WronaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■Fast, reproducible, and simple sampleThe increasing complexity of biotherapeutics is driving the need forpreparation...
Key words
chains, chainslight, lightquantification, quantificationadalimumab, adalimumabmab, mabmonoclonal, monoclonalxevo, xevotriple, tripleantibody, antibodypolyphenyl, polyphenylsubunit, subunitquadrupole, quadrupolebioresolve, bioresolveplasma, plasmaalkylation
Accurate and Sensitive LC-MS/MS Quantification of Adalimumab inSerum/Plasma: Impact of Sample Preparation on Method PerformanceCaitlin Dunning, Mary Lame, Steven Calciano, and Kelly DoeringWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Speed and reproducibility of a generic kit-Adalimumab (HUMIRA®) is a humanized monoclonal antibody...
Key words
adalimumab, adalimumabserum, serumglewvsaitwnsghidyadsvegr, glewvsaitwnsghidyadsvegrquantification, quantificationnylawyqqkpgk, nylawyqqkpgkapytfgqgtk, apytfgqgtkproteinworks, proteinworksplasma, plasmaprotein, proteinspe, spepeptide, peptidedigestion, digestionaccurate, accuratedigest, digestsensitive
Development of a Hybrid Immunoaffinity-LC-MS/MS Method for theQuantification of Active Biotherapeutics Targeting TNF-α in SerumCaitlin Dunning and Mary LameWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■High analytical sensitivityTumor Necrosis Factor (TNF) is a vital protein that plays a key role in theLC-MS/MS...
Key words
infliximab, infliximabimmunoaffinity, immunoaffinitynylawyqqkpgk, nylawyqqkpgkadalimumab, adalimumabbiotherapeutics, biotherapeuticssinsathyaesvk, sinsathyaesvketanercept, etanercepttnf, tnfictcrpgwycalsk, ictcrpgwycalskquantification, quantificationserum, serumhybrid, hybridapytfgqgtk, apytfgqgtkactive, activedilltqspailsvspger
 

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