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High Salt—High Reproducibility - Analysis of antibody drug conjugates using hydrophobic interaction chromatography with the Agilent 1290 Infinity II Bio LC System

 

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Application Note Biopharma/Pharma Convenient and Reliable Analysis of Antibody Drug Conjugates Drug-to-antibody determination with ternary gradients on the Agilent 1260 Infinity II Prime Bio LC ×101 1.20 D2 1.15 1.10 1.05 1.00 0.95 0.90 0.85 0.80 D4 0.75 Response (mAU)…
Key words
brentuximab, brentuximabvedotin, vedotinisopropanol, isopropanolhic, hicternary, ternarydar, darspecies, speciesantibody, antibodyorganic, organicbio, biodrug, drugbuffers, bufferssolvent, solventsalt, saltsst
Analysis of Cysteine-Linked Antibody Drug Conjugates
2017|Agilent Technologies|Applications
Analysis of Cysteine-Linked Antibody Drug Conjugates Using Hydrophobic Interaction Chromatography on the Agilent 1260 Infinity II Bio-inert LC Application Note Biologics and Biosimilars Author Abstract Sonja Schneider Hydrophobic interaction chromatography (HIC) is frequently used for the Agilent Technologies, Inc. determination…
Key words
brentuximab, brentuximabvedotin, vedotindar, darhic, hicdrug, drugantibody, antibodyhydrophobic, hydrophobicmmae, mmaeadcs, adcsadc, adctige, tigeinteraction, interactionmab, mablinked, linkedcysteine
Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…
Key words
dimension, dimensiondar, daradcs, adcsadc, adcsecond, secondnative, nativehic, hicadvancebio, advancebiocounts, countsmab, mabdeconvoluted, deconvoluteddrug, drugfirst, firstconjugated, conjugateddenatured
Agilent InfinityLab Bio LC Solutions High-Performance Biopharma Analysis Application compendium 2 Overcome Analytical Challenges in Biopharma The growing complexity of biopharma analysis calls for innovation that delivers excellence across the biopharmaceutical workflow. The Agilent InfinityLab Bio LC Solutions comprise a…
Key words
retention, retentionbio, biomin, mingradient, gradienttime, timenistmab, nistmabresponse, responsemau, maupeptide, peptidemapping, mappingcharge, chargeagilent, agilentmab, mabrsd, rsdantibody
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