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Agilent-NISTmAbAggregate andFragment AnalysisAgilent BioHPLC ColumnsApplication Compendium ContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass information. A certificate of...
Key words
page, pagecontents, contentsmobile, mobileback, backbuffer, buffersec, secmau, mauexclusion, exclusionnacl, naclmonomer, monomerhwm, hwmdimer, dimerphase, phasesize, sizeresolution
Mobile Phase Optimization in SEC Method Development
2018|Agilent Technologies|Applications
Application NotePharma & BiopharmaMobile Phase Optimization in SECMethod DevelopmentAuthorRichard HurteauAgilent Technologies, Inc.,Wilmington, DE, USAAbstractAggregation of monoclonal antibody (mAb) products has an adverse effect ontheir efficacy as therapeutic agents. Size exclusion chromatography (SEC) is ahighly effective method for the detection of...
Key words
mau, maumin, minigg, iggphosphate, phosphatekda, kdaaggregation, aggregationinsulin, insulinbuffer, bufferadc, adccytochrome, cytochromeproteins, proteinscolumns, columnstherapeutic, therapeuticnriu, nriupeak
Agilent BioHPLC ColumnsCharacterization of NIST MonoclonalAntibody Critical Quality AttributesApplication Compendium ContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass...
Key words
mab, mabglycan, glycanadvancebio, advancebiomapping, mappingpeptide, peptidecounts, countsmonoclonal, monoclonalagilent, agilentglycans, glycansmin, minprotein, proteinnistmab, nistmabmass, masscolumn, columnantibody
A Comprehensive Workflow toOptimize and Execute ProteinAggregate StudiesCombining Size Exclusion Chromatography with MethodDevelopment and Light ScatteringApplication NoteBiotherapeutics and BiosimilarsAuthorsAbstractAndy Coffey and Matthew RainThis Application Note illustrates a comprehensive aggregate analysis workflow to:Agilent Technologies, Inc•Optimize mobile phase conditions for high-performance size...
Key words
rituximab, rituximabrituxumab, rituxumabsec, secbiosimilar, biosimilarmobile, mobileaggregate, aggregatebio, bioaggregates, aggregatesbuffer, bufferdetector, detectorresponse, responseinnovator, innovatortime, timemin, minphase
 

Similar PDF

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Agilent-NISTmAbAggregate andFragment AnalysisAgilent BioHPLC ColumnsApplication Compendium ContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass information. A certificate of...
Key words
page, pagecontents, contentsmobile, mobileback, backbuffer, buffersec, secmau, mauexclusion, exclusionnacl, naclmonomer, monomerhwm, hwmdimer, dimerphase, phasesize, sizeresolution
Mobile Phase Optimization in SEC Method Development
2018|Agilent Technologies|Applications
Application NotePharma & BiopharmaMobile Phase Optimization in SECMethod DevelopmentAuthorRichard HurteauAgilent Technologies, Inc.,Wilmington, DE, USAAbstractAggregation of monoclonal antibody (mAb) products has an adverse effect ontheir efficacy as therapeutic agents. Size exclusion chromatography (SEC) is ahighly effective method for the detection of...
Key words
mau, maumin, minigg, iggphosphate, phosphatekda, kdaaggregation, aggregationinsulin, insulinbuffer, bufferadc, adccytochrome, cytochromeproteins, proteinscolumns, columnstherapeutic, therapeuticnriu, nriupeak
Agilent BioHPLC ColumnsCharacterization of NIST MonoclonalAntibody Critical Quality AttributesApplication Compendium ContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass...
Key words
mab, mabglycan, glycanadvancebio, advancebiomapping, mappingpeptide, peptidecounts, countsmonoclonal, monoclonalagilent, agilentglycans, glycansmin, minprotein, proteinnistmab, nistmabmass, masscolumn, columnantibody
A Comprehensive Workflow toOptimize and Execute ProteinAggregate StudiesCombining Size Exclusion Chromatography with MethodDevelopment and Light ScatteringApplication NoteBiotherapeutics and BiosimilarsAuthorsAbstractAndy Coffey and Matthew RainThis Application Note illustrates a comprehensive aggregate analysis workflow to:Agilent Technologies, Inc•Optimize mobile phase conditions for high-performance size...
Key words
rituximab, rituximabrituxumab, rituxumabsec, secbiosimilar, biosimilarmobile, mobileaggregate, aggregatebio, bioaggregates, aggregatesbuffer, bufferdetector, detectorresponse, responseinnovator, innovatortime, timemin, minphase
 

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