High-Throughput Analysis of Epigenetic Targets with Agilent RapidFire/MS Systems: Sirtuin (SIRT) Enzymes

 

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A study of SIRT1- and SIRT2‑Mediated Deacetylation
2022|Agilent Technologies|Applications
Application Note Drug Discovery A study of SIRT1- and SIRT2‑Mediated Deacetylation Using the Agilent RapidFire high-throughput mass spectrometry system Authors Abstract Peter Rye, Lauren Frick, and William Lamarr Agilent Technologies, Inc. The Agilent RapidFire high-throughput mass spectrometry (MS) system is…
Key words
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High-Throughput MS Detection of Histone H3 Demethylation by Lysine-Specific Demethylase 1 (LSD1) Application Note Author Introduction Peter Rye, Lauren Frick, and William LaMarr Agilent Technologies, Inc. Wakefield, MA USA The field of epigenetics focuses on the investigation of enzymes that…
Key words
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Ultrafast Histone Deacetylase Selectivity Screening Using the Agilent RapidFire High-Throughput Mass Spectrometry System Application Note Authors Abstract Lauren E. Frick and William A. LaMarr Selectivity screening of a promising new compound requires testing against a Agilent Technologies, Inc. host of…
Key words
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High-Throughput Lead Discovery with Agilent RapidFire/MS Systems: Analysis of UDP-3-O-(R-3-hydroxymyristoyl)-NAcetylglucosamine Deacetylase (LpxC) Application Note Authors Introduction William Lamarr, Lauren Frick, and Peter Rye Agilent Technologies, Inc. Wakefield, MA USA The RapidFire High-throughput Mass Spectrometry System provides drug discovery researchers with…
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