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High-Throughput Lead Discovery withAgilent RapidFire/MS Systems:Analysis of Stearoyl-Coenzyme ADesaturase (SCD)Application NoteAuthorsIntroductionWilliam Lamarr, Lauren Frick,and Peter RyeAgilent Technologies, Inc.Wakefield, MA USAThe RapidFire High-throughput Mass Spectrometry System provides drug discoveryresearchers with mass spectrometry-based, high-throughput screening solutionsfor targets that have proven challenging to...
Key words
rapidfire, rapidfirestearoyl, stearoylscd, scdcoenzyme, coenzymethroughput, throughputdesaturation, desaturationassay, assaydiscovery, discoveryradiometric, radiometricdesaturase, desaturasehigh, highspectrometry, spectrometryoleoyl, oleoylintractable, intractablemass
High-Throughput Analysis ofEpigenetic Targets withAgilent RapidFire/MS Systems:Sirtuin (SIRT) EnzymesApplication NoteAuthorIntroductionPeter Rye, Lauren Frick,and William LaMarrAgilent Technologies, Inc.Wakefield, MA USAHistones and other proteins are subject to a variety of posttranslationalmodifications that regulate a host of biological processes. One such modificationis the...
Key words
rapidfire, rapidfiresirt, sirtsirtuins, sirtuinspeptide, peptidesirtuin, sirtuinsustained, sustaineddirect, directkinetic, kineticsecondary, secondarystudying, studyingsubstrate, substratemultiple, multipleproducts, productsdeacetylases, deacetylasesobviating
High-Throughput Lead Discoverywith Agilent RapidFire/MS Systems:Analysis of Acetyl-Coenzyme ACarboxylase (ACC)Application NoteAuthorsIntroductionWilliam Lamarr, Lauren Frick,and Peter RyeAgilent Technologies, Inc.Wakefield, MA USAThe RapidFire High-throughput Mass Spectrometry System provides drug discoveryresearchers with mass spectrometry-based high-throughput screening solutionsfor targets that have proven challenging to...
Key words
coenzyme, coenzymerapidfire, rapidfireacc, accacoa, acoaacetyl, acetylcarboxylase, carboxylasethroughput, throughputcoa, coadiscovery, discoveryintractable, intractablemalonyl, malonyllabeling, labelingspectrometry, spectrometrydifficult, difficultmass
Ultrafast Histone DeacetylaseSelectivity Screening Using theAgilent RapidFire High-ThroughputMass Spectrometry SystemApplication NoteAuthorsAbstractLauren E. Frick and William A. LaMarrSelectivity screening of a promising new compound requires testing against aAgilent Technologies, Inc.host of enzymes related to the target of interest, resulting in the...
Key words
multiplex, multiplexunit, unitpos, posnormalized, normalizedsubstrate, substrateinhibition, inhibitionindividual, individualrapidfire, rapidfiremultiplexed, multiplexeddeacetylase, deacetylasetubacin, tubacinreactions, reactionsbottleneck, bottleneckthroughput, throughputselectivity
 

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High-Throughput Lead Discovery withAgilent RapidFire/MS Systems:Analysis of Stearoyl-Coenzyme ADesaturase (SCD)Application NoteAuthorsIntroductionWilliam Lamarr, Lauren Frick,and Peter RyeAgilent Technologies, Inc.Wakefield, MA USAThe RapidFire High-throughput Mass Spectrometry System provides drug discoveryresearchers with mass spectrometry-based, high-throughput screening solutionsfor targets that have proven challenging to...
Key words
rapidfire, rapidfirestearoyl, stearoylscd, scdcoenzyme, coenzymethroughput, throughputdesaturation, desaturationassay, assaydiscovery, discoveryradiometric, radiometricdesaturase, desaturasehigh, highspectrometry, spectrometryoleoyl, oleoylintractable, intractablemass
High-Throughput Analysis ofEpigenetic Targets withAgilent RapidFire/MS Systems:Sirtuin (SIRT) EnzymesApplication NoteAuthorIntroductionPeter Rye, Lauren Frick,and William LaMarrAgilent Technologies, Inc.Wakefield, MA USAHistones and other proteins are subject to a variety of posttranslationalmodifications that regulate a host of biological processes. One such modificationis the...
Key words
rapidfire, rapidfiresirt, sirtsirtuins, sirtuinspeptide, peptidesirtuin, sirtuinsustained, sustaineddirect, directkinetic, kineticsecondary, secondarystudying, studyingsubstrate, substratemultiple, multipleproducts, productsdeacetylases, deacetylasesobviating
High-Throughput Lead Discoverywith Agilent RapidFire/MS Systems:Analysis of Acetyl-Coenzyme ACarboxylase (ACC)Application NoteAuthorsIntroductionWilliam Lamarr, Lauren Frick,and Peter RyeAgilent Technologies, Inc.Wakefield, MA USAThe RapidFire High-throughput Mass Spectrometry System provides drug discoveryresearchers with mass spectrometry-based high-throughput screening solutionsfor targets that have proven challenging to...
Key words
coenzyme, coenzymerapidfire, rapidfireacc, accacoa, acoaacetyl, acetylcarboxylase, carboxylasethroughput, throughputcoa, coadiscovery, discoveryintractable, intractablemalonyl, malonyllabeling, labelingspectrometry, spectrometrydifficult, difficultmass
Ultrafast Histone DeacetylaseSelectivity Screening Using theAgilent RapidFire High-ThroughputMass Spectrometry SystemApplication NoteAuthorsAbstractLauren E. Frick and William A. LaMarrSelectivity screening of a promising new compound requires testing against aAgilent Technologies, Inc.host of enzymes related to the target of interest, resulting in the...
Key words
multiplex, multiplexunit, unitpos, posnormalized, normalizedsubstrate, substrateinhibition, inhibitionindividual, individualrapidfire, rapidfiremultiplexed, multiplexeddeacetylase, deacetylasetubacin, tubacinreactions, reactionsbottleneck, bottleneckthroughput, throughputselectivity
 

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