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Host Cell Protein Analysis Using Agilent AssayMAP Bravo and 6545XT AdvanceBio LC/Q-TOF

Applications | 2018 | Agilent TechnologiesInstrumentation
Sample Preparation, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Industries
Clinical Research
Manufacturer
Agilent Technologies
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Application Note Biotherapeutics Quantification of Host Cell Protein Impurities Using the Agilent 1290 Infinity II LC Coupled with the 6495B Triple Quadrupole LC/MS System Authors Linfeng Wu and Yanan Yang Agilent Technologies, Inc. Santa Clara, CA, USA Introduction Host Cell…
Key words
protein, proteinsil, silpeptide, peptideskyline, skylinecounts, countstargeted, targetedamol, amolassaymap, assaymaphcp, hcppeptides, peptidesquantification, quantificationdpgvldr, dpgvldrllleyleek, llleyleekvfdviir, vfdviirbravo
Application Note Pharma & Biopharma Quantification of Host Cell Protein Impurities using the Agilent 6495C Triple Quadrupole LC/MS Author Linfeng Wu Agilent Technologies, Inc., Abstract This Application Note describes a method for sub-ppm host cell protein quantification in a mAb…
Key words
amol, amolpeptide, peptideprotein, proteinhcp, hcpsil, silhost, hostagilent, agilentlloq, lloqskyline, skylinequantification, quantificationdpgvldr, dpgvldrppm, ppmassaymap, assaymapresponses, responsespeptides
Application Note Biotherapeutics and Biosimilars In-depth Peptide Mapping with Iterative MS/MS Acquisition on the Agilent 6545XT AdvanceBio LC/Q‑TOF Authors Introduction Linfeng Wu and David L. Wong Agilent Technologies, Inc. Santa Clara, CA, USA Therapeutic monoclonal antibodies (mAbs) represent one of…
Key words
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Application Note Biotherapeutics and Biosimilars LC/MS/MS Peptide Mapping Comparison of Innovator and Biosimilars of Rituximab Author Suresh Babu C.V. Agilent Technologies, Inc. Abstract The development and manufacturing of biosimilars require comparability studies with innovator biotherapeutic products. This Application Note presents…
Key words
innovator, innovatorpeptide, peptidecounts, countsmapping, mappingchain, chainbiosimilar, biosimilarcharge, chargeunmodified, unmodifiedptms, ptmsheavy, heavyassaymap, assaymapbravo, bravomabs, mabsttppvldsdgsfflyskl, ttppvldsdgsfflysklbiosimilars
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