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TIMS enabled quantification of small moleculesin MALDI ImagingtimsTOF fleX was used to demonstrate quantitative mass spectrometry imaging onseveral drug compounds.AbstracttimsTOF fleX was able to separatenear-isobaric ions by their ionmobilities, significantly improvingtargeted compound specificityand sensitivity for quantitation in acomplex molecular environment.Higher...
Key words
timstof, timstofflex, flextims, timsmaldi, maldiions, ionsisobaric, isobaricgadavist, gadavistqmsi, qmsitopotecan, topotecanimaging, imagingtissue, tissuemmae, mmaeintensity, intensitydrug, drugpasef
QUANTITATIVE IMAGING MASS SPECTROMETRY OF ENDOGENOUS METABOLITES USING IN-LINEINTERNAL STANDARDS AND STABLE ISOTOPE LABELED MIMETIC MODELBindesh Shrestha,1 Khaja Muneeruddin,2 Scott A. Shaffer21Waters Corporation, Beverly, MA 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical SchoolINTRODUCTION•Quantitative spatial distributions of small...
Key words
imaging, imagingdesi, desimimetic, mimeticinaccessible, inaccessiblemetabolites, metabolitespixel, pixeltissue, tissuemolecules, moleculesmaldi, maldiendogenous, endogenousexogeneous, exogeneousquantiation, quantiationfuture, futuremass, massquantitative
[ TECHNOLOGY BRIEF ]Ovarian Cancerous Tissue Identification byDESI Imaging for Clinical ResearchLuisa Doria,1 Emmanuelle Claude, 2 and Zoltan Takats1Imperial College, London, UK; 2Waters Corporation, Wilmslow, UK1The use of DESI can help distinguish between severaldifferent tissue types in ovarian cancer samples...
Key words
desi, desitissue, tissueovarian, ovariantumor, tumorstroma, stromamsi, msiimages, imagesimaging, imagingstained, stainedcancer, cancerrois, roiscarcinoma, carcinomasupervised, supervisedbrief, briefassociated
[ APPLICATION NOTEBOOK ]MS IMAGING AND AMBIENT IONIZATION-MSFOR METABOLOMICS AND LIPIDOMICS1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245ENTABLE OF CONTENTS3 Introduction4 Biomarker Discovery Directly from Tissue Xenograph Using High Definition ImagingMALDI Combined with Multivariate...
Key words
imaging, imagingtissue, tissuemaldi, maldidesi, desihdi, hdisection, sectiondefinition, definitionmobility, mobilityion, ionhdms, hdmsimage, imagebiomarker, biomarkerspatial, spatialxenograph, xenographdata
 

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TIMS enabled quantification of small moleculesin MALDI ImagingtimsTOF fleX was used to demonstrate quantitative mass spectrometry imaging onseveral drug compounds.AbstracttimsTOF fleX was able to separatenear-isobaric ions by their ionmobilities, significantly improvingtargeted compound specificityand sensitivity for quantitation in acomplex molecular environment.Higher...
Key words
timstof, timstofflex, flextims, timsmaldi, maldiions, ionsisobaric, isobaricgadavist, gadavistqmsi, qmsitopotecan, topotecanimaging, imagingtissue, tissuemmae, mmaeintensity, intensitydrug, drugpasef
QUANTITATIVE IMAGING MASS SPECTROMETRY OF ENDOGENOUS METABOLITES USING IN-LINEINTERNAL STANDARDS AND STABLE ISOTOPE LABELED MIMETIC MODELBindesh Shrestha,1 Khaja Muneeruddin,2 Scott A. Shaffer21Waters Corporation, Beverly, MA 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical SchoolINTRODUCTION•Quantitative spatial distributions of small...
Key words
imaging, imagingdesi, desimimetic, mimeticinaccessible, inaccessiblemetabolites, metabolitespixel, pixeltissue, tissuemolecules, moleculesmaldi, maldiendogenous, endogenousexogeneous, exogeneousquantiation, quantiationfuture, futuremass, massquantitative
[ TECHNOLOGY BRIEF ]Ovarian Cancerous Tissue Identification byDESI Imaging for Clinical ResearchLuisa Doria,1 Emmanuelle Claude, 2 and Zoltan Takats1Imperial College, London, UK; 2Waters Corporation, Wilmslow, UK1The use of DESI can help distinguish between severaldifferent tissue types in ovarian cancer samples...
Key words
desi, desitissue, tissueovarian, ovariantumor, tumorstroma, stromamsi, msiimages, imagesimaging, imagingstained, stainedcancer, cancerrois, roiscarcinoma, carcinomasupervised, supervisedbrief, briefassociated
[ APPLICATION NOTEBOOK ]MS IMAGING AND AMBIENT IONIZATION-MSFOR METABOLOMICS AND LIPIDOMICS1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245ENTABLE OF CONTENTS3 Introduction4 Biomarker Discovery Directly from Tissue Xenograph Using High Definition ImagingMALDI Combined with Multivariate...
Key words
imaging, imagingtissue, tissuemaldi, maldidesi, desihdi, hdisection, sectiondefinition, definitionmobility, mobilityion, ionhdms, hdmsimage, imagebiomarker, biomarkerspatial, spatialxenograph, xenographdata
 

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