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SPATIAL MAPPING OF LIPIDS AND NEUROTRANSMITTER IN RAT BRAIN SECTIONS USING DESIION MOBILITY MASS SPECTROMETRYRoy Martin1, Anthony J. Midey1, Hernando J. Olivos1, Emmanuelle Claude2, Bindesh Shrestha11Waters Corporation, Milford, MA, USA and 2 Waters Corporation, Wimslow, United KingdomMETHODSABSTRACTDesorption Electrospray Ionization (DESI)...
Key words
desi, desisections, sectionsmobility, mobilitylipids, lipidsimaging, imagingmsi, msitissue, tissueccs, ccsbrain, braincollisional, collisionalion, ionmass, massmetabolite, metabolitecross, crossaided
[ TECHNOLOGY BRIEF ]Ion Mobility Separation Coupled With Desorption ElectrosprayIonization Mass Spectrometry for High Specificity MS ImagingEmmanuelle ClaudeDesorption Electrospray Ionization (DESI) imaging directlyfrom tissue section, followed by gas phase separation ofmolecules using ion mobility mass spectrometer.GOALTo demonstrate the advantages of...
Key words
desi, desiimaging, imagingtrendlines, trendlinescharged, chargeddoubly, doublyelectrospray, electrospraymobility, mobilityganglioside, gangliosideglycosphingolipids, glycosphingolipidsbrain, braintriply, triplymouse, mousedrift, driftions, ionscontinuum
[ APPLICATION NOTEBOOK ]MS IMAGING AND AMBIENT IONIZATION-MSFOR METABOLOMICS AND LIPIDOMICS1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245ENTABLE OF CONTENTS3 Introduction4 Biomarker Discovery Directly from Tissue Xenograph Using High Definition ImagingMALDI Combined with Multivariate...
Key words
imaging, imagingtissue, tissuemaldi, maldidesi, desihdi, hdisection, sectiondefinition, definitionmobility, mobilityion, ionhdms, hdmsimage, imagebiomarker, biomarkerspatial, spatialxenograph, xenographdata
Waters SYNAPT XS High Resolution Mass Spectrometer
2020|Waters|Brochures and specifications
Ultimate flexibility forDEEPERDISCOVERY Without discovery,decisions are made in the dark.In the arena of scientific discovery, the slow pace of advancement and escalatingcosts of research can prove challenging. Without efficient, expedient discovery thescientific translation process is obstructed, ultimately hindering the creation andimprovement...
Key words
sonar, sonarfragmentation, fragmentationsynapt, synaptims, imssuccess, succession, ionmobility, mobilitywaters, watersimaging, imagingmixtures, mixturespusher, pushertoolkit, toolkitstepwave, stepwavehdx, hdxyour
 

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SPATIAL MAPPING OF LIPIDS AND NEUROTRANSMITTER IN RAT BRAIN SECTIONS USING DESIION MOBILITY MASS SPECTROMETRYRoy Martin1, Anthony J. Midey1, Hernando J. Olivos1, Emmanuelle Claude2, Bindesh Shrestha11Waters Corporation, Milford, MA, USA and 2 Waters Corporation, Wimslow, United KingdomMETHODSABSTRACTDesorption Electrospray Ionization (DESI)...
Key words
desi, desisections, sectionsmobility, mobilitylipids, lipidsimaging, imagingmsi, msitissue, tissueccs, ccsbrain, braincollisional, collisionalion, ionmass, massmetabolite, metabolitecross, crossaided
[ TECHNOLOGY BRIEF ]Ion Mobility Separation Coupled With Desorption ElectrosprayIonization Mass Spectrometry for High Specificity MS ImagingEmmanuelle ClaudeDesorption Electrospray Ionization (DESI) imaging directlyfrom tissue section, followed by gas phase separation ofmolecules using ion mobility mass spectrometer.GOALTo demonstrate the advantages of...
Key words
desi, desiimaging, imagingtrendlines, trendlinescharged, chargeddoubly, doublyelectrospray, electrospraymobility, mobilityganglioside, gangliosideglycosphingolipids, glycosphingolipidsbrain, braintriply, triplymouse, mousedrift, driftions, ionscontinuum
[ APPLICATION NOTEBOOK ]MS IMAGING AND AMBIENT IONIZATION-MSFOR METABOLOMICS AND LIPIDOMICS1 This notebook is an excerpt from the larger Waters’ Application Notebook on Metabolomics and Lipidomics #720005245ENTABLE OF CONTENTS3 Introduction4 Biomarker Discovery Directly from Tissue Xenograph Using High Definition ImagingMALDI Combined with Multivariate...
Key words
imaging, imagingtissue, tissuemaldi, maldidesi, desihdi, hdisection, sectiondefinition, definitionmobility, mobilityion, ionhdms, hdmsimage, imagebiomarker, biomarkerspatial, spatialxenograph, xenographdata
Waters SYNAPT XS High Resolution Mass Spectrometer
2020|Waters|Brochures and specifications
Ultimate flexibility forDEEPERDISCOVERY Without discovery,decisions are made in the dark.In the arena of scientific discovery, the slow pace of advancement and escalatingcosts of research can prove challenging. Without efficient, expedient discovery thescientific translation process is obstructed, ultimately hindering the creation andimprovement...
Key words
sonar, sonarfragmentation, fragmentationsynapt, synaptims, imssuccess, succession, ionmobility, mobilitywaters, watersimaging, imagingmixtures, mixturespusher, pushertoolkit, toolkitstepwave, stepwavehdx, hdxyour
 

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