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[ TECHNOLOGY BRIEF ]Evaluating BioAccord LC-MS System Performance for Deployment of aCompact, SmartMS-Enabled Biopharma Solution in Late Stage Developmentand QC Environment – Intact Mass AnalysisHenry Shion, Jonathan Pugh, Jill Lord, Yun Alelyunas, Ying Qing Yu and Weibin Chen. Waters Corporation,...
Key words
bioaccord, bioaccordsystem, systeminter, interglycoforms, glycoformsintact, intactfive, fiveintra, intrareproducibility, reproducibilitymajor, majormass, massrsd, rsdstudy, studysystems, systemsbrief, briefabundance
Meeting the Challenges of Implementing Accurate-Mass Mass Spectrometry for Biotherapeutic Development inRegulated/non-Regulated EnvironmentsHenry Shion; Nilini Ranbaduge; Ximo Zhang; Ying Qing Yu; Weibin Chen; and Scott BergerWaters CorporaƟon, Milford , MA, USAINTRODUCTIONDespite the widespread practice of exact-mass massspectrometry (MS) analysis in...
Key words
bioaccord, bioaccordmab, mabnist, nistmass, massanalysis, analysisglycan, glycanmapping, mappingintact, intactsubunit, subunitpeptide, peptidechallenges, challengesimplementing, implementingsystem, systembiotheropeutics, biotheropeuticsrapiflour
[ TECHNOLOGY BRIEF ]Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometryon the BioAccord SystemHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USADrug-to-Antibody Ratio (DAR) determination of Lys andCys conjugated ADCs was accomplished using analyticalscale size...
Key words
bioaccord, bioaccordconjugated, conjugatedadc, adcdar, daradcs, adcsnative, nativedrug, drugsystem, systemantibody, antibodycovalent, covalentbrief, briefsec, secconjugates, conjugatescysteine, cysteinelysine
BIOPHARMACEUTICALPLATFORM SOLUTIONKey Applications TABLE OF CONTENTSBiopharmaceutical Platform Solution with UNIFI:Key ApplicationsIntact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I BioseparationsBiotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drugconjugates (ADCs) – are among the fastest growing...
Key words
unifi, unifibiopharmaceutical, biopharmaceuticaluplc, uplcglycan, glycanacquity, acquityplatform, platformglycoworks, glycoworksglycans, glycanspeptide, peptidesolution, solutionbiosimilar, biosimilarintact, intactanalysis, analysisinnovator, innovatorwaters
 

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[ TECHNOLOGY BRIEF ]Evaluating BioAccord LC-MS System Performance for Deployment of aCompact, SmartMS-Enabled Biopharma Solution in Late Stage Developmentand QC Environment – Intact Mass AnalysisHenry Shion, Jonathan Pugh, Jill Lord, Yun Alelyunas, Ying Qing Yu and Weibin Chen. Waters Corporation,...
Key words
bioaccord, bioaccordsystem, systeminter, interglycoforms, glycoformsintact, intactfive, fiveintra, intrareproducibility, reproducibilitymajor, majormass, massrsd, rsdstudy, studysystems, systemsbrief, briefabundance
Meeting the Challenges of Implementing Accurate-Mass Mass Spectrometry for Biotherapeutic Development inRegulated/non-Regulated EnvironmentsHenry Shion; Nilini Ranbaduge; Ximo Zhang; Ying Qing Yu; Weibin Chen; and Scott BergerWaters CorporaƟon, Milford , MA, USAINTRODUCTIONDespite the widespread practice of exact-mass massspectrometry (MS) analysis in...
Key words
bioaccord, bioaccordmab, mabnist, nistmass, massanalysis, analysisglycan, glycanmapping, mappingintact, intactsubunit, subunitpeptide, peptidechallenges, challengesimplementing, implementingsystem, systembiotheropeutics, biotheropeuticsrapiflour
[ TECHNOLOGY BRIEF ]Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometryon the BioAccord SystemHenry Shion, Ying Qing Yu, and Weibin ChenWaters Corporation, Milford, MA, USADrug-to-Antibody Ratio (DAR) determination of Lys andCys conjugated ADCs was accomplished using analyticalscale size...
Key words
bioaccord, bioaccordconjugated, conjugatedadc, adcdar, daradcs, adcsnative, nativedrug, drugsystem, systemantibody, antibodycovalent, covalentbrief, briefsec, secconjugates, conjugatescysteine, cysteinelysine
BIOPHARMACEUTICALPLATFORM SOLUTIONKey Applications TABLE OF CONTENTSBiopharmaceutical Platform Solution with UNIFI:Key ApplicationsIntact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I BioseparationsBiotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drugconjugates (ADCs) – are among the fastest growing...
Key words
unifi, unifibiopharmaceutical, biopharmaceuticaluplc, uplcglycan, glycanacquity, acquityplatform, platformglycoworks, glycoworksglycans, glycanspeptide, peptidesolution, solutionbiosimilar, biosimilarintact, intactanalysis, analysisinnovator, innovatorwaters
 

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