SmartMS-ENABLED LC-MS SYSTEM FOR BIOTHERAPEUTIC DEVELOPMENT IN REGULATED/NON-REGULATED ENVIRONMENTS

 

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BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…
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APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…
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Integrated characterization of a lysine-linked antibody-drug conjugate by native intact mass analysis and peptide mapping performed on a hybrid quadrupole-Orbitrap mass spectrometer with high mass range Aaron O. Bailey 1, Stephane Houel 1, Eugen Damoc 2, Kai Scheffler 3, Jonathan…
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Meeting the Challenges of Implementing Accurate-Mass Mass Spectrometry for Biotherapeutic Development in Regulated/non-Regulated Environments Henry Shion; Nilini Ranbaduge; Ximo Zhang; Ying Qing Yu; Weibin Chen; and Scott Berger Waters CorporaƟon, Milford , MA, USA INTRODUCTION    Despite the…
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