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HIGH SENSITIVITY LC-MS PROFILING OF ANTIBODY DRUG CONJUGATES WITH DIFLUOROACETIC ACID ION PAIRING AND A HIGH-COVERAGE PHENYL-BONDED STATIONARY PHASE

 

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[ APPLICATION NOTE ] A Novel Phenyl Bonded Phase for Improved Reversed-Phase Separations of Proteins Jennifer M. Nguyen, Lavelay Kizekai, Dan Walsh, Jim Cook, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Polyphenyl bonded phase…
Key words
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Using Hydrophilic Interaction Chromatography for Heightened Product Characterization to Overcome Challenges with Hydrophobic Monoclonal Antibodies and Antibody Drug Conjugates Jacquelynn Smith,1 Matthew A. Lauber,3 Stephan M. Koza,3 Erin E. Chambers,3 Jason C. Rouse,2 and Olga V. Friese1 Biotherapeutics Pharm. Sci.,…
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[ APPLICATION NOTE ] Improving the Recovery of Intact Antibodies from Reversed-Phase Separations Using a BioResolve RP mAb Polyphenyl Column Ximo Zhang, Robert Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Method for improving the…
Key words
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Biomolecule Purification, Characterization, and Analysis
2019|Waters|Brochures and specifications
Biomolecule Purification, Characterization, and Analysis Innovative Technologies from the Leader in Separation Science and Analytical Biochemistry Advances in the areas of genomics, proteomics, metabolomics, and molecular and system biology continue to revolutionize the diagnosis and treatment of diseases and increase…
Key words
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