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Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column

 

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[ APPLICATION NOTE ] Development of pH Gradient Mobile Phase Concentrates for Robust, High Resolution mAb Charge Variant Analysis Qi Wang, Susan C. Rzewuski, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Platform method…
Key words
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[ APPLICATION NOTE ] Designing a New Particle Technology for Robust Charge Variant Analysis of mAbs Matthew A. Lauber, Susan C. Rzewuski, Qi Wang, Hua Yang, Stephan Koza, MingCheng Xu, Mike Morris, Justin McLaughlin, Steve Shiner, and Bei Niu Waters…
Key words
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METHOD DEVELOPMENT OF IONIC-STRENGTH GRADIENT CATION EXCHANGE CHROMATOGRAPHY FOR MONOCLONAL ANTIBODY CHARGE VARIANT ANALYSIS Authors: Hua Yang, Bill Warren and Stephan M. Koza Affiliations: Waters Corporation, Milford, MA 01757 INTRODUCTION Charge heterogeneity in therapeutic proteins including monoclonal antibodies (mAbs) needs…
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[ APPLICATION NOTE ] Optimizing LC-MS Separations of mAbs using a BioResolve SCX mAb Column and IonHance CX-MS pH Concentrates Andrew Schmudlach, Samantha Ippoliti, Qi Wang, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION A novel…
Key words
ionhance, ionhanceconcentrates, concentratesbioresolve, bioresolvescx, scxmab, mabmonoclonal, monoclonalmabs, mabsoptimizing, optimizingacquity, acquityexchange, exchangeammonium, ammoniumcharge, chargeseparations, separationsvariant, variantnote
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