Epistane analysis

The Epistane Analysis is a targeted laboratory test designed to confirm the identity and determine the amount of epistane in oral dosage forms and raw active pharmaceutical ingredient (API) powders. 

The analysis is suitable for tablets and capsules, with results reported in milligrams per individual dosage unit. Raw API powders can be evaluated by percentage content, with optional purity reporting in % (m/m).

About Epistane

Epistane, also known as methylepitiostanol or 2,3-thioepoxy madol, is a synthetic, orally active anabolic-androgenic steroid structurally related to dihydrotestosterone (DHT). It is a 17α-methylated derivative of epitiostanol and interacts with androgen receptors, producing anabolic and androgenic effects.

Epistane has been identified in products marketed as dietary or performance-enhancing supplements. Scientific studies have also associated its use with a risk of liver injury, including cholestasis.

Key Features

• Targeted identification and quantification of epistane
• Suitable for tablets, capsules, and raw API powders
• Analysis by HPLC
• Results for oral products reported in mg per tablet or capsule
• Results for raw API powders reported as percentage content
• Optional purity reporting in % (m/m) for raw API powders
• Minimum sample amount of three tablets or capsules
• Minimum sample amount of 200 mg for raw API powders
• Average turnaround time of 7 business days

Analysis Parameters

• Target compound: Epistane
• Other names: Hemapolin, 2,3-thioepoxy madol
• CAS number: 4267-80-5
• Testing method: HPLC
• Minimum amount of target compound for evaluation in oral products: 4 mg per tablet / capsule
• Minimum content of target compound for evaluation in raw API powders: 10%
• Result format for oral products: mg per tablet or capsule
• Result format for raw API powders: % [98%+, 96%+ or % value such as 94.15%]
• Minimum sample amount for oral products: 3 tablets / capsules
• Minimum sample amount for raw API powders: 200 mg
• Average turnaround time: 7 business days

Optional Additional Analyses

The following optional laboratory services are available:

• Complete Raw Analytical Data
• Alternative Result Format: Purity in % (m/m) - only for raw API powders
• Batch Variance Testing
• Fentanyl Screening
• GC–MS Contamination Screening
• Heavy Metals Analysis (As, Cd, Pb, Hg)
• Additional Laboratory Report