<div><div><div><p><strong>Scientists at IOCB Prague have developed a breakthrough technology that streamlines aptamer development. The new method integrates several biochemical and bioinformatics steps and paves the way for new diagnostic and therapeutic applications. Ongoing applications include wearable sensors that monitor selected biomarkers in real time and provide early warnings of impending health complications. The findings were published in </strong><i><strong>Nature Communications</strong></i><strong>.</strong></p></div></div><div><p>Aptamers are short DNA or RNA strands that can recognize and bind to a specific target molecule with high precision. Similar to antibodies, they can be used to detect these molecules or modulate their activity. Unlike antibodies, they are much more stable, can be produced synthetically, and can be chemically modified to achieve the desired properties. As a result, they can offer capabilities that cannot be achieved with antibodies.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg" alt="IOCHB Prague: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Chemically modified DNA aptamer bound to the target protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg 228w," sizes="100vw" width="1343" height="916"></p><p>As demand grows for accurate and rapid diagnostic tools, aptamers are often better suited to these applications than antibodies. However, developing aptamers is both experimentally demanding and time-consuming. A team of scientists from IOCB Prague, led by Dr. Marek Ondruš and <a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en"><strong>Prof. Michal Hocek</strong></a>, has now developed a technology that significantly shortens the development process.</p><p><i>“Developing an aptamer is often like looking for a needle in a haystack. Among trillions of different DNA sequences, we search for the one that binds strongly and specifically to a target molecule. Our new approach first screen for ‘aptamer families’ – hundreds of related sequences – and then identify the best-performing member of the family. This approach can reduce development time from several months to only a few days,” </i>says Marek Ondruš.</p><blockquote><p><strong>Video:</strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=_3zXUeVMugU"> New technology streamlines the development of aptamers, synthetic alternatives to antibodies&nbsp;</a></p></blockquote><p>The team has also expanded the potential applications of aptamers by chemically modifying their building blocks. For example, introducing functional groups similar to those found naturally in amino acids allows the resulting molecules to combine the advantages of both DNA and antibodies: Their sequence is encoded by the order of nucleotides in DNA, while the attached chemical modifications greatly expand their ability to recognize biologically relevant targets and mimic interactions between proteins that are underlying many biological processes.</p><p>The researchers demonstrated the potential of this new method using the human insulin receptor, a key protein that regulates blood sugar levels. They developed an aptamer that specifically binds to the receptor and elucidated the molecular basis of this interaction using cryo-electron microscopy. <i>“We have shown that chemically introduced functional groups play a crucial role not only in target recognition and formation of the aptamer–protein complex, but also in stabilizing the DNA aptamer’s structure. Our findings provide new insights into how chemically modified nucleic acids can mimic key properties of proteins,”</i> says Marek Ondruš.</p><p>In the future, the technology could complement – or, in some applications, even replace – antibody-based diagnostic tools. Researchers are collaborating with <a target="_blank" rel="noopener noreferrer" href="http://iocbtech.cz/">IOCB Tech</a> on its further development, as the company helps to bring discoveries from IOCB Prague into practical applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg" alt="IOCHB Prague/Tomáš Belloň: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Dr. Marek Ondruš, first author of the study, and Prof. Michal Hocek, head of the Bioorganic and Medicinal Chemistry of Nucleic Acids research group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg 234w," sizes="100vw" width="2000" height="1335"></p><blockquote><h4><strong>Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-73676-y#citeas"><strong>Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries</strong></a></h4><p>ablo Alberto Franco-Urquijo, Marek Ondruš, Jaroslav Kurfürst, Jana Škerlová, Irena Selicharová, Lucie Mužíková Čechová, Hana Šváchová, Alena Semerádtová, Anatolij Filimoněnko, Adéla Fejfarová, Jiří Homola, Tomáš Kouba &amp; Michal Hocek</p><p><i><strong>Nat. Commun., 2026</strong></i></p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41467-026-73676-y"><span>https://doi.org/10.1038/s41467-026-73676-y</span></a><span>&nbsp;</span></p><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable of identifying high-affinity modified aptamers. Double partition followed by amplification of eluted sequences, NGS analysis and clustering provides fast identification of aptamer candidates. Screening of modified DNA libraries containing modified adenine and uracil nucleotides bearing hydrophobic aromatic phenyl and indole moieties results in development of an aptamer binding human insulin receptor with sub-nanomolar affinity and exquisite specificity. Cryo-EM structure reveals the importance of each aromatic modification, either in stabilizing the secondary structure or facilitating interactions with the protein surface. This approach addresses the main drawbacks of aptamer selection and has potential for high-throughput screening and accelerating the development of next-generation aptamers for diagnostics or therapeutics.</p></div>

New technology streamlines the development of aptamers, synthetic alternatives to antibodies

<p><strong>Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity</strong></a><strong> 10.2 highlights</strong></h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4><strong>Instrument control modules</strong></h4><p>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"></p><h4><strong>MS data import/export improvements</strong></h4><p>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"></p><h4><strong>Obsolete hardware support terminated</strong></h4><p>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"></p><blockquote><p><strong>Explore the complete list of all changes, fixes, and additions in version 10.2.</strong></p><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1"><strong>See the complete changelog&nbsp;</strong></a></p></blockquote>

Clarity Chromatography Software 10.2 released!

<p><strong>🎤Dr. Leigh Terry (University of Alabama)</strong></p><p><strong>In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.</strong></p><p>While most regulatory methods focus on a small number of compounds like PFOA and PFOS, there may be thousands of PFAS compounds in the environment—and much of that burden goes undetected.</p><h4><strong>In this episode, we cover:</strong></h4><ul><li>Why PFAS are called “forever chemicals” (and why that label is evolving)</li><li>The limitations of targeted<strong> LC-MS/MS methods</strong></li><li>What the fluorine mass balance problem reveals about PFAS destruction</li><li>How combustion ion chromatography (<strong>CIC</strong>) helps measure total organofluorine</li><li>Why “99.99% removal” doesn’t always mean what you think</li><li>Where PFAS actually end up in wastewater treatment systems</li><li>The most effective technologies for PFAS removal today</li><li>Why drinking water may only account for ~20% of total PFAS exposure</li></ul><h4><strong>Key Insight:</strong></h4><p>Even when analyzing dozens of PFAS compounds, researchers may only be capturing a small fraction of total organic fluorine—raising major questions about how we monitor and regulate these contaminants.</p><h3><strong>Video Transcription</strong></h3><p>In this episode of <i>Concentrating on Chromatography</i>, Dr. Leigh Terry discusses PFAS contamination in drinking water, the analytical challenges associated with measuring these compounds, current treatment technologies, and future directions for monitoring and regulation. The conversation highlights how analytical chemistry, environmental engineering, and public health intersect in addressing one of today's most discussed classes of emerging contaminants.</p><h4><strong>Understanding PFAS and Their Significance</strong></h4><h5><strong>The University of Alabama Water Quality Research Center</strong></h5><p>Dr. Leigh Terry is part of the University of Alabama's Center for Water Quality Research. The center operates an analytical laboratory focused on drinking water quality and the detection of contaminants at extremely low concentrations.</p><p>The laboratory specializes in:</p><ul><li>Drinking water analysis</li><li>Organic contaminants</li><li>Emerging contaminants</li><li>PFAS monitoring</li><li>Water quality research</li></ul><p>Their work supports both research initiatives and practical solutions for water utilities and environmental agencies.</p><h4><strong>Why Focus on PFAS?</strong></h4><p>Although PFAS compounds have existed since the 1940s, public awareness has increased dramatically only in recent years.</p><p>According to Dr. Terry, several factors contributed to the rapid growth of PFAS research:</p><ul><li>Increased media attention</li><li>New regulatory initiatives</li><li>Growing evidence of human exposure</li><li>Expanding research opportunities</li><li>Greater understanding of potential health risks</li></ul><p>PFAS are not new contaminants. Rather, society is only beginning to understand their prevalence in the environment and their potential impacts on human health.</p><h4><strong>The Development of Standardized PFAS Methods</strong></h4><p>One major advancement in PFAS analysis has been the development of standardized EPA methods.</p><p>These methods allow:</p><ul><li>Consistent testing procedures</li><li>Comparable results between laboratories</li><li>Regulatory monitoring</li><li>Reliable data interpretation</li></ul><p>Dr. Terry notes that many of these standardized approaches began appearing around 2018–2019, providing a common framework for analytical laboratories and researchers.</p><h4><strong>How Large Is the PFAS Universe?</strong></h4><p>Many people are familiar with PFOA and PFOS, two of the most heavily studied PFAS compounds. However, these represent only a small fraction of the broader PFAS family.</p><p>PFOA and PFOS are often referred to as:</p><ul><li>Legacy PFAS compounds</li><li>Original PFAS contaminants</li><li>Early commercial PFAS chemicals</li></ul><p>The challenge is that even minor modifications to molecular structure create entirely new PFAS compounds.</p><p>Researchers estimate:</p><ul><li>Thousands of PFAS compounds exist</li><li>Some estimates exceed 10,000 compounds</li><li>Exact numbers depend on how PFAS are defined</li></ul><p>Scientific debate continues regarding classification and definition, making precise counting difficult.</p><h4><strong>Why PFAS Are Called "Forever Chemicals"</strong></h4><p>Dr. Terry notes that the phrase "forever chemicals" has become widely used, although she suggests the terminology could benefit from rebranding.</p><p>PFAS persistence results from two key chemical properties.</p><h5><strong>1. Amphiphilic Structure</strong></h5><p>PFAS molecules contain:</p><ul><li>A water-loving (hydrophilic) head group</li><li>A water-repelling (hydrophobic) fluorinated tail</li></ul><p>This unusual combination allows PFAS to partition between:</p><ul><li>Water</li><li>Solids</li><li>Air-water interfaces</li><li>Foam</li></ul><p>Unlike many organic compounds, PFAS can interact effectively with multiple environmental phases.</p><h5><strong>2. Extremely Strong Carbon–Fluorine Bonds</strong></h5><p>The carbon–fluorine bond is among the strongest bonds in organic chemistry.</p><p>As Dr. Terry explains:</p><ul><li>Large amounts of energy are required to break these bonds</li><li>Natural degradation processes are often ineffective</li><li>Destruction can require highly aggressive treatment conditions</li></ul><p>These properties make PFAS extremely persistent in both environmental systems and biological organisms.</p><h4><strong>Toxicity, Regulations, and Environmental Behavior</strong></h4><h5><strong>Understanding PFAS Toxicity</strong></h5><p>One of the biggest challenges in PFAS regulation is the incomplete understanding of toxicity.</p><p>Dr. Terry explains that EPA regulations generally consider three factors:</p><ul><li>Presence in drinking water sources</li><li>Toxicity to humans</li><li>Availability of practical treatment options</li></ul><p>While some PFAS compounds are known to be harmful, many others remain insufficiently studied. Furthermore, PFAS often occur as mixtures rather than individual compounds.</p><p>This creates important scientific questions:</p><ul><li>What is the toxicity of individual PFAS?</li><li>What is the toxicity of PFAS mixtures?</li><li>How should cumulative exposure be evaluated?</li></ul><p>These uncertainties continue to drive active research.</p><h4><strong>What Happens to PFAS in Wastewater Treatment Plants?</strong></h4><p>PFAS do not behave like many conventional contaminants.</p><p>Rather than remaining fully dissolved in water, they often accumulate at interfaces such as:</p><ul><li>Water-solid interfaces</li><li>Water-air interfaces</li><li>Foam layers</li><li>Biological solids</li></ul><p>As a result:</p><ul><li>Some PFAS accumulate in biosolids</li><li>Some partition into foam</li><li>Some remain in treated effluent</li></ul><p>Their distribution depends on wastewater composition and treatment processes.</p><h4><strong>Regulatory Monitoring and Targeted LC-MS Analysis</strong></h4><p>Current EPA regulations focus on targeted analysis of specific PFAS compounds.</p><p>Examples include:</p><ul><li>PFOA</li><li>PFOS</li></ul><p>Drinking water regulations currently establish maximum contaminant levels (MCLs) for these compounds at extremely low concentrations.</p><p>Advantages of targeted LC-MS analysis include:</p><ul><li>Clearly defined analytes</li><li>Established regulatory limits</li><li>High analytical sensitivity</li><li>Reliable quantitation</li></ul><p>However, limitations remain:</p><ul><li>Only a small subset of PFAS is measured</li><li>Many PFAS compounds remain undetected</li><li>Total PFAS burden may be underestimated</li></ul><p>As Dr. Terry notes, targeted analysis provides only part of the overall picture.</p><h4><strong>The Fluorine Mass Balance Problem</strong></h4><p>One of the most important concepts discussed in the interview is fluorine mass balance.</p><p>When PFAS degrade, fluorinated fragments may remain in the environment.</p><p>This creates a critical question:</p><p>Are treatment technologies truly destroying PFAS, or merely transforming them into shorter-chain PFAS compounds?</p><p>To answer this, researchers perform fluorine mass balance calculations using:</p><ul><li>Targeted PFAS analysis</li><li>Fluoride measurements</li><li>Total organic fluorine measurements</li></ul><p>A successful destruction process should ultimately convert PFAS into fluoride ions rather than simply producing smaller PFAS molecules.</p><h4><strong>Advanced Analysis, Treatment Technologies, and Future Directions</strong></h4><h5><strong>Combining Targeted and Bulk Fluorine Measurements</strong></h5><p>Dr. Terry's group complements targeted LC-MS analysis with measurements of total organic fluorine.</p><p>Approaches include:</p><ul><li>Absorbable Organic Fluorine (AOF)</li><li>Extractable Organic Fluorine (EOF)</li><li>Combustion Ion Chromatography (CIC)</li></ul><p>In these methods:</p><ul><li>Organic fluorine is captured</li><li>Samples are combusted</li><li>Released fluoride is quantified</li></ul><p>This provides insight into total fluorinated content, although contributions may originate from sources beyond PFAS, including pharmaceuticals and consumer products.</p><h4><strong>Surprising Findings from Combined Analysis</strong></h4><p>One important finding from wastewater studies was that targeted PFAS measurements accounted for only a small fraction of total organic fluorine.</p><p>Dr. Terry reports that:</p><ul><li>Approximately 4% of measured AOF could be explained by targeted PFAS compounds</li><li>The majority of organic fluorine remained unidentified</li></ul><p>This suggests that environmental fluorine chemistry is considerably more complex than currently represented by routine monitoring programs.</p><h4><strong>Preventing PFAS Contamination in the Laboratory</strong></h4><p>PFAS analysis requires exceptionally strict quality control.</p><p>Dr. Terry's laboratory routinely:</p><ul><li>Tests every new batch of SPE cartridges</li><li>Tests carbon tubes before use</li><li>Uses DI water blanks</li><li>Verifies consumables labeled as PFAS-free</li><li>Collects field blanks</li><li>Monitors analytical blanks throughout workflows</li></ul><p>These practices help prevent contamination from laboratory materials and consumables, a common challenge in ultra-trace PFAS analysis.</p><h4><strong>Current PFAS Treatment Technologies</strong></h4><p>Three technologies currently dominate PFAS removal in drinking water treatment:</p><ul><li>Granular Activated Carbon (GAC)</li><li>Ion Exchange Resins</li><li>Reverse Osmosis (RO)</li></ul><p>Selection depends on:</p><ul><li>PFAS concentration</li><li>Water quality</li><li>Local operating conditions</li><li>Utility infrastructure</li></ul><p>Although many emerging technologies are being investigated, these remain the most widely implemented solutions.</p><h4><strong>Membrane Filtration and Pretreatment</strong></h4><p>Dr. Terry collaborates with colleagues studying membrane-based PFAS treatment.</p><p>Her own work focuses on pretreatment through biological filtration.</p><p>The strategy involves:</p><ul><li>Removing natural organic matter</li><li>Reducing membrane fouling</li><li>Improving membrane performance</li><li>Extending operational efficiency</li></ul><p>This integrated approach demonstrates how multiple treatment technologies can work together to improve PFAS removal.</p><h4><strong>Regional Monitoring Projects</strong></h4><p>The University of Alabama team participates in EPA-supported monitoring efforts along the Gulf Coast.</p><p>Their observations indicate:</p><ul><li>PFAS rarely occur alone</li><li>Multiple PFAS compounds frequently co-occur</li><li>Contamination often originates from identifiable point sources</li></ul><p>Examples include:</p><ul><li>Industrial facilities</li><li>Manufacturing operations</li><li>Military installations</li><li>Carpet manufacturing facilities</li></ul><p>Source identification remains a critical component of environmental monitoring programs.</p><h4><strong>Future Directions for PFAS Monitoring</strong></h4><p>Looking ahead, Dr. Terry sees several opportunities for improvement.</p><p>Desired advances include:</p><ul><li>In situ monitoring technologies</li><li>Portable detection systems</li><li>Reduced analytical complexity</li><li>Lower instrument costs</li><li>Less expensive consumables</li><li>Faster analysis workflows</li></ul><p>Current PFAS testing requires substantial expertise, specialized instrumentation, and rigorous quality control, making widespread implementation challenging.</p><h4><strong>Dr. Terry's Perspective on Long-Term Solutions</strong></h4><p>When asked what major PFAS challenge she would most like to solve, Dr. Terry offered a broader perspective.</p><p>Rather than focusing solely on remediation, she emphasized prevention.</p><p>Her view is that society should:</p><ul><li>Better evaluate chemical toxicity before commercialization</li><li>Assess risks before large-scale deployment</li><li>Reduce introduction of harmful compounds into the environment</li><li>Support utilities tasked with contaminant removal</li></ul><p>She notes that water utilities often bear the responsibility of removing contaminants they did not create, highlighting the need for broader societal and regulatory support.</p><h4><strong>Final Thoughts</strong></h4><p>Dr. Terry encourages consumers to:</p><ul><li>Learn where their drinking water originates</li><li>Read annual water quality reports</li><li>Stay informed about local water quality</li><li>Consider appropriate home filtration where needed</li></ul><p>At the same time, she emphasizes confidence in municipal water systems and the importance of continued investment in water quality research, monitoring, and treatment technologies.</p><h4><strong>Conclusion</strong></h4><p>PFAS remain one of the most complex challenges in environmental chemistry and water treatment. Through advanced analytical methods such as LC-MS/MS, combustion ion chromatography, fluorine mass balance approaches, and large-scale monitoring programs, researchers like Dr. Leigh Terry are helping improve our understanding of these persistent contaminants.</p><p>The interview highlights that solving the PFAS challenge will require a combination of better analytical tools, improved treatment technologies, stronger regulatory frameworks, and a greater emphasis on prevention before contaminants enter the environment.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

PFAS in Water: Why We’re Missing 96% of the Problem

Article

Product

Video

Scientists

Environment

Water

Interview

Science and research

Software

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Watrex Streamline™ UV1 HPLC detector, Stainless Steel

The Streamline™ UV1 HPLC detector offers an excellent signal-to-noise ratio, making it ideal for demanding applications.

<p>Watrex Streamline™ UV1 programmable UV/VIS detector exhibits excellent <strong>signal-to-noise</strong> ratio for even the most demanding applications. It is equipped with standard analytical cell. It has a <strong>2-lamp source</strong> (deuterium + tungsten), <strong>variable wavelength detector configuration</strong> suitable for operation between <strong>190 and 800 nm</strong>.</p><blockquote><p class="cke-user_style-important"><strong>Price 4 788 € ex VAT</strong></p></blockquote><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_Streamline_UV_1_UV_VIS_detector_686c6c9937.jpg" alt="Watrex: Streamline™ UV1 detector, Stainless Steel" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Watrex_Streamline_UV_1_UV_VIS_detector_686c6c9937.jpg 245w," sizes="100vw" width="945" height="436"></p><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Light Source:</strong> Deuterium Lamp, Tungsten Lamp</li><li><strong>Wavelength Range:</strong> 190 – 800 nm</li><li><strong>Baseline Noise:</strong> 1 x 10-5 AU (@240 nm, 2 sec. risetime)</li><li><strong>Baseline Drift:</strong> better than 3 x 10-4 AU/h</li><li><strong>Wavelenghth Reproducibility:</strong> ± 0.1 nm</li><li><strong>Linearity:</strong> better than 2.5 AU</li><li><strong>Analog Output:</strong> 1x 1 V</li></ul><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/detectors/uv-vis-detectors/streamline-uv1-detector/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

SIELC Alltesta Mini UV-Vis Detector

The Alltesta™ UV-Vis Multi-wavelength Mini Detector is a compact and versatile device that can continuously monitor the optical properties of solutions flowing through it.

<p><strong>The Alltesta™ UV-Vis Multi-wavelength Mini Detector is a compact and versatile device that can continuously monitor the optical properties of solutions flowing through it. The Mini Detector is ideal for use in HPLC, Flow Injection Analysis (FIA), and preparative and flash chromatography.</strong></p>
<p>The device comes standard with four different wavelength channels, including 470 nm (Blue), 520 nm (Green), 630 nm (Red), and a choice between 255 nm or 275 nm for the UV channel. The Mini Detector features a simple setup process with a USB interface that allows it to communicate with the <a href="https://lcms.labrulez.com/products/1242"><strong>Alltesta™ Gradient Automated Analyzer</strong></a> or <a href="https://lcms.labrulez.com/products/1243"><strong>Alltesta™ Cromite Analyzer</strong></a> or integrate with other instrumentation.</p>
<p>Powered solely by its USB port, this mini detector is capable of monitoring multiple analytes simultaneously. It has a low optical cell volume of &lt; 3 µL, which results in minimal dispersion even at low flow rates, and can collect data at rates of up to 20 sps for all four channels, making it suitable for demanding applications. The Mini Detector boasts low noise and linearity over more than 4 orders of magnitude.</p>
<p>In addition to its compact size and versatility, the Mini Detector also has zero warm-up time and exceptional durability. The detector cell volume is available in two sizes: 3 μL and 10 μL.</p>
<h4><strong>Specifications</strong></h4>
<ul>
<li>Dimensions (WHL): 63 x 46 x 116 mm / 2.48 x 1.81 x 4.57 in</li>
<li>Weight: 0.25 kg / 0.55 lb</li>
<li>Sample Cell Volume: &lt; 3µL</li>
<li>Cell Optical Path: 7.0mm</li>
<li>Liquid Ports: 10-32 UNF</li>
<li>Wavelength Range: 250nm &amp; up</li>
<li>Simultaneous Wavelengths: Up to 4</li>
<li>Data Rate: 20 sps</li>
<li>Noise Level: 0.03 mAU</li>
<li>Power: USB Type B</li>
</ul>
<h4><strong>Software</strong></h4>
<p>The Multi-wavelength Detector can be controlled:</p>
<ul>
<li>directly via serial commands (Alltesta™ protocol available upon request, please contact us at support@sielc.com),</li>
<li>directly via our demo software, allowing to learn the whole functionality of the unit (<a href="https://sielc.com/wp-content/uploads/2022/12/Alltesta_Detector_Control_Windows_10.zip"><strong>Windows 10, 32/64bit</strong></a>, 5Mb, <a href="https://sielc.com/wp-content/uploads/2022/12/Alltesta_Detector_Control_Windows_7.zip"><strong>Windows 7, 32/64bit</strong></a>, 127Mb)</li>
<li>remotely through our cloud software (as a part of <a href="https://lcms.labrulez.com/products/1242"><strong>Alltesta™ Gradient Automated Analyzer</strong></a> and <a href="https://lcms.labrulez.com/products/1243"><strong>Alltesta™ Cromite Analyzer</strong></a>).</li>
</ul>
<p>Serial Communication Drivers are available <a href="https://ftdichip.com/drivers/vcp-drivers/"><strong>here</strong></a>.</p>


ECOM LED20M FIX Dual UV Detector with display

The LED20M FIX Dual UV Detector with a display uses Light Emitting Diodes (LED) as the light source. It is used for flash chromatography.

<div style="display:block;" aria-labelledby="tab_item-0"><p>The <strong>LED20M FIX Dual UV Detector</strong> with a display uses <strong>Light Emitting Diodes (LED) </strong>as the light source. It is used for flash chromatography.</p><h3><strong>Why choose LED20M FIX detectors for your application</strong></h3><ul><li>The LED detectors allow easy and convenient detection in the UV-VIS range. They are manufactured in single or dual channel models with fixed wavelength setup.</li><li>The detectors are widely used in chromatography techniques using gravity glass columns for purification and isolation of organic small molecules and other compounds of interest. Long-lasting and reliable light source is provided by LED.</li><li>The <strong>optical flow cell </strong>is <strong>easily accessible </strong>and <strong>replaceable</strong>, this feature allows flexible choice of detection sensitivity if required. Low cell heating due to <strong>low power dissipation of LEDs</strong> makes this detector ideal for applications where analytes may be susceptible to degradation due to elevated temperatures. Absorbance information is displayed in detail on the <strong>integrated OLED display </strong>in <strong>numerical and graphical formats</strong>.</li><li>The units have convenient USB-C connectivity and power. When the detector is connected to a PC, the recorded data can be stored and processed using the ECOMAC software. ECOMAC basic software license is available with the price of the product without any additional fees. All these features and capabilities allow LED20M FIX to be an affordable, cost-effective, reliable and robust choice of an UV-VIS detector.</li></ul><h4><strong>Wavelengths</strong></h4><ul><li>The dual UV detector version measures at two fixed wavelengths, which are adjusted in production and given by the built-in LEDs.</li><li>By default, diodes with wavelengths of 255 and 280 nm are used. Optionally, the customer can select a wavelength in the range of 255–⁠⁠⁠⁠⁠⁠600 nm in steps of 5 nm.</li></ul><h4><strong>Control</strong></h4><ul><li>The detector can work without any additional SW support, but it is also possible to interconnect it via USB-C cable to a PC with <strong>ECOMAC SW</strong>, to get a data set for later use or to get reports for unit diagnostics.</li><li>The unit has an innovative PCB board that powers the LEDs, controls the unit, and has many new features, including higher sampling speed.</li></ul><h4><strong>Key features and benefits</strong></h4><ul><li><strong>OLED display</strong></li><li><strong>Numerical and graphical view mode</strong></li><li><strong>Long lifetime</strong> of the <strong>LED</strong> light source</li><li><strong>Low cell heating </strong>due to <strong>low power losses of the LEDs</strong></li><li><strong>USB C</strong> powering and communication port</li><li><strong>ECOMAC Basic software for free</strong></li><li><strong>Autozero</strong> function</li><li><strong>Easy flow cell replacement</strong></li><li>Small dimensions</li><li><strong>ECOMAC SW </strong>- &nbsp;sophisticated software for data acquisition and for diagnostics</li></ul></div>

ECOM LED20M FIX Single UV Detector with display

The LED20M FIX Single UV Detector with a display uses Light Emitting Diodes (LED) as the light source. It is used for flash chromatography.

<div style="display:block;" aria-labelledby="tab_item-0"><p>The <strong>LED20M FIX Single UV Detector</strong> with a display uses <strong>Light Emitting Diodes (LED) </strong>as the light source. It is used for flash chromatography.</p><h3><strong>Why choose LED20M FIX detectors for your application</strong></h3><ul><li>The LED detectors allow easy and convenient detection in the UV-VIS range. They are manufactured in single or dual channel models with fixed wavelength setup.</li><li>The detectors are widely used in chromatography techniques using gravity glass columns for purification and isolation of organic small molecules and other compounds of interest. Long-lasting and reliable light source is provided by LED.</li><li>The <strong>optical flow cell </strong>is <strong>easily accessible </strong>and <strong>replaceable</strong>, this feature allows flexible choice of detection sensitivity if required. Low cell heating due to <strong>low power dissipation of LEDs</strong> makes this detector ideal for applications where analytes may be susceptible to degradation due to elevated temperatures. Absorbance information is displayed in detail on the <strong>integrated OLED display </strong>in <strong>numerical and graphical formats</strong>.</li><li>The units have convenient USB-C connectivity and power. When the detector is connected to a PC, the recorded data can be stored and processed using the ECOMAC software. ECOMAC basic software license is available with the price of the product without any additional fees. All these features and capabilities allow LED20M FIX to be an affordable, cost-effective, reliable and robust choice of an UV-VIS detector.</li></ul><h3><strong>Wavelengths</strong></h3><ul><li>The single UV detector version measures at 1 fixed wavelength, which is adjusted in production and given by the built-in LEDs.</li><li>By default, diodes with wavelengths of 255 or 280 nm are used. Optionally, customers can select a wavelength within the range of 255–⁠⁠⁠⁠⁠⁠600 nm in steps of 5 nm.</li></ul><h3><strong>Control</strong></h3><ul><li>The detector can work without any additional SW support, but it is also possible to interconnect it via USB-C cable to a PC with <strong>ECOMAC SW</strong>, to get a data set for later use or to get reports for unit diagnostics.</li><li>The unit has an innovative PCB board that powers the LEDs, controls the unit, and has many new features, including higher sampling speed.</li></ul><h3><strong>Key features and benefits</strong></h3><ul><li><strong>Practical OLED display</strong></li><li><strong>Numerical and graphical view mode</strong></li><li><strong>Long lifetime</strong> of the <strong>LED</strong> light source</li><li><strong>Low cell heating </strong>due to <strong>low power losses of the LEDs</strong></li><li><strong>USB -C</strong> powering and communication port</li><li><strong>Autozero</strong> function</li><li><strong>Easy flow cell replacement</strong></li><li>Small dimensions</li><li><strong>ECOMAC SW </strong>- &nbsp;sophisticated software for data acquisition and for diagnostics</li></ul><p><strong>Note:</strong> A preparative cell PFC 200 Basic is supplied with the unit. Other flow cells are available at request.</p></div>

ECOM LED20G Dual UV Detector

LED20G Dual UV detector for preparative and flash chromatography. ECOM's unique patented technology radically improves the detectors´ features. LEDs are used as the source of light.

<div style="display:block;" aria-labelledby="tab_item-0"><p><strong>LED20G Dual UV LED detector for preparative and flash liquid chromatography.</strong> LEDs (Light Emitting Diodes) are used as the light source. <strong>A unique and patented ECOM technology radically improves the detector characteristics.&nbsp;</strong></p><p>The LEDs themselves typically have a peak wavelength with a tolerance of +/- 5 nm and a spectral half-width of 10-20 nm, which is unacceptable for some applications, as e.g. for FPLC. This ECOM solution, however, allows the spectral width to be narrowed and, thanks to our patented technology, the exact wavelength to be selected from the LED spectrum.</p><p>This version of the dual UV detector measures at two fixed wavelengths given by the installed LEDs.</p><p>The default wavelengths are 254 and 280 nm. Optionally, the customer can select a wavelength in the range 254-600 nm in 1 nm steps.</p><p>The unit is controlled by an innovative printed circuit board that powers the LEDs, controls the unit, and has many new features including higher sampling speed.</p><h3><strong>Key features and benefits</strong></h3><ul><li>Sharp, high, and symmetrical peaks thanks to the ECOM patented technology</li><li>Excellent linearity</li><li>Excellent price-performance ratio</li><li>Compact device dimensions</li><li>Low cell heating due to LED low power supply (0.7 W) allows use for peptide analysis or FPLC</li><li>Easy flow cell replacement</li><li>Higher sampling speed</li><li>Sophisticated diagnostic software</li><li>Diodes with wavelengths of 254 and 280 nm and a PFC cell with an optical path length of 2 mm are used as standard.</li><li>Other cells and wavelengths on request.</li></ul><h3><strong>Parameters</strong></h3><ul><li><strong>Number of channels (Signals):</strong> Two fix wavelength</li><li><strong>Typical spectral half-width&nbsp;:</strong> 4</li><li><strong>Light source:</strong> LEDs</li><li><strong>Noise level at test cell (254 nm, TC 0.75 s):</strong> ± 10x10-6 AU</li><li><strong>Drift at test cell (254 nm after 1 h):</strong> 1x10-3 AU/hr</li><li><strong>Communication:</strong> Remote digital I/O</li><li><strong>Power supply:</strong> 12-24 V DC</li><li><strong>Power input:</strong> 2 W</li><li><strong>Materials in contact with mobile phase:</strong> FEP; fused silica, stainless steel (cell)</li><li><strong>Communication interface:</strong> USB-C</li><li><strong>Optical cables:</strong> no</li><li><strong>Dimensions W x H x D:</strong> 193 x 70 x 40 mm (7.60 x 2.76 x 1.57 in)</li><li><strong>Weight:</strong> 0.66 kg (1.46 Ibs)</li></ul></div>

Watrex Streamline™ UV1 HPLC detector, PEEK

The Streamline™ UV1 detector offers an excellent signal-to-noise ratio, making it ideal for demanding applications.

<p>Watrex Streamline™ UV1 programmable UV/VIS detector exhibits excellent <strong>signal-to-noise</strong> ratio for even the most demanding applications. It is equipped with standard analytical cell. It has a <strong>2-lamp source</strong> (deuterium + tungsten), <strong>variable wavelength detector configuration</strong> suitable for operation between <strong>190 and 800 nm</strong>.</p><blockquote><p class="cke-user_style-important"><strong>Price 4 788 € ex VAT</strong></p></blockquote><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_Streamline_UV_1_UV_VIS_detector_686c6c9937.jpg" alt="Watrex: Streamline™ UV1 detector, PEEK" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Watrex_Streamline_UV_1_UV_VIS_detector_686c6c9937.jpg 245w," sizes="100vw" width="945" height="436"></p><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Light Source:</strong> Deuterium Lamp, Tungsten Lamp</li><li><strong>Wavelength Range:</strong> 190 – 800 nm</li><li><strong>Baseline Noise:</strong> 1 x 10-5 AU (@240 nm, 2 sec. risetime)</li><li><strong>Baseline Drift:</strong> better than 3 x 10-4 AU/h</li><li><strong>Wavelenghth Reproducibility:</strong> ± 0.1 nm</li><li><strong>Linearity:</strong> better than 2.5 AU</li><li><strong>Analog Output:</strong> 1x 1 V</li></ul><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/detectors/uv-vis-detectors/streamline-uv1-detector-2/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

KNAUER AZURA MWD 2.1L Multiwavelength Detector

KNAUER AZURA® MWD 2.1L is an 8-channel UV/VIS detector with 190–700 nm coverage, LightGuide technology, high sensitivity, and upgradeability to a DAD system.

<p><strong>The KNAUER AZURA® MWD 2.1L is a sensitive 8-channel UV/VIS multiwavelength detector designed for analytical, semi-preparative, and preparative liquid chromatography. Combining excellent performance, user-friendly operation, and affordability, it provides a versatile solution for routine and advanced LC applications.</strong></p><p>The detector features a newly developed optical unit and intelligent temperature management to ensure maximum sensitivity with minimal baseline drift. Optional LightGuide flow cells based on total internal reflection technology maximize light throughput and minimize peak dispersion, resulting in an optimized signal-to-noise ratio. An optional fiber-optic adapter allows physical separation of the flow cell from the detector, increasing safety when handling hazardous, explosive, or toxic materials.</p><p>The <strong>AZURA® MWD 2.1L</strong> can also be upgraded to a full <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2423"><strong>AZURA® DAD 2.1L diode array detector</strong></a>, protecting future investments and enabling greater analytical flexibility.</p><h3><strong>Key Features</strong></h3><ul><li>Sensitive <strong>8-channel UV/VIS multiwavelength detector</strong></li><li>Wavelength range<strong> from 190 to 700 nm</strong></li><li>Simultaneous monitoring of <strong>up to 8 digital channels</strong></li><li>LightGuide flow cell technology for improved sensitivity and signal-to-noise ratio</li><li>Intelligent temperature management for minimal baseline drift</li><li>Wide selection of analytical, semi-preparative, and preparative flow cells</li><li>Optional fiber-optic adapter for remote flow cell positioning</li><li>Internal holmium filter for wavelength verification</li><li>Integrated leak sensor</li><li>Front-access lamp replacement</li><li>Upgradeable to the AZURA® DAD 2.1L diode array detector</li><li>Compatible with <strong>ClarityChrom®, OpenLAB®, Chromeleon™, PurityChrom®</strong>, and <strong>Mobile Control</strong></li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Detection System</strong></h4><ul><li><strong>Detector type: </strong>Multiwavelength Detector (MWD)</li><li><strong>Digital channels: </strong>8</li><li><strong>Analog channels:</strong> 4</li><li><strong>Light source: </strong>Deuterium lamp with integrated GLP chip</li><li><strong>Wavelength range: </strong>190–700 nm</li><li><strong>Spectral resolution: </strong>&lt;10 nm (FWHM)</li><li><strong>Slit width: </strong>7.0 nm</li><li><strong>Wavelength accuracy: </strong>±1 nm</li><li><strong>Wavelength repeatability: </strong>±0.1 nm</li></ul><h4><strong>Performance</strong></h4><ul><li><strong>Noise:</strong> ±5 µAU at 254 nm</li><li><strong>Drift:</strong> 400 µAU/h at 254 nm</li><li><strong>Linearity:</strong> &gt;2.0 AU at 274 nm</li><li><strong>Maximum data rate:</strong><ul><li>100 Hz via LAN</li><li>12.5 Hz via analog output</li></ul></li></ul><h4><strong>Flow Cells</strong></h4><ul><li>Flow cells sold separately</li><li>Stainless-steel and bio-inert configurations available</li><li>Optional LightGuide total-reflection technology</li></ul><h4><strong>Control and Communication</strong></h4><ul><li>LAN (RJ-45)</li><li>USB service interface</li><li>Analog inputs and outputs</li><li>Mobile Control stand-alone operation</li><li>Full software integration with chromatography data systems</li></ul><h4><strong>GLP Functions</strong></h4><ul><li>Lamp identification</li><li>Lamp operating hours</li><li>Lamp ignition count</li><li>Comprehensive GLP reporting</li></ul><h4><strong>Power and Dimensions</strong></h4><ul><li><strong>Power supply:</strong> 100–240 V, 50–60 Hz</li><li><strong>Power consumption: </strong>75 W</li><li><strong>Dimensions (W × H × D):</strong> 361 × 158 × 523 mm</li><li><strong>Weight:</strong> 12.2 kg</li></ul>

KNAUER AZURA VWD 2.1L Variable Wavelength Detector

Flexible UV/VIS detector with up to four wavelengths, conductivity, temperature, and optional pH monitoring. Ideal for HPLC, FPLC, and purification applications.

<p><strong>The KNAUER AZURA® VWD 2.1L is a versatile variable wavelength detector designed for analytical HPLC, FPLC, and purification applications. Combining UV/VIS detection with optional conductivity, temperature, and pH monitoring, it provides exceptional flexibility for a wide range of chromatographic workflows.</strong></p><p>The detector supports simultaneous monitoring of up to four UV/VIS wavelengths across a broad spectral range from 190 to 900 nm. When equipped with KNAUER’s patented <strong>CombiLight flow cell</strong>, it can simultaneously measure UV absorbance, conductivity, and eluent temperature. An optional pH electrode further extends functionality by enabling real-time pH monitoring during chromatographic separations.</p><h3><strong>Key Features</strong></h3><ul><li>Variable wavelength UV/VIS detector <strong>for analytical HPLC and FPLC</strong></li><li>Simultaneous monitoring of <strong>up to 4 UV/VIS wavelengths</strong></li><li>Broad wavelength range from <strong>190 to 900 nm</strong></li><li>Optional conductivity monitoring up to <strong>1000 mS/cm</strong></li><li>Integrated temperature monitoring</li><li>Optional real-time pH measurement</li><li>Compatible with patented KNAUER CombiLight flow cell technology</li><li>Convertible between flow-cell and fiber-optic configurations</li><li>Internal holmium oxide filter for wavelength verification</li><li>Adjustable leak sensor for enhanced operational safety</li><li>Front-access lamp and flow-cell replacement</li><li>Comprehensive GLP functionality with component recognition</li><li>Suitable for analytical, preparative, and purification workflows</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Detection System</strong></h4><ul><li><strong>Detection channels:</strong><ul><li>4 × UV/VIS</li><li>1 × Conductivity</li><li>1 × Temperature</li><li>1 × pH</li></ul></li><li><strong>Wavelength range:</strong> 190–900 nm</li><li><strong>Light source:</strong><ul><li>High-brightness deuterium lamp</li><li>Halogen lamp</li><li>Integrated GLP chip</li></ul></li><li><strong>Flow cell:</strong> Not included</li><li><strong>Optional display:</strong> Mobile Control</li></ul><h4><strong>UV/VIS Performance</strong></h4><ul><li><strong>Spectral bandwidth:</strong> 6 nm (FWHM)</li><li><strong>Wavelength accuracy: </strong>±1.5 nm</li><li><strong>Wavelength precision:</strong> 0.4 nm</li><li><strong>Baseline noise: </strong>±7.5 µAU at 254 nm</li><li><strong>Baseline drift:</strong> 200 µAU/h at 254 nm</li><li><strong>Linearity: </strong>&gt;2.5 AU at 274 nm</li><li><strong>Maximum data rate:</strong><ul><li>100 Hz (single UV channel)</li><li>5 Hz (four UV channels)</li></ul></li></ul><h4><strong>Conductivity Monitoring</strong></h4><ul><li><strong>Measurement range: </strong>0.1–1000 mS/cm</li><li><strong>Accuracy:</strong> ±2% or ±0.5 mS/cm (whichever is greater)</li></ul><h4><strong>pH Monitoring</strong></h4><ul><li><strong>Measurement range: </strong>pH 0–14</li><li><strong>Accuracy: </strong>±0.1 pH (between pH 2–12)</li></ul><h4><strong>Temperature Monitoring</strong></h4><ul><li><strong>Measurement range</strong>: 1–99 °C</li><li><strong>Accuracy</strong>: ±1.5 °C (4–40 °C)</li></ul><h4><strong>System Functions</strong></h4><ul><li>Internal holmium oxide filter for wavelength verification</li><li>Adjustable leak sensor</li><li>Automatic integration time</li><li>User-selectable time constants:</li></ul><h4><strong>GLP Functions</strong></h4><ul><li>Lamp recognition</li><li>Operating hours tracking</li><li>Light source lifetime monitoring</li><li>Flow-cell recognition</li><li>Detailed GLP reporting</li></ul><h4><strong>Maintenance</strong></h4><ul><li>Front-accessible deuterium lamp</li><li>Front-accessible halogen lamp</li><li>Front-accessible flow cell</li><li>Simplified service procedures</li></ul><h3><strong>Applications</strong></h3><ul><li>Analytical HPLC</li><li>FPLC systems</li><li>Protein purification</li><li>Biopharmaceutical analysis</li><li>Process chromatography</li><li>Preparative chromatography</li><li>Method development</li><li>Quality control laboratories</li><li>UV/VIS monitoring of purification processes</li></ul>

KNAUER AZURA UVD 2.1L UV/VIS Detector

Compact and affordable UV/VIS detector for routine HPLC and fast LC applications, featuring 190–750 nm wavelength range and flexible flow-cell options.

<p><strong>The KNAUER AZURA® UVD 2.1L is a cost-effective UV/VIS detector designed for routine HPLC applications, including fast liquid chromatography methods. Combining reliable performance, compact dimensions, and flexible flow-cell options, it provides an ideal solution for analytical and preparative chromatography laboratories seeking dependable UV detection at an attractive price point.</strong></p><p>The detector utilizes a deuterium lamp covering the wavelength range <strong>from 190 to 750 nm</strong> and offers excellent sensitivity and stability for everyday chromatographic analysis. Its smart mechanical design allows quick and easy access to the flow cell, minimizing maintenance time and maximizing instrument uptime.</p><p>A wide range of interchangeable flow cells is available, including stainless-steel and bio-inert versions suitable for analytical, semi-preparative, and preparative LC applications with <strong>flow rates ranging from 10 μL/min up to 10 L/min</strong>. The detector integrates seamlessly into virtually any LC system through LAN communication, analog I/O, and compatibility with leading chromatography software packages.</p><h3><strong>Key Features</strong></h3><ul><li><strong>Cost-effective UV/VIS detector </strong>for routine HPLC applications</li><li>Suitable for fast LC methods</li><li>Wavelength range <strong>from 190 to 750 nm</strong></li><li>Single-channel variable wavelength detection</li><li><strong>Deuterium lamp </strong>with integrated GLP chip</li><li>Compact and robust instrument design</li><li>Easily accessible flow cell for rapid replacement</li><li>Wide selection of interchangeable flow cells</li><li>Compatible with analytical and preparative LC applications</li><li><strong>Flow rates from 10 μL/min up to 10 L/min</strong></li><li>Integrated leak sensor</li><li>Automatic integration time adjustment</li><li>LAN and analog communication interfaces</li><li>Comprehensive GLP functionality</li><li><strong>Compatible with ClarityChrom®, OpenLAB®, Chromeleon™, ChromGate®, PurityChrom®</strong>, and <strong>Mobile Control</strong></li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Detection System</strong></h4><ul><li><strong>Detection channels:</strong> 1</li><li><strong>Light source: </strong>Deuterium (D₂) lamp with integrated GLP chip</li><li><strong>Wavelength range:</strong> 190–750 nm</li><li><strong>Spectral bandwidth: </strong>11 nm (FWHM)</li><li><strong>Wavelength accuracy:</strong> ±2.5 nm</li><li><strong>Wavelength precision:</strong> 0.3 nm</li></ul><h4><strong>Performance</strong></h4><ul><li><strong>Noise:</strong> ±15 µAU at 254 nm</li><li><strong>Drift: </strong>300 µAU/h at 254 nm</li><li><strong>Linearity:</strong> &gt;2.0 AU at 274 nm</li><li><strong>Maximum data rate:</strong><ul><li>50 Hz via LAN</li><li>20 Hz via analog output</li></ul></li></ul><h4><strong>Flow Cells</strong></h4><ul><li>Flow cells sold separately</li><li>Stainless-steel and bio-inert options available</li><li>Suitable for analytical and preparative chromatography</li><li>Flow rates from 10 μL/min to 10 L/min</li></ul><h4><strong>Communication and Control</strong></h4><ul><li>LAN communication</li><li>Analog input/output</li><li>Mobile Control software</li><li>Event control</li><li>Terminal protocol</li></ul><h4><strong>Inputs</strong></h4><ul><li>Error (IN)</li><li>Start (IN)</li><li>Autozero</li><li>0–10 V Analog (IN)</li></ul><h4><strong>Outputs</strong></h4><ul><li>Events 1–3</li><li>+5 V</li><li>24 V Valve</li></ul><h4><strong>Analog Output</strong></h4><ul><li>1 × 0–5 V scalable</li><li>20-bit resolution</li><li>Adjustable offset</li></ul><h4><strong>Programming Functions</strong></h4><ul><li>Timed wavelength programming</li><li>Event programming</li><li>Fraction valve control</li><li>Wake-up functions</li><li>Up to 9 programs</li><li>Up to 50 program lines</li></ul><h4><strong>GLP Functions</strong></h4><ul><li>Lamp recognition</li><li>Operating hours tracking</li><li>Lamp operating hours</li><li>Lamp ignition counter</li><li>Detailed GLP reports</li></ul><h4><strong>Safety and Maintenance</strong></h4><ul><li>Integrated leak sensor</li><li>Easy-access flow cell compartment</li><li>Front-access maintenance</li><li>Minimal downtime for service operations</li></ul><h4><strong>Environmental Conditions</strong></h4><ul><li><strong>Operating temperature:</strong> 4–40 °C</li><li><strong>Humidity:</strong> &lt;90% non-condensing</li></ul><h4><strong>Power and Dimensions</strong></h4><ul><li><strong>Power supply: </strong>100–240 V, 50–60 Hz</li><li><strong>Power consumption: </strong>65 W</li><li><strong>Dimensions (W × H × D):</strong> 361 × 158 × 523 mm</li><li><strong>Weight: </strong>5.9 kg</li></ul><h3><strong>Applications</strong></h3><ul><li>Routine HPLC analysis</li><li>Fast LC methods</li><li>Pharmaceutical quality control</li><li>Food and beverage analysis</li><li>Environmental testing</li><li>Chemical analysis</li><li>Preparative liquid chromatography</li><li>Academic and research laboratories</li></ul>

KNAUER AZURA UVD 2.1S UV Detector

Compact single-wavelength UV detector for routine HPLC applications with 190–500 nm range, flexible flow-cell options, and seamless software integration.

<p><strong>The KNAUER AZURA® UVD 2.1S is a compact, cost-effective single-wavelength UV detector designed for routine HPLC applications. Despite its small footprint, it delivers reliable performance and excellent technical specifications, making it one of the most compact HPLC UV detectors available on the market.</strong></p><p>Equipped with a deuterium lamp covering the <strong>wavelength range from 190 to 500 nm</strong>, the detector is suitable for a broad range of analytical chromatography applications. Its intelligent design provides quick access to the flow cell, enabling fast replacement and simplified maintenance. A wide selection of interchangeable flow cells is available, including bio-inert and stainless-steel versions for analytical and preparative LC applications with <strong>flow rates ranging from 10 μL/min up to 10 L/min</strong>.</p><h3><strong>Key Features</strong></h3><ul><li>Compact single-wavelength UV detector for HPLC</li><li>One of the smallest HPLC UV detectors available</li><li>Wavelength range <strong>from 190 to 500 nm</strong></li><li>Deuterium lamp with integrated GLP chip</li><li>Suitable for routine analytical applications</li><li>Compact AZURA® housing design</li><li>Easily accessible flow cell for rapid replacement</li><li>Wide range of interchangeable flow cells available</li><li>Compatible with analytical and preparative LC applications</li><li><strong>Flow rates from 10 μL/min up to 10 L/min</strong></li><li>Stand-alone operation via front panel</li><li><strong>LAN, RS-232</strong>, and analog communication interfaces</li><li>Compatible with major chromatography data systems</li><li>Available as a module for <strong>AZURA® ASM 2.2L</strong></li><li>Low maintenance requirements</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Detection System</strong></h4><ul><li><strong>Detection channels: </strong>1</li><li><strong>Light source:</strong> Deuterium (D₂) lamp with integrated GLP chip</li><li><strong>Wavelength range:</strong> 190–500 nm</li><li><strong>Spectral bandwidth: </strong>13 nm (FWHM)</li><li><strong>Wavelength accuracy: </strong>±3 nm</li><li><strong>Wavelength precision: </strong>0.7 nm</li></ul><h4><strong>Performance</strong></h4><ul><li><strong>Noise:</strong> ±20 µAU at 254 nm</li><li><strong>Drift:</strong> 300 µAU/h at 254 nm</li><li><strong>Linearity:</strong> &gt;2.0 AU at 274 nm</li><li><strong>Maximum data rate:</strong><ul><li>50 Hz via LAN</li><li>20 Hz via analog output</li><li>10 Hz via RS-232</li></ul></li></ul><h4><strong>Flow Cells</strong></h4><ul><li>Flow cells sold separately</li><li>Bio-inert and stainless-steel options available</li><li>Suitable for analytical and preparative chromatography</li><li>Flow rates from 10 μL/min to 10 L/min</li></ul><h4><strong>Communication and Control</strong></h4><ul><li>Front panel operation</li><li>Mobile Control software</li><li>Software control</li><li>Event control</li><li>Analog control</li><li>Terminal protocol</li></ul><h4><strong>Interfaces</strong></h4><ul><li>LAN (RJ-45)</li><li>RS-232 (SUB-D 9)</li><li>Multi-pin connector</li><li>Analog interface (RCA connector)</li></ul><h4><strong>Inputs</strong></h4><ul><li>Autozero</li><li>Start (IN)</li><li>Error (IN/OUT)</li><li>0–10 V Analog Input</li></ul><h4><strong>Outputs</strong></h4><ul><li>Error (OUT/IN)</li></ul><h4><strong>Analog Signals</strong></h4><ul><li>Analog wavelength input: 0–10 V</li><li>Analog output: 1 × ±2.5 V scalable</li><li>Resolution: 20-bit</li></ul><h4><strong>GLP Functions</strong></h4><ul><li>Lamp operating hours monitoring</li></ul><h4><strong>Display</strong></h4><ul><li>LED display</li></ul><h4><strong>Environmental Conditions</strong></h4><ul><li><strong>Operating temperature:</strong> 4–40 °C</li><li><strong>Humidity</strong>: &lt;90% non-condensing</li></ul><h4><strong>Power and Dimensions</strong></h4><ul><li><strong>Power supply:</strong><ul><li>Input: 100–240 V</li><li>Output: 24 V DC</li></ul></li><li><strong>Power consumption: </strong>60 W</li><li><strong>Dimensions (W × H × D):</strong> 121 × 129 × 187 mm</li><li><strong>Weight: </strong>1.5 kg</li></ul><h3><strong>Applications</strong></h3><ul><li>Routine HPLC analysis</li><li>Quality control laboratories</li><li>Pharmaceutical analysis</li><li>Food and beverage testing</li><li>Environmental analysis</li><li>Academic research</li><li>Preparative liquid chromatography</li><li>Compact and space-limited laboratory environments</li></ul>

Products from category UV-Vis HPLC detectors focused on HPLC - page 1

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