<p><strong>The team of Professor&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en"><strong>Michal Hocek</strong></a><strong> at IOCB Prague explores the limits of the structure and function of DNA and successfully pushes forward known boundaries. An article presenting the results of their latest research has just been published in the major scientific journal </strong><i><strong>Nucleic Acids Research</strong></i><strong>. They prove that even heavily modified double helices of DNA are stable enough to be used for special applications. This discovery might expand the possibilities of utilizing modified DNA, for example, in medicine.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg" alt="ÚOCHB: Scientists from IOCB Prague are pushing the limits of DNA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg 245w," sizes="100vw" width="1910" height="1000"></p><p>DNA consists of two long negatively charged chains that hold together even though they repel each other. This is made possible by what is known as stacking interactions and base pairing. Michal Hocek and his colleagues advanced the known limits when they modified DNA by adding an extra negative charge to each letter of the genetic code. This doubled the repulsive forces, yet the DNA double helix remained stable. They also found that such modified DNA not only holds together but that it can also be synthesized or replicated and sequenced using the enzyme DNA polymerase.</p><p><i>"Think of DNA as a scaffold on which you can attach various chemical compounds with different functions. These are small molecules, such as side chains of amino acids, which occur naturally only in peptides and proteins. In current medicine, we are able to use these molecules only to a relatively limited extent. The reason is that they are markedly unstable and get decomposed rapidly when inside an organism. One solution to this would be a stable skeleton to which they could be firmly attached. And DNA could be just such a base structure in the future,"</i> says Prof. Michal Hocek.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg" alt="ÚOCHB / Tomáš Belloň: Prof. Michal Hocek, Distinguished Chair and head of Bioorganic and Medicinal Chemistry of Nucleic Acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg 234w," sizes="100vw" width="1500" height="1001"></p><p>The aim of this research carried out at IOCB Prague is to create DNA molecules that will mimic other chemical compounds. This would enable us to leverage the medicinal potential of certain biomolecules that are difficult to retain in the body. Examples of such biomolecules are the already mentioned peptides or proteins.</p><p>The Hocek group has already made significant progress, although research in this direction is at its beginning worldwide. The team has, for example, succeeded at developing a novel modified aptamer, which is a short DNA sequence that can bind to a specific target molecule, most frequently a protein. Aptamers have similar properties to antibodies, but they are much more stable. For this reason, aptamers can potentially replace antibodies employed in medicine. However, the number of approved therapeutic aptamers globally can still be counted on the fingers of one hand.</p><p>The current research exploring the limits of DNA is part of a larger project led by Michal Hocek, for which he has secured a prestigious EXPRO grant from the Czech Science Foundation. This is the second time its results have drawn interest from the journal <i>Nucleic Acids Research</i>. Previously, scientists from IOCB Prague published a method for the enzymatic synthesis of fully artificial DNA. During this synthesis, all nucleotides forming natural DNA are replaced by their modified versions with attached hydrophobic (i.e. water-repelling) molecules.</p>

Scientists from IOCB Prague are pushing the limits of DNA

<p><strong>Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease caused by the protozoan parasite </strong><i><strong>Trichomonas vaginalis</strong></i><strong>, especially because of the recent appearance of strains that are resistant to conventional treatment. In an effort to find a new weak spot of this parasite, the </strong><a target="_blank" rel="noopener noreferrer" href="https://boura.group.uochb.cz/en"><strong>research group</strong></a><strong> led by Dr. Evžen Bouřa has succeeded in preparing a key enzyme complex – the proteasome. This has made it possible to gain knowledge that is indispensable for the development of new effective medicines. The research was carried out in collaboration with colleagues from the University of California San Diego. An article presenting the work has been published in the scientific journal </strong><i><strong>Nature Communications</strong></i><strong>.</strong></p><p>The proteasome is a complex protease that works as a device for recycling old proteins in cells. It is a cylindrical enzyme complex composed of seven subunits arranged in four superposed circles. When old proteins enter this cylinder, they get broken down into small pieces later used by the cell to make new proteins. If it functions incorrectly, old proteins accumulate, leading to the cell’s demise. This is why the blocking of proteasome activity is used, for example, against certain types of malignant tumours.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_Dr_Evzen_Boura_vedouci_vedecke_skupiny_Strukturni_biologie_membran_UOCHB_783ec20050.jpg" alt="IOCB Prague / Tomáš Belloň: Dr. Evžen Bouřa, head of the Structural Membrane Biology group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_Dr_Evzen_Boura_vedouci_vedecke_skupiny_Strukturni_biologie_membran_UOCHB_783ec20050.jpg 234w," sizes="100vw" width="1500" height="1001"></p><div><p>In the same way, it should also be possible to treat the widespread sexually transmitted infection trichomoniasis, which increases the risk of contracting HIV. The aim is therefore to identify substances that block the function of the proteasome inside <i>Trichomonas vaginalis</i> cells. However, the proteasome of this single-cell organism had never been satisfactorily isolated, so the research group from IOCB Prague prepared an artificial proteasome that is identical to the natural one. Curiously, they used insect cells to do so. This part of their research, on which the success of the whole project was hinged, proved the most complicated. That the team has prevailed in describing the previously unknown structure of the parasite’s proteasome is therefore of critical importance.</p><p><i>‘The proteasome looks the same in every animal or protozoan, but the details of this cylindrical structure differ. It is these details that we need to know in order to create a substance that is toxic to the parasite but not harmful to the human body. That is a crucial precondition for drug development. Our greatest success is that we have been able to prepare a recombinant, artificial proteasome that can provide us with the necessary information,’</i> explains Evžen Bouřa.</p><p>The researchers used advanced electron microscopy, allowing them to see almost every single atom. Armed with this capability, they tested the effects of two potential proteasome-inhibiting substances. They saw how they bind to the active site of the proteasome and under what circumstances the proteasome stops working, which is fatal to the cell of the parasite.</p><p>The research was carried out within the <a target="_blank" rel="noopener noreferrer" href="https://nivb.cz/en/">National Institute of Virology and Bacteriology</a> (LX22NPO5103), funded by the <a target="_blank" rel="noopener noreferrer" href="https://www.uochb.cz/en/exceles">EXCELES</a> program.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_1_8ff5bf4e71.jpg" alt="IOCB Prague: Dr. Evžen Bouřa, head of the Structural Membrane Biology group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_1_8ff5bf4e71.jpg 245w," sizes="100vw" width="1386" height="632"></p><p>&nbsp;</p></div>

Scientists from IOCB Prague help to improve medical drugs

<p><strong>In the week of October 14, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Metrohm: Electrochemical techniques for battery research and testing</strong></h5><ul><li><div><div>Tu, 15.10.2024 10:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4337">Registration</a></div></li></ul><p>Theoretical and practical aspects of various electrochemical techniques for battery research and testing.</p><h5><strong>2.&nbsp;Waters Corporation: Leveraging light scattering techniques for enhanced biotherapeutic characterization and development</strong></h5><ul><li><div><div>Tu, 15.10.2024 10:30 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4336">Registration</a></div></li></ul><p>How different light scattering techniques can be used for advanced characterization of biopharmaceutical samples.</p><h5><strong>3.&nbsp;Thermo Fisher Scientific: Solutions for environmental and food contaminant testing</strong></h5><div><ul><li><div>Tu, 15.10.2024 10:30 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4238">Registration</a></div></li></ul></div><p>New and advancing workflows to meet and exceed European regulations.</p><h5><strong>4.&nbsp;Agilent Technologies: Single Quad mass detection for Chromatographers</strong></h5><ul><li><div><div>Tu, 15.10.2024 11:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4261">Registration</a></div></li></ul><p>We will look at the development of single quads together and highlight the possibilities offered by today's single quads and how they support the user.</p><h5><strong>5.&nbsp;Agilent Technologies: MassHunter Acquisition Q-TOF Part II – Advance Settings</strong></h5><div><div><ul><li><div>Tu, 15.10.2024 14:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4343">Registration</a></div></li></ul></div><p>Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.</p></div><h5><strong>6.&nbsp;Thermo Fisher Scientific: High-throughput and automation in novel modalities (msAbs, ADCs, AOCs) screening, characterization, and beyond</strong></h5><ul><li><div><div>Tu, 15.10.2024 17:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4352">Registration</a></div></li></ul><p>Integrated advanced techniques such as automation and machine learning to achieve unprecedented mass spectrometry-focused sample handling capabilities and rapid turnover rates.</p><h5><strong>7.&nbsp;Phenomenex: Solid Phase Extraction Troubleshooting Tips and Tricks</strong></h5><ul><li><div><div>Tu, 15.10.2024 19:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4338">Registration</a></div></li></ul><p>Identify the common challenges associated with solid phase extraction methods.</p><h5><strong>8.&nbsp;Waters Corporation: Streamlined Proteomics with the Power of Andrew+</strong></h5><ul><li><div><div>We, 16.10.2024 11:00 CEST</div></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4339">Registration</a></div></li></ul><p>How the Andrew+ liquid handling robot has helped streamline their sample preparation workflows for proteomic analysis.</p><h5><strong>9.&nbsp;Agilent Technologies: Advancements in Host Cell Protein Analysis</strong></h5><div><ul><li><div>We, 16.10.2024 11:30 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4357">Registration</a></div></li></ul></div><p>Join us in this unique webinar where experts from Industry, pharmacopeia and Agilent will share insights on latest advancements on HCP analysis.</p><h5><strong>10.&nbsp;Waters Corporation: Free Testosterone and Free T3/T4</strong></h5><div><ul><li><div>We, 16.10.2024 14:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4356">Registration</a></div></li></ul></div><p>Simplified Equilibrium Dialysis and SPE Method for the UPLC-MS/MS Analysis of Free Thyroxine (FT4) and Triiodothyronine (FT3) for Clinical Research.</p><h5><strong>11.&nbsp;Technology Networks/Thermo Fisher Scientific: Streamlining Data for Superior Therapeutic Manufacturing</strong></h5><div><ul><li><div>We, 16.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4377">Registration</a></div></li></ul></div><p>This webinar explores how to implement digitization to accelerate decision-making, meet regulatory demands and eliminate bottlenecks in biotherapeutic development.</p><h5><strong>12.&nbsp;Waters Corporation: Analyzing mRNA and sgRNA with Advanced Enzymes, Mass Spectrometry, and Informatics</strong></h5><div><ul><li><div>We, 16.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4355">Registration</a></div></li></ul></div><p>This webinar will feature insights from Quality Assistance a leading European Contract Research Organisation (CRO) offering a range of services including mRNA and CRISPR sgRNA testing.</p><h5><strong>13.&nbsp;Separation Science/Merck: Empowering Tomorrow’s Therapeutics with LC-MS Capillary Chromatography</strong></h5><div><ul><li><div>Th, 17.10.2024 10:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4359">Registration</a></div></li></ul></div><p>This webinar emphasizes the significance of capillary HPLC coupled with mass spectrometry.</p><h5><strong>14.&nbsp;Waters Corporation: Empower Tips: Ask Me Anything About Processing Data - Part 2</strong></h5><div><div><ul><li><div>Th, 17.10.2024 16:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4360">Registration</a></div></li></ul></div><p>This is the second in our three-part Ask Me Anything webinar series on one of the most frequently asked about topics - processing data.</p></div><h5><strong>15.&nbsp;Waters Corporation: Nitrosamines</strong></h5><div><div><ul><li><div>Th, 17.10.2024 19:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/3445">Registration</a></div></li></ul></div><p>This webinar will address analytical challenges in the detection and control of nitrosamines and Nitrosamine Drug-Substance Related Impurities (NDSRIs).</p></div>

Webinars LabRulezLCMS Week 42/2024

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Webinars

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Science and research

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Ústav organické chemie a biochemie AV ČR

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Watrex SCI-AQUA ROWAPUR BASIC Water Purification System

Fully automatic system for the preparation of pure water based on reverse osmosis. Reverse osmosis membrane is protected by three-stage pre-filtration consisting of sediment filter and two carbon adsorption filters.

<p><strong>Fully automatic system for the preparation of pure water based on reverse osmosis. Reverse osmosis membrane is protected by three-stage pre-filtration consisting of sediment filter and two carbon adsorption filters.</strong></p><p><strong>Watrex SCI-AQUA BASIC</strong> is driven by water pressure from water distribution network, it <strong>does not require electric power</strong>. It prepares water free of mechanical impurities, chlorine, 95-99% of all dissolved substances are removed.&nbsp;</p><p>Depending on input water composition and supply pressure <strong>the output water has a specific conductivity in the range of 10-20 µS/cm</strong>.</p><p><span style="font-size:18px;"><strong>Price: </strong><bdi><span class="wmc-cache-pid woocommerce-Price-amount amount" data-wmc_product_id="24487"><strong>384&nbsp;</strong></span><span class="wmc-cache-pid woocommerce-Price-amount amount woocommerce-Price-currencySymbol" data-wmc_product_id="24487"><strong>€</strong></span></bdi><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong> </strong></span><small class="woocommerce-price-suffix"><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong>ex. VAT</strong></span></small></span></p><h4>Features</h4><ul><li>Removes 95 – 99% of dissolved substances</li><li>Typical specific conductivity of produced water 10 – 20 µS/cm</li><li>6 to 12 months filters lifetime</li><li>2 – 5 years RO membrane lifetime</li><li>No electricity is required for operation</li><li>Supplied from water distribution network</li></ul><h4>Technical specification</h4><ul><li><strong>Daily production capacity: </strong>50 – 70 liters</li><li><strong>Input water pressure: </strong>0,3 – 0,7 MPa</li><li><strong>Input water temperature: </strong>&lt; 35 °C</li><li><strong>Maximum input water TDS: </strong>1200 mg/l</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"></p><p>Basic requirements for laboratory operations include the easy availability of <strong>pure laboratory water</strong> in the necessary <strong>quantity and quality</strong>. Distillation, a popular technique for producing purified water in the past, has virtually completely supplanted by less energy-intensive and operationally dependable alternatives today. <strong>Reverse osmosis</strong> is the foundation of the majority of contemporary systems for <strong>producing purified water</strong>; in reality, this principle is supplemented with <strong>adsorption</strong>, <strong>ion exchange</strong>, <strong>filtration</strong>, <strong>ultrafiltration</strong>, and other physical-chemical techniques.</p>

Watrex SCI-AQUA ROWAPUR DEMI 90 Water Purification System

Fully automatic system for the preparation of clean water based on reverse osmosis combined with purification by a mixed ion exchanger.

<p><strong>Fully automatic system for the preparation of clean water based on reverse osmosis combined with purification by a mixed ion exchanger. Reverse osmosis membrane is protected by two-stage pre-filtration consisting of sediment and carbon filter.</strong></p><p><strong>Watrex ROWAPUR DEMI</strong> is driven by water pressure from water distribution network, it <strong>does not require electric power</strong>.</p><p>The output water has a specific <strong>conductivity less than &lt;1 µS/cm</strong>. The system includes a conductivity tester with optical indication of output water quality.</p><p><span style="font-size:18px;"><strong>Price: </strong><bdi><span class="wmc-cache-pid woocommerce-Price-amount amount" data-wmc_product_id="24487"><strong>761 </strong></span><span class="wmc-cache-pid woocommerce-Price-amount amount woocommerce-Price-currencySymbol" data-wmc_product_id="24487"><strong>€</strong></span></bdi><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong> </strong></span><small class="woocommerce-price-suffix"><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong>ex. VAT</strong></span></small></span></p><h4>Features</h4><ul><li>Specific conductivity of produced water &lt;1 µS/cm</li><li>6 to 12 months filters lifetime</li><li>2 – 5 years RO membrane lifetime</li><li>1000 – 2000 liters polishing filter capacity</li><li>No electricity is required for operation</li><li>Supplied from water distribution network</li></ul><h4>Technical specification</h4><ul><li><strong>Specific conductivity of produced water: </strong>&lt; 1 µS/cm</li><li><strong>Daily production capacity:</strong>&nbsp;up to 90 liters</li><li><strong>Input water pressure:</strong>&nbsp;0,3 – 0,7 MPa</li><li><strong>Input water temperature:</strong>&nbsp;&lt; 35 °C</li><li><strong>Maximum input water TDS:</strong>&nbsp;1200 mg/l</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"></p><p>Basic requirements for laboratory operations include the easy availability of <strong>pure laboratory water</strong> in the necessary <strong>quantity and quality</strong>. Distillation, a popular technique for producing purified water in the past, has virtually completely supplanted by less energy-intensive and operationally dependable alternatives today. <strong>Reverse osmosis</strong> is the foundation of the majority of contemporary systems for <strong>producing purified water</strong>; in reality, this principle is supplemented with <strong>adsorption</strong>, <strong>ion exchange</strong>, <strong>filtration</strong>, <strong>ultrafiltration</strong>, and other physical-chemical techniques.</p>

Watrex SCI-AQUA ROWAPUR DEMI 180 Water Purification System

<p><strong>Fully automatic system for the preparation of clean water based on reverse osmosis combined with purification by a mixed ion exchanger. Reverse osmosis membrane is protected by two-stage pre-filtration consisting of sediment and carbon filter.</strong></p><p><strong>Watrex ROWAPUR DEMI</strong> is driven by water pressure from water distribution network, it <strong>does not require electric power</strong>.</p><p>The output water has a specific <strong>conductivity less than &lt;1 µS/cm</strong>. The system includes a conductivity tester with optical indication of output water quality.</p><p><span style="font-size:18px;"><strong>Price: 833</strong><bdi><span class="wmc-cache-pid woocommerce-Price-amount amount" data-wmc_product_id="24487"><strong> </strong></span><span class="wmc-cache-pid woocommerce-Price-amount amount woocommerce-Price-currencySymbol" data-wmc_product_id="24487"><strong>€</strong></span></bdi><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong> </strong></span><small class="woocommerce-price-suffix"><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong>ex. VAT</strong></span></small></span></p><h4>Features</h4><ul><li>Specific conductivity of produced water &lt;1 µS/cm</li><li>6 to 12 months filters lifetime</li><li>2 – 5 years RO membrane lifetime</li><li>1000 – 2000 liters polishing filter capacity</li><li>No electricity is required for operation</li><li>Supplied from water distribution network</li></ul><h4>Technical specification</h4><ul><li><strong>Specific conductivity of produced water: </strong>&lt; 1 µS/cm</li><li><strong>Daily production capacity:</strong>&nbsp;up to 180 liters</li><li><strong>Input water pressure:</strong>&nbsp;0,3 – 0,7 MPa</li><li><strong>Input water temperature:</strong>&nbsp;&lt; 35 °C</li><li><strong>Maximum input water TDS:</strong>&nbsp;1200 mg/l</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"></p><p>Basic requirements for laboratory operations include the easy availability of <strong>pure laboratory water</strong> in the necessary <strong>quantity and quality</strong>. Distillation, a popular technique for producing purified water in the past, has virtually completely supplanted by less energy-intensive and operationally dependable alternatives today. <strong>Reverse osmosis</strong> is the foundation of the majority of contemporary systems for <strong>producing purified water</strong>; in reality, this principle is supplemented with <strong>adsorption</strong>, <strong>ion exchange</strong>, <strong>filtration</strong>, <strong>ultrafiltration</strong>, and other physical-chemical techniques.</p>

Watrex SCI-AQUA ROWAPUR 090 Water Purification System

Fully automatic system for the preparation of pure water based on reverse osmosis.

<p><strong>Fully automatic system for the preparation of pure water based on reverse osmosis. Reverse osmosis membrane is protected by three-stage pre-filtration consisting of sediment filter and two carbon adsorption filters.</strong></p><p><strong>Watrex ROWAPUR</strong> is driven by water pressure from water distribution network, it <strong>does not require electric power</strong>.</p><p>It prepares water <strong>free of mechanical impurities</strong>, <strong>chlorine</strong>, <strong>95-99% of all dissolved substances</strong> are removed. Depending on input water composition and supply pressure the output water has a specific <strong>conductivity in the range of 10-20 µS/cm</strong>.</p><p><span style="font-size:18px;"><strong>Price: 500</strong><bdi><span class="wmc-cache-pid woocommerce-Price-amount amount" data-wmc_product_id="24487"><strong>&nbsp;</strong></span><span class="wmc-cache-pid woocommerce-Price-amount amount woocommerce-Price-currencySymbol" data-wmc_product_id="24487"><strong>€</strong></span></bdi><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong> </strong></span><small class="woocommerce-price-suffix"><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong>ex. VAT</strong></span></small></span></p><h4>Features</h4><ul><li>Removes 95 – 99% of dissolved substances</li><li>Typical specific conductivity of produced water 10 – 20 µS/cm</li><li>6 to 12 months filters lifetime</li><li>2 – 5 years RO membrane lifetime</li><li>No electricity is required for operation</li><li>Supplied from water distribution network</li></ul><h4>Technical specification</h4><ul><li><strong>Daily production capacity:</strong>&nbsp;up to 90 liters</li><li><strong>Input water pressure:</strong>&nbsp;0,3 – 0,7 MPa</li><li><strong>Input water temperature:</strong>&nbsp;&lt; 35 °C</li><li><strong>Maximum input water TDS: </strong>1200 mg/l</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"></p><p>Basic requirements for laboratory operations include the easy availability of <strong>pure laboratory water</strong> in the necessary <strong>quantity and quality</strong>. Distillation, a popular technique for producing purified water in the past, has virtually completely supplanted by less energy-intensive and operationally dependable alternatives today. <strong>Reverse osmosis</strong> is the foundation of the majority of contemporary systems for <strong>producing purified water</strong>; in reality, this principle is supplemented with <strong>adsorption</strong>, <strong>ion exchange</strong>, <strong>filtration</strong>, <strong>ultrafiltration</strong>, and other physical-chemical techniques.</p>

Watrex SCI-AQUA ROWAPUR 180 Water Purification System

<p><strong>Fully automatic system for the preparation of pure water based on reverse osmosis. Reverse osmosis membrane is protected by three-stage pre-filtration consisting of sediment filter and two carbon adsorption filters.</strong></p><p><strong>Watrex ROWAPUR</strong> is driven by water pressure from water distribution network, it <strong>does not require electric power</strong>.</p><p>It prepares water <strong>free of mechanical impurities</strong>, <strong>chlorine</strong>, <strong>95-99% of all dissolved substances</strong> are removed. Depending on input water composition and supply pressure the output water has a specific <strong>conductivity in the range of 10-20 µS/cm</strong>.</p><p><span style="font-size:18px;"><strong>Price: 541</strong><bdi><span class="wmc-cache-pid woocommerce-Price-amount amount" data-wmc_product_id="24487"><strong>&nbsp;</strong></span><span class="wmc-cache-pid woocommerce-Price-amount amount woocommerce-Price-currencySymbol" data-wmc_product_id="24487"><strong>€</strong></span></bdi><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong> </strong></span><small class="woocommerce-price-suffix"><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong>ex. VAT</strong></span></small></span></p><h4>Features</h4><ul><li>Removes 95 – 99% of dissolved substances</li><li>Typical specific conductivity of produced water 10 – 20 µS/cm</li><li>6 to 12 months filters lifetime</li><li>2 – 5 years RO membrane lifetime</li><li>No electricity is required for operation</li><li>Supplied from water distribution network</li></ul><h4>Technical specification</h4><ul><li><strong>Daily production capacity:</strong>&nbsp;up to 180 liters</li><li><strong>Input water pressure:</strong>&nbsp;0,3 – 0,7 MPa</li><li><strong>Input water temperature:</strong>&nbsp;&lt; 35 °C</li><li><strong>Maximum input water TDS: </strong>1200 mg/l</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"></p><p>Basic requirements for laboratory operations include the easy availability of <strong>pure laboratory water</strong> in the necessary <strong>quantity and quality</strong>. Distillation, a popular technique for producing purified water in the past, has virtually completely supplanted by less energy-intensive and operationally dependable alternatives today. <strong>Reverse osmosis</strong> is the foundation of the majority of contemporary systems for <strong>producing purified water</strong>; in reality, this principle is supplemented with <strong>adsorption</strong>, <strong>ion exchange</strong>, <strong>filtration</strong>, <strong>ultrafiltration</strong>, and other physical-chemical techniques.</p>

Watrex SCI-AQUA ROWAPUR 270 Water Purification System

<p><strong>Fully automatic system for the preparation of pure water based on reverse osmosis. Reverse osmosis membrane is protected by three-stage pre-filtration consisting of sediment filter and two carbon adsorption filters.</strong></p><p><strong>Watrex ROWAPUR</strong> is driven by water pressure from water distribution network, it <strong>does not require electric power</strong>.</p><p>It prepares water <strong>free of mechanical impurities</strong>, <strong>chlorine</strong>, <strong>95-99% of all dissolved substances</strong> are removed. Depending on input water composition and supply pressure the output water has a specific <strong>conductivity in the range of 10-20 µS/cm</strong>.</p><p><span style="font-size:18px;"><strong>Price: 592</strong><bdi><span class="wmc-cache-pid woocommerce-Price-amount amount" data-wmc_product_id="24487"><strong>&nbsp;</strong></span><span class="wmc-cache-pid woocommerce-Price-amount amount woocommerce-Price-currencySymbol" data-wmc_product_id="24487"><strong>€</strong></span></bdi><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong> </strong></span><small class="woocommerce-price-suffix"><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong>ex. VAT</strong></span></small></span></p><h4>Features</h4><ul><li>Removes 95 – 99% of dissolved substances</li><li>Typical specific conductivity of produced water 10 – 20 µS/cm</li><li>6 to 12 months filters lifetime</li><li>2 – 5 years RO membrane lifetime</li><li>No electricity is required for operation</li><li>Supplied from water distribution network</li></ul><h4>Technical specification</h4><ul><li><strong>Daily production capacity:</strong>&nbsp;up to 270 liters</li><li><strong>Input water pressure:</strong>&nbsp;0,3 – 0,7 MPa</li><li><strong>Input water temperature:</strong>&nbsp;&lt; 35 °C</li><li><strong>Maximum input water TDS: </strong>1200 mg/l</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"></p><p>Basic requirements for laboratory operations include the easy availability of <strong>pure laboratory water</strong> in the necessary <strong>quantity and quality</strong>. Distillation, a popular technique for producing purified water in the past, has virtually completely supplanted by less energy-intensive and operationally dependable alternatives today. <strong>Reverse osmosis</strong> is the foundation of the majority of contemporary systems for <strong>producing purified water</strong>; in reality, this principle is supplemented with <strong>adsorption</strong>, <strong>ion exchange</strong>, <strong>filtration</strong>, <strong>ultrafiltration</strong>, and other physical-chemical techniques.</p>

Watrex SCI-AQUA ULTRAPUR Water Purification System

WATREX ULTRAPURE is dedicated to preparaton of ultrapure water for analytical, biochemical and other laboratories.

<p><strong>WATREX ULTRAPURE is dedicated to preparaton of ultrapure water for analytical, biochemical and other laboratories where the water with specific conductivity values below 0.1 µS/cm and a TOC value of less than 50 ppb is required.</strong></p><p>The device is <strong>fed with pressurized pre-treated water</strong>, preferably with conductivity values below 15 µS/cm (e.g. water treated by reverse osmosis).</p><p><strong>Watrex ULTRAPUR</strong> is supplied with a <strong>digital flow conductometer</strong> that allows monitoring the proper functioning of the device and the need to replace exhausted filter cartridges.</p><p>The water treated by ULTRAPURE system is <strong>suitable for HPLC, AA, ICP</strong> and other demanding analyses.</p><p><strong>The maintenance of the device is very simple</strong> and consists only in replacing the filter inserts after they are exhausted.</p><p><span style="font-size:18px;"><strong>Price: 923</strong><bdi><span class="wmc-cache-pid woocommerce-Price-amount amount" data-wmc_product_id="24487"><strong>&nbsp;</strong></span><span class="wmc-cache-pid woocommerce-Price-amount amount woocommerce-Price-currencySymbol" data-wmc_product_id="24487"><strong>€</strong></span></bdi><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong> </strong></span><small class="woocommerce-price-suffix"><span class="wmc-cache-pid" data-wmc_product_id="24487"><strong>ex. VAT</strong></span></small></span></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Water_purification_systems_8810a2c48a.jpg" alt="Watrex: Water purification systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Water_purification_systems_8810a2c48a.jpg 245w," sizes="100vw" width="2286" height="1130"></p><p>Basic requirements for laboratory operations include the easy availability of <strong>pure laboratory water</strong> in the necessary <strong>quantity and quality</strong>. Distillation, a popular technique for producing purified water in the past, has virtually completely supplanted by less energy-intensive and operationally dependable alternatives today. <strong>Reverse osmosis</strong> is the foundation of the majority of contemporary systems for <strong>producing purified water</strong>; in reality, this principle is supplemented with <strong>adsorption</strong>, <strong>ion exchange</strong>, <strong>filtration</strong>, <strong>ultrafiltration</strong>, and other physical-chemical techniques.</p>

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