<div><p><strong>Mulching films used in agriculture gradually break down and can become a significant source of microplastics in soils. A new study shows that these particles affect not only soil structure but also microbial life and nitrogen cycling.</strong></p><p><i>“We wanted to understand how microplastics from both conventional and biodegradable mulching films influence soil properties, microbial diversity and functions in real conditions,”</i> explains <strong>Klára Šmídová</strong>, the study’s co-author . <i>“That’s why we added realistic amounts of microplastics to soils in experimental plots in Finland, Germany, and Spain, monitored them over two growing seasons, and compared them with the control plots.”</i></p><p>The results revealed that microplastics alter soil characteristics and microbial communities, although not always in the same way. <i>“ However, a consistent finding was the decline in microbial activity associated with key processes, including nitrogen cycling, with negative effects increasing at higher microplastic concentrations and becoming more pronounced in the second year,” </i>Šmídová adds. Because the microplastic levels used in the study reflect amounts already found in European soils, the findings highlight real risks to soil health. <i>“We also found that the effects were stronger in southern than in northern Europe, likely due to differences in climate and soil conditions. This means that protecting soils from plastic pollution will require region-specific risk assessments,”</i> she says.</p><p>Over 60% of European soils are estimated to be unhealthy, with ongoing degradation driven by unsustainable land use, contamination, climate change, and extreme weather events. In response, the EU Parliament adopted the Soil Monitoring Law in October 2025, aiming to achieve healthy soils across Europe by 2050. <i>“The law highlights the role of soil health in food security, water quality, and climate objectives, and establishes consistent soil monitoring across Member States. It includes measures to support farmers and foresters, while also creating a public list of potentially contaminated sites and an indicative watch list of emerging soil contaminants,” </i>explains Klára Šmídová.</p><p>The project brought together 19 research groups across Europe. <i>“After each season, hundreds of samples were colle cted and sent to partners for analysis. This paper focuses on soil properties, microbial diversity, and greenhouse gas emissions. Two more manuscripts—on plastic additives and microplastic fate, and on soil invertebrates—are in preparation. Together, they will give us a complete picture of how agricultural microplastics affect soil ecosystems,” </i>concludes Klára Šmídová.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg" alt="RECETOX: New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_RECETOX_Vysledky_nove_studie_ukazaly_ze_mikroplasty_meni_vlastnosti_pudy_a_mikrobialni_spolecenstva_i_v_realnych_podminkach_6ee3413a7b.jpg 171w," sizes="100vw" width="738" height="674"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0269749125015866?via%3Dihub#sec2"><span><strong>Conventional and biodegradable agricultural microplastics: effects on soil properties and microbial functions across a European pedoclimatic gradient</strong></span></a></h4><p>Šmídová K., Soinne H., Kim S. W., Tirronniemi J., Meffe R., Redondo-Hasselerharm P. E., Braun M., Rillig M. C., Fritze H., Adamczyk B., Nikama J., Kaseva J., Saartama V., Amelung W., Hurley R., Hofman J., Nizzetto L., Selonen S., Velmala S.</p><p>Environ. Pollut. 386 (2025) 127212</p><p><a href="DOI:%2010.1016/j.envpol.2025.127212"><span>DOI:&nbsp;10.1016/j.envpol.2025.127212</span></a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><div><p>Agricultural plastics like mulching films may become a major source of microplastic (MP) soil contamination during their degradation and fragmentation. This study investigates the effects of agricultural MPs from conventional (linear low-density polyethylene, PE) and biodegradable (starch-blended polybutylene adipate co-terephthalate, PBAT-BD) mulching films on soil physicochemical properties, aggregation, microbial diversity and functions, litter decomposition, and greenhouse gases emissions (GHG). For this purpose, MPs were mixed into soils at realistic MP concentrations of 0.005&nbsp;% and 0.05&nbsp;% (w/w) in 2022 on experimental plots in three EU countries representing different pedoclimatic conditions (Finland, Germany and Spain), followed by monitoring of the above-mentioned variables in the subsequent growing seasons 2022 and 2023. We found several significant MP-induced effects for soil properties, aggregation, microbial diversity, litter decomposition, and GHG, but the effect endpoints were less pronounced or varied considerably. Contrarily, microbial activity, contributing to soil functions such as nitrogen cycling, was consistently reduced by both conventional and biodegradable MPs. The reductions were more pronounced after the second season and for the higher MP treatment. As the higher MP concentration (i.e., 0.05&nbsp;% w/w) is environmentally relevant in Europe, our findings emphasize the potential effects of environmentally relevant MP concentrations on soil health. Furthermore, the effects increased from north to south, probably modulated by varying pedoclimatic conditions, inducing reflection of a need for regionally tailored risk</p></div></div>

New Study Reveals How Agricultural Plastics Impact Soil Health In Real Conditions

<h3><strong>Charged for Action: The Hidden Secrets of AEX Oligonucleotide Analysis</strong></h3><p><strong>Oligonucleotides—short, well-defined fragments of DNA or RNA—have become indispensable tools in modern life sciences. They underpin cutting-edge applications in molecular diagnostics, gene therapy, and pharmaceutical development. Before oligonucleotides can be confidently used in research or clinical settings, however, their quality must be rigorously assessed. Purity, sequence integrity, length distribution, and chemical modifications all play a decisive role in their performance.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg" alt="KNAUER: Oligos Made Easy - Part 2: AEX" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg 245w," sizes="100vw" width="1534" height="711"></p><p>Among the analytical techniques available today, <strong>anion exchange chromatography (AEX)</strong> stands out as a robust and highly informative method for characterizing oligonucleotides. By exploiting their intrinsic negative charge, AEX provides detailed insight into product composition and impurity profiles that are difficult to obtain by other approaches.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6808"><strong>Part 1 of the Oligos series: A Practical Guide to Oligonucleotide Production – From Concept to Final Product</strong></a></p></blockquote><h4><strong>How Scientists Read Oligonucleotides Using Charge</strong></h4><p>At the core of AEX lies a simple but powerful principle: oligonucleotides carry a negatively charged phosphate backbone. This charge increases in a predictable way with strand length and, to a lesser extent, sequence composition. Anion exchange chromatography uses this property to separate oligonucleotides based on differences in charge strength and interaction with a positively charged stationary phase.</p><p>As a result, AEX has become one of the most widely used analytical tools for evaluating oligonucleotide quality. It allows scientists to distinguish full-length products from truncated species, degradation products, or closely related variants—often with single-nucleotide resolution.</p><h4><strong>Why Ion Exchange Works: Binding, Retention, and Release</strong></h4><p>Ion exchange chromatography (IEX) relies on electrostatic interactions between analytes and a charged stationary phase. In the case of oligonucleotides, <strong>anion exchange</strong> is used, where negatively charged molecules interact with positively charged functional groups on the resin—most commonly quaternary amines.</p><p>The system consists of two main components:</p><ul><li><strong>Stationary phase:</strong> A positively charged resin that binds anionic analytes.</li><li><strong>Mobile phase:</strong> An aqueous buffer system, typically combined with a salt gradient, that controls both pH and elution strength.</li></ul><p>Retention in AEX is governed primarily by charge. Molecules with weaker overall charge interact less strongly with the stationary phase and elute earlier, while more highly charged oligonucleotides bind more tightly and require stronger elution conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 1 IEX overview including elution order dependency on analyte charge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg 245w," sizes="100vw" width="1583" height="654"></p><h4><strong>The Five-Step Workflow of Ion Exchange Chromatography</strong></h4><p>AEX separations generally follow a well-established sequence of steps:</p><ol><li><strong>Column equilibration</strong><br>The column is conditioned with the starting buffer until the baseline and pH are stable. This ensures that all charged sites on the resin are ready for interaction.</li><li><strong>Sample loading</strong><br>Samples, prepared in the starting buffer, are introduced under conditions that promote binding of the target oligonucleotides while minimizing retention of unwanted impurities.</li><li><strong>Washing</strong><br>The column is washed with the starting buffer to remove uncharged or weakly interacting components. The baseline stabilizes as these species are flushed away.</li><li><strong>Elution</strong><br>Bound oligonucleotides are released using a salt or pH gradient. Increasing ionic strength introduces competing ions that displace the analytes from the resin. Weakly bound species elute first; strongly charged oligonucleotides elute later.</li><li><strong>Regeneration and re-equilibration</strong><br>A high-salt buffer removes any remaining bound material. The column is then returned to starting conditions in preparation for the next analysis.</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 2  Five steps of IEX procedure (in blue), outlined using an example chromatogram (in red)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg 245w," sizes="100vw" width="1583" height="674"></p><h4><strong>Why AEX Is Especially Effective for Oligonucleotides</strong></h4><p>The repeating phosphate backbone of oligonucleotides gives rise to a strong and uniform anionic character across a wide pH range (typically pH 7–9). This makes oligonucleotides exceptionally well suited for anion exchange separations.</p><p>Key factors influencing AEX behavior include:</p><ul><li><strong>Charge density:</strong> Longer oligonucleotides carry more negative charges and therefore exhibit stronger retention.</li><li><strong>Resin chemistry:</strong> Strong and weak anion exchangers differ in functional groups and pH stability, influencing selectivity and robustness.</li><li><strong>Buffer composition:</strong> The choice of buffering ions and salt gradients directly affects elution strength and resolution.</li></ul><p>Salt gradients—commonly based on chloride ions—compete with the oligonucleotide backbone for binding sites on the resin. By carefully tuning gradient slope and composition, analysts can achieve highly reproducible and finely resolved separations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 3 Ionic interactions and pH influence on Anion Exchange Chromatography (AEX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg 245w," sizes="100vw" width="1547" height="593"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 4 AEX buffer selection and gradient strategy (chromatogram with red buffer gradient curve)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg 245w," sizes="100vw" width="1600" height="327"></p><h4><strong>AEX as the Gold Standard for Oligonucleotide Separation</strong></h4><p>Anion exchange chromatography has become the method of choice for both analytical and preparative oligonucleotide workflows. Its advantages include:</p><ul><li><strong>High resolving power:</strong> Closely related impurities, including n–1 or n–2 species, can often be separated and quantified.</li><li><strong>Predictable retention behavior:</strong> In many cases, retention time correlates linearly with oligonucleotide length, simplifying identification.</li><li><strong>Compatibility with modified oligonucleotides:</strong> Even chemically modified sequences retain their anionic nature, allowing AEX to resolve both products and related impurities.</li><li><strong>Excellent control via gradient elution:</strong> Salt gradients provide precise tuning of selectivity and resolution.</li></ul><p>Typically, shorter or degraded oligonucleotides elute at lower ionic strength, while full-length products with higher charge density appear later in the chromatogram.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 5 AEX Advantages and Challenges." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg 245w," sizes="100vw" width="1535" height="707"></p><h4><strong>Final Perspective: Mastering AEX with Confidence</strong></h4><p>Anion exchange chromatography may appear complex at first, but with thoughtful optimization of pH, buffer composition, and gradient conditions, it becomes a highly precise and reliable tool for oligonucleotide analysis. When properly applied, AEX delivers sharp peaks, excellent resolution, and robust performance—even for challenging sequences and modifications.</p><p>For laboratories developing or refining oligonucleotide workflows, AEX offers both analytical depth and operational confidence.</p><blockquote><p>If you would like to discuss AEX method development or optimization for oligonucleotides, feel free to contact us at <strong>sales@knauer.net</strong>. More insights into practical oligonucleotide analysis will follow in our <i>“Oligos Made Easy”</i> series.</p><p>For technical questions or in-depth discussion, the author can be reached at <strong>kindler@knauer.net</strong></p></blockquote>

Oligos Made Easy - Part 2: AEX

News from LabRulezLCMS Library - Week 07, 2026

Article

Application

Plastics

Environment

Science and research

Poster

RECETOX (Research Centre for Toxic Compounds in the Environment) is an independent department of the Faculty of Science of Masaryk University in Brno, which has been established in 1983. RECETOX is focused on the research and education in cross-cutting area of Environment and Health. It addresses interactions among chemicals, environment, and biological systems, including consequences at local, regional, and global levels.

RECETOX - Centrum pro výzkum toxických látek v prostředí

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Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

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Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer

Triple quadrupole Thermo Scientific TSQ Certis built for long-term robustness, up to 900 SRMs/s, and stable performance across tens of thousands of injections using OptaMax Plus ion source and advanced Stellar ion optics.

<p><strong>The Thermo Scientific TSQ Certis is a high-performance triple quadrupole LC-MS/MS system designed for targeted quantitative analysis in demanding routine and regulated environments. Built on the proven </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/404"><strong>TSQ Altis Plus </strong></a><strong>platform, it integrates advanced front-end hardware, innovative ion optics, and compliance-ready software to deliver superior performance and uptime.</strong></p><p>Powered by the <strong>OptaMax Plus ion source</strong> and <strong>Stellar ion vector optics</strong>, TSQ Certis provides exceptional sensitivity, long-term robustness, and reproducible performance even for complex sample matrices. 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Restoring data quality demands time-consuming maintenance. The TSQ Certis Mass Spectrometer proves its durability by maintaining stable, precise performance through tens of thousands of injections—minimizing downtime and maximizing throughput.</p></div></div></div></div></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_0ec820459f.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Raw peak area of 15pg Ascomycin on column was determined in whole blood for 10,209 injections. The experiment was run over a 5-week period, and the system delivered an RSD of 13.8% with no cleaning of the ion transfer tube or the sweep cone." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_0ec820459f.jpg 245w," sizes="100vw" width="2048" height="1152"></p><div><div><div><div><div><h3><strong>Endocrinology application: superior performance for steroid quantitation</strong></h3></div></div><div><div><p>Liquid chromatography coupled with triple quadrupole (LC–QqQ) mass spectrometry has become the industry standard for the quantitative determination of steroids in biological matrices. Compared to immunoassays, LC–QqQ MS offers superior analytical specificity, lower detection limits, and improved reproducibility, making it ideal for regulated pharmacokinetic, endocrinological, and clinical research applications. The TSQ Certis Mass Spectrometer provides the speed, specificity, and ultra-high sensitivity necessary for reliable steroid quantitation.&nbsp;</p></div></div></div></div></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_2_3a48cc4deb.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: LC SRM chromatogram of 18 steroids in BSA run using the Thermo Scientific Vanquish Flex UHPLC System and TSQ Certis Mass Spectrometer. This is an 8-minute chromatography run utilizing the Thermo Scientific Hypersil Gold C18 Column for separation. The samples were protein crashed from 0.05% BSA in PBS, and injecting 5µL." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_2_3a48cc4deb.jpg 245w," sizes="100vw" width="2048" height="1152"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_3_62ede15e59.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Highly sensitive triple quadrupole instrumentation, often with advanced ion optics, is needed for Dihydrotestosterone (DHT) quantitation. The DHT quantitation peak and calibration curve of DHT run at 0.4pg on column with an RSD of 8.2%." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_3_62ede15e59.jpg 245w," sizes="100vw" width="2048" height="1152"></p>

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<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Altis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3><strong>Ultimate quantitative performance made possible</strong></h3><p>Overcome the most demanding quantitative workflow challenges. With superior <strong>acquisition speeds, enhanced sensitivity, prototypical selectivity</strong>, and <strong>exceptional robustness</strong>, the <strong>TSQ Altis Plus mass spectrometer </strong>delivers unprecedented accuracy and precision <strong>for low-level compound detection</strong> and <strong>quantitation in complex matrices </strong>that redefines ultimate instrument performance.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt7" comp-id="A1"><div><h3 style="text-align:left;"><strong>Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity&nbsp;</strong></h3><p>Greater than <strong>6 orders</strong> of linear dynamic range with high selectivity. 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New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. <strong>Thermo Scientific Chromeleon Chromatographic Data System</strong> (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. <strong>Direct method transfer </strong>from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Database integration</strong></h3><p>Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of <strong>experimental libraries </strong>created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in <strong>Thermo Scientific TraceFinder software</strong> can be directly imported into the instrument method editor, streamlining large-scale study creation.</p><p>Discovery experiments, however, may not contain all compounds targeted in a study. Integration with <strong>Thermo Scientific mzCloud databases</strong> enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.</p></div></div></div></div></div></div></div></div>

Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer

The Thermo Scientific TSQ Quantis Plus mass spectrometer provides effortless method set up with industry-leading multi-channel solutions and automated reporting.

<h3><strong>Advance quantitative workflows and increase productivity</strong></h3><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h2><strong>TSQ Quantis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Extended quantitative performance made accessible</strong></h3><p>Experience reliability and sensitivity, and report results with confidence. The <strong>Thermo Scientific TSQ Quantis Plus mass spectrometer </strong>provides effortless method set up with <strong>industry-leading multi-channel solutions</strong> and <strong>automated reporting</strong> that enable robust high-throughput quantitation.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p><strong>Advanced instrument control software, compound database integration,</strong> and <strong>predefined method templates</strong> simplify operations, enabling LC-MS/MS users of all skill sets to obtain high-confidence data.</p><p>Achieve next-level productivity, versatility, and performance for method development and routine sample analysis. The Thermo Scientific TSQ Quantis Plus triple quadrupole mass spectrometer combines <strong>enhanced acquisition speed</strong> and <strong>sensitivity with proven robustness and reliability </strong>to deliver confident targeted screening and quantitation for high-throughput applications.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Reducing the barrier to productivity: Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. <strong>Predefined method templates</strong> with<strong> integration to databases</strong>, including the <strong>Thermo Scientific mzCloud database</strong>, enable targeted quantitation method creation based on empirical knowledge. Also, direct method transfer from previous Thermo Scientific TSQ Quantis mass spectrometers can be loaded and operated <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to transitions is automated based on user-defined chromatographic peak width, with the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg" alt="Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Speed with selectivity and sensitivity</strong></h3><p>Achieve superior acquisition speeds on the TSQ Quantis Plus mass spectrometer, which can acquire <strong>600 SRMs/sec</strong> and when combined with a new power supply enables <strong>5 ms polarity switching</strong> and allows the required number of data points to be acquired for expanded number of target compounds, even with ultra-high performance liquid chromatography (UHPLC) separation.</p><p>The TSQ Quantis Plus mass spectrometer delivers excellent quantitative performance in both selected reaction monitoring (SRM) and high-resolution selected reaction monitoring (H-SRM) for fit-for-purpose selectivity. The enhanced active<strong> Q2 collision cell </strong>improves product ion transmission, especially for low-mass product ions, which can increase detection efficiency.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the TSQ Quantis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and high performance ion chromotagraphy (HPIC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific<strong> Chromeleon Chromatography Data System</strong> (CDS) controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Robust and reliable quantitation</strong></h3><p>Innovative designs in the ion source, neutral blocker, and mass analyzers maintain optimal performance while maximizing instrument uptime. The ion transfer tube enables simple extraction and cleaning in minutes, without breaking the instrument vacuum or requiring instrument calibration. New integrated instrument performance check and calibration routine reduce manual interaction, maximizing data acquisition and instrument productivity.</p></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer

The TSQ Fortis Plus provides a seamless user experience for clinical research laboratories that focus on processing and analyzing a large number of samples.

<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Fortis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Robust quantitative performance made simple</strong></h3><p>The <strong>TSQ Fortis Plus</strong> provides a seamless user experience for <strong>clinical research laboratories</strong> that focus on processing and analyzing a <strong>large number of samples</strong>. Designed for ease, it enables confident quantitation of hundreds of <strong>samples in complex matrices</strong>, every day.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_1_5021103aa3/Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_1_5021103aa3/thumbnail_Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2 id="menu1"><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p>Accelerate your path to quantitative productivity with the <strong>Thermo Scientific TSQ Fortis Plus triple quadrupole mass spectrometer</strong>. Enhanced acquisition speed and sensitivity, combined with proven robustness and reliability, deliver next-level performance and value for <strong>high-throughput analyses</strong>. Simplified operations integrated with powerful Thermo Scientific chromatographic systems and market-leading software ensure users of all skill levels obtain reproducible, high-confidence results that meet laboratory requirements.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Reducing the barrier to productivity: Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. <strong>Predefined method templates</strong> with integration to databases, including the <strong>Thermo Scientific mzCloud database</strong>, enable targeted quantitation method creation based on empirical knowledge. Also, <strong>direct method transfer from previous TSQ Fortis mass spectrometers </strong>can be loaded and operated without optimization.</p><p>Experimental determination of dwell times assigned to transitions is automated based on user-defined chromatographic peak width, with the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.&nbsp;</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Speed with selectivity and sensitivity</strong></h3><p>Achieve superior acquisition speeds on the <strong>TSQ Fortis Plus mass spectrometer</strong>, which can acquire <strong>600 SRMs/sec</strong> and when combined with a new power supply enables <strong>5 ms </strong>polarity switching and allows the required number of data points to be acquired for expanded number of target compounds, even with ultra-high performance liquid chromatography (UHPLC) separation.</p><p>The TSQ&nbsp;Fortis Plus mass spectrometer delivers excellent quantitative performance in both selected reaction monitoring (SRM) and high-resolution selected reaction monitoring (H-SRM) for fit-for-purpose selectivity. The enhanced active <strong>Q2 collision cell </strong>improves product ion transmission, especially for low-mass product ions, which can increase detection efficiency.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_a876fda658/Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_a876fda658/thumbnail_Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the <strong>TSQ Fortis Plus mass spectrometer</strong> address regulated requirements targeting a growing list of diverse compounds. New UHPLC and high performance ion chromotagraphy (HPIC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. The <strong>Thermo Scientific Chromeleon Chromatography Data System</strong> (CDS) controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Robust and reliable quantitation</strong></h3><p><strong>Innovative designs in the ion source, neutral blocker</strong>, and<strong> mass analyzers</strong> maintain optimal performance while maximizing instrument uptime. The ion transfer tube enables simple extraction and cleaning in minutes, without breaking the instrument vacuum or requiring instrument calibration. New integrated instrument performance checks and calibration routine reduce manual interaction, maximizing data acquisition and instrument productivity.</p></div></div></div></div></div></div></div></div>

Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Quantis™ Triple Quadrupole MS offers best-in-class sensitivity, robustness, and seamless integration for efficient targeted quantitation across diverse molecular species.

<p><strong>Easily answer critical analytical challenges during targeted quantitation workflows in your laboratory. With its segmented quadrupoles, faster rod drivers, and improved electron multipliers, the Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer delivers unprecedented robustness with best-in-class sensitivity for everyday use and for every user.</strong></p><p>The <strong>TSQ Quantis MS</strong> seamlessly integrates with <strong>industry-leading quantitation software</strong>, <strong>HPLCs and UHPLCs</strong>, and <strong>sample preparation solutions</strong>; it also offers <strong>enhanced efficiency</strong> during targeted quantitation workflows for a <strong>wide array of molecular species</strong>. Other benefits include:</p><ul><li><strong>Superb sensitivity</strong> that generates data for all molecular species, even in <strong>complex matrices</strong>.</li><li><strong>Outstanding robustness</strong> that enables <strong>increased confidence in data</strong> while <strong>prolonging instrument uptime</strong>.</li><li><strong>Reliability and reproducibility</strong> improve <strong>data quality</strong> for <strong>every run and every sample</strong>.</li><li><strong>Close integration with application-specific software</strong> ensures <strong>increased productivity</strong> across all application markets.</li><li><strong>Simplicity and ease-of-use</strong> allow users of all expertise levels to acquire <strong>high quality data</strong> with <strong>improved confidence in results</strong>.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></p><h3><strong>Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer Specifications</strong></h3><ul><li><strong>For Use With (Application):</strong> Pharmaceutical, Environmental, Food Safety, Clinical Research, and Forensic Toxicology</li><li><strong>Mass Range:</strong> 5 to 3000 m/z</li><li><strong>Type:</strong> Triple Quadrupole LC-MS</li><li><strong>Unit Size:</strong> Each</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg" alt="Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></p>

Products from category Triple quadrupoles - page 1

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