The Thermo Scientific TSQ Certis is a high-performance triple quadrupole LC-MS/MS system designed for targeted quantitative analysis in demanding routine and regulated environments. Built on the proven TSQ Altis Plus platform, it integrates advanced front-end hardware, innovative ion optics, and compliance-ready software to deliver superior performance and uptime.
Powered by the OptaMax Plus ion source and Stellar ion vector optics, TSQ Certis provides exceptional sensitivity, long-term robustness, and reproducible performance even for complex sample matrices. With an acquisition speed of up to 900 SRMs per second, the system is ideally suited for pharmaceutical, clinical, forensic toxicology, environmental, and food safety laboratories.
Its rugged design supports tens of thousands of injections between cleanings, while an integrated early-warning maintenance system helps prevent unplanned downtime. Full compatibility with Chromeleon CDS, TraceFinder, Xcalibur, FreeStyle, and mzCloud ensures seamless integration into both routine and advanced analytical workflows.
Analyzing human whole blood by LC-MS presents persistent challenges: matrix contaminants can accumulate within the ion source and API stack, compromising signal integrity and reproducibility. Restoring data quality demands time-consuming maintenance. The TSQ Certis Mass Spectrometer proves its durability by maintaining stable, precise performance through tens of thousands of injections—minimizing downtime and maximizing throughput.
Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Raw peak area of 15pg Ascomycin on column was determined in whole blood for 10,209 injections. The experiment was run over a 5-week period, and the system delivered an RSD of 13.8% with no cleaning of the ion transfer tube or the sweep cone.
Liquid chromatography coupled with triple quadrupole (LC–QqQ) mass spectrometry has become the industry standard for the quantitative determination of steroids in biological matrices. Compared to immunoassays, LC–QqQ MS offers superior analytical specificity, lower detection limits, and improved reproducibility, making it ideal for regulated pharmacokinetic, endocrinological, and clinical research applications. The TSQ Certis Mass Spectrometer provides the speed, specificity, and ultra-high sensitivity necessary for reliable steroid quantitation.
Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: LC SRM chromatogram of 18 steroids in BSA run using the Thermo Scientific Vanquish Flex UHPLC System and TSQ Certis Mass Spectrometer. This is an 8-minute chromatography run utilizing the Thermo Scientific Hypersil Gold C18 Column for separation. The samples were protein crashed from 0.05% BSA in PBS, and injecting 5µL.
Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Highly sensitive triple quadrupole instrumentation, often with advanced ion optics, is needed for Dihydrotestosterone (DHT) quantitation. The DHT quantitation peak and calibration curve of DHT run at 0.4pg on column with an RSD of 8.2%.
