<p><strong>In the intricate world of metabolomics, understanding the complete set of metabolites within a biological sample is key to unlocking insights into metabolic pathways and the physiological state of an organism. The </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1149"><strong>Thermo Scientific Stellar mass spectrometer</strong></a><strong> from Thermo Fisher Scientific is revolutionizing this field with its advanced capabilities, making it an indispensable tool for researchers. Let’s delve into how the Stellar MS is transforming metabolomics research.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Unveiling_the_Power_of_the_Stellar_Mass_Spectrometer_in_Metabolomics_6923cbceb2.jpg" alt="Thermo Fisher Scientific: Unveiling the Power of the Stellar Mass Spectrometer in Metabolomics" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Unveiling_the_Power_of_the_Stellar_Mass_Spectrometer_in_Metabolomics_6923cbceb2.jpg 245w," sizes="100vw" width="1024" height="536"></p><article><div><h3><strong>The importance of metabolomics</strong></h3><p>Metabolomics is the comprehensive study of small molecules, or metabolites, within cells, tissues, or organisms. These metabolites are the end products of cellular processes and provide a snapshot of the physiological state of an organism. By analyzing these metabolites, researchers can gain valuable insights into metabolic pathways, disease mechanisms, and potential therapeutic targets.</p><h3><strong>Why the Stellar mass spectrometer?</strong></h3><p>The <strong>Thermo Scientific Stellar MS</strong> stands out as an ideal instrument for metabolomics due to its high sensitivity, specificity, and throughput. Here are some key features that make it a game-changer in this field:</p><ol><li><strong>High sensitivity and specificity</strong>:<ul><li>The dual-pressure linear ion trap technology of the Stellar MS enhances both sensitivity and specificity. This is crucial for detecting and quantifying low-abundance metabolites in complex biological matrices, where accurate measurement is often challenging.</li></ul></li><li><strong>Wide dynamic range</strong>:<ul><li>The Stellar MS can reproducibly quantify metabolites across a broad dynamic range. This ensures accurate measurement of both high and low-abundance compounds, providing a comprehensive metabolic profile.</li></ul></li><li><strong>Rapid data acquisition</strong>:<ul><li>With hyper-fast acquisition rates, the Stellar MS can quickly acquire detailed data, making it ideal for high-throughput metabolomics studies. This capability allows researchers to process large numbers of samples in a short amount of time.</li></ul></li><li><strong>Reduced matrix effects</strong>:<ul><li>Complex biological samples often contain various interfering substances. The Stellar MS minimizes these matrix effects, ensuring reliable quantification of metabolites even in complex samples, which is essential for accurate metabolomics analysis.</li></ul></li><li><strong>Streamlined method development</strong>:<ul><li>The Stellar MS simplifies method development, allowing researchers to quickly set up and optimize experiments for metabolite analysis. This is particularly beneficial when transitioning from method development to large-scale studies.</li></ul></li></ol><h3><strong>Application example: metabolic profiling in disease research</strong></h3><p>Let’s consider a practical example of how the Stellar MS can be used in metabolomics, specifically in disease research.</p><p><strong>A research team is investigating metabolic changes associated with a specific disease. Using the Stellar MS, they can:</strong></p><ul><li><strong>Method development</strong>: Quickly develop and optimize methods for detecting and quantifying a wide range of metabolites, including both primary and secondary metabolites. The system’s PRM Conductor software aids in automating method creation, enhancing productivity.</li><li><strong>Data acquisition</strong>: Leverage the system’s rapid full-scan MSn acquisition to gather comprehensive data on metabolites, providing a detailed metabolic profile of the samples. This detailed data helps identify key metabolic changes associated with the disease.</li><li><strong>Quantification</strong>: Accurately quantify metabolites across a wide dynamic range, ensuring that both high and low-abundance metabolites are measured reliably. This is crucial for identifying subtle metabolic changes that may be indicative of disease.</li><li><strong>High throughput</strong>: Process large numbers of samples efficiently, enabling the team to conduct extensive metabolic profiling studies in a short amount of time. The ability to process 96-well plates in just nine hours accelerates the research process.</li></ul><p>The Stellar MS’s capabilities allow the research team to generate detailed metabolic profiles, providing insights into metabolic pathways and identifying potential biomarkers for the disease. This information can be used to understand disease mechanisms, identify therapeutic targets, and develop diagnostic tools.</p><h3><strong>Conclusion</strong></h3><p>The Stellar mass spectrometer is a powerful tool for metabolomics, offering high sensitivity, wide dynamic range, rapid data acquisition, reduced matrix effects, and streamlined method development. These features make it an ideal instrument for comprehensive metabolic profiling, enabling researchers to gain deeper insights into metabolic pathways and the physiological state of organisms. Invest in the Stellar MS to enhance your metabolomics research and accelerate discoveries in disease mechanisms, biomarkers, and therapeutic targets. With the Stellar MS, the future of metabolomics is brighter than ever.</p><blockquote><p>Explore the capabilities of the Stellar mass spectrometer and see how it can transform your metabolomics research. Contact us for more information or to schedule a demo. Let’s revolutionize metabolomics together.</p><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong>LinkedIn:</strong></a><strong>&nbsp;</strong>#MassSpectrometry #Metabolomics #BiomarkerDiscovery #StellarMS</p></blockquote></div></article><section><blockquote><h4><strong>Dane Walker</strong></h4><p>Dane Walker is Regional Marketing Manager at Thermo Fisher Scientific, focused on LC-MS systems across EMEA. With a PhD in Surface Science and a background in scientific instrumentation, he blends technical expertise with strategic marketing to drive data-led campaigns. Passionate about communicating science and enabling innovation, Dane enjoys powerboating, cycling, stargazing, and talking endlessly about mass spectrometry.</p></blockquote></section>

Unveiling the Power of the Stellar Mass Spectrometer in Metabolomics

<p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=136&amp;manufacturerItems=50&amp;page=2"><strong>Solid phase extraction</strong></a> is routinely selected as a sample preparation technique prior to HPLC and GC analysis. It provides:</p><ul><li><strong>Clean-up;</strong></li><li><strong>Analyte pre-concentration;</strong></li><li><strong>Solvent switching.</strong></li></ul><p>This works well for any homogeneous liquid samples, but clearly a<strong> solid sample cannot be applied directly</strong> to an SPE device. Here we will consider how best to approach the handling of solid samples prior to SPE.</p><p>The first stage of sample pre-treatment involves <strong>homogenising the solid sample with a suitable solvent</strong>. The solvent selected for this purpose will:</p><ul><li>Be effective at <strong>solubilising the analyte</strong>.</li><li>Be effective at <strong>solubilising the sample matrix</strong>, although this is not necessary providing the sample is blended well with the solvent.</li><li>Ideally it will be a weak solvent when it comes to the SPE stage. This may not be possible, and it may be necessary to <strong>dry down and reconstitute</strong> the sample prior to loading on to the SPE cartridge.</li></ul><p>Having formed a suspension of the sample in a suitable solvent the sample should be <strong>vortexed </strong>to promote thorough mixing, and then <strong>centrifuged </strong>to pellet the insoluble components of the matrix. The solvent should then be removed for further treatment.</p><p><strong>At this point the SPE mechanism needs to be selected:&nbsp;</strong></p><h3><strong>Reversed Phase SPE Method</strong></h3><p><strong>Mechanism / Weak Solvent / Strong Solvent</strong></p><ul><li><strong>Reversed phase</strong> – Water/buffer – Acetonitrile/Methanol (hexane strongest)</li><li><strong>Normal phase</strong> – Hexane/Heptane – Mid polar organic such as DCM, MTBE, IPA (strongest is water)</li><li><strong>Ion exchange</strong> – Aqueous buffer at a pH which promotes ion exchange interactions between analyte and SPE sorbent – Organic solvent, typically methanol with pH adjustment to disrupt the ion exchange interactions.</li></ul><p><strong>Analyte properties and sample diluent</strong> both need to be considered at this point. <strong>Reversed phase extractions</strong> are effective for <strong>moderately polar to moderately hydrophobic analytes</strong>, but only if they are dissolved in a <strong>weak solvent such as water</strong>. If the sample is dissolved in a <strong>mid-polar solvent</strong> the sample will either need to be <strong>diluted</strong>, or alternatively <strong>dried down and reconstituted</strong>. The same is true for <strong>normal phase</strong>, where samples need to be <strong>dissolved in hexane/heptane</strong> for analytes to be successfully retained during sample loading onto the SPE device.</p><p>These examples will hopefully illustrate this concept.</p><h4><strong>The extraction of PCBs from soil.</strong></h4><p><strong>PCBs</strong> are <strong>hydrophobic</strong> and will dissolve readily in a <strong>non-polar solvent</strong>. Soil can be dried, weighed and then extracted using <strong>hexane (or heptane)</strong>. Once thoroughly mixed and centrifuged the resulting solution can be applied directed to a conditioned <strong>silica SPE tube</strong> allowing for a <strong>normal phase extraction</strong> to be conducted.</p><h4><strong>Tylosin from meat.</strong></h4><p><strong>Tylosin</strong> is an <strong>antibiotic</strong>, with a <strong>log P of 1.0</strong>. Extracting from meat with a mixture of <strong>acetonitrile and water (80:20)</strong> will break any hydrophobic interactions releasing the tylosin. After centrifugation the resulting liquid sample will require further <strong>dilution with water</strong> to reduce the <strong>loading solvent strength</strong> prior to a <strong>reversed phase extraction</strong>.</p><h4><strong>Enilconazole from oranges.</strong></h4><p><strong>Enilconazole</strong> is a <strong>fungicide</strong> widely used in agriculture and is often used with citrus fruits. It can readily be extracted from oranges using <strong>acetonitrile</strong>. As enilconazole is <strong>basic</strong>, the addition of <strong>HCl</strong> to the acetonitrile extract will promote <strong>protonation of the analyte</strong>, allowing for it to be directly retained on a <strong>strong cation exchange SPE material</strong>. This greatly simplifies the extraction process as <strong>no dilution of the sample is required</strong> (in contrast to reversed phase, or normal phase extraction where <strong>100% acetonitrile</strong> would cause the analyte to be unretained during loading).</p>

Considerations when working with solid samples and SPE

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 14th July 2025? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you posters by <strong>Agilent Technologies / ASMS, Shimadzu / ASMS, Thermo Fisher Scientific / ASMS </strong>and<strong> Waters Corporation / ASMS!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Faster Than the Speed of Life: A Rapid Screening Method for Select PFAS Compounds in Serum by RapidFire-MS</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_rapidfire_ms_pfas_serum_asms_2025_wp_243_en_agilent_c8b56f4dd5.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Per- and polyfluoroalkyl substances (PFAS) are a broad class of compounds with a high degree of fluorination used in a variety of industries and consumer products over the past seventy years. Because of their widespread use, as well as their persistence and poorly understood effects on the human body, laboratories have started to monitor their presence in biological fluids, including serum. Biological samples are commonly prepared with protein precipitation. Additional cleanup steps such as solid phase extraction (SPE) with either C18 or weak anion exchange (WAX) sorbent can be used for increased sensitivity and cleanup. Alternatively, a pass-through cleanup using Captiva EMR-Lipid removes proteins and phospholipids through filtration, which significantly reduces sample complexity.</p><h4><strong>Experimental</strong></h4><p>Purchased serum was aliquoted into two sets of samples, one for protein precipitation (ppt) only and one for a protein precipitation plus Captiva EMR-Lipid based cleanup. For each preparation, 100 µL serum was aliquoted into a tube and spiked with 25 native and extracted isotopically labeled (EIS) compounds (EPA 533 list). The samples were vortexed for 1 minute and then crashed with 1% formic acid in cold ACN. They were vortexed for 3 minutes and then spun for 10 minutes to complete the crash. Samples undergoing the Captiva-EMR Lipid cleanup were then loaded onto a pre-rinsed cartridge and allowed to filter through (Figure 1). All samples were then spiked with the additional non-extracted isotopically labelled (NIS) compounds, vortexed, and transferred to a plate for analysis.</p><p>The RF/TQ system consisted of a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?manufacturerItems=1&amp;search=RapidFire+400"><strong>RapidFire 400</strong></a> front end with a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?manufacturerItems=1&amp;search=6495D+triple+quadrupole"><strong>6495D triple quadrupole mass spectrometer</strong></a> for detection. Samples were introduced into the mass spectrometer using a RapidFire cartridge for additional cleanup, and the total cycle time was about 12.5 seconds, with analytes detected in negative polarity. Specific method conditions are detailed in Tables 1 (RF) and 2 (MS).</p><h4><strong>Results and Discussion</strong></h4><h5><strong>Early Development Work&nbsp;</strong></h5><p>Feasibility studies for detection of PFAS compounds in serum using the RapidFire started by looking for PFAS background in the instrument and in all steps of the workflow. Early testing demonstrated no detectable background from any stage of the process.</p><p>RapidFire method development tested a variety of cartridges for optimal binding of the PFAS compounds, as well as determining the best state times and solvent conditions. For the preliminary work, the C18 cartridge appeared to have the best results, while the optimized elution solvent was 5 mM ammonium acetate in methanol.</p><p>Early experiments were performed to understand the effects of dilution and sample prep on the overall sensitivity of the method. When only a protein precipitation preparation was employed, dilution had a significant positive effect on analyte sensitivity, as shown in Figure 2. However, when the sample prep routine utilized protein precipitation in combination with a Captiva EMR-Lipid cleanup, additional dilution was not necessary and in fact decreased overall sensitivity, as shown in Figure 3. This is attributed to the removal of extraneous matrix using the Captiva EMR-Lipid device, which has a unique selectivity for unbranched alkane chains, capturing phospholipids while allowing PFAS compounds to pass through the sorbent bed unretained.</p><h5><strong>Custom Cartridge Work&nbsp;</strong></h5><p>This preliminary work was done using the C18 cartridge, but the cartridge had poor retention of the short-chain PFAS compounds (C5 and below). To address this issue, a cartridge was custom-packed with mixed mode material that included C18 and anion exchange resins. Further testing and method optimization for this specific packing material yielded better results across the board, but especially for the short-chain PFAS compounds. Sensitivity for most analytes was at or below 0.1 ppb, as summarized in Table 3, with a calibration range of 0.01- 10 ppb tested for all analytes.</p><h4><strong>Conclusions</strong></h4><ul><li>LOQs for most PFAS analytes of interest in serum were 0.1 ppb or below</li><li>Samples were injected every 12 seconds, allowing for high throughput analysis</li><li>Custom mixed mode cartridge had best overall performance&nbsp;</li><li>There was no background PFAS contribution from the RapidFire system</li></ul><h3><strong>2. Shimadzu / ASMS: Benchtop Matrix Assisted Laser Desorption Ionization Mass Spectrometry of PFAS for preliminary screening of environmental samples</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ASMS_2025_MP_588_4c415fced0.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants which negatively impact human health and the environment.&nbsp;<br>High concentrations of PFAS in test samples can cause contamination of sensitive LC-MS/MS instruments requiring extensive decontamination procedures, resulting in significant downtime and costly delays in sample processing.&nbsp;</p><p>We present the development of a simple, cost-effective method for the rapid screening of PFAS samples using an entry-level linear benchtop MALDI-TOF mass spectrometer to identify samples containing high levels before they enter the analytical workflow.</p><h4><strong>Methods</strong></h4><p>PFOA and PFOS standards were purchased from Merck, UK. Stock solutions (1 ppm prepared in acetonitrile) were diluted in water to the required concentrations.&nbsp;</p><p>Samples were tested with a variety of MALDI matrices (CHCA, DHB, DHAP, DAN, NRM and TMGN), with norharmane (NRM) and 1,8-bis(tetramethylguanidino)-naphthalene (TMGN) identified for further investigation. Diluted samples were mixed with NRM (1 mg/mL) or TMGN (5 mg/mL) in 70:30 Acetonitrile:Water. Blank samples of UHP water were prepared to ensure no contamination was present. 1 µL of the mixture was spotted onto a FlexiMassSR48 slide and the samples were analysed using a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?manufacturerItems=3&amp;search=MALDI-8030"><strong>MALDI-8030 MALDI-TOF mass spectrometer</strong></a> (Shimadzu). Analysis conditions are shown in Fig 1. Peaks at m/z 314.2 and m/z 499.2 were monitored for PFOA and PFOS, respectively. 13C8PFOS (m/z 507) was used as an internal standard for PFOS samples with a final sample concentration of 6.25 ng/mL (see Fig. 2). MALDI-MSI was used to assess spot homogeneity and limits of detection were established.</p><p>Subsequently, PFHxA and PFBS standards were purchased from Merck, UK and analysed using the same method</p><h4><strong>Conclusion</strong></h4><ul><li>We have shown, in principle, that it is possible to use MALDITOF mass spectrometry to implement a simple pre-screening method for aqueous samples to prevent widespread contamination in a PFAS monitoring laboratory. Using just a 200 µL sample and minimal preparation, a full slide of samples can be acquired in less than 15 minutes&nbsp;</li><li>Spot imaging during method development highlighted the differences in homogeneity of PFOS and PFOA spots suggesting that multiple internal standards would be necessary to pursue semi-quantitative analysis.&nbsp;</li><li>Whole slide imaging can provide quick results for multiple samples across a range of PFAS concentrations in a single run with easy visual identification of potentially problematic samples.&nbsp;</li><li>As a linear MALDI-TOF method, these results do not confirm the presence of PFAS but may be used as an indicative result to modify further testing protocols. Confirmatory LC-MS/MS analysis is required to determine the presence and concentration of any PFAS.</li></ul><h3><strong>3. Thermo Fisher Scientific / ASMS: Enhanced resolution with multi-pass mode on the Orbitrap Astral Zoom mass spectrometer&nbsp;</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/PO_319_ms_ASMS_25_Astral_Zoom_TMT_po319_na_en_a16d57e473.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The introduction of Thermo Scientific TMT 32-plex, with reporter ions clustered into quadruplets spaced by 3 mDa, demands a resolving power of approximately 90 k at low m/z, which challenges state-of-the-art time-of-flight mass analyzers. The Thermo Scientific Orbitrap Astral mass spectrometer [1] typically achieves around 60 k resolution at m/z = 138, falling to 50 k under high space charge influence.&nbsp;</p><p>Here we present an enhanced resolution multi-pass method implemented in the new Thermo Scientific <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1959"><strong>Orbitrap Astral Zoom mass spectrometer</strong></a> [2], significantly improving the resolving power at low m/z enabling TMT 32-plex on the Thermo Scientific Astral analyzer. The ions are repeatedly guided through a switchable prism deflector to extend the ion path while the principal aberrations are compensated, thereby more than doubling the resolution.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1959"><strong>The Orbitrap Astral Zoom Mass Spectrometer</strong></a></h4><p>The Orbitrap Astral Zoom mass spectrometer incorporates a range of novel technologies for higher speed, sensitivity, dynamic range and resolving power. A faster ion filter and quadrupole switching in combination with improved ion transfer times in the ion-routing multipole (IRM) and ion processor allow DIA methods (Thermo Scientific Pierce FlexMix calibration solution, 2 Th isolation window, 350-980 m/z range, Thermo Scientific Orbitrap MS and Astral MS/MS) with scan rates faster than 270 Hz (DDA methods &gt; 180 Hz). A duty cycle of up to 80 % at 270 Hz is made possible by a new accumulation stage in the bent trap (linear to 106 ions) which increases the effective ion injection into the IRM by up to 40 % (additional ~0.75 ms on top of 2 ms IT in a DIA method). Furthermore, an additional mode of the high-dynamic range detector of the Astral analyzer for low-input sample applications like single-cell proteomics boosts the single ion detection efficiency by about 10 % and thereby the sensitivity. In combination with a new peak deconvolution algorithm for enhanced spectral processing, this increases the depth of analysis. In addition, modified IRM hardware allows for faster stepped collision energy experiments for deeper spectral coverage (2 CE: 80 Hz (OT Astral), 180 Hz (Orbitrap Astral Zoom MS), 3 CE: 60 Hz, 150 Hz). A modified AGC filling in the Orbitrap by a new enhanced dynamic range mode (EDR) provides additional spectral complexity and sensitivity. Here, multiplexed ion injections with different accumulation times are used for different mass ranges taking the variation in signal intensity into account. In addition, the Astral analyzer incorporates a new multi-pass mode which enhances the resolving power for small masses by more than a factor of two, enabling TMT 32-plex measurement in the Astral analyzer.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>The TMT HR Mode advances the capabilities of the Astral analyzer. Fast electronic switching of the relay prism opens an ion trap and guides the ions after three times their normal flight distance to the detector. This greatly boosts the resolving power, especially for small m/z ratios, thereby enabling baseline-resolved quadruplets of reporter ions in a TMT 32-plex sample. First results show a peak resolution well above 100 k while maintaining high mass accuracy and shot-to-shot stability. The TMT HR Mode is utilized within a novel acquisition scheme delivering greater throughput for protein identification and quantitation for multiplexing up to 32 samples. Achieving a throughput of over 440 samples per day, the proteome coverage included 4,299 quantified protein groups and 22,146 peptides.</p><h3><strong>4. Waters Corporation / ASMS: Assessing the Impact of Part-per-Billion Mass Accuracy Upon Forensic Toxicology Data-Independent Analysis Screening&nbsp;</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008882_68ab66ac31.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This poster presents a forensic toxicology screening approach using <strong>ultra-high mass accuracy</strong> to improve specificity and efficiency in the analysis of complex biological matrices, such as urine. The need for rapid, accurate, and cost-effective screening is critical in forensic laboratories. The study evaluates the impact of <strong>parts-per-billion (ppb) mass accuracy</strong> using the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1148"><strong>Waters Xevo MRT Mass Spectrometer</strong></a><strong> </strong>compared to previous DIA methods.</p><p>The method involved analyzing a commercial standard and ten anonymized urine samples, diluted and analyzed via the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/199"><strong>ACQUITY UPLC I-Class FTN PLUS System</strong></a> coupled with the <strong>Xevo MRT MS</strong>. Data acquisition was performed in <strong>MSE mode</strong> (data-independent acquisition) under positive electrospray ionization (ESI+) using a 15-minute gradient. Data were processed in waters_connect software, leveraging a comprehensive spectral library with over 2000 compounds.</p><p>Results demonstrated a <strong>root mean square (RMS) mass error of just 571 ppb</strong> for precursor ions, with 94% of compounds detected within 1 ppm, and 96% of fragment ions within the same tolerance. A key example illustrated how reducing fragment ion tolerance from 2 mDa to 0.2 mDa eliminated a false positive (Anabasine), correctly identifying Nicotine as the true analyte, showing how ppb-level accuracy increases identification confidence and minimizes misidentifications.</p><p>The study concludes that ppb mass accuracy significantly reduces false positives, lowers review workloads, and facilitates independent analysis by less experienced personnel. Additionally, it supports cost savings by minimizing the need for confirmatory testing, potentially reducing both financial and environmental burdens in forensic laboratories.</p>

News from LabRulezLCMS Library - Week 29, 2025

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Thermo Scientific ISQ™ EC/EM Single Quadrupole Mass Spectrometer

Enhance your IC or LC analysis with ISQ EC/EM mass spectrometers. Enjoy fast setup, high sensitivity, and reliable quantification—even in complex samples—with easy, seamless system integration.

<h4><strong>Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer</strong></h4><p><strong>Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) systems. Both novices and experts alike can quickly master MS to gain more insights from every sample.</strong></p><h5><strong>Gain more insights</strong></h5><ul><li>Higher sensitivity and more accurate quantitation</li><li>Chromatographic peak mass confirmation, eliminating false negatives and false positives</li></ul><h5><strong>Resolve complexity</strong></h5><ul><li>Improved resolution of analytes in complex matrices</li><li>Better selectivity</li><li>Resolve co-eluting peaks using their mass-to-charge ratio</li></ul><h5><strong>Easily mastered</strong></h5><ul><li>Save time spent on user training with integrated tools to help master MS</li><li>Experience hassle-free, seamless integration with your IC or LC system</li><li>Save time using the Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ Chromatography Data System (CDS) software</strong></a> for data analysis, which also has embedded control of the ISQ EC mass spectrometer</li></ul><h4><strong>Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer</strong></h4><p>Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Detect and quantify a variety of analytes by choosing to use either heated electrospray ionization (HESI) or atmospheric pressure chemical ionization (APCI). Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.</p><h5><strong>Gain more insights</strong></h5><ul><li>Extended mass range enables you to detect and quantify small and large molecules</li><li>Durable atmospheric pressure ionization (API) source with two interchangeable probes included, enabling HESI or dual HESI/APCI</li><li>Sensitive and accurate quantitation of more samples</li><li>Chromatographic peak mass confirmation to eliminate false negatives and false positives</li></ul><h5><strong>Resolve complexity</strong></h5><ul><li>Consistent response even with complex matrices</li><li>Better selectivity and sensitivity with chromatographic peak mass confirmation</li><li>Resolution of co-eluting peaks via mass-to-charge ratio</li></ul><h5><strong>Easy mastery</strong></h5><ul><li>Reduce time spent on user training with integrated tools to help master MS</li><li>Unique software translates analyte physical properties into optimal method parameters, helping novice and experts develop methods and improve productivity</li><li>Hassle-free, seamless integration with existing LC systems</li><li>Facilitate data analysis with Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ Chromatography Data System (CDS) software</strong></a>, which features embedded control of the ISQ EM mass spectrometer</li></ul><h4><strong>Key Features ISQ™ EC/EM Single Quadrupole Mass Spectrometers:</strong></h4><ul><li><strong>Mass Range:</strong>&nbsp;<ul><li><strong>EC:</strong> 10–1250 m/z with unit mass resolution</li><li><strong>EM:</strong> 10–2000 m/z with unit mass resolution</li></ul></li><li><strong>Polarity Switching:</strong> 25 ms (in HESI mode)</li><li><strong>Scan Rate:</strong> Up to 20,000 Da/sec</li><li><strong>Sensitivity:</strong><ul><li><i>HESI Positive:</i> 10 pg Reserpine, 400:1 RMS at 400 μL/min</li><li><i>HESI Negative:</i> 20 pg p-Nitrophenol, 500:1 RMS at 400 μL/min</li></ul></li><li><strong>Gas Requirements:</strong> Nitrogen (≥ 99% purity), 30 L/min @ 90–110 psig</li><li><strong>Power Supply:</strong> 100–240 V, 50/60 Hz</li><li><strong>Dimensions:</strong> 52 (H) × 42 (W) × 91 (D) cm</li><li><strong>Weight:</strong> Approx. 71 kg (157 lb)</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Quantis™ Triple Quadrupole MS offers best-in-class sensitivity, robustness, and seamless integration for efficient targeted quantitation across diverse molecular species.

<p><strong>Easily answer critical analytical challenges during targeted quantitation workflows in your laboratory. With its segmented quadrupoles, faster rod drivers, and improved electron multipliers, the Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer delivers unprecedented robustness with best-in-class sensitivity for everyday use and for every user.</strong></p><p>The <strong>TSQ Quantis MS</strong> seamlessly integrates with <strong>industry-leading quantitation software</strong>, <strong>HPLCs and UHPLCs</strong>, and <strong>sample preparation solutions</strong>; it also offers <strong>enhanced efficiency</strong> during targeted quantitation workflows for a <strong>wide array of molecular species</strong>. Other benefits include:</p><ul><li><strong>Superb sensitivity</strong> that generates data for all molecular species, even in <strong>complex matrices</strong>.</li><li><strong>Outstanding robustness</strong> that enables <strong>increased confidence in data</strong> while <strong>prolonging instrument uptime</strong>.</li><li><strong>Reliability and reproducibility</strong> improve <strong>data quality</strong> for <strong>every run and every sample</strong>.</li><li><strong>Close integration with application-specific software</strong> ensures <strong>increased productivity</strong> across all application markets.</li><li><strong>Simplicity and ease-of-use</strong> allow users of all expertise levels to acquire <strong>high quality data</strong> with <strong>improved confidence in results</strong>.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></p><h3><strong>Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer Specifications</strong></h3><ul><li><strong>For Use With (Application):</strong> Pharmaceutical, Environmental, Food Safety, Clinical Research, and Forensic Toxicology</li><li><strong>Mass Range:</strong> 5 to 3000 m/z</li><li><strong>Type:</strong> Triple Quadrupole LC-MS</li><li><strong>Unit Size:</strong> Each</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg" alt="Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></p>

Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.

<h3><strong>Quantitate with Absolute Power</strong></h3><ul><li><strong>Harness Absolute Power for Confident, Fast Decisions</strong></li></ul><p><strong>The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.</strong></p><h4><strong>Absolute&nbsp;Performance</strong></h4><p>Achieve lower limits of quantitation to meet regulatory requirements with up to <strong>15x more sensitivity</strong> for challenging negative ionizing compounds than the previous product.</p><h4><strong>Absolute Efficiency &nbsp;</strong></h4><p>Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses <strong>up to 50% less electricity and gas and produces 50% less heat</strong> than most other high performance TQ mass spectrometry instruments on the market.</p><h4><strong>Absolute&nbsp;Productivity</strong></h4><p>Boost your productivity with flexible software solutions, including waters_connect,™ the modern, intuitive informatics solution that can<strong> save up to 50% of your data review time </strong>while facilitating data integrity.&nbsp;</p><h4><strong>Absolute Confidence</strong></h4><p>Ensure consistent robustness and reproducibility so you can <strong>maintain performance and productivity </strong>over a longer time period.</p><h3><strong>Absolute Performance</strong></h3><h4><strong>Increased sensitivity with lower limits of quantitation</strong></h4><p>One of the largest challenges facing many labs is the need to achieve lower limits of quantitation and meet regulatory requirements, particularly for challenging negative ionizing compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: *Xevo TQ Absolute shows up to 15x better ion response as compared to the Xevo TQ-XS and up to 6x better ion response than another leading high-performance LC-MS/MS instrument." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/thumbnail_Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp 245w," sizes="100vw" width="1024" height="540"></p><p>Ensure you have the confidence in your data to make decisions fast with an instrument that provides Absolute Performance. <strong>Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds</strong> than the previous product, so you can make decisions quickly and efficiently.</p><h3><strong>Absolute Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it.&nbsp;</p><p>Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. During development of the Xevo TQ Absolute, Waters has addressed these challenges by providing an instrument with lower electricity consumption, gas consumption, and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p>The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, enabling laboratory managers to fully optimize their facilities and increase efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute Efficiency." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg 206w," sizes="100vw" width="1050" height="794"></p><p>*Source: <a target="_blank" rel="noopener noreferrer" href="https://sciex.com/content/dam/SCIEX/pdf/customer-docs/site-planning-guide/7500-site-planning-guide-en.pdf">https://sciex.com/</a></p><h3><strong>Absolute Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions&nbsp;</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ Absolute is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements</p><h5><strong>waters_connect</strong></h5><p>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><h5><strong>MassLynx</strong></h5><p>Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Absolute Confidence</strong></h3><h4><strong>Tackle your toughest challenges</strong></h4><p>Analytical laboratories face several challenges that are constantly changing, so it’s important to have Absolute Confidence that your analytical instrumentation can keep pace.&nbsp;</p><p>The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility, so you can maintain performance and productivity over a longer time period.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: New source shield technology featured in the Xevo TQ Absolute Mass Spectrometer minimizes contamination and increases uptime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/thumbnail_Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Better by design</strong></h4><p>Optimal probe positioning guidance ensures you can achieve the best possible performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument. A new source shield maximizes uptime by minimizing contamination of the source from sample matrix or mobile phase salts.</p><h3><strong>Absolute Support</strong></h3><h4><strong>Ensure your success with world-renowned services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute support." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/thumbnail_Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp 234w," sizes="100vw" width="1024" height="682"></p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ Absolute, you can:</strong></p><h4><strong>Get Up And Running Quicly</strong></h4><p>Get the onsite training and consultation you need to integrate the Xevo TQ Absolute into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet Your Lab’s Unique Requirements&nbsp;</strong></h4><p>Protect your high-performance instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitates Compliance</strong></h4><p>Simplify the process of qualification, validation, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce Total Cost Of Ownership</strong></h4><p>FlexCAPITAL<strong>** </strong>is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage Your Existing Technology</strong></h4><p>With the FlexUP technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ Absolute – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>** </strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer confidently and routinely characterize, quantify, and confirm in a single analysis using a single mass spectrometer.

<p><strong>Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.</strong></p><h5><strong>Superior Quantitation</strong></h5><ul><li><strong>Advanced quadrupole technology (AQT)</strong> improves precursor selection and transmission for more-accurate quantitation of low-abundance analytes in complex matrices</li><li><strong>Sophisticated data-independent acquisition (DIA)</strong> and parallel reaction monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence</li><li>An <strong>advanced active beam guide (AABG) </strong>reduces noise and extends maintenance intervals</li></ul><h5><strong>Enhanced Analysis of Intact Proteins</strong></h5><ul><li><strong>Optional intact protein mode</strong> provides superior trapping of large molecules for improved analysis of intact proteins and protein complexes</li><li><strong>Optional enhanced resolution </strong>ensures maximum ID confidence in top-down proteomics and lipidomics</li></ul><h5><strong>High-Confidence Results</strong></h5><ul><li><strong>HR/AM and full-scan capabilities </strong>capture all sample data, all of the time, enabling retrospective data analysis without need to re-run samples</li><li><strong>Resolving power up to 140,000 FWHM </strong>eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices</li><li><strong>Better than 1-ppm mass accuracy</strong> in full- and all-ion fragmentation (AIF) scan modes ensures confident compound identification</li><li><strong>Fast scanning at 12 Hz</strong> and spectral multiplexing suited to UHPLC applications</li><li><strong>Rapid polarity switching</strong> maximizes information obtained</li><li><strong>AIF and multiple dissociation techniques</strong> — in-source CID and HCD — aid in compound identification</li><li><strong>Mass range to 6000 m/z </strong>enhances detection of singly charged small molecules and biomolecules</li><li><strong>More than four orders of magnitude</strong> intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan</li></ul>

Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer

Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS offers ultra-high mass range native MS with top-down capabilities, extreme sensitivity, and resolution up to 80,000 m/z.

<h3><strong>Go beyond what you thought possible with native mass spectrometry</strong></h3><p>The Thermo Scientific™ Q Exactive™ UHMR is the first hybrid quadrupole-Orbitrap™ mass spectrometer designed specifically for ultra-high mass range (UHMR) native MS and top-down protein analysis. It combines exceptional sensitivity, ultra-high resolution at high m/z, and unique pseudo-MS³ capabilities, enabling detailed characterization of intact protein assemblies and complex biological systems.</p><h3>🔬 <strong>Breakthrough in Native Mass Spectrometry</strong></h3><p>Native mass spectrometry preserves the non-covalent structure and interactions of proteins and protein complexes, making it an indispensable tool for structural biology and biopharma. The Q Exactive UHMR system enables direct mass analysis of intact macromolecules, including membrane proteins, virus capsids, and ribosomal particles—with unrivaled detail.</p><ul><li><strong>Ultra-high mass range detection</strong> up to <strong>80,000 m/z</strong></li><li><strong>Native top-down analysis</strong> of protein complexes and assemblies</li><li><strong>High sensitivity</strong> for precious or low-abundance samples</li><li><strong>Resolve mass differences</strong> even in heterogeneous megaDalton assemblies</li></ul><h3>⚙️ <strong>Technological Innovations</strong></h3><p>The Q Exactive UHMR system integrates multiple hardware advancements to overcome the historical limitations of native MS:</p><ul><li><strong>In-source trapping</strong> for efficient desolvation and controlled dissociation</li><li><strong>Advanced quadrupole mass filter</strong> with selection up to <strong>25,000 m/z</strong></li><li><strong>Reduced RF frequencies</strong> across the ion path for better high-mass transmission</li><li><strong>Pseudo-MS³ capability</strong>: fragment large complexes into subunits, then sequence them in HCD cell</li></ul><h3>🧬 <strong>Applications and Capabilities</strong></h3><h4><strong>Confident characterization of complex biological systems:</strong></h4><ul><li><strong>Virus capsid analysis:</strong> Differentiation and sequencing of 3–4 MDa hepatitis B virus capsids</li><li><strong>Ribosome studies:</strong> Resolution of substoichiometric proteins in E. coli 70S particles</li><li><strong>Membrane proteins:</strong> Gentle liberation from micelles and native top-down sequencing (e.g., AmtB trimer)</li><li><strong>Chaperonin complexes:</strong> Native top-down analysis of GroEL tetradecamer</li></ul><h4><strong>Detect and resolve small differences in high-mass species:</strong></h4><ul><li>Post-translational modifications</li><li>Ligand binding</li><li>Protein truncations and isoforms</li></ul><h3>💡 <strong>Software for Confident Data Interpretation</strong></h3><p>Maximize the power of native MS with industry-leading software:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837"><strong>BioPharma Finder™ Software</strong> </a>– For intact mass confirmation, top-down analysis, and PTM localization</li><li><strong>ProSightPC™ Software</strong> – Advanced top-down proteomics with integrated UniProt database search</li></ul><h3>🧪 <strong>Who Is It For?</strong></h3><p>Ideal for research groups and industry labs focused on:</p><ul><li>Structural biology</li><li>Biotherapeutic development</li><li>Native and top-down proteomics</li><li>Protein-ligand interaction studies</li></ul><h3>🧭 <strong>Summary of Key Features</strong></h3><ul><li><strong>Mass range:</strong> Up to 80,000 m/z</li><li><strong>Quadrupole isolation:</strong> Up to 25,000 m/z</li><li><strong>Sensitivity:</strong> Orders of magnitude higher at high m/z</li><li><strong>Fragmentation:</strong> HCD, pseudo-MS<sup>3</sup> for native top-down</li><li><strong>In-source trapping:</strong> Yes, optimized for membrane protein assemblies</li><li><strong>Software:</strong> BioPharma Finder, ProSightPC</li><li><strong>Compatible analyses:</strong> Native MS, top-down, intact mass, charge detection</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp" alt="Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/thumbnail_Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp 156w," sizes="100vw" width="650" height="650"></p>

Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer

Know your unknown compounds with confidence, using intelligent mass spectrometry that combines ease-of-use with smart acquisition methods to deliver higher data certainty.

<p><strong>Designed to unravel complex chemical structures while delivering the highest versatility and comprehensive workflow support for unknown compound ID and small molecule analysis, the Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ mass spectrometer empowers you to collect more meaningful data.</strong></p><p>Combining <strong>industry-leading mass analyzer technology</strong> analysis with <strong>intelligent acquisition</strong>, <strong>intuitive software</strong> and <strong>remote, hands free calibration</strong>, discover a new level of <strong>improved confidence in structure elucidation</strong>, with <strong>on-the-fly identification of small molecules</strong> to reveal more chemical structures with ease.</p><p>The <strong>Orbitrap IQ-X Tribrid MS</strong> seamlessly integrates with <strong>industry-leading solutions</strong> to provide a <strong>complete workflow solution</strong>, including <strong>Thermo Scientific™ Vanquish™ Duo UHPLC Systems</strong>, <strong>Thermo Scientific™ FAIMS Pro Duo interface for differential ion mobility</strong>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Thermo Scientific™ Compound Discoverer™ data analysis software</strong></a>, and the <strong>most comprehensive spectral libraries</strong> available on <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong>Thermo Scientific™ mzCloud™</strong></a>, enabling an <strong>intelligent MSⁿ data acquisition strategy</strong> to easily conduct <strong>small molecule structural elucidation, identification, and characterization</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp 238w," sizes="100vw" width="1447" height="949"></p><h5><strong>Other benefits of this mass spectrometry system include:</strong></h5><ul><li>A combination of the best of <strong>quadrupole</strong>, <strong>linear ion trap</strong> and <strong>Thermo Scientific™ Orbitrap™ mass analyzer technology</strong> for acquisition of the <strong>richest MSⁿ data per sample</strong>.</li><li><strong>Spend more time on results, less time on instrument set-up</strong> with the new <strong>Auto-Ready ion source</strong> for <strong>remote, hands free calibration</strong>, combined with the <strong>Thermo Scientific™ EASY-IC™ (Internal Calibration)</strong> source to deliver <strong>superior mass accuracy</strong> in every scan, mass calibration can be <strong>fully automated</strong>, increasing productivity.</li><li><strong>Real-Time Library Search</strong> provides <strong>higher confidence small molecule analysis</strong> using <strong>on-the-fly spectral matching</strong> for <strong>decision-based triggering</strong> of MSⁿ scan events that increase certainty.</li><li><strong>Expanded </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1763"><strong>Thermo Scientific™ AcquireX workflow</strong></a><strong> capabilities</strong> provide <strong>easy and intelligent acquisitions</strong> to <strong>find more compounds</strong> by integrating independent experiments into an <strong>automated workflow</strong> for <strong>efficient and comprehensive sample and study characterization</strong>.</li><li><strong>Flexible fragmentation choices</strong> for <strong>structural determination</strong> of lipids, metabolites, and other small molecules utilizing <strong>Collision induced dissociation (CID)</strong>, <strong>Higher-energy collisional dissociation (HCD)</strong> and optional <strong>Ultraviolet Photodissociation (UVPD)</strong>.</li><li><strong>Improved unknown analysis</strong> and <strong>fine isotope detection</strong> with optional <strong>1,000,000 (1M) FWHM resolution at m/z 200</strong>.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1880" height="822"></p><h3><strong>Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer Specifications</strong></h3><ul><li><strong>Dimensions (D x W x H):</strong> 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li><strong>Dynamic Range:</strong> &gt;5000 within a single scan</li><li><strong>Mass Accuracy:</strong>&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li><strong>Polarity Switching:</strong> One Full Cycle in 1.1 sec</li><li><strong>Scan Rates:</strong>&nbsp;<ul><li><strong>OTMSⁿ: </strong>Up to 40 Hz</li><li><strong>ITMSⁿ: </strong>Up to 45 Hz</li></ul></li><li><strong>Weight (Metric):</strong> 318 kg (700 lb.)</li><li><strong>Mass Range:</strong> Full MS Mass Range: 50 to 2000 m/z to MSⁿ Mass Range: 40 to 2000 m/z</li><li><strong>Max. Resolution:</strong> Up to 500,000 at m/z 200</li><li><strong>Resolution:</strong>&nbsp;<ul><li>7500 to 500,000 (FWHM) at m/z 200</li><li><strong>1M Option:</strong> up to 1,000,000 (FWHM) at m/z 200</li></ul></li><li><strong>Type:</strong> Orbitrap IQ-X Tribrid MS IC</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer

With enhanced performance and usability, the Orbitrap Eclipse Tribrid MS makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.

<p><strong>Introducing the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer, our newest generation instrument designed with your most difficult analytical challenges in mind. With enhanced performance and usability, the Orbitrap Eclipse Tribrid mass spectrometer makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.</strong></p><p>Obtain <strong>high confidence insights</strong> for very complex molecules with the <strong>Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer</strong>. It combines <strong>industry-leading versatility and usability</strong> with the <strong>exceptional performance</strong> afforded by its <strong>built-in intelligence</strong> and <strong>revolutionary Thermo Scientific™ Tribrid™ architecture</strong> to deliver an instrument designed to address the <strong>most difficult analytical challenges</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp 245w," sizes="100vw" width="596" height="310"></p><h5><strong>This newest Tribrid platform includes:</strong></h5><ul><li><strong>Advanced Ion Management Technology (AIM+)</strong> with the new <strong>QR5 segmented quadrupole mass filter</strong></li><li><strong>Real-Time Search</strong></li><li><strong>Enhanced Vacuum Technology</strong></li><li>Optional <strong>Proton Transfer Charge Reduction (PTCR)</strong></li><li>Optional <strong>High Mass Range MSⁿ (HMRⁿ)</strong> mode</li></ul><h5><strong>Collectively, these features make this instrument uniquely suited for:</strong></h5><ul><li><strong>Accurate and high-throughput full-proteome quantitation</strong></li><li><strong>Characterization of complex mixtures</strong> of protein or small molecule-based pharmaceuticals</li><li><strong>Deciphering higher-order protein structures</strong></li></ul><p>The <strong>Orbitrap Eclipse Tribrid MS</strong> makes it easy to tackle these difficult analyses and collect the <strong>high-quality data required to drive the right decisions</strong>, <strong>pushing your science beyond today's discovery</strong>.</p><p>With its <strong>built-in intelligence and versatility</strong>, the Orbitrap Eclipse Tribrid MS makes it easy to produce the <strong>high quality data required to drive the right decisions</strong>.</p><ul><li><strong>Exceptional precursor selectivity and sensitivity</strong> with the next generation quadrupole mass filter</li><li><strong>Unmatched depth and accuracy of TMT analysis</strong> with novel Real-Time Search</li><li><strong>High Mass Range MSⁿ (HMRⁿ)</strong> option for comprehensive analysis of native protein complexes</li><li><strong>Unique Proton Transfer Charge Reduction (PTCR)</strong> option for simplifying complex top-down spectra</li><li><strong>Full experimental flexibility</strong> with revolutionary instrument control</li><li><strong>A wide range of optional functionalities</strong> for unprecedented versatility</li><li><strong>Common user interface</strong> with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/401"><strong>Thermo Scientific™ Orbitrap Exploris™ 480</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=TSQ"><strong>TSQ™ triple quadrupole mass spectrometers</strong></a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1452" height="710"></p><h3><strong>Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer </strong><span><strong>Specifications</strong></span></h3><ul><li><strong>Dimensions (D x W x H):</strong> 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li><strong>Dynamic Range:</strong> &gt;5000 with a single OTMS spectrum</li><li><strong>Mass Accuracy:</strong>&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li><strong>Model:</strong> Tribrid MS</li><li><strong>Polarity Switching:</strong> One Full Cycle in &lt; 1.1 sec</li><li><strong>Scan Rates:</strong>&nbsp;<ul><li><strong>OTMSⁿ: </strong>Up to 40 Hz</li><li><strong>ITMSⁿ: </strong>Up to 45 Hz</li></ul></li><li><strong>Weight (Metric):</strong> 180 kg (400 lb.)</li><li><strong>Mass Range:</strong>&nbsp;<ul><li><strong>Standard mass range:</strong> 50 to 2000 m/z</li><li><strong>Mid mass range: </strong>200 to 6000 m/z</li><li><strong>Optomenal HMRⁿ mass range: </strong>500 to 8000 m/z</li></ul></li><li><strong>Max. Resolution:</strong> Up to 500,000 at m/z 200</li><li><strong>Type:</strong> Orbitrap LC-MS</li><li><strong>Unit Size:</strong> Each</li></ul>

Waters Xevo G3 QTof Mass Spectrometer

The Xevo™ G3 QTof, an analytical workhorse, is designed to characterize and quantify a diverse set of molecules.

<h3><strong>Complete Coverage for Confident Characterization</strong></h3><p><strong>The Xevo™ G3 QTof, an analytical workhorse, is designed to characterize and quantify a diverse set of molecules.</strong></p><h4><strong>ULTIMATE PERFORMANCE</strong></h4><p>Ensure maximum coverage of analytes and with improved transmission low m/z ions, labile species, while still excelling in <strong>traditional biopharmaceutical workflows</strong> and addressing emerging needs to <strong>characterize new modalities</strong>.</p><h4><strong>CONNECTED PRODUCTIVITY</strong></h4><p>Harmonize workflows across development, manufacturing and QC by deploying the <strong>Xevo G3 QTof</strong> and the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/289"><strong>BioAccord™ System</strong></a> with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/191"><strong>ACQUITY™ Premier</strong></a> within the waters_connect™ ecosystem.</p><h4><strong>EXTENDED FLEXIBILITY</strong></h4><p>Improved quantitative capabilities, with wider inter- and intra-spectrum dynamic range for comprehensive quantitative/qualitative analysis, ideal for screening and targeted applications.</p><h4><strong>UNQUESTIONED CONFIDENCE</strong></h4><p>Ensure high quality data with consistent robustness and reproducibility through advances in ion optics, maintaining performance and productivity over a longer time period.</p><h3><strong>Ultimate Performance</strong></h3><h4><strong>Increase your application coverage</strong></h4><p>As labs extend their capabilities, more is required from their analytical systems. The Xevo G3 QTof incorporates new technology building blocks that improve a scientists’ ability to characterize:</p><ol><li>Complex biologics with inclusion of a <strong>m/z 16,000 calibration range</strong> and <strong>tailored informatics</strong>.</li><li>Challenging small molecules with updates to the ion optics and detection system that <strong>maximize transmission and dynamic range</strong>.</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G3_Q_Tof_The_Xevo_G3_Q_Tof_equipped_with_the_Step_Wave_XS_ion_guide_efficiently_transmits_low_mz_ions_labile_species_increasing_compound_coverage_and_analytical_fidelity_73db146372.jpg" alt="Waters Xevo G3 QTof: The Xevo G3 QTof, equipped with the StepWave™ XS ion guide, efficiently transmits low mz ions, labile species, increasing compound coverage and analytical fidelity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G3_Q_Tof_The_Xevo_G3_Q_Tof_equipped_with_the_Step_Wave_XS_ion_guide_efficiently_transmits_low_mz_ions_labile_species_increasing_compound_coverage_and_analytical_fidelity_73db146372.jpg 234w," sizes="100vw" width="1024" height="682"></p><h3><strong>Connected Productivity</strong></h3><h4><strong>Harmonize your workflows across the pipeline</strong></h4><p>Harmonizing workflows across development, manufacturing and QC is key to ensuring lab productivity. The Xevo G3 QTof is ideal for <strong>characterizing biomolecules</strong> and processes before transitioning to dedicated attribute monitoring assays on either the Xevo G3 QTof or <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/289"><strong>BioAccord System</strong></a> with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/191"><strong>ACQUITY Premier</strong></a>.</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544"><strong>waters_connect</strong></a><strong> </strong>Ecosystem offers seamless, compliant-ready workflows to understand and monitor biotherapeutic variation. Systems and users can be connected through waters_connect, with security-controlled access, full data traceability, with the operational efficiency and scalability of networked deployment.</p><p>Achieve robust and unbiased performance for analysis of your biotherapeutics with ACQUITY Premier Systems and Columns and an expanding array of informatics tools, including <strong>Peptide MAM</strong>, <strong>INTACT Mass</strong>, and <strong>CONFIRM Sequence</strong> applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G3_Q_Tof_Harmonize_your_workflows_with_Xevo_G3_Q_Tof_the_Bio_Accord_System_and_tailored_informatics_f9cc61424f.jpg" alt="Waters Xevo G3 QTof: Harmonize your workflows with Xevo G3 QTof, the BioAccord System and tailored informatics." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G3_Q_Tof_Harmonize_your_workflows_with_Xevo_G3_Q_Tof_the_Bio_Accord_System_and_tailored_informatics_f9cc61424f.jpg 237w," sizes="100vw" width="1024" height="674"></p><h3><strong>Delivering Qualitative and Quantitative Performance</strong></h3><h4><strong>Is it detected and how much is detected?</strong></h4><p>Analytical laboratories are under pressure to maximize system usage, so a flexible multifunctional instrument that can deliver high quality qualitative and quantitative data sets is critical.</p><p>The Xevo G3 QTof, has evolved to address those needs, with updates to core technology delivering <strong>up to 5 orders of linear dynamic range</strong> through application of adaptive intensity control for <strong>targeted Tof-MRM analysis</strong>.</p><p>For untargeted and screening experiments, with up to 4x increase in-spectrum dynamic range, the Xevo G3 QTof is able detect and quantify components of interest in the most challenging of complex matrices.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_Xevo_G3_Q_Tof_jako_instruemtnace_pro_ziskani_kvalitativnich_a_kvantitativnich_dat_daa8aa1ef4/Waters-Corporation-Waters-Xevo-G3-QTof-jako-instruemtnace-pro-ziskani-kvalitativnich-a-kvantitativnich-dat.webp" alt="Waters Xevo G3 QTof: Utilizing Tof-MRM to answer critical questions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_Xevo_G3_Q_Tof_jako_instruemtnace_pro_ziskani_kvalitativnich_a_kvantitativnich_dat_daa8aa1ef4/thumbnail_Waters-Corporation-Waters-Xevo-G3-QTof-jako-instruemtnace-pro-ziskani-kvalitativnich-a-kvantitativnich-dat.webp 245w," sizes="100vw" width="984" height="497"></p><h3><strong>Complete Confidence</strong></h3><h3><strong>High quality reliable data sets every time</strong></h3><p>Instrument stability and uptime are unquestioned necessities in a fast-paced high-throughput environment. The evolved design of the Xevo G3 QTof has been engineered to deliver consistent robustness and reproducibility, maintaining performance and productivity over a longer time period. With updated ion optics and optimized ion beam conditioning the Xevo G3 QTof is a true analytical workhorse that deliverables high quality data routinely.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Konstrukce_hmotnostniho_spektrometru_Xevo_G3_Q_Tof_10fbbd6639/Waters-Corporation-Konstrukce-hmotnostniho-spektrometru-Xevo-G3-QTof.webp" alt="Waters Xevo G3 QTof: The Xevo G3 QTof, equipped with the StepWave™ XS ion guide, efficiently transmits low m/z ions, labile species, increasing compound coverage and analytical fidelity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Konstrukce_hmotnostniho_spektrometru_Xevo_G3_Q_Tof_10fbbd6639/thumbnail_Waters-Corporation-Konstrukce-hmotnostniho-spektrometru-Xevo-G3-QTof.webp 175w," sizes="100vw" width="1695" height="1514"></p><h3><strong>Unhindered Analytical Capabilities</strong></h3><h4><strong>Extending the reach of characterization</strong></h4><p>Having an extensive toolkit at your disposal protects against future unknowns and the ever-increasing complexity of samples.</p><p>The Xevo G3 QTof is equipped with the universal source architecture, maximizing versatility and minimizing downtown. With options including<strong> ESI, ESCi,™ APCI, APGC,™ ASAP,™ UniSpray,™ nanoFlow ESI, </strong>and <strong>DESI XS*</strong> the Xevo G3 QTof can be used for many different applications and molecule types — swap your source not your instrument.</p><p>Support of a range of inlets including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/191"><strong>ACQUITY Premier System</strong></a><strong>, ACQUITY UPLC™ PLUS Series, ACQUITY UPLC M-Class,</strong> and <strong>ACQUITY 2D-LC* </strong>ensures your lab is equipped for the future and can handle challenging and complex samples.&nbsp;<br><strong>* </strong>For specific configuration requirements consult with your Waters Representative.</p><p>The Xevo G3 QTof is available on both our <strong>waters_connect</strong> and <strong>MassLynx™ Software</strong> platforms, providing the ultimate flexibility to meet your labs analytical requirements.</p><p><strong>waters_connect: </strong>The modern, app-based software platform, waters_connect, offers seamless, compliant-ready workflows ensuring data traceability and transferability in a fast paced, highly connected laboratory.</p><p><strong>MassLynx:</strong> The well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G3_Q_Tof_Sequence_coverage_map_of_a_21mer_heavily_modified_oligonucleotide_within_the_CONFIRM_Sequence_application_displaying_all_the_confirmed_fragment_ions_4c7a8a75cf.jpg" alt="Waters Xevo G3 QTof: Sequence coverage map of a 21mer heavily modified oligonucleotide within the CONFIRM Sequence application, displaying all the confirmed fragment ions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G3_Q_Tof_Sequence_coverage_map_of_a_21mer_heavily_modified_oligonucleotide_within_the_CONFIRM_Sequence_application_displaying_all_the_confirmed_fragment_ions_4c7a8a75cf.jpg 235w," sizes="100vw" width="1237" height="822"></p>

Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer

Be ready for tomorrow’s most challenging demands. Exceed experimental expectation with the MultiOmics, Structural Biology, and BioPharma Editions of the Thermo Scientific Orbitrap Ascend Editions Tribrid Mass Spectrometer.

<p><strong>Exceed experimental expectation with the MultiOmics, Structural Biology, and BioPharma Editions of the Thermo Scientific Orbitrap Ascend Editions Tribrid Mass Spectrometer.</strong></p><p><strong>With new capabilities for multiplexed quantitative proteomics, native protein characterization, and deep biopharmaceutical analyses, the three new Editions deliver ultimate experimental throughput, versatility, and ease-of-use for your specific needs.</strong></p><p>Detect and characterize the most difficult protein complexes and native samples without losing low <i>m/z</i> instrument performance and flexibility with the new Native MS option, including world class Orbitrap detection up to <i>m/z</i> 16,000 and ion isolation in the ion trap and quadrupole up to <i>m/z</i> 8,000, with isolation widths down to <i>m/z</i> 100 and <i>m/z</i> 5, respectively.</p><figure class="image"><img style="aspect-ratio:1937/796;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Orbitrap_Ascend_Tribrid_hmotnostni_spektrometr_3_03576fcf9a/Thermo-Scientific-Orbitrap-Ascend-Tribrid-hmotnostni-spektrometr_3.jpg" alt="Thermo Fisher Scientific: Key innovations for Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer" width="1937" height="796"></figure><h3><strong>Orbitrap Ascend Editions Tribrid MS</strong></h3><div><ul><li><strong>Orbitrap Ascend MultiOmics Tribrid MS: </strong>Discover more from comprehensive metabolomics to proteomics.</li><li><strong>Orbitrap Ascend Structural Biology Tribrid MS:</strong> Take advantage of ultimate versatility for native protein characterization.</li><li><strong>Orbitrap Ascend BioPharma Tribrid MS: </strong>Successfully characterize your most complex biotherapeutics.</li></ul><div><h3><strong>Introducing the Orbitrap Ascend Editions Tribrid MS</strong></h3></div><div><div><div id="container-deb530bb93"><div><div><div id="container-fffbeb2334"><div><div><div id="text-1451003751"><p>Eliminate the guesswork from your purchase decision with the MultiOmics, BioPharma, and Structural Biology Editions of the Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer.&nbsp;Simplify your decisions and streamline your research with a tailored configuration for your unique application space.</p><p>Employ cutting edge native structural and biopharmaceutical analyses with multiple fragmentation and ion manipulation techniques. With the new Native MS option, detect protein complexes up to <i>m/z</i> 16,000 in the Orbitrap mass analyzer and isolate proteoforms&nbsp;up to <i>m/z</i> 8,000 with an isolation width as low as <i>m/z</i> 5 in the quadrupole.</p><p>Quantify more peptides, identify more proteins, confidently assign more labile-PTMs, and discover more previously undetectable protein complexes. Characterize proteoforms and modified compounds with more precision than ever before.&nbsp;</p></div></div></div></div></div></div></div></div></div><h3><strong>System highlights</strong></h3><h5><strong>Spend less time on instrument set-up and focus on your science</strong></h5><p>With the integrated Auto-Ready ion source, trigger on-demand or scheduled system calibrations remotely and without disruption to your LC-MS system.</p><h5><strong>Gain increased characterization from lipids to intact proteins to oligonucleotides with orthogonal fragmentation &nbsp;</strong></h5><p>The Orbitrap Ascend Editions mass spectrometers have multiple fragmentation techniques that provide complementary information.</p><ul><li>Standard collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD) can be used for multiple analytes.</li><li>Optional electron transfer dissociation (ETD) increases coverage for proteins and glycopeptide experiments, and ultraviolet photodissociation (UVPD) benefits protein, oligonucleotide, and lipid analysis.</li></ul><h5><strong>Study the largest protein complexes using native MS techniques, all on the same system as bottom-up proteomics techniques</strong></h5><p>The Native MS option comprises the extension of the Orbitrap mass range to m/z 16,000, ion trap ion isolation up to 8,000 with MSn capabilities, and more sensitive and selective extended quadrupole isolation up to m/z 8,000. With the Native MS option, you can detect large protein complexes and characterize the subunits by multiple fragmentation techniques.</p><h5><strong>Environmentally friendly dry pumps decrease energy usage and maintenance</strong></h5><p>By changing the fore pumps from oil-based to a dry pump, we reduce the heat output by 22%. They also eliminate the production of oil vapors and the need for oil checks and changes, lowering maintenance.</p><p>The Orbitrap Ascend Editions mass spectrometers have also received the ACT label, the standard for determining the environmental impact of laboratory products to help labs make informed, sustainable purchasing decisions.</p><h5><strong>Software solutions for your application</strong></h5><p>Streamlined instrument control software across all next-generation Thermo Scientific platforms for ease-of-use through different systems. Edition-specific application templates are ready to use and built into the method editor so you can get meaningful results faster.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_The_most_versatile_platform_for_deep_untargeted_and_accurate_targeted_metabolomics_336c0b833d.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - The most versatile platform for deep untargeted and accurate targeted metabolomics" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_The_most_versatile_platform_for_deep_untargeted_and_accurate_targeted_metabolomics_336c0b833d.jpg 245w," sizes="100vw" width="2349" height="1165"></p><h4><strong>Orbitrap Ascend MultiOmics Tribrid MS</strong></h4><p>Benefit from experimental throughput, versatility, and ease-of-use. With industry leading capabilities, the Thermo Scientific Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer delivers ultimate data quality. Quantify more samples at lower concentrations using intelligent acquisition and faster Real-Time Search.</p><h5><strong>Applications</strong></h5><ul><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>Lipidomics experiments benefit from AqcuireX software and alternative fragmentation capabilities</li></ul><h4><strong>Orbitrap Ascend Structural Biology Tribrid MS</strong></h4><div><div id="container-26e6c6fa34"><div><div><div id="text-872767366"><p>Be prepared for tomorrow's challenges in structural analysis with this powerful solution. Achieve greater coverage and explore different ion manipulation options with an expanded <i>m/z</i> range and multiple fragmentation options.</p><ul><li>Characterize complex molecules (Native MS option) with a recommended mass range up to <i>m/z</i> 16,000 and an extended quadrupole isolation range of up to <i>m/z</i> 8,000.</li><li>Take advantage of multiple fragmentation options (ETD, EThcD, UVPD) and Proton-Transfer Charge Reduction to achieve comprehensive sequence coverage of your protein target.</li></ul><h5><strong>Applications</strong></h5><ul><li>Native MS option facilitates the identification of membrane proteins by top-down MS&nbsp;</li><li>Utilizing PTCR for complex mixture analysis enables more identification across the <i>m/z</i> range &nbsp;</li><li>Crosslinking experimentation is aided by Real-Time Library Search available on the Orbitrap Ascend Structural Biology MS&nbsp;&nbsp;</li><li>Comprehensive disulfide bond mapping analysis using FAIMS and EThcD</li><li>Characterize larger proteoforms by top-down proteomics</li><li>Characterize larger proteoforms by top-down proteomics</li><li>Native MS option extends ion detection of large protein complexes</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_Lipidomics_experiments_benefit_from_Aqcuire_X_software_and_alternative_fragmentation_capabilities_da54862143.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - Lipidomics experiments benefit from AqcuireX software and alternative fragmentation capabilities" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_Lipidomics_experiments_benefit_from_Aqcuire_X_software_and_alternative_fragmentation_capabilities_da54862143.jpg 245w," sizes="100vw" width="3257" height="850"></p><h4><strong>Orbitrap Ascend BioPharma Tribrid MS</strong></h4></div></div></div></div></div><p>Elevate your analytical capabilities and successfully characterize your most complex products from peptides to native protein characterization with the Thermo Scientific Orbitrap Ascend BioPharma Tribrid Mass Spectrometer.&nbsp; Achieve greater coverage for oligonucleotide sequences and analyze even the largest and most complex molecules.</p><ul><li>Recommended alternate fragmentation techniques enable detailed structural elucidation.</li><li>Automated Auto-Ready ion source and application-specific pre-built method templates streamline instrument setup.</li></ul><h5><strong>Applications</strong></h5><ul><li>Comprehensive native analysis of complex therapeutic proteins using Native MS option and PTCR</li><li>Comprehensively characterize antibody-drug conjugates combining orthogonal fragmentation techniques</li><li>Enhanced speed and sensitivity for high sequence coverage and low abundant PTM identifications in peptide mapping experiments</li><li>Improved sensitivity allows highly confident identification of ppb Host Cell Proteins at analytical flow rates</li><li>Characterize intact sgRNA up to 100 base pairs using low-q CID fragmentation</li><li>Unparalleled characterization of low-abundant modifications in oligonucleotides</li></ul><p>&nbsp;</p></div>

Thermo Scientific Orbitrap Astral Mass Spectrometer

A new horizon for single-cell, quantitative, and translational proteomics.

<div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p><strong>Looking to unlock additional insights into biology and disease mechanisms? With faster throughput, deeper coverage, higher sensitivity, and accurate and precise quantitation; the Thermo Scientific Orbitrap Astral Mass Spectrometer enables you to dramatically expand the scale and scope of your experiments.</strong></p><p>See how it sets a new standard for mass spectrometry performance and redefines what is possible for discovery and translational research to help you rapidly and comprehensively capture the dynamic, temporal, and spatial complexity of biology.</p><h3><strong>Key benefits</strong></h3><h4><strong>Faster throughput</strong></h4><p>Achieve faster throughput with a high throughput injection-to-injection cycle of just 8 minutes.</p><ul><li>Analyze one sample in only 8 minutes</li><li>In one day, analyze over 1.4 million protein groups from 180 samples</li></ul><h4><strong>Deeper coverage</strong></h4><p>The near whole-proteome coverage of these methods reduces the chances of missing out on important proteins of interest.</p><ul><li>See more in less time or spend more time and go even deeper</li><li>Double the depth and quadruple the throughput for phosphoproteomics</li></ul><h4><strong>Higher sensitivity</strong></h4><p>The high dynamic range of the proteome necessitates the measurement of not only high abundance proteins, but also proteins with just a few copies.</p><ul><li>Deeper coverage from single cells at faster throughput</li><li>1 ng HeLa DIA/18 min (80 SPD)</li></ul><h4><strong>Accurate and precise quantitation</strong></h4><p>Biological changes are quantitative in nature, requiring accurate and precise measurements to determine statistically significant biomarkers.</p><ul><li>Accurate and precise quantitation of three-proteome mixtures</li><li>The Orbitrap Astral mass spectrometer enables accurate and precise quantitation with 88% of identified proteins having 20% CV or less and 75% having 10% CV or less</li></ul><p><img style="aspect-ratio:1224/513;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Konstrukce_hmotnostniho_spektrometru_Thermo_Orbitrap_Astral_e38e10580c/Pragolab-Konstrukce-hmotnostniho-spektrometru-Thermo-Orbitrap-Astral.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap Astral Mass Spectrometer" width="1224" height="513"></p><h3><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer.html"><strong>An overview</strong></a><strong> of the Orbitrap Astral MS from Alexander Makarov, Ph.D.</strong></h3><p>The new Astral analyzer builds on Thermo Fisher Scientific’s proven Orbitrap mass spectrometry platform with novel technology to deliver up to two times deeper proteome coverage and up to four times more throughput compared to current mass spectrometers.</p><p>Alexander Makarov, Ph.D., Director Global Research LSMS, Thermo Fisher Scientific, claims the Astral analyzer represents a new class of high-resolution accurate-mass analyzers with a unique performance envelope.</p><p>"The introduction of the Astral analyzer represents a starting point in the future evolution of its technology to new frontiers of performance," said Makarov.</p><h3><strong>What customers are saying</strong></h3><h4><strong>A New Standard for Data-Independent Acquisition</strong></h4><p>Learn how the Orbitrap Astral mass spectrometer will enable precision medicine at scale with revolutionary new DIA methods for plasma proteomics.</p><p>The future of proteomics lies in the accurate and precise measurement of thousands of proteins across thousands of samples. Data-independent Acquisition (DIA) facilitates deep proteome coverage with high quantitative accuracy and precision using label-free quantitation (LFQ) due to the unbiased and reproducible nature of mass spectrometry measurements.</p><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331001711112">Mike MacCoss, Ph.D.</a>, Professor, Department of Genome Sciences, University of Washington</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331014977112">Jennifer Van Eyk, Ph.D.</a>, Director, Basic Science Research, Barbra Streisand Women’s Heart Center Director, Advanced Clinical Biosystem Institute Center, Cedars-Sinai</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331000425112">Jesper Olsen, Ph.D.</a>, Deputy Center Director, Professor, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331001022112">Qing Yu</a>, Research Associate at Harvard Medical School</li></ul></div></div></div><h4><strong>The Era of Single-Cell Proteomics Has Arrived</strong></h4><p>Single cell proteomics can determine the dynamic nature of the proteome across cell types in both time and space. The increased resolution that is gained by measuring single cells instead of bulk samples provides a deeper insight into disease mechanisms and fundamental biological processes to unravel the complexity of biology. Learn how the Orbitrap Astral mass spectrometer opens a new horizon for single-cell proteomics by empowering higher throughput and deeper coverage without sacrificing quantitative accuracy and precision.</p><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331010858112">Erwin Schoof, Ph.D.</a>, Associate Professor, Department of Biotechnology and Biomedicine, Section for Protein Science and Biotherapeutics, Cell Diversity Lab, Technical University of Denmark</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331001916112">Joshua Coon, Ph.D.</a>, Professor of Biomolecular Chemistry at the University of Wisconsin-Madison</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331012816112">Nikolai Slavov, Ph.D.</a>, Founding Director of Parallel Squared Technology Institute and Professor at Northeastern University</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331016836112">Sophia Steigerwald, Ph.D.</a>, Student at the Max Planck Institute of Biochemistry</li></ul></div></div></div><h3><strong>How it works</strong></h3><p>The Orbitrap Astral Mass Spectrometer combines three mass analyzers: a quadrupole mass analyzer for high selectivity and high ion transmission; an Orbitrap mass analyzer for high dynamic range and high-resolution measurements; and a novel Astral analyzer for fast and sensitive measurements. The front end, from the ion source up to the segmented quadrupole mass filter, is designed to maximize instrument sensitivity and robustness. Ions are trapped and concentrated in the ion routing multipole, which facilitates the transfer of ions to either of the high-resolution accurate-mass (HRAM) analyzers. Synchronization of ion transfer and processing throughout the instrument enables the parallel handling of five separate ion packets simultaneously. This synchronization enables each mass analyzer to be used in combination to optimize performance and experimental flexibility.</p><p>The Orbitrap analyzer is ideally suited for the acquisition of high dynamic range HRAM MS and MS<sup>2</sup> spectra, including an optional Biopharma mode to extend the mass range up to <i>m/z</i> 8,000. The Astral Mass Analyzer delivers high acquisition rates up to 200 Hz, single ion detection sensitivity, and high dynamic range HRAM SIM and MS<sup>2</sup> measurements that are fully synchronized with parallel Orbitrap analyzer operation. Due to this synchronization the Orbitrap Astral Mass Spectrometer excels at many data acquisition strategies including High Resolution Data-Independent Acquisition (HR-DIA) and data-dependent acquisition (DDA). These acquisition strategies combined with the high resolution and dynamic range of the Orbitrap and Astral analyzers enable accurate and precise quantitation using either Label-Free Quantitation (LFQ) or multiplexing with Tandem Mass Tag (TMT)-labeled peptides.</p></div></div></div><p class="cke-user_style-important"><strong>A 3D tour of the instrument can be found </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/virtual/orbitrap-astral-ms-3d-tour.html"><strong>here</strong></a><strong>.</strong></p>

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