Thermo Scientific EASY-Spray Sources

Thermo Scientific™ EASY-Spray™ Sources are integrated nano-electrospray ion sources designed for nanoflow LC-MS. Their temperature-controlled column-emitter assembly and single nanoViper™ connection simplify nanoLC-MS operation while delivering highly reproducible separations, stable spray performance, and high LC-MS sensitivity

Integrated Design

• Integrated temperature-controlled column and emitter assembly
• Single nanoViper™ connection between the LC system and ion source
• Integrated zero-dead-volume (ZDV) connections minimize dead volume
• Simple plug-and-spray installation with quick column replacement

Chromatographic Performance

• Stable nano-electrospray ionization for reliable LC-MS analysis
• Supports long columns and small particle sizes for high peak-capacity separations
• Column heating (30–60 °C) reduces solvent viscosity and backpressure
• Ultra-sharp chromatographic peaks improve separation efficiency

Thermo Scientific EASY-Spray Sources: The entire assembly is designed for heavy use so you can utilize the full pressure range of your UHPLC front-end (up to 1000 bar) and benefit from small particles and long columns. Longer columns and longer gradients both contribute to more identifications.

Reproducibility

• Stable performance during extended analytical operation
• Excellent run-to-run reproducibility
• Outstanding column-to-column reproducibility for large studies and multi-site laboratories

Ease of Use

• Plug-and-spray operation requiring minimal setup
• Integrated camera provides an illuminated, magnified view of the emitter tip
• Eliminates the most error-prone nanoLC connections

Compatibility

Compatible with Thermo Scientific EASY-Spray columns and selected Thermo Scientific nanoLC systems and mass spectrometers, including:

• Thermo Scientific™ LCQ Deca XP MAX™, LTQ™-series, and Velos™ series ion trap mass spectrometers
• Thermo Scientific™ LTQ Orbitrap™-series and Orbitrap Velos™ series hybrid ion trap-Orbitrap mass spectrometers
• Thermo Scientific™ Exactive™ series Orbitrap mass spectrometers
• Thermo Scientific™ Q Exactive™ series hybrid quadrupole-Orbitrap mass spectrometers
• Thermo Scientific™ TSQ Quantum™ series and TSQ Vantage™ triple-stage quadrupole mass spectrometers

The EASY-Spray NG ion source works in conjunction with the latest next-generation Thermo Scientific mass spectrometers:

• Thermo Scientific™ Orbitrap™ Fusion™ Tribrid™ Mass Spectrometer
• Thermo Scientific™ TSQ Endura™ Triple-stage Quadrupole Mass Spectrometer
• Thermo Scientific™ TSQ Quantiva™ Triple-stage Quadrupole Mass Spectrometer