Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer

Revolutionary tribrid architecture for comprehensive structural analysis and deep proteome coverage

The Orbitrap Fusion Tribrid mass spectrometer combines a quadrupole, a linear ion trap, and an Orbitrap mass analyzer in a unique architecture that delivers unmatched analytical performance. It provides life scientists with advanced MSⁿ capabilities, flexibility in fragmentation techniques, and exceptional resolution and speed — ideal for tackling the most complex analytical challenges in proteomics, PTMs, metabolomics, lipidomics, and small molecule research.

Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer

Key Features and Benefits

🔬 Revolutionary Tribrid Design

• Combines quadrupole, linear ion trap, and Orbitrap analyzers
• Perform MSⁿ up to n = 10 with detection in either ion trap or Orbitrap
• Fragmentation options: CID, HCD, ETD, and EThcD at any MS stage
• Synchronous Precursor Selection (SPS): up to 20 precursors per scan for MS³

⚙️ High Performance & Resolution

• Resolving power up to 500,000 FWHM at m/z 200
• <1 ppm mass accuracy with EASY-IC™ internal calibration
• Polarity switching in 1.1 s full cycle
• Scan speeds up to 20 Hz for Orbitrap and ion trap MSn

🧪 Versatility in Applications

• Analyze low-abundance, high-complexity, or structurally complex samples
• Confidently resolve isobaric interferences and detect PTMs
• Full compatibility with intact protein analysis, glycoproteomics, and TMT SPS-MS³ quantitation workflows

🔁 Efficient Ion Handling

• EASY-Max NG or NanoSpray Flex NG ion sources
• Active Beam Guide and S-Lens for efficient ion transmission
• Dynamic Scan Management optimizes scan scheduling and parallelization

💡 Ease of Use

• Intuitive Tune and Method Editors
• Method templates for routine and advanced workflows
• Quanfirmation: HRAM SIM for quantitation + ion trap MS/MS for confirmation
• Automated calibration, AGC, and exclusion logic

🧬 Compatible Software

• Xcalibur™, Proteome Discoverer™, ProSight™, Mass Frontier™, Compound Discoverer™, and others
• Support for data-dependent, targeted, and deconvolution workflows

Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer