Waters Cyclic IMS P20 Mass Spectrometer

The Waters Cyclic IMS P20 Mass Spectrometer is a next-generation ion mobility-enabled mass spectrometry platform designed to reveal molecular structure with greater confidence by combining high-resolution cyclic ion mobility separation with accurate mass analysis. The system resolves co-eluting, isomeric, and isobaric species, providing deeper structural insight into complex biological samples.

Built for advanced research applications, the Cyclic IMS P20 supports proteomics, metabolomics, lipidomics, native mass spectrometry, and mass spectrometry imaging workflows. Multi-pass ion mobility separations, Wideband Enhancement (WBE), and advanced fragmentation technologies provide exceptional analytical depth and sensitivity.

The platform supports MALDI XS and DESI XS imaging workflows, enabling high-confidence spatial analysis and molecular visualization. Additional capabilities including CIU, HDX, ECD, and SID make the system ideally suited for investigating biomolecular structure, stability, dynamics, and intermolecular interactions.

Waters: Cyclic IMS P20 Mass Spectrometer with MALDI XS and DESI XS

Key Features

• High-resolution Cyclic Ion Mobility Spectrometry
• Separation of isomeric, isobaric, and co-eluting species
• Multi-pass ion mobility separation
• Wideband Enhancement (WBE) technology
• Up to 10× improvement in MS/MS sensitivity
• Advanced native MS capabilities
• Dynamic Field Declustering (DFD)
• Quadrupole mass selection up to 32,000 m/z
• Extended mass range beyond 100,000 m/z
• Electron Capture Dissociation (ECD)
• Surface-Induced Dissociation (SID)
• Integrated Collision-Induced Unfolding (CIU)
• Hydrogen-Deuterium Exchange (HDX) workflows
• MALDI XS and DESI XS imaging support
• Automated CCS calibration
• Intuitive software environment
• Modular and future-proof platform

Technical Specifications

Technology

• Cyclic Ion Mobility Spectrometry (Cyclic IMS)
• Orthogonal Acceleration Time-of-Flight (oaTOF)
• Multi-pass ion mobility separation
• IMSⁿ experiments

Advanced Capabilities

• Wideband Enhancement (WBE)
• Dynamic Field Declustering (DFD)
• Collision-Induced Unfolding (CIU)
• Electron Capture Dissociation (ECD)
• Surface-Induced Dissociation (SID)
• Hydrogen-Deuterium Exchange (HDX)

Mass Range

• Quadrupole selection up to 32,000 m/z
• Detection beyond 100,000 m/z

Imaging Applications

• MALDI XS
• DESI XS
• High-resolution molecular imaging
• Isomeric lipid separation

Software

• Automated CCS calibration
• Advanced method development
• IMS data processing and interpretation
• HDX and CIU workflow support

Typical Applications

• Proteomics
• Native mass spectrometry
• Structural biology
• Lipidomics
• Metabolomics
• Biotherapeutic characterization
• GLP-1 research
• Protein complex analysis
• Molecular imaging
• Forensics
• Environmental analysis