Waters Xevo CDMS charge detection mass spectrometer

Understanding the mass and heterogeneity of large and complex biomolecules has long been a barrier to advancement. Conventional techniques fail to resolve the information needed to reconstruct the detailed nuance of structure, especially for megadalton molecular assemblies. It can take months or even years of tedious, expensive research to understand the basics of biomolecular structures.

Waters: Xevo CDMS charge detection mass spectrometer

Not anymore. With the breakthrough Xevo CDMS instrument, you can achieve precise measurement of challenging large and highly heterogeneous molecules—including viral vectors, virus-like particles (VLPs), RNA, and protein complexes—that were previously out of reach for mass characterization.

With this incredible innovation in charge detection mass spectrometry (CDMS), your lab can answer questions that were previously unaskable, unlocking the future of biological science, drug development, cell and gene therapy, and precision medicine.

Specifications

• Technology: Charge detection mass spectrometry with single-ion detection
• Detection: Direct mass measurement powered by ELIT technology
• Mass Range: 100 MDa and beyond with molecular weight characterization and purity determination of the​ largest, most heterogenous biotherapeutics
• Resolution: High-resolution MS analysis of complex mixtures
• Sample Types: Ideal for a variety of sample types including viral particles, protein assemblies, and exosomes
• Instrument Footprint: Modern benchtop design with revolutionary nanoESI source
• User Interface: Intuitive software with guided workflows

Waters: Xevo CDMS - The ELIT system enables ultra-sensitive detection by isolating and measuring individual ions—a capability not available in traditional MS systems.

Overview

• Uncover hidden dimensions in biomolecular analysis across cell and gene therapy, biotherapeutics, biophysical science, and nanoparticle research
• Investigate protein structure, function, and mechanisms of diseases at scale with measurement of massive, heterogeneous molecules that were previously invisible
• Achieve real mass clarity with direct, unambiguous, single-ion mass measurement of highly complex, high-mass molecules
• Gain powerful therapeutic insights with characterization of viral vectors, mRNA, and protein complexes
• Get intuitive, ready to submit data workflows, and GxP-ready architecture

Recommended Use: For direct analysis of biomolecules in the megadalton range and beyond.

Expand biomolecular analysis beyond traditional tools with CDMS

Traditional characterization methods like SEC-MALS, analytical ultracentrifugation, and mass photometry often fall short for today’s biomolecules. They require large sample volumes, extended run times, or lack specificity. Xevo CDMS overcomes these limitations with direct, single-ion mass measurement across an extraordinary range, from below 1 MDa to beyond 100 MDa, using as little as 10 µL of sample. With streamlined workflows, faster results, and practical precision, Xevo CDMS delivers insights that conventional tools cannot match, making it a powerful complement or alternative in advanced biomolecular research.

Waters: Xevo CDMS charge detection mass spectrometer