Waters Xevo MRT P10 QTof Mass Spectrometer

The Waters Xevo MRT P10 Mass Spectrometer is a next-generation high-resolution accurate mass system built on revolutionary Multi-Reflecting Time-of-Flight (MRT) technology. Combining exceptional sensitivity, ultrafast acquisition speed, and outstanding mass accuracy, it establishes a new benchmark for both research and routine analytical laboratories.

Delivering up to 20-fold higher MS/MS sensitivity compared with the previous Xevo MRT platform, the system enables confident detection and quantification of low-abundance compounds in highly complex matrices. With acquisition rates of up to 100 Hz in MS mode and 200 Hz in MS/MS mode, the Xevo MRT P10 captures comprehensive analytical information without compromising mass accuracy or resolution.

Advanced acquisition capabilities, including state-of-the-art DDA, DIA, and SONAR Pulse Acquisition Mode, provide deeper analytical insight, improved precursor specificity, and enhanced workflow flexibility for proteomics, lipidomics, metabolomics, spatial biology, and other multiomics applications.

Combined with the waters_connect™ Software Platform, the system supports seamless conversion to mzML format and straightforward integration into existing analytical and bioinformatics workflows.

Key Features

• Revolutionary Multi-Reflecting Time-of-Flight (MRT) technology
• Up to 20× higher MS/MS sensitivity than Xevo MRT
• Up to 100,000 FWHM mass resolution
• MS acquisition rates up to 100 Hz
• MS/MS acquisition rates up to 200 Hz
• Outstanding mass accuracy and isotopic fidelity
• Advanced DDA and DIA acquisition modes
• SONAR Pulse Acquisition Mode
• Hybrid targeted and untargeted acquisition workflows
• Deep proteome, lipidome, and metabolome coverage
• Suitable for single-cell analysis
• Direct mzML data export
• waters_connect™ software integration
• Compact benchtop design
• Compatible with DESI XS imaging workflows

Technical Specifications

Mass Analyzer

• Technology: Multi-Reflecting Time-of-Flight (MRT)
• System type: High-Resolution Accurate Mass (HRAM)

Performance

• Mass resolution: up to 100,000 FWHM
• Mass accuracy: high accuracy in both MS and MS/MS
• Isotopic fidelity: high-quality isotope pattern accuracy

Data Acquisition

• MS acquisition speed: up to 100 Hz
• MS/MS acquisition speed: up to 200 Hz
• Data-Dependent Acquisition (DDA)
• Data-Independent Acquisition (DIA)
• SONAR Pulse Acquisition Mode
• Hybrid targeted and untargeted acquisition

Software

• waters_connect™ Software Platform
• mzML export support
• Bioinformatics workflow integration
• Advanced data processing capabilities

Applications

• Proteomics
• Lipidomics
• Metabolomics
• Multiomics research
• Single-cell analysis
• Biomarker discovery
• Pharmaceutical research
• Translational medicine
• Food analysis
• Environmental testing
• Mass spectrometry imaging

Imaging Applications

• Compatible with DESI XS Source
• High-resolution molecular imaging
• Acquisition speeds up to 200 Hz
• Up to 100,000 FWHM resolution