<p><strong>When every peptide bond matters, fragmentation is where discovery begins. The </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958"><strong>Thermo Scientific Orbitrap Excedion Pro mass spectrometer</strong></a><strong> brings EASY-ETD and HCD together on a single, ultra-high-performance Orbitrap platform—delivering clarity across proteomics, biopharma, and structural biology.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg 245w," sizes="100vw" width="1024" height="512"></p><h3><strong>Two fragmentation technologies, one hybrid advantage</strong></h3><h4><strong>EASY-ETD — gentle by design, powerful by nature</strong></h4><p>EASY-ETD transfers electrons to peptide/protein ions, breaking the backbone while <strong>preserving labile PTMs and fragile linkages</strong>, generating <strong>c- and z-ions</strong> ideal for confident site localization.<br><strong>Especially valuable for:</strong> phosphorylation, glycosylation, deamidation, <strong>isomer discrimination</strong> (Asp/IsoAsp; Leu/IsoLeu), and <strong>ADC linker–payload integrity</strong>.</p><h5><strong>Example — isomer discrimination with diagnostic ions</strong></h5><p>In a UHPLC-HRAM ddMS² peptide-mapping experiment on <strong>NISTmAb</strong>, <strong>EThcD</strong> (EASY-ETD + supplemental HCD) produced the ETD-diagnostic <strong>c+57</strong> and <strong>z–57</strong> ions and <strong>unambiguously identified isoAsp</strong> in a <strong>23-aa, 3+</strong> deamidated peptide present at <strong>0.18%</strong>, with <strong>&lt;8 ppm</strong> mass error for both signatures (<strong>Figure 1</strong>). This shows how electron-based fragmentation retains the information needed to resolve subtle isomerization that collision-only methods can miss.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 1: EASY-ETD/EThcD reveals isoAsp with signature ions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg 245w," sizes="100vw" width="1024" height="550"></p><p>EThcD full-MS² spectrum from a NISTmAb tryptic peptide-mapping run. Zoom-in panels highlight <strong>z6–57</strong> and <strong>c17+57</strong> confirming <strong>isoAsp</strong> at 0.18% with <strong>&lt;8 ppm</strong> error.</p><h4><strong>HCD — High-Energy Confidence for every workflow</strong></h4><p><strong>HCD</strong> generates rich <strong>b- and y-ion</strong> spectra for robust sequencing and quantitative reproducibility. With the Excedion Pro’s <strong>ultra-high-field Orbitrap</strong> (MS² up to <strong>70 Hz</strong>) and—on the <strong>BioPharma edition</strong>—an <strong>extended mass range to m/z 12,000</strong>, HCD supports <strong>full sequence coverage</strong>, consistent <strong>DIA/DDA</strong> quantitation, and confident identification of oxidation, deamidation, and truncation variants. Together, EASY-ETD and HCD provide <strong>orthogonal fragmentation</strong>—comprehensive coverage and high-confidence confirmation in one analysis.</p><h3><strong>Why combine EASY-ETD and HCD?</strong></h3><ul><li><strong>PTM localization:</strong> EASY-ETD preserves fragile sites; HCD confirms sequence context.</li><li><strong>ADC characterization:</strong> EASY-ETD keeps linker–payload intact; HCD supports quant and variant checks.</li><li><strong>Isomer detection:</strong> EASY-ETD resolves Asp/IsoAsp; HCD adds complementary evidence.</li><li><strong>Quant proteomics:</strong> EASY-ETD maintains structural integrity; HCD delivers reproducible intensity.</li><li><strong>Throughput:</strong> Electron-driven fragmentation + fast collision MS² (<strong>up to 70 Hz</strong>).</li></ul><h3><strong>Applications that push the limits</strong></h3><h4><strong>Biopharma Characterization</strong></h4><ul><li>Map <strong>DARs</strong> and conjugation sites in <strong>ADCs</strong> with confidence</li><li>Detect <strong>low-level PTMs</strong> impacting efficacy</li><li>Combine <strong>native intact MS</strong> and <strong>EThcD mapping</strong> for complete characterization</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 2. EThcD maps ADC conjugation without cleaving the payload." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg 245w," sizes="100vw" width="1024" height="372"></p><p>EThcD MS² spectrum of <strong>ADYEK(188-MCC-DM1)HK</strong> (light chain, z=3). Colored arrows mark <strong>c</strong> and <strong>z</strong> fragments used to localize the conjugation site at <strong>K188</strong>; complementary <strong>y/c</strong> ions provide sequence context. Data acquired on the <strong>Orbitrap Excedion Pro BioPharma</strong> platform.</p><h4><strong>Advanced proteomics</strong></h4><ul><li>Expand <strong>sequence coverage</strong> in complex proteomes with complementary ion types</li><li>Support <strong>Hybrid-DIA</strong> for accurate quantitation with fewer false positives</li><li>Profile <strong>labile PTMs</strong> that collision-only methods may miss</li></ul><h4><strong>Structural biology &amp; HDX-MS</strong></h4><ul><li>Preserve <strong>H/D labeling</strong> and delicate interactions</li><li>Enable <strong>low-flow DIA-HDX</strong> with high sensitivity and throughput</li></ul><h3><strong>Hardware that makes it possible</strong></h3><ul><li><strong>OptaMax Plus Ion Source</strong> — enhanced spray stability and ease of use</li><li><strong>Advanced Quadrupole Technology (AQT)</strong> — ultra-selective precursor isolation</li><li><strong>Ion-Routing Multipole (IRM)</strong> — <strong>HCD, ETD, and EThcD</strong> in a single module</li><li><strong>Electrodynamic Ion Funnel (EDIF)</strong> — optimized transmission for labile compounds</li><li><strong>Ultra-high-field Orbitrap analyzer</strong> — high mass accuracy and throughput; <strong>BioPharma edition</strong> supports <strong>m/z 12,000</strong></li></ul><h3><strong>Answering the “How” behind advanced fragmentation</strong></h3><ul><li><strong>How does EASY-ETD improve peptide analysis vs standard ETD?</strong><br>Optimized ion routing with optional supplemental activation (<strong>EThcD</strong>) yields efficient electron transfer and improved sequence coverage—especially for labile or larger peptides.<br>&nbsp;</li><li><strong>Can HCD and EASY-ETD be used in one workflow?</strong><br>Yes—<strong>EThcD</strong> provides complementary <strong>c/z</strong> and <strong>b/y</strong> information in a single MS² event, ideal for PTM localization and conjugation analysis.<br>&nbsp;</li><li><strong>What’s the benefit for biopharma labs?</strong><br><strong>More insight per sample.</strong> EASY-ETD localizes modifications or conjugation sites while HCD supports robust quantitation—accelerating analytical development and QC.</li></ul><h3><strong>From complexity to confidence</strong></h3><p>The <strong>Orbitrap Excedion Pro</strong> lets scientists choose the right fragmentation energy for every molecule—uncovering fine-structure detail without sacrificing throughput. From intact ADCs to complex proteomes, <strong>EASY-ETD + HCD</strong> deliver the most complete view of molecular structure available on a hybrid Orbitrap platform.</p><p>Learn more about <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958"><strong>Orbitrap Excedion Pro Mass Spectrometers</strong></a></p><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#OrbitrapExcedionPro #Orbitrap #MassSpectrometry</p></blockquote>

Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation

<p><strong>A quick reminder that an important ISC2026 deadline is just around the corner - now is the time to act! Register and complete your payment on time to secure the best rate. Authors of oral presentations are kindly requested to complete their payment to ensure their contributions are included in the program.</strong></p><blockquote><ul><li><strong>Early-bird registration &amp; payment deadline:</strong> May 15, 2026</li><li><strong>Payment deadline for authors of oral presentations: </strong>May 15, 2026</li></ul></blockquote><h3><strong>REGISTRATION</strong></h3><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal"><strong>Register NOW and do not miss the deadline</strong></a></p></blockquote><h4><strong>REGISTRATION FEES in EUR including VAT&nbsp;</strong></h4><h5><strong>Early-Bird Registration (until 15 May 2026)</strong></h5><ul><li><strong>Industry: </strong>850</li><li><strong>Academic, Government: </strong>650</li><li><strong>Student*:</strong> 290</li><li><strong>Student* + 3 short courses: </strong>390</li><li><strong>Short Courses**: </strong>190</li><li><strong>Accompanying Persons: </strong>190</li><li><strong>Gala Dinner:</strong> 100</li></ul><h5><strong>Late Registration (until 25 August 2026)</strong></h5><ul><li><strong>Industry: </strong>1,000</li><li><strong>Academic, Government: </strong>780</li><li><strong>Student*:</strong> 340</li><li><strong>Student* + 3 short courses: </strong>-</li><li><strong>Short Courses**: </strong>230</li><li><strong>Accompanying Persons: </strong>190</li><li><strong>Gala Dinner:</strong> 100</li></ul><h5><strong>Onsite Registration (from 26 August 2026)</strong></h5><ul><li><strong>Industry: </strong>1,150</li><li><strong>Academic, Government: </strong>890</li><li><strong>Student*:</strong> 390</li><li><strong>Student* + 3 short courses: </strong>-</li><li><strong>Short Courses**: </strong>270</li><li><strong>Accompanying Persons: </strong>190</li><li><strong>Gala Dinner:</strong> 100</li></ul><p><i><strong>*</strong>The student fee applies only to full-time students. This does not include individuals who are employed and pursuing a PhD or other degree part-time. Participants registering under this category are required to upload a valid proof of full time student status (e.g., confirmation from the university or a student ID) directly in the registration form.</i></p><p><i><strong>**</strong>The price covers up to 3 short courses for a single flat rate.</i></p><p><i>All the above fees are in EUR and include a local VAT of 21 %.</i></p><h5><strong>FULL REGISTRATION FEES INCLUDE:&nbsp;</strong></h5><ul><li>Access to oral and poster sessions&nbsp;</li><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li><li>Electronic Book of Abstracts&nbsp;</li><li>Prague public transportation pass&nbsp;</li></ul><h5><strong>ACCOMPANYING PERSON FEES INCLUDE:&nbsp;</strong></h5><ul><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li></ul><p><i>The accompanying persons do not have access to the scientific programme.&nbsp;</i></p><h4><strong>Short Courses - New Addition</strong></h4><p>Our short course program continues to grow! In addition to the existing courses, we’ve added a new course on <strong>LC-MS data analysis using mzmine</strong>, offering even more hands-on learning opportunities.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/short-courses/"><strong>Explore all available courses on the website.</strong></a></p></blockquote><h4><strong>Exhibition &amp; Sponsorship Opportunities</strong></h4><p>The ISC 2026 exhibition is filling up, but a few final spots are still available for companies interested in showcasing their products and connecting with the community.</p><h4><strong>Stay Updated</strong></h4><p>The ISC 2026 website is regularly updated with the latest information on the program, speakers, and symposium activities - make sure to check it out.</p><p>Don’t miss these key deadlines - we’re looking forward to seeing you at ISC 2026 in Prague!</p><p>Best regards,</p><p>The ISC 2026 Organizing Committee</p>

ISC 2026 Early-Bird Registration & Payment Deadline

<p><strong>We are pleased to announce the following awards that will be presented at RIVA 2026.</strong></p><h4><strong>MARCEL GOLAY AWARD</strong></h4><p>The <strong>Marcel Golay award</strong> was instituted in honor of Marcel Jules Eduard Golay, the inventor of capillary columns.</p><p>Dr. Golay, one of the <strong>pioneers of gas chromatography</strong>, introduced the theory of dispersion in open tubular columns (capillary columns) and demonstrated their efficacy at the second International Symposium on Gas Chromatography in 1958. Dr. Golay joined PerkinElmer in 1962 as a senior scientist, and invented the Golay infrared sensor, which at the time was the most sensitive infrared sensor available.</p><p>Golay’s invention helped establish PerkinElmer as a major source of infrared technology. He also extended the theory of preparative columns and examined the properties of various chromatography sampling systems. The open tubular gas chromatography column is the most popular analytical gas chromatography column in use today. Dr. Golay worked as was a senior scientist at PerkinElmer up until his death in 1989. The Marcel Golay award is presented to a scientist in recognition of a lifetime of achievement in capillary chromatography.</p><p><strong>Carlo Bicchi</strong> is Full Professor at the Faculty of Pharmacy of the University of Turin since 1990. His research focuses on the development of advanced analytical technologies for the study of biologically active specialized metabolites in plant matrices, including essential oils, terpenoids, phenolic compounds, and alkaloids, as well as on aroma profiling and fingerprinting of major industrial food crops such as coffee, cocoa, hazelnuts, olive oil, and tea. His work encompasses all aspects of sample preparation, advanced chromatographic techniques, and chemometric methods for profiling and fingerprinting. Prof. Bicchi has actively promoted the development of analytical sciences through international collaboration, mentoring, and participation in scientific boards, conferences, and editorial activities.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Carlo_Bicchi_a0672a9dbb.jpg" alt="ISCC &amp; GCxGC Symposium: Carlo Bicchi" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Carlo_Bicchi_a0672a9dbb.jpg 156w," sizes="100vw" width="285" height="285"></p><h4><strong>GIORGIO NOTA AWARD</strong></h4><p>The <strong>Giorgio Nota Award</strong> was instituted in honor of Giorgio Nota, who first introduced open tubular LC.</p><p>The Giorgio Nota award is presented to a scientist in recognition of a lifetime of achievement in capillary liquid chromatography.</p><p>The <strong>Giorgio Nota Award 2026 is sponsored by </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/325"><strong>Waters</strong></a>.</p><p><strong>Fernando Mauro Lanças</strong> is a full Professor at the Institute of Chemistry of the University of São Paulo at São Carlos, Brazil, where he &nbsp;founded and currently coordinates the Chromatography Laboratory. His commitment to promoting and disseminating the culture of chromatography in Latin America, as founder of the Latin American Congress of Chromatography (COLACRO), the Brazilian Symposium on Chromatography (SIMCRO), and the International Institute of Chromatography (IIC), has made it possible to build a lasting bridge between Latin America and the rest of the world, fostering scientific collaboration, advancing research excellence, and strengthening the global chromatographic community. His primary research interest is currently focused on the complete miniaturization and automation of sustainable sample preparation – chromatography – mass spectrometry techniques and the practical implementation of the Unified Chromatography concept.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Fernando_Mauro_Lancas_e1e0ff9e6a.jpg" alt="ISCC &amp; GCxGC Symposium: Fernando Mauro Lanças" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Fernando_Mauro_Lancas_e1e0ff9e6a.jpg 156w," sizes="100vw" width="285" height="285"></p><h4><strong>GC×GC LIFETIME ACHIEVEMENT AWARD</strong></h4><p>The award honors an experienced GC×GC scientist who has made significant contributions to the field.</p><p>The Scientific Achievement Award &nbsp;was instituted in 2011 and recognizes GC×GC scientists who have 15 or more years of continuous contributions in the field.</p><p>The <strong>2026 GC×GC Lifetime Achievement Award</strong> is sponsored by <strong>SepSolve Analytical, Markes International and LECO</strong>.</p><p><strong>Prof. James Harynuk</strong> is currently a Full Professor at the University of Alberta, Canada. His research focuses on developing advanced analytical tools to tackle challenges such as complex samples, faster analysis times, and lower detection limits. He specializes in multidimensional gas-phase separations, including GC×GC, heart-cut GC (GC-GC), and advanced data handling tools. Applications of his work span health research, metabolite profiling, forensic science, petrochemicals, and environmental science.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_James_Harynuk_c40ab9f6cc.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. James Harynuk" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_James_Harynuk_c40ab9f6cc.jpg 156w," sizes="100vw" width="285" height="285"></p><p><strong>Christopher Reddy</strong> is senior scientist at the Department of Marine Chemistry and Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. Reddy received his B.S. degree in chemistry from Rhode Island College and his Ph.D. in chemical oceanography from the Graduate School of Oceanography at the University of Rhode Island. His research focuses on the environmental fate of organic pollutants in the ocean, often using advanced analytical techniques such as GC×GC and compound-specific isotope analysis. Drawing on lessons from past pollution, he works to design safer, more environmentally friendly materials.&nbsp;<br><br><strong>Robert K. Nelson</strong> is an organic geochemist invece di research specialist in the Department of Marine Chemistry &amp; Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. He earned a B.A. in biology from Central Connecticut State University and he later expanded his scientific training through additional coursework in organic chemistry at the University of Massachusetts Dartmouth and in physical chemistry at Northeastern University, strengthening his expertise in chemistry as applied to environmental sciences. With an extensive career in organic geochemistry and environmental analysis, Nelson is widely recognized for his contributions to the study of petroleum hydrocarbons and anthropogenic contaminants in the marine environment.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg" alt="ISCC &amp; GCxGC Symposium: Christopher Reddy, Robert K. Nelson" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg 234w," sizes="100vw" width="768" height="512"></p><h4><strong>JOHN PHILLIPS AWARD</strong></h4><p>Comprehensive two-dimensional gas chromatograpy, or GC×GC, was invented by the late <strong>Professor John Bruce Phillips </strong>of Southern Illinois University at Carbondale and his then graduate student, Dr. Zaiyou Liu. The Phillips Prize will be awarded every other year to individuals who have made outstanding contributions to the field of GC×GC analysis. The Phillips Award first given in 2004 recognizes individuals who have typically worked in the GC×GC field for less than 10 years but have demonstrated good leadership through their scientific peer-reviewed work.</p><p>The <strong>2026 John Phillips Award sponsored by LECO</strong> consists of a cash prize and a scroll with the winner’s name.</p><p><strong>Dr. Meriem Gaida </strong>obtained Ph.D. in Analytical Chemistry from the University of Liège (Belgium) in August 2023, specializing in separation science with expertise in GC×GC-ToFMS. Her research focused on advanced analytical strategies for complex chemical profiling and data interpretation, and she further expanded her expertise as a visiting researcher at the University of Washington (USA). After completing her doctorate, she joined SepSolve Analytical Ltd. (UK) as an Applications Specialist, where she developed and optimized customized GC×GC-ToFMS solutions for industrial and academic clients, providing technical support, method development, and training. In September 2024, she moved to LUZI AG (Switzerland), where she currently serves as Product Safety Science Manager, overseeing regulatory compliance, safety assessments of fragrance ingredients, and product safety documentation in line with European regulations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Dr_Meriem_Gaida_fa7cd655a2.jpg" alt="ISCC &amp; GCxGC Symposium: Dr. Meriem Gaida" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Dr_Meriem_Gaida_fa7cd655a2.jpg 156w," sizes="100vw" width="400" height="400"><br><br><strong>Petr Vozka </strong>is an Associate Professor of Chemistry and Biochemistry at California State University, Los Angeles, where he directs the Complex Chemical Composition Analysis Laboratory (C3AL). He earned a B.S. in Chemistry and Chemical Technologies, and an M.S. in Chemistry and Technology of Fuels and Environment from the University of Chemistry and Technology, Prague, followed by a Ph.D. from Purdue University focused on analytical chemistry of liquid transportation fuels. His research group develops and applies advanced separation and detection strategies, especially comprehensive two-dimensional gas chromatography (GC×GC) coupled with mass spectrometry, to resolve and quantify highly complex mixtures that challenge conventional methods. Application areas include alternative and sustainable fuels, microplastics and related environmental matrices, and forensic analyses such as chemical imaging of fingerprints.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Petr_Vozka_952f1c6248.jpg" alt="ISCC &amp; GCxGC Symposium: Petr Vozka" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Petr_Vozka_952f1c6248.jpg 186w," sizes="100vw" width="768" height="644"></p><h4><strong>Fritz Pregl Medal of the Austrian Society of Analytical Chemistry awarded to Prof. Christian Huber</strong></h4><p>The <strong>Fritz Pregl award of the Austrian Society of Analytical Chemistry (ASAC)</strong> was established in 1955. Since then, it is awarded at irregular intervals primarily at national and international scientific events and symposia.</p><p>The medal’s namesake, Friedrich Michael Raimund PREGL, received the Nobel Prize in Chemistry in 1923 for his groundbreaking work in the field of microchemical methods, which are closely linked to microanalytical applications. Fritz Pregl is the doyen of Austrian analysts. In his honor, the ASAC established the Pregl Medal, which is awarded to individuals who have made significant and outstanding contributions in the field of analytical chemistry, particularly organic trace analysis.</p><p><strong>Prof. Christian Huber</strong> is currently professor of chemistry for biosciences at the Paris Lodron University in Salzburg, Austria. After finishing his masters and Ph.D. at the university of Innsbruck he continued as an assistant professor at this university.</p><p>In 1996 Prof. Huber spent several months researching at Yale university in the group of Prof. Csaba Horvath. A year later he was appointed Associate Professor in Innsbruck. From 2002 he held the position of Professor of Analytical Chemistry at the Department of Chemistry, Division of Instrumental Analysis and Bioanalysis, Saarland University, Saarbrücken, Germany. From there he moved to Salzburg in 2008. Prof. Huber is a worldwide known researcher with a strong focus on separation sciences in particular for the analysis of large bio-molecules. According to Google Scholar his work has been cited more than 13500 times with an h-index of 63. In recognition of his contributions to HPLC and HPLC-MS, Prof. Huber will receive the Pregl Award Medal from the Austrian Society of Analytical Chemistry.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_Christian_Huber_31e539d0d9.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. Christian Huber" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_Christian_Huber_31e539d0d9.jpg 156w," sizes="100vw" width="285" height="285"></p>

Awards at the 44th International Symposium on Capillary Chromatography and 21st GCxGC Symposium

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

ISCC & GC×GC Symposium bring together global experts to discuss advances in capillary and multidimensional chromatography, mass spectrometry, and analytical technologies for complex sample analysis.

International Symposium on Capillary Chromatography (ISCC) and GCxGC Symposium

Thermo Scientific mzCloud Mass Spectral Library

mzCloud is a high-resolution, accurate-mass MSⁿ spectral library that helps identify unknown compounds when no reference standards are available, especially in complex studies.

<div colctrl-id="1-1"><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><h3><strong>Confident identification for unknown small molecules</strong></h3></div></div><div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Mass spectral libraries and databases may be required to identify unknown compounds when reference standards are not available. This is particularly true for studies in areas such as metabolomics, forensic toxicology, food &amp; beverage, environmental emerging contaminants or extractables &amp; leachables.</strong></p></div></div></div></div><div><p>In these situations, a mass spectral library, particularly a high-resolution and accurate-mass MS<sup>n</sup> fragmentation library, such as the mzCloud mass spectral library, can provide the information required to confidently identify unknown compounds.</p><h3><strong>Key benefits</strong></h3><h5><strong>Confidence for unknown identification</strong></h5><p>Comprehensive curation of all library content with extensive, fully annotated and searchable fragmentation spectra to provide confidence in your results.</p><h5><strong>Know more unknowns&nbsp;&nbsp;&nbsp;&nbsp;</strong></h5><p>Identify unknowns with automated deconvolution and library searching against extensive fragmentation spectra covering a wide chemical space, including small molecule applications.</p><h5><strong>From spectra to structure&nbsp;&nbsp;</strong></h5><p>With solutions to cover infusion or LC-MS, nominal or high-resolution data, you can be sure that your MS<sup>n</sup> spectra will provide you with actionable results, even when there is no spectral library match.</p><h5><strong>Flexibility for research and routine applications</strong></h5><p>Search for free online at <a target="_blank" rel="noopener noreferrer" href="http://www.mzcloud.org/" aria-label="mzCloud.org - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="http://www.mzcloud.org/$mzcloud.org"><span style="white-space:nowrap;">mzCloud.org</span></a>, or directly access through the Thermo Scientific Compound Discoverer and Mass Frontier software packages. Not online? mzVault provides you with the ability to perform offline spectral library searching.</p><figure class="image"><img style="aspect-ratio:1398/1002;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_ecc79fe9bf.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: mzCloud is easily and freely accessed online. Anyone can search, review, and use its extensive information. Note that the numbers above were correct at time of publication. For the most up to date numbers visit mzCloud.org." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_ecc79fe9bf.jpg 218w," sizes="100vw" width="1398" height="1002"></figure><h3><strong>What is in the mzCloud mass spectral library?</strong></h3><div style="height:auto;" id="whatismzcloud"><div><div><div><div><p>mzCloud is an extensively curated, high-quality mass spectral fragmentation library that contains significant amounts of spectra and metadata for each entry. Each entry also includes exhaustive high-resolution <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html?open=multi-stage-fragmentation#multi-stage-fragmentation">MS/MS and multi-stage MS<sup>n</sup> spectra</a>, which have been acquired at various collision energies and using different fragmentation techniques.</p><p><strong>Each raw mass spectrum</strong> has been filtered to remove noise, recalibrated to ensure absolute mass accuracy, fully annotated and <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html?open=content-curation#content-curation">curated</a> to ensure quality and consistency.</p><p>Finally, the contents of the library are <strong>updated weekly</strong> to provide coverage of a wide chemical space, ensuring relevance to all small-molecule application areas.</p></div><div><figure class="image"><img style="aspect-ratio:740/410;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_2_77a6795676.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: Example of the Mass Frontier software utilizing the contents of mzCloud to identify an unknown compound through a sub-structural search; the experimental fragmentation spectrum (top left) is searched against the mzCloud mass spectral database, with corresponding spectral hits shown in a given spectral tree (top, middle), with supporting spectral information (bottom left) and the identified precursor structure from the matched fragmentation spectra (bottom right), and the library compound structure from which the fragment originated (top right)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_2_77a6795676.jpg 245w," sizes="100vw" width="740" height="410"></figure></div><div><p>Distinguishing among types of databases is important, as the contents and quality of the contents typically differs significantly and may have an impact upon the reliability of the data and the confidence in any results obtained.</p><ul><li><strong>Chemical database</strong>: A collection of chemical information with, at minimum, a name and a formula. It may also include structures, elemental composition, retention time information, and additional biological or chemical metadata.</li><li><strong>Accurate-mass (AM) database</strong>: An AM database contains accurate mass formulas.</li><li><strong>Accurate-mass retention-time (AMRT) database</strong>: An AMRT database contains accurate mass and retention time(s) for specific analytical methods.</li><li><strong>Library</strong>: A library is a database (AM or AMRT) that, in addition to the above, also contains reference mass spectral data, MS/MS, and/or MS<sup>n</sup> data on compounds.</li></ul><h3><strong>Multi-stage fragmentation in the mzCloud mass spectral library</strong></h3><div style="height:auto;" id="multistagefragmentation"><div><div><div><div><figure class="image"><img style="aspect-ratio:740/420;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_3_792a9d9a59.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: A schematic representation of a spectral tree within mzCloud. The MS spectra are acquired for a given compound in multiple polarities (ESI +/-), and for a range of adducts. Each precursor is exhaustively fragmented using different fragmentation techniques (CID, HCD) and at multiple collision energies to produce collections of fragmentation spectra at each fragmentation level (MS2, MS3, MS4 etc.), generating a comprehensive spectral tree of information for each library entry." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_3_792a9d9a59.jpg 245w," sizes="100vw" width="740" height="420"></figure><p>mzCloud is an<strong> all-encompassing mass spectral library </strong>with content based on a wide chemical space (therefore covering all small-molecule application areas), and acquiring high-resolution and accurate-mass data at various collision energies, for multiple adducts, using CID and HCD. Approximately 10–20 collision energies are included for every precursor ion; this multi-stage, multidimensional MS<sup>n</sup> spectral data are arranged into spectral trees, which are both extensive and comprehensive, typically containing many hundreds to thousands of spectra for each compound, with many exceeding MS<sup>4</sup> fragmentation steps.</p><p>The extensive data for each library entry is critical for accurate compound identifications, matching experimentally obtained data to that of the library contents, with fit confidence and data visualization <strong>provided in the</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong> Compound Discoverer</strong></a><strong> and </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1757"><strong>Mass Frontier</strong></a><strong> data analysis software.</strong> Additional tools in Compound Discoverer and Mass Frontier software, including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1762"><strong>mzLogic</strong></a>, use the extensive fragmentation information to confidently identify unknowns that cannot be identified based upon the spectral library compound entries alone.</p><h3><strong>Content curation in the mzCloud mass spectral library</strong></h3><div style="height:auto;" id="contentcuration"><div><div><div><div><figure class="image"><img style="aspect-ratio:740/342;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_4_c7064c2ca2.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: An example of the mass spectral content curation tool available within the Mass Frontier software. It contains all the functionality used to manually curate the content contained within mzCloud. The power of mzCloud lies in both the extent and high quality of its content, which helps make confident compound identifications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_4_c7064c2ca2.jpg 245w," sizes="100vw" width="740" height="342"></figure><p>Despite the fact that <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=orbitrap"><strong>Thermo Scientific Orbitrap-based mass analyzers</strong></a> routinely deliver sub 3-ppm mass errors, there is a small amount of inaccuracy in any experimental data used to search against a library; these errors would be compounded if the library itself also contained data with mass errors. The compounded errors would mean that any identifications could be harder to make or have lower confidence due to match scores being higher.</p><p>Curating the content within mzCloud guards against error and variability in the reference spectra against which data is compared. <strong>The process of curation involves:</strong></p><ul><li>Averaging multiple, individually acquired spectra</li><li>The removal of mass spectral noise</li><li>Recalibration of the mass spectra based upon the predicted formulas for the fragment ion elemental compositions, based upon the known elemental composition and structure of the precursor ion</li><li>Annotation of all fragment ions with the fragment structure</li><li>Addition of large amounts of metadata, including the source of the data and all original raw data files</li></ul><p>This curation process is performed <strong>for every spectra</strong> - every collision energy, every fragmentation type, every MS<sup>n</sup> level and for each precursor ion. As such, the spectral data in mzCloud is of <strong>exceedingly high quality </strong>and offers significant advantages over crowd-sourced libraries due to the high levels of control.</p><figure class="image"><img style="aspect-ratio:740/350;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_5_0c3fdc4c6c.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: A recalibrated fragmentation spectrum showing no error on the highlighted peak at m/z 213.05462, along with all of the annotation that is provided for each spectra, at each collision energy, for each fragmentation type at each MSn level." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_5_0c3fdc4c6c.jpg 245w," sizes="100vw" width="740" height="350"></figure><div><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><h3><strong>How can I use the mzCloud mass spectral library?</strong></h3><p>Accelerate your small molecule unknown identification studies with <strong>mzCloud</strong>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1762"><strong>mzLogic</strong></a>, and the other data analysis and mass spectral prediction tools available in<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Compound Discoverer</strong></a> software and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1757"><strong>Mass Frontier</strong></a><strong> </strong>software.</p><p><img style="aspect-ratio:860/261;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_7_a8cefb0028.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: Connectivity of mzCloud and mzVault to Mass Frontier." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_7_a8cefb0028.jpg 245w," sizes="100vw" width="860" height="261"></p><p>The content within mzCloud is accessible through Compound Discoverer and Mass Frontier software packages, provided you have an internet connection. No internet? No problem – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1760"><strong>mzVault</strong></a>, provides you with the MS and MS/MS content of mzCloud in an offline format.</p><div style="height:auto;" id="accessmzcloud"><div><div><div><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt8" comp-id="B1"><div><p><img style="aspect-ratio:860/242;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_6_ae3c0a28e1.jpg" alt="Thermo Scientific mzCloud Mass Spectral Library: Connectivity of mzCloud and mzVault to Compound Discoverer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_mz_Cloud_Mass_Spectral_Library_6_ae3c0a28e1.jpg 245w," sizes="100vw" width="860" height="242"></p><p>Due to security concerns or local firewalls, not everyone can connect processing PCs to the internet. With that in mind, the contents of mzCloud are combined into an offline version twice a year. The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1760"><strong>mzVault</strong></a><strong> </strong>software application helps you access this information. In addition to accessing the offline version of mzCloud, the mzVault application can store and search your high-quality custom in-house (offline) MS/MS spectral libraries.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

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