Pipetting Made Easy - Part 3: Pipette Selection

<p><strong>Sample preparation is one of the most important stages of the analytical process in an LC-MS/MS laboratory. The quality of this step has a significant impact on result reproducibility, laboratory throughput, and the overall efficiency of the analytical method. In our laboratory, we therefore use the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1914"><strong>Organomation 80 Position MULTIVAP® nitrogen evaporator</strong></a><strong> for sample preparation in the determination of steroid hormones and in our newly developed method for the determination of vitamins B3 (nicotinamide), B5 (pantothenic acid), and B7 (biotin). The system has proven to be a reliable solution for the rapid and reproducible evaporation of organic solvents.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SPADIA_LAB_Organomation_80_Position_MULTIVAP_2975e64fc4.jpg" alt="SPADIA LAB: Organomation 80 Position MULTIVAP® nitrogen evaporator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SPADIA_LAB_Organomation_80_Position_MULTIVAP_2975e64fc4.jpg 117w," sizes="100vw" width="1600" height="2133"></p><p>In our workflow, the instrument is primarily used to evaporate <strong>methanol and methyl tert-butyl ether (MTBE)</strong> following sample extraction. Rapid removal of these solvents is an important step before subsequent sample reconstitution and LC-MS/MS analysis. Uniform nitrogen flow combined with controlled heating enables efficient solvent evaporation while maintaining high reproducibility throughout sample preparation.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SPADIA_LAB_Stanoveni_volnych_plazmatickych_metanefrinu_pomoci_kapalinove_chromatografie_s_tandemovou_hmotnostni_detekci_4adb0c95ca.jpg" alt="SPADIA LAB: Laboratory of Clinical Biochemistry Ostrava, Department of Chromatography and Spectrometry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SPADIA_LAB_Stanoveni_volnych_plazmatickych_metanefrinu_pomoci_kapalinove_chromatografie_s_tandemovou_hmotnostni_detekci_4adb0c95ca.jpg 235w," sizes="100vw" width="800" height="533"></p><p>The instrument combines <strong>nitrogen blow-down evaporation</strong> with controlled heating using an aluminum dry block. This combination enables gentle analyte concentration while reducing evaporation time. A major advantage is the ability to process <strong>up to 80 samples simultaneously</strong>, significantly increasing laboratory capacity when analyzing larger sample batches.</p><p>The MULTIVAP is equipped with digital temperature control over a range of <strong>30–120 °C</strong>, maintaining the set temperature with an accuracy of approximately ±2 °C. Uniform nitrogen distribution through stainless-steel needles provides consistent evaporation conditions across all positions. Another practical feature is the ability to independently shut off the nitrogen supply to individual rows of ten samples, enabling more efficient gas consumption when working with smaller batches. The instrument also provides nitrogen flow control from <strong>0–25 L/min</strong> and features a precision-machined aluminum block optimized for a specific tube diameter, ensuring efficient heat transfer and high process reproducibility.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SPADIA_LAB_Organomation_80_Position_MULTIVAP_2_468fbd4d0d.jpg" alt="SPADIA LAB: Organomation 80 Position MULTIVAP® nitrogen evaporator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SPADIA_LAB_Organomation_80_Position_MULTIVAP_2_468fbd4d0d.jpg 117w," sizes="100vw" width="1600" height="2133"></p><p>In everyday operation, we particularly appreciate the stable performance, straightforward operation, and ability to process a large number of samples in parallel without compromising sample preparation quality. The instrument has proven effective both for routine steroid hormone analyses and during the development of new LC-MS/MS methods for the determination of B vitamins. Its major benefits include not only shorter sample preparation times but also highly reproducible evaporation across the entire sample batch.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SPADIA_Laborator_chromatografie_a_spektometire_Ostrava_2_fdaa4ab8e5/SPADIA-Laborator-chromatografie-a-spektometire-Ostrava-2.jpg" alt="SPADIA LAB: Laboratory of Clinical Biochemistry Ostrava, Department of Chromatography and Spectrometry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SPADIA_Laborator_chromatografie_a_spektometire_Ostrava_2_fdaa4ab8e5/thumbnail_SPADIA-Laborator-chromatografie-a-spektometire-Ostrava-2.jpg 234w," sizes="100vw" width="800" height="533"></p><p>Based on our experience, we consider the <strong>Organomation MULTIVAP</strong> a robust and reliable laboratory instrument that has become an integral part of our analytical workflow. Its combination of high sample capacity, efficient nitrogen utilization, and precise temperature control makes it a suitable solution for laboratories using modern LC-MS/MS methods.</p><h3><strong>What Other Tests Are Performed by the Laboratory of Clinical Biochemistry Ostrava, Department of Chromatography and Spectrometry?</strong></h3><ul><li><strong>Vitamins:</strong> B1, B2, B6, A, C, D2 (25-OH), D3 (25-OH), E, coenzyme Q10</li><li><strong>Ions, trace elements, and toxic elements:</strong> magnesium in erythrocytes, zinc, copper, selenium, manganese, chromium, cobalt, molybdenum, titanium, aluminum, nickel, cadmium, lead, mercury</li><li><strong>Fatty acid profile analysis:</strong> including determination of the Omega-6/Omega-3 ratio and three additional nutritional indicators</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SPADIA_LAB_LC_MS_MS_system_pro_mereni_mastnych_kyselin_na_oddeleni_chromatografie_a_spektrometrie_SPADIA_LAB_8227b1ac3f.jpg" alt="SPADIA LAB: LC-MS-MS system for measuring fatty acids in the Chromatography and Spectrometry Department" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SPADIA_LAB_LC_MS_MS_system_pro_mereni_mastnych_kyselin_na_oddeleni_chromatografie_a_spektrometrie_SPADIA_LAB_8227b1ac3f.jpg 208w," sizes="100vw" width="2284" height="1713"></p><ul><li><strong>Therapeutic drug monitoring (TDM):</strong> digoxin, theophylline, amiodarone, antibiotics, antiepileptics, benzodiazepines, antipsychotics, antidepressants</li><li><strong>Toxicology:</strong> toxicological screening (amphetamines, benzodiazepines, cannabinoids, cocaine, tricyclic antidepressants, opiates, methadone, kratom), toxicological confirmation (LC-MS/MS, GC/MS)</li><li><strong>Biogenic amines and their metabolites:</strong> catecholamines, metanephrines, serotonin, vanillylmandelic acid, homovanillic acid, 5-hydroxyindoleacetic acid</li><li><strong>Steroid hormones:</strong> dihydrotestosterone, androstenedione, 17-OH-progesterone</li><li><strong>Porphyria diagnostics:</strong> 5-aminolevulinic acid, porphobilinogen</li><li><strong>Other specialized tests:</strong> fecal hemoglobin (FOB), serum amyloid A, complement activity (CH50), angiotensin-converting enzyme, bile acids, beta-hydroxybutyrate, urinary oxalates</li><li><strong>Veterinary testing:</strong> CRP, SAA (serum amyloid A), SDMA (symmetric dimethylarginine)</li></ul>

Efficient Sample Evaporation Using the Organomation MULTIVAP® Nitrogen Evaporator

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 3rd August 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you posters by <strong>Agilent Technologies / ASMS, Shimadzu / ASMS, Thermo Fisher Scientific / HPLC Symposium </strong>and<strong> Waters Corporation / ASMS </strong>and application note by<strong> Metrohm!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Ultra-Trace Quantification of N-Nitroso-desmethyl-sumatriptan with Interference Resolution Using LC–TQ</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/1290_infinity_iii_uhplc_6495d_lc_tq_desmethyl_sumatriptan_asms_2026_mp_667_agilent_ebb0888227.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Sumatriptan succinate, an antimigraine drug contains nitrosylating functional groups and is susceptible to forming its own nitrosamine drug substance-related impurity (NDSRI), specifically N-nitroso-desmethylsumatriptan. As a Category 1 genotoxic impurity, its specification limit is established at 0.0428 ppm with respect to the API. In this study, samples and standards were prepared in methanol:water (1:1, v/v). The LC/TQ method was developed with a target limit of detection (LOD) at least 20-fold lower than the specification limit to ensure adequate sensitivity. Analytical data were collected in replicate for a 10 mg/mL API sample, as well as LOQ- and specification-level spiked samples, to evaluate recovery, relative standard deviation (RSD), linearity, and repeatability.</p><h4><strong>Experimental</strong></h4><ul><li><strong>LC System: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1290+Infinity+III+UHPLC"><strong>1290 Infinity III UHPLC</strong></a></li><li><strong>MS:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=6495D"><strong>6495D LC/TQ</strong></a></li><li><strong>Column:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=Poroshell+120+EC+C18"><strong>Poroshell 120 EC C18</strong></a>, 3x150mmx2.7µm, 40 Deg C</li></ul><h4><strong>Conclusions&nbsp;</strong></h4><ul><li>A sensitive and robust method has been developed for N-nitroso-desmethyl Sumatriptan in Sumatriptan.&nbsp;</li><li>Method LOQ is 10% lower than specification level, RSD of &lt;5%, and linearity across 0.00214 to 0.1 ppm.&nbsp;</li><li>The recovery of NDSRI in Sumatriptan at LOQ level and specification level are 95%.</li></ul><h3><strong>2. Metrohm: Moisture analysis of rebaudioside M by Karl Fischer titration</strong></h3><p><strong>Simplified rebaudioside M moisture determination via volumetric Karl Fischer titration paired with an oven system</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_k_075_download_59f185c238.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Natural sweeteners like stevia and its derivatives are an increasingly important part of the global sweetener market as more consumers substitute sugar with healthier alternatives. Stevia’s derivatives are significantly sweeter than table sugar. These compounds are estimated to be 50 to 300 times sweeter in comparison. This sweet taste coupled with the fact that the human body cannot metabolize steviol glycosides (i.e., they contribute zero calories to one’s diet), makes them a very attractive sugar replacement.&nbsp;</p><p>The moisture content of stevia materials is a crucial factor when discussing their shelf life and stability. Measuring the moisture content of a stevia derivative, rebaudioside M, using an oven system coupled with volumetric Karl Fischer (KF) titration provided a repeatable approach for quantifying the moisture content of this material.</p><h4><strong>Experimental</strong></h4><p>The analysis was carried out with a Double Pt ring electrode for volumetry (6.00346.100). Testing was executed on the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=220&amp;search=874+Oven+Sample+Processor"><strong>874 Oven Sample Processor</strong></a> (2.874.0120) coupled with an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=220&amp;search=852+Titrando"><strong>852 Titrando</strong></a> (2.852.0060). Approximately 0.2 g of sample was weighed into an 874 Oven Sample Processor 6 mL vial and placed onto the rack. The oven was set to a temperature of 100 °C, and the evaporated moisture was carried to the volumetric titration vessel by nitrogen gas flow at 70 mL/min. The moisture from the sample was titrated with Hydranal Comp 5 reagent.</p><h4><strong>Conclusion</strong></h4><p>Natural low-calorie sweeteners like stevia derivatives are growing in popularity as people choose healthier alternatives to sugar. Working to develop standardized, specific methodology can help support sweetener industry development, effective quality assessment, and the evaluation of rebaudioside M and other steviol glycosides’ stability.&nbsp;</p><p>This Application Note provides a foundation for the analysis of stevia powder by Karl Fischer titration. An oven system paired with volumetric Karl Fischer analysis provides an accurate, repeatable method to evaluate stevia powder and its derivatives. This method’s compatibility with the 874 Oven Sample Processor allows increased sample throughput through automation, providing operators even more time to complete other important tasks in parallel.</p><h3><strong>3. Shimadzu / ASMS: Quantitative analysis of 6 beta blockers on an LCMS-8045RX</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/WP_131_Quantitative_analysis_of_6_beta_blockers_on_an_LCMS_8045_RX_f596f609f4.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Beta-adrenergic blocking agents, commonly known as beta blockers, competitively inhibit the binding of catecholamines such as epinephrine and norepinephrine to β-adrenergic receptors, thereby reducing heart rate and blood pressure. These drugs are widely prescribed for the treatment of hypertension, angina and heart failure<sup>1</sup> . However, beta blockers may also be misused by athletes resulting in their inclusion on the World Anti-Doping Agency (WADA) prohibited list<sup>2</sup> . Owing to both their therapeutic importance and potential misuse, sensitive and selective analytical methods are required for reliable detection and quantification. Liquid chromatography tandem mass spectrometry (LC-MS/MS) offers high sensitivity and specificity for such analyses.</p><h4><strong>Method</strong></h4><p>Nadolol, metoprolol, propranolol, atenolol &amp; carvedilol were purchased from Sigma Aldrich and Thermo Fisher Scientific. Standards were prepared in 1 mg/mL in LCMS grade methanol. <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexera+40"><strong>Nexera 40-series HPLC system</strong></a> connected to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=LCMS-8045RX"><strong>LCMS-8045RX</strong></a> was used for data acquisition. The mixture of standards was further diluted in LCMS grade methanol (Sigma Aldrich) and Sigmatrix urine diluent to create the standards for the calibration curves. A Shim-pack Velox Biphenyl column was used for the chromatographic separation. All analytes were ionized with electrospray ionization (ESI) in positive ion mode.</p><h4><strong>Conclusion&nbsp;</strong></h4><ul><li>Superior sensitivity in complex matrices: Limit of Detection (at accuracy ±20% and S/N &gt; 3) of 0.010 ng/mL for all the analytes evaluated in this study.</li><li>Excellent linearity and accuracy: Linear responses (with R2 &gt; 0.99) observed across the evaluated concentration range, and consistent accuracy within ±20% for all 17 calibrants included in this study.&nbsp;</li><li>Optimized throughput: Automated interface and MRM optimization via LabSolutions Connect MRM ensured maximum signal-to-noise determination for this study, while the high-organic flush at the end of each run, maintained column integrity</li></ul><h3><strong>4. Thermo Fisher Scientific / HPLC Symposium: A switchable 2D-LC platform in PAT: routine UV monitoring or MS-based characterization of mAb PQAs directly from the bioreactor</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_004764_hplc_vanquish_2dlc_mabs_analysis_bioreactor_samples_po004764_na_en_7a99c1b683.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Monitoring quality attributes throughout the upstream processing of mAbs is critical due to potential effects of biological variability on product safety and efficacy. Thus, there is a growing need for streamlined analytical workflows that provide timely and reliable insights to enable fast and informed process decisions.</p><h4><strong>Materials and methods</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743"><strong>Thermo Scientific Vanquish Flex Simple</strong></a> Switch 2D-LC system for loop heart-cutting consisting of Quaternary Pump F (VF-P20-A), Binary Pump F (VF-P10-A-01), Dual Split Sampler FT (VF-A40-A-02), 2x Column Compartment H (VH-C10-A-03), and Diode Array Detector FG (VF-D11-A-01)&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1490"><strong>Thermo Scientific Orbitrap Exploris MX Mass Detector</strong></a> (BRE725536) with BioPharma option (BRE725539)&nbsp;</li><li>Thermo Scientific MAbPac Protein A column, 12 µm, 4 x 35 mm (PN 082539)&nbsp;</li><li>Thermo Scientific ProPac 3R SCX, 2 x 50 mm, 3 µm (PN 43103-052068)&nbsp;</li><li>Thermo Scientific MAbPac SEC-1, 5 µm, 4 x 300 mm (PN 074696)</li></ul><h4><strong>Data analysis&nbsp;</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon 7.3.2 Chromatography Data System (CDS) </strong></a>and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837"><strong>Thermo Scientific BioPharma Finder 5.2 software</strong></a></p><h4><strong>Conclusions&nbsp;</strong></h4><ul><li>Switchable 2D-LC-UV/MS offers a streamlined approach for at-line monitoring of mAb titer, charge and size variants directly from the bioreactor in &lt;1h.&nbsp;</li><li>UV monitoring provides quick and simple trendlines, while HRAM-MS allows deep characterization at intact level.&nbsp;</li><li>Near real-time information supports in-time process decisions to protect yield and product quality.</li></ul><h3><strong>5. Waters Corporation / ASMS: SOFTWARE TOOLS FOR AUTOMATED LC/MS ANALYSIS OF CRITICAL QUALITY ATTRIBUTES OF mRNA MOLECULES</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009414_52de0bb71a.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><p>This poster presents an automated LC-MS workflow for evaluating three critical quality attributes (CQAs) of mRNA therapeutics: <strong>5′-capping efficiency, Poly(A) tail length and heterogeneity, and mRNA sequence integrity</strong>. A custom firefly luciferase (Fluc) mRNA construct containing a Cap-1 structure, 1,919 nucleotides, and a Poly(A) tail was used as the model sample. Importantly, all three CQAs were assessed using a <strong>single LC-MS assay</strong>, supported by specialized waters_connect software tools designed to streamline nucleic acid characterization from sequence entry through final data processing.</p><p>The analytical platform consisted of a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/191"><strong>Waters ACQUITY Premier Binary UPLC System</strong></a><strong> with TUV detector coupled to a </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1148"><strong>Xevo MRT Q-Tof Mass Spectrometer</strong></a>, which uses multi-reflectron time-of-flight technology. Separations were performed on an ACQUITY Premier OST 1.7 µm, 300 Å, 2.1 × 150 mm column, while data-independent acquisition was carried out in MSE mode. Data processing used the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544"><strong>waters_connect</strong></a><strong> Informatics Platform together with SYNTHETIC Library 2.0, MAP Sequence 2.0, and INTACT Mass 1.9</strong> applications. For sequence mapping, the mRNA was independently digested using four endonucleases—RNase T1, RapiZyme MC1, RapiZyme Cusativin, and human RNase4—providing complementary cleavage patterns.</p><p>The workflow produced detailed information on both capping and Poly(A) tail characteristics. The Fluc mRNA showed <strong>100% capping efficiency</strong>, with 62.7% carrying an m7GpppAm Cap-1 structure and 37.3% an m7GpppGm Cap-1 structure; no uncapped digestion product or Cap-related impurities were detected. Poly(A) tail analysis identified ten major species ranging from <strong>98-mer to 107-mer</strong>, resulting in an average Poly(A) tail length of <strong>102.3 nucleotides</strong>. The Xevo MRT Q-Tof provided high-resolution measurements—approximately 100,000 resolution in the examples shown—and very good mass accuracy for the detected Poly(A) species.</p><p>For sequence integrity, combining the four complementary enzymatic digestions achieved <strong>93.7% unambiguous mRNA sequence coverage</strong>, demonstrating the value of a multi-enzyme approach for comprehensive sequence confirmation. MAP Sequence 2.0 also automatically distinguished structural isomers using elevated-energy fragment-ion information, helping resolve isobaric and isomeric digestion products with less manual interpretation. Overall, the poster demonstrates that high-resolution MSE acquisition on the <strong>Xevo MRT Q-Tof combined with automated waters_connect informatics</strong> can provide an integrated and efficient approach for comprehensive characterization of key mRNA quality attributes.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 32, 2026

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<h4><strong>An experienced partner in the LC-MS/MS analysis industry</strong></h4><p>If you are interested in performing quantitative, qualitative or mixed analysis using LC-MS/MS analytical methods but lack such capabilities due to lack of equipment, “know-how” or are looking for a team to perform analysis for a project - you have come to the right place. We work on <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/315"><strong>equipment</strong></a> with high sensitivity, speed and specificity. Our team is a group of specialists with comprehensive experience in the industry. The LabExperts <a target="_blank" rel="noopener noreferrer" href="https://labexperts.com.pl/zespol/">team</a> has participated in many scientific projects, R&amp;D and commercial implementations. We take an individual and factual approach to developing a new method and performing analyses:</p><ul><li>In the first stage, we get to know your requirements - to align expectations with capabilities;</li><li>Next, we will form and approve the framework for cooperation, ensuring the observance of confidentiality by signing a non-disclosure agreement (NDA);</li><li>We will plan together and, for our part, meet the deadlines for the completion of the set tasks;</li><li>We will perform preliminary studies, after which we will decide together whether and to what extent we continue to develop the methods;</li><li>We will handle the development of the sample preparation procedure;</li><li>We will select the best parameters for the LC-MS/MS analytical method;</li><li>The analytical method along with the sample preparation procedure will be validated according to generally accepted guidelines and standards, or we will establish the required acceptance criteria and ranges for your needs;</li><li>We will perform LC-MS/MS analyses of a series of samples;</li><li>We will provide results in the form of easy-to-read reports at each required stage;</li><li>We will evaluate the feasibility and assist in the transfer of the method to your laboratory.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Development_of_LC_MS_MS_method_2594c9fd54.jpg" alt="Bioanalytic: Bioanalytic Development of LC-MS-MS method." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Development_of_LC_MS_MS_method_2594c9fd54.jpg 234w," sizes="100vw" width="1536" height="1024"></p><p>Pricing and the framework for cooperation are always determined individually depending on the scope of the study. This is influenced by the amount of work and the complexity of the development of the sample preparation procedure and analytical method and routine analytics. As a rule, the final price consists of three separately priced elements: the cost of preliminary studies, method validation, and the cost of analysis of one sample within a series of analyses.</p><p>Don't beat your head against the wall - we will help you achieve your goal!</p><p>We look forward to working with you!</p>

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News from LabRulezLCMS Library - Week 32, 2026

Efficient Sample Evaporation Using the Organomation MULTIVAP® Nitrogen Evaporator

Pipetting Made Easy - Part 3: Pipette Selection