<div><div><div><p><strong>Scientists at IOCB Prague have developed a breakthrough technology that streamlines aptamer development. The new method integrates several biochemical and bioinformatics steps and paves the way for new diagnostic and therapeutic applications. Ongoing applications include wearable sensors that monitor selected biomarkers in real time and provide early warnings of impending health complications. The findings were published in </strong><i><strong>Nature Communications</strong></i><strong>.</strong></p></div></div><div><p>Aptamers are short DNA or RNA strands that can recognize and bind to a specific target molecule with high precision. Similar to antibodies, they can be used to detect these molecules or modulate their activity. Unlike antibodies, they are much more stable, can be produced synthetically, and can be chemically modified to achieve the desired properties. As a result, they can offer capabilities that cannot be achieved with antibodies.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg" alt="IOCHB Prague: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Chemically modified DNA aptamer bound to the target protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg 228w," sizes="100vw" width="1343" height="916"></p><p>As demand grows for accurate and rapid diagnostic tools, aptamers are often better suited to these applications than antibodies. However, developing aptamers is both experimentally demanding and time-consuming. A team of scientists from IOCB Prague, led by Dr. Marek Ondruš and <a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en"><strong>Prof. Michal Hocek</strong></a>, has now developed a technology that significantly shortens the development process.</p><p><i>“Developing an aptamer is often like looking for a needle in a haystack. Among trillions of different DNA sequences, we search for the one that binds strongly and specifically to a target molecule. Our new approach first screen for ‘aptamer families’ – hundreds of related sequences – and then identify the best-performing member of the family. This approach can reduce development time from several months to only a few days,” </i>says Marek Ondruš.</p><blockquote><p><strong>Video:</strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=_3zXUeVMugU"> New technology streamlines the development of aptamers, synthetic alternatives to antibodies&nbsp;</a></p></blockquote><p>The team has also expanded the potential applications of aptamers by chemically modifying their building blocks. For example, introducing functional groups similar to those found naturally in amino acids allows the resulting molecules to combine the advantages of both DNA and antibodies: Their sequence is encoded by the order of nucleotides in DNA, while the attached chemical modifications greatly expand their ability to recognize biologically relevant targets and mimic interactions between proteins that are underlying many biological processes.</p><p>The researchers demonstrated the potential of this new method using the human insulin receptor, a key protein that regulates blood sugar levels. They developed an aptamer that specifically binds to the receptor and elucidated the molecular basis of this interaction using cryo-electron microscopy. <i>“We have shown that chemically introduced functional groups play a crucial role not only in target recognition and formation of the aptamer–protein complex, but also in stabilizing the DNA aptamer’s structure. Our findings provide new insights into how chemically modified nucleic acids can mimic key properties of proteins,”</i> says Marek Ondruš.</p><p>In the future, the technology could complement – or, in some applications, even replace – antibody-based diagnostic tools. Researchers are collaborating with <a target="_blank" rel="noopener noreferrer" href="http://iocbtech.cz/">IOCB Tech</a> on its further development, as the company helps to bring discoveries from IOCB Prague into practical applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg" alt="IOCHB Prague/Tomáš Belloň: New technology streamlines the development of aptamers, synthetic alternatives to antibodies: Dr. Marek Ondruš, first author of the study, and Prof. Michal Hocek, head of the Bioorganic and Medicinal Chemistry of Nucleic Acids research group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg 234w," sizes="100vw" width="2000" height="1335"></p><blockquote><h4><strong>Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-73676-y#citeas"><strong>Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries</strong></a></h4><p>ablo Alberto Franco-Urquijo, Marek Ondruš, Jaroslav Kurfürst, Jana Škerlová, Irena Selicharová, Lucie Mužíková Čechová, Hana Šváchová, Alena Semerádtová, Anatolij Filimoněnko, Adéla Fejfarová, Jiří Homola, Tomáš Kouba &amp; Michal Hocek</p><p><i><strong>Nat. Commun., 2026</strong></i></p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41467-026-73676-y"><span>https://doi.org/10.1038/s41467-026-73676-y</span></a><span>&nbsp;</span></p><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Discovery of functional nucleic acids from randomized libraries typically relies on multiple, time-consuming iterative rounds of in vitro selection with low success rate. Here, we present a single-round selection strategy for rapid screening of multiple over-represented nucleobase-modified DNA libraries and various selection conditions, capable of identifying high-affinity modified aptamers. Double partition followed by amplification of eluted sequences, NGS analysis and clustering provides fast identification of aptamer candidates. Screening of modified DNA libraries containing modified adenine and uracil nucleotides bearing hydrophobic aromatic phenyl and indole moieties results in development of an aptamer binding human insulin receptor with sub-nanomolar affinity and exquisite specificity. Cryo-EM structure reveals the importance of each aromatic modification, either in stabilizing the secondary structure or facilitating interactions with the protein surface. This approach addresses the main drawbacks of aptamer selection and has potential for high-throughput screening and accelerating the development of next-generation aptamers for diagnostics or therapeutics.</p></div>

New technology streamlines the development of aptamers, synthetic alternatives to antibodies

<p><strong>Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity</strong></a><strong> 10.2 highlights</strong></h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4><strong>Instrument control modules</strong></h4><p>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"></p><h4><strong>MS data import/export improvements</strong></h4><p>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"></p><h4><strong>Obsolete hardware support terminated</strong></h4><p>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"></p><blockquote><p><strong>Explore the complete list of all changes, fixes, and additions in version 10.2.</strong></p><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1"><strong>See the complete changelog&nbsp;</strong></a></p></blockquote>

Clarity Chromatography Software 10.2 released!

<p><strong>🎤Dr. Leigh Terry (University of Alabama)</strong></p><p><strong>In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.</strong></p><p>While most regulatory methods focus on a small number of compounds like PFOA and PFOS, there may be thousands of PFAS compounds in the environment—and much of that burden goes undetected.</p><h4><strong>In this episode, we cover:</strong></h4><ul><li>Why PFAS are called “forever chemicals” (and why that label is evolving)</li><li>The limitations of targeted<strong> LC-MS/MS methods</strong></li><li>What the fluorine mass balance problem reveals about PFAS destruction</li><li>How combustion ion chromatography (<strong>CIC</strong>) helps measure total organofluorine</li><li>Why “99.99% removal” doesn’t always mean what you think</li><li>Where PFAS actually end up in wastewater treatment systems</li><li>The most effective technologies for PFAS removal today</li><li>Why drinking water may only account for ~20% of total PFAS exposure</li></ul><h4><strong>Key Insight:</strong></h4><p>Even when analyzing dozens of PFAS compounds, researchers may only be capturing a small fraction of total organic fluorine—raising major questions about how we monitor and regulate these contaminants.</p><h3><strong>Video Transcription</strong></h3><p>In this episode of <i>Concentrating on Chromatography</i>, Dr. Leigh Terry discusses PFAS contamination in drinking water, the analytical challenges associated with measuring these compounds, current treatment technologies, and future directions for monitoring and regulation. The conversation highlights how analytical chemistry, environmental engineering, and public health intersect in addressing one of today's most discussed classes of emerging contaminants.</p><h4><strong>Understanding PFAS and Their Significance</strong></h4><h5><strong>The University of Alabama Water Quality Research Center</strong></h5><p>Dr. Leigh Terry is part of the University of Alabama's Center for Water Quality Research. The center operates an analytical laboratory focused on drinking water quality and the detection of contaminants at extremely low concentrations.</p><p>The laboratory specializes in:</p><ul><li>Drinking water analysis</li><li>Organic contaminants</li><li>Emerging contaminants</li><li>PFAS monitoring</li><li>Water quality research</li></ul><p>Their work supports both research initiatives and practical solutions for water utilities and environmental agencies.</p><h4><strong>Why Focus on PFAS?</strong></h4><p>Although PFAS compounds have existed since the 1940s, public awareness has increased dramatically only in recent years.</p><p>According to Dr. Terry, several factors contributed to the rapid growth of PFAS research:</p><ul><li>Increased media attention</li><li>New regulatory initiatives</li><li>Growing evidence of human exposure</li><li>Expanding research opportunities</li><li>Greater understanding of potential health risks</li></ul><p>PFAS are not new contaminants. Rather, society is only beginning to understand their prevalence in the environment and their potential impacts on human health.</p><h4><strong>The Development of Standardized PFAS Methods</strong></h4><p>One major advancement in PFAS analysis has been the development of standardized EPA methods.</p><p>These methods allow:</p><ul><li>Consistent testing procedures</li><li>Comparable results between laboratories</li><li>Regulatory monitoring</li><li>Reliable data interpretation</li></ul><p>Dr. Terry notes that many of these standardized approaches began appearing around 2018–2019, providing a common framework for analytical laboratories and researchers.</p><h4><strong>How Large Is the PFAS Universe?</strong></h4><p>Many people are familiar with PFOA and PFOS, two of the most heavily studied PFAS compounds. However, these represent only a small fraction of the broader PFAS family.</p><p>PFOA and PFOS are often referred to as:</p><ul><li>Legacy PFAS compounds</li><li>Original PFAS contaminants</li><li>Early commercial PFAS chemicals</li></ul><p>The challenge is that even minor modifications to molecular structure create entirely new PFAS compounds.</p><p>Researchers estimate:</p><ul><li>Thousands of PFAS compounds exist</li><li>Some estimates exceed 10,000 compounds</li><li>Exact numbers depend on how PFAS are defined</li></ul><p>Scientific debate continues regarding classification and definition, making precise counting difficult.</p><h4><strong>Why PFAS Are Called "Forever Chemicals"</strong></h4><p>Dr. Terry notes that the phrase "forever chemicals" has become widely used, although she suggests the terminology could benefit from rebranding.</p><p>PFAS persistence results from two key chemical properties.</p><h5><strong>1. Amphiphilic Structure</strong></h5><p>PFAS molecules contain:</p><ul><li>A water-loving (hydrophilic) head group</li><li>A water-repelling (hydrophobic) fluorinated tail</li></ul><p>This unusual combination allows PFAS to partition between:</p><ul><li>Water</li><li>Solids</li><li>Air-water interfaces</li><li>Foam</li></ul><p>Unlike many organic compounds, PFAS can interact effectively with multiple environmental phases.</p><h5><strong>2. Extremely Strong Carbon–Fluorine Bonds</strong></h5><p>The carbon–fluorine bond is among the strongest bonds in organic chemistry.</p><p>As Dr. Terry explains:</p><ul><li>Large amounts of energy are required to break these bonds</li><li>Natural degradation processes are often ineffective</li><li>Destruction can require highly aggressive treatment conditions</li></ul><p>These properties make PFAS extremely persistent in both environmental systems and biological organisms.</p><h4><strong>Toxicity, Regulations, and Environmental Behavior</strong></h4><h5><strong>Understanding PFAS Toxicity</strong></h5><p>One of the biggest challenges in PFAS regulation is the incomplete understanding of toxicity.</p><p>Dr. Terry explains that EPA regulations generally consider three factors:</p><ul><li>Presence in drinking water sources</li><li>Toxicity to humans</li><li>Availability of practical treatment options</li></ul><p>While some PFAS compounds are known to be harmful, many others remain insufficiently studied. Furthermore, PFAS often occur as mixtures rather than individual compounds.</p><p>This creates important scientific questions:</p><ul><li>What is the toxicity of individual PFAS?</li><li>What is the toxicity of PFAS mixtures?</li><li>How should cumulative exposure be evaluated?</li></ul><p>These uncertainties continue to drive active research.</p><h4><strong>What Happens to PFAS in Wastewater Treatment Plants?</strong></h4><p>PFAS do not behave like many conventional contaminants.</p><p>Rather than remaining fully dissolved in water, they often accumulate at interfaces such as:</p><ul><li>Water-solid interfaces</li><li>Water-air interfaces</li><li>Foam layers</li><li>Biological solids</li></ul><p>As a result:</p><ul><li>Some PFAS accumulate in biosolids</li><li>Some partition into foam</li><li>Some remain in treated effluent</li></ul><p>Their distribution depends on wastewater composition and treatment processes.</p><h4><strong>Regulatory Monitoring and Targeted LC-MS Analysis</strong></h4><p>Current EPA regulations focus on targeted analysis of specific PFAS compounds.</p><p>Examples include:</p><ul><li>PFOA</li><li>PFOS</li></ul><p>Drinking water regulations currently establish maximum contaminant levels (MCLs) for these compounds at extremely low concentrations.</p><p>Advantages of targeted LC-MS analysis include:</p><ul><li>Clearly defined analytes</li><li>Established regulatory limits</li><li>High analytical sensitivity</li><li>Reliable quantitation</li></ul><p>However, limitations remain:</p><ul><li>Only a small subset of PFAS is measured</li><li>Many PFAS compounds remain undetected</li><li>Total PFAS burden may be underestimated</li></ul><p>As Dr. Terry notes, targeted analysis provides only part of the overall picture.</p><h4><strong>The Fluorine Mass Balance Problem</strong></h4><p>One of the most important concepts discussed in the interview is fluorine mass balance.</p><p>When PFAS degrade, fluorinated fragments may remain in the environment.</p><p>This creates a critical question:</p><p>Are treatment technologies truly destroying PFAS, or merely transforming them into shorter-chain PFAS compounds?</p><p>To answer this, researchers perform fluorine mass balance calculations using:</p><ul><li>Targeted PFAS analysis</li><li>Fluoride measurements</li><li>Total organic fluorine measurements</li></ul><p>A successful destruction process should ultimately convert PFAS into fluoride ions rather than simply producing smaller PFAS molecules.</p><h4><strong>Advanced Analysis, Treatment Technologies, and Future Directions</strong></h4><h5><strong>Combining Targeted and Bulk Fluorine Measurements</strong></h5><p>Dr. Terry's group complements targeted LC-MS analysis with measurements of total organic fluorine.</p><p>Approaches include:</p><ul><li>Absorbable Organic Fluorine (AOF)</li><li>Extractable Organic Fluorine (EOF)</li><li>Combustion Ion Chromatography (CIC)</li></ul><p>In these methods:</p><ul><li>Organic fluorine is captured</li><li>Samples are combusted</li><li>Released fluoride is quantified</li></ul><p>This provides insight into total fluorinated content, although contributions may originate from sources beyond PFAS, including pharmaceuticals and consumer products.</p><h4><strong>Surprising Findings from Combined Analysis</strong></h4><p>One important finding from wastewater studies was that targeted PFAS measurements accounted for only a small fraction of total organic fluorine.</p><p>Dr. Terry reports that:</p><ul><li>Approximately 4% of measured AOF could be explained by targeted PFAS compounds</li><li>The majority of organic fluorine remained unidentified</li></ul><p>This suggests that environmental fluorine chemistry is considerably more complex than currently represented by routine monitoring programs.</p><h4><strong>Preventing PFAS Contamination in the Laboratory</strong></h4><p>PFAS analysis requires exceptionally strict quality control.</p><p>Dr. Terry's laboratory routinely:</p><ul><li>Tests every new batch of SPE cartridges</li><li>Tests carbon tubes before use</li><li>Uses DI water blanks</li><li>Verifies consumables labeled as PFAS-free</li><li>Collects field blanks</li><li>Monitors analytical blanks throughout workflows</li></ul><p>These practices help prevent contamination from laboratory materials and consumables, a common challenge in ultra-trace PFAS analysis.</p><h4><strong>Current PFAS Treatment Technologies</strong></h4><p>Three technologies currently dominate PFAS removal in drinking water treatment:</p><ul><li>Granular Activated Carbon (GAC)</li><li>Ion Exchange Resins</li><li>Reverse Osmosis (RO)</li></ul><p>Selection depends on:</p><ul><li>PFAS concentration</li><li>Water quality</li><li>Local operating conditions</li><li>Utility infrastructure</li></ul><p>Although many emerging technologies are being investigated, these remain the most widely implemented solutions.</p><h4><strong>Membrane Filtration and Pretreatment</strong></h4><p>Dr. Terry collaborates with colleagues studying membrane-based PFAS treatment.</p><p>Her own work focuses on pretreatment through biological filtration.</p><p>The strategy involves:</p><ul><li>Removing natural organic matter</li><li>Reducing membrane fouling</li><li>Improving membrane performance</li><li>Extending operational efficiency</li></ul><p>This integrated approach demonstrates how multiple treatment technologies can work together to improve PFAS removal.</p><h4><strong>Regional Monitoring Projects</strong></h4><p>The University of Alabama team participates in EPA-supported monitoring efforts along the Gulf Coast.</p><p>Their observations indicate:</p><ul><li>PFAS rarely occur alone</li><li>Multiple PFAS compounds frequently co-occur</li><li>Contamination often originates from identifiable point sources</li></ul><p>Examples include:</p><ul><li>Industrial facilities</li><li>Manufacturing operations</li><li>Military installations</li><li>Carpet manufacturing facilities</li></ul><p>Source identification remains a critical component of environmental monitoring programs.</p><h4><strong>Future Directions for PFAS Monitoring</strong></h4><p>Looking ahead, Dr. Terry sees several opportunities for improvement.</p><p>Desired advances include:</p><ul><li>In situ monitoring technologies</li><li>Portable detection systems</li><li>Reduced analytical complexity</li><li>Lower instrument costs</li><li>Less expensive consumables</li><li>Faster analysis workflows</li></ul><p>Current PFAS testing requires substantial expertise, specialized instrumentation, and rigorous quality control, making widespread implementation challenging.</p><h4><strong>Dr. Terry's Perspective on Long-Term Solutions</strong></h4><p>When asked what major PFAS challenge she would most like to solve, Dr. Terry offered a broader perspective.</p><p>Rather than focusing solely on remediation, she emphasized prevention.</p><p>Her view is that society should:</p><ul><li>Better evaluate chemical toxicity before commercialization</li><li>Assess risks before large-scale deployment</li><li>Reduce introduction of harmful compounds into the environment</li><li>Support utilities tasked with contaminant removal</li></ul><p>She notes that water utilities often bear the responsibility of removing contaminants they did not create, highlighting the need for broader societal and regulatory support.</p><h4><strong>Final Thoughts</strong></h4><p>Dr. Terry encourages consumers to:</p><ul><li>Learn where their drinking water originates</li><li>Read annual water quality reports</li><li>Stay informed about local water quality</li><li>Consider appropriate home filtration where needed</li></ul><p>At the same time, she emphasizes confidence in municipal water systems and the importance of continued investment in water quality research, monitoring, and treatment technologies.</p><h4><strong>Conclusion</strong></h4><p>PFAS remain one of the most complex challenges in environmental chemistry and water treatment. Through advanced analytical methods such as LC-MS/MS, combustion ion chromatography, fluorine mass balance approaches, and large-scale monitoring programs, researchers like Dr. Leigh Terry are helping improve our understanding of these persistent contaminants.</p><p>The interview highlights that solving the PFAS challenge will require a combination of better analytical tools, improved treatment technologies, stronger regulatory frameworks, and a greater emphasis on prevention before contaminants enter the environment.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

PFAS in Water: Why We’re Missing 96% of the Problem

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Thermo Scientific Dionex IonPac AS9-SC IC Columns

Separate inorganic anions and oxyhalides in simple matrices using an isocratic carbonate/bicarbonate eluent with the Thermo Scientific™ Dionex™ IonPac™ AS9-SC Carbonate Eluent Anion-Exchange Column.

<p><strong>Separate inorganic anions and oxyhalides in simple matrices using an isocratic carbonate/bicarbonate eluent with the Thermo Scientific™ Dionex™ IonPac™ AS9-SC Carbonate Eluent Anion-Exchange Column. The Dionex IonPac AS9-SC column is specified in US EPA Method 300.0 (B), and meets or exceeds the performance requirements of this method. However, the advanced, high-capacity Dionex IonPac AS23 Carbonate Eluent Anion-Exchange column is recommended for determination of oxyhalides and inorganic anions, such as trace bromate, in ozonated drinking water.</strong></p><h5><strong>Fast Separation of Inorganic Anion and Oxyhalides in Simple Matrices</strong></h5><ul><li>Compliance monitoring of common anions and oxyhalides in drinking water as specified in U.S. EPA Methods 300.0 (B)</li><li>Simple, isocratic separation of inorganic anions in less than 10 minutes in drinking water</li><li>Fast isocratic separation of inorganic anions and oxyhalides in ozonated drinking water matrices</li><li>Solvent compatibility permits easy column cleanup after the analysis of samples with hydrophobic components.</li></ul><h5><strong>Formats Available for Application Flexibility</strong></h5><ul><li>4x250mm analytical columns</li><li>4x50mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Column Capacity: </strong>30 to 35 μeq</li><li><strong>Column Chemistry:</strong> Carbonate/Bicarbonate</li><li><strong>For Use With (Application):</strong> Separation of Oxyhalides and Inorganic Anions, Anion Exchange</li><li><strong>Ion Exchange Group: </strong>Alkyl Quaternary Ammonium</li><li><strong>Max. Pressure:</strong> 4000 psi (275 bar)</li><li><strong>Solvent Compatibility:</strong> pH 2 to 11, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> IonPac AS9-SC</li><li><strong>Packing Material:</strong> Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS23-4μm IC Columns

Analyze trace bromate and other oxyhalides in drinking water, ground water, wastewater, and other diverse matrices using the Thermo Scientific™ Dionex™ IonPac™ AS23-4μm columns. 

<p><strong>Analyze trace bromate and other oxyhalides in drinking water, ground water, wastewater, and other diverse matrices using the Thermo Scientific™ Dionex™ IonPac™ AS23-4μm columns. The high capacity and selectivity of this column facilitates the determination of trace bromate at low-μg/L levels in the presence of high amounts of chloride, sulfate, and carbonate. Compared to </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2058"><strong>Dionex IonPac AS23 column</strong></a><strong>, the new Dionex IonPac AS23-4μm columns use smaller resin particles for more efficient separations resulting in more accurate peak integration and more reliable results.</strong></p><h5><strong>Designed Specifically for Trace Bromate Analysis in Drinking Water</strong></h5><ul><li>Use the Dionex IonPac AS23-4μm for diverse matrices including drinking water, ground water, and waste water.</li><li>High capacity allows routine drinking water analysis without sample pretreatment or preconcentration.</li><li>Improved efficiencies and resolution compared to the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2058"><strong>Dionex IonPac AS23 column</strong></a>.</li><li>Easily transfer applications from the Dionex IonPac AS23 column to the AS23-4μm column due to the similar selectivity.</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, and facilitate effective column clean-up.</li></ul><h5><strong>Use With a High-Pressure IC System</strong></h5><p>Higher resolution is achieved through the use of smaller resin particles, which produce a column backpressure over 3000psi at the standard flow rates. A high-pressure IC system, such as the Thermo Scientific™ Dionex™ ICS-5000+ HPIC™ or the Thermo Scientific™ Dionex™ Integrion™ HPIC™ system is required to operate this column under standard conditions and take advantage of elevated flow rates and faster run times.</p><h5><strong>Multiple Formats Available</strong></h5><ul><li>4x250mm and 2x250mm analytical columns</li><li>4x50mm and 2x50mm guard columns</li></ul><p><strong>Note:</strong> <i>Use the Dionex AS23 Eluent Concentrate for simple, accurate eluent preparation.</i></p><h4><strong>Specifications</strong></h4><ul><li><strong>Anion Exchange Capacity:</strong> 320 μeq</li><li><strong>Crosslinking: </strong>55% DVB</li><li><strong>Column Capacity: </strong>320 μeq</li><li><strong>Column Chemistry:</strong> Carbonate/Bicarbonate</li><li><strong>For Use With (Application):</strong> Anion Exchange</li><li><strong>Ion Exchange Group: </strong>Alkanol Quaternary Ammonium Ion</li><li><strong>Max. Pressure:</strong> 5000 psi (345 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> IonPac AS23-4μm</li><li><strong>Format:</strong> Standard Bore</li><li><strong>Packing material:</strong> Polyvinylbenzyl Ammonium Polymer/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS22 Fast IC Columns

Thermo Scientific™ Dionex™ IonPac™ AS22-Fast column combines the selectivity of the Dionex IonPac AS22 column with super-fast separation times. 

<p><strong>Designed specifically for compliance monitoring of inorganic anions in accordance with U.S. EPA Methods 300.0 (A), the Thermo Scientific™ Dionex™ IonPac™ AS22-Fast column combines the selectivity of the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2057"><strong>Dionex IonPac AS22 column</strong></a><strong> with super-fast separation times. With the Dionex IonPac AS22-Fast column, you can quickly and simply separate common inorganic anions from a variety of sample matrices including drinking water, wastewater, process streams, and scrubber solutions.</strong></p><h5><strong>Super Fast Analysis of Inorganic Anions and Low Molecular Weight Organic Acids in Diverse Matrices</strong></h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Super-fast isocratic separation of common inorganic anions in less than 5 min in diverse matrices such as drinking water, surface water, groundwater, and wastewater</li><li>Sufficient capacity to maintain resolution even in a short column format, which helps laboratories achieve higher productivity and increased throughput</li><li>Excellent resolution of the carbonate peak away from the common inorganic anions</li><li>Faster alternative, using carbonate/bicarbonate eluents, for Dionex IonPac AS4A-SC, AS12A, AS14, AS14A and AS22 inorganic anion applications.</li><li>Solvent compatibility permits easy column cleanup after the analysis of samples with hydrophobic components.</li></ul><h5><strong>Multiple Formats Available for Application Flexibility</strong></h5><ul><li>4x150mm, 2x150mm analytical columns</li><li>4x30mm, 2x30mm guard columns</li><li>Shorter 150mm columns produce faster runs of relatively clean matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><p><strong>Note: </strong><i>For simple, accurate eluent preparation, use the Dionex IonPac AS22 Eluent Concentrate.</i></p><h4><strong>Specifications</strong></h4><ul><li><strong>Anion Exchange Capacity:</strong> 126 μeq</li><li><strong>Crosslinking: </strong>55% DVB</li><li><strong>Column Capacity:</strong> 126 μeq</li><li><strong>Column Chemistry:</strong> Carbonate/Bicarbonate</li><li><strong>For Use With (Application):</strong> Anion Exchange</li><li><strong>Ion Exchange Group: </strong>Alkanol Quaternary Ammonium Ion</li><li><strong>Max. Pressure:</strong> 3000 psi (207 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> IonPac AS22-Fast</li><li><strong>Format:</strong> Standard Bore</li><li><strong>Packing Material: </strong>Polymeric</li></ul>

Thermo Scientific Dionex IonPac AS22 Fast-4μm IC Columns

Attain the optimal combination of chromatographic speed and resolution using the Thermo Scientific™ Dionex™ IonPac™ AS22-Fast-4μm column.

<p><strong>Attain the optimal combination of chromatographic speed and resolution using the Thermo Scientific™ Dionex™ IonPac™ AS22-Fast-4μm column. Designed specifically for compliance monitoring of inorganic anions in accordance with U.S. EPA Method 300.0 (A), this moderate capacity column combines the selectivity of the Dionex IonPac AS22-Fast column with fast high resolution separations. Compared to the Dionex IonPac AS22-Fast column, the new Dionex IonPac AS22-Fast-4μm column uses smaller resin particles for more efficient separations resulting in faster run times, more accurate peak integration and more reliable results.</strong></p><h5><strong>Fast separation of common inorganic anions with excellent resolution</strong></h5><ul><li>Obtain the highest peak efficiency, through the use of smaller resin particles, of common inorganic anions in diverse sample matrices</li><li>Attain fast isocratic separation of the common inorganic anions in less than 5 min</li><li>Perform compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Achieve excellent separation of inorganic anions and low-molecular weight acids in diverse sample matrices</li><li>Obtain high peak efficiency and increased peak resolution for more consistent integration and more reliable results</li><li>Transfer application easily--this 4μm column has the the same selectivity as the Dionex IonPac AS22-Fast column</li><li>Achieve excellent resolution of the carbonate peak away from the common inorganic anions</li><li>Reduce run time without loss of resolution compared to the Dionex IonPac AS22-Fast column</li><li>Faster alternative, using carbonate/bicarbonate eluents, for Dionex IonPac AS4A-SC, AS12A, AS14, AS14A and AS22 inorganic anion applications</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5><strong>Use with a high-pressure IC system</strong></h5><p>Higher resolution is achieved through the use of smaller resin particles, which can produce a column backpressure over 3000 psi. When operating the Dionex IonPac AS22-Fast-4μm column, a high-pressure IC system, such as the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/410"><strong>Thermo Scientific™ Dionex™ ICS-6000 HPIC</strong></a> system is required.</p><h5><strong>Use the format that fits your lab</strong></h5><ul><li>4x150mm, 2x150mm analytical columns</li><li>4x30mm, 2x30mm guard columns</li><li>Shorter 150mm columns facilitate faster runs while the smaller particle size maintains a higher resolution separation</li></ul><p><strong>Note: </strong><i>For simple, accurate eluent preparation, use the Dionex IonPac AS22 Eluent Concentrate or the Dionex Eluent Generator (Dionex EGC 500 K2CO3 cartridge with Dionex EPM 500 pH modifier).</i></p><h4><strong>Specifications</strong></h4><ul><li><strong>Anion Exchange Capacity:</strong> 126 μeq</li><li><strong>Crosslinking: </strong>55% DVB</li><li><strong>Column Capacity:</strong> 126 μeq</li><li><strong>Column Chemistry:</strong> Carbonate/Bicarbonate</li><li><strong>For Use With (Application):</strong> Anion Exchange</li><li><strong>Ion Exchange Group: </strong>Alkanol Quaternary Ammonium Ion</li><li><strong>Max. Pressure:</strong> 5000 psi (345 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> Super Macroporous Resin</li><li><strong>Format:</strong> Standard Bore</li><li><strong>Packing Material: </strong>Polymeric</li></ul>

Thermo Scientific Dionex IonPac AS19-4μm IC Columns

Achieve high resolution separations of trace oxyhalides and inorganic anions in drinking water using the Thermo Scientific™ Dionex™ IonPac™ AS19-4μm hydroxide-selective anion-exchange column.

<p><strong>Achieve high resolution separations of trace oxyhalides and inorganic anions in drinking water using the Thermo Scientific™ Dionex™ IonPac™ AS19-4μm hydroxide-selective anion-exchange column. Its high resolution, high capacity and selectivity allow the determination of bromate in drinking water at the low-μg/L level. Compared to the previous </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2055"><strong>Dionex IonPac AS19 column</strong></a><strong>, this anion-exchange column uses smaller resin particles for more efficient separations resulting in more accurate peak integration and more reliable results.</strong></p><h5><strong>Easy Method Transfer</strong></h5><p>With similar selectivity and increased peak efficiencies, you can easily transfer applications from the Dionex IonPac AS19 column to the Dionex IonPac AS19-4μm column.</p><h5><strong>Significantly Reduce Eluent Usage</strong></h5><p>The Dionex IonPac AS19-4μm Capillary Column is packed with the same material as the equivalent standard bore version (providing the same performance as a 4mm column), but requires only 1/100th the eluent flow rate. The capillary format provides the advantage of significantly reduced eluent consumption, which helps reduce operating costs.</p><h5><strong>Dionex IonPac AS19-4μm Capillary Column Features</strong></h5><ul><li>Choose from three formats: 4×250mm, 2×250mm and 0.4×250mm</li><li>Recommended hydroxide-selective column for trace bromate in drinking water matrices</li><li>Meets or exceeds performance requirements of US EPA Method 300.0 and US EPA Method 300.1</li><li>High capacity: 240μeq per column (4×250mm)</li><li>Column selectivity is optimized for 30 °C operating temperature</li><li>Compatible with organic solvents</li></ul><p>These capillary columns require high pressure Thermo Scientific™ Dionex™ ICS-5000+ or Dionex ICS-4000 HPIC™ system to run at standard flow rates.</p><h4><strong>Specifications</strong></h4><ul><li><strong>Anion Exchange Capacity:</strong> 240 μeq</li><li><strong>Crosslinking: </strong>55% DVB</li><li><strong>Column Capacity: </strong>240 μeq</li><li><strong>Column Chemistry:</strong> Hydroxide</li><li><strong>For Use With (Application):</strong> Anion Exchange</li><li><strong>Ion Exchange Group: </strong>Alkanol Quaternary Ammonium Ion</li><li><strong>Max. Pressure:</strong> 5000 psi (345 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> IonPac AS19-4 μm</li><li><strong>Format:</strong> Standard Bore</li><li><strong>Packing Material: </strong>Polymeric</li></ul>

Thermo Scientific Dionex IonPac AS18-Fast IC Columns

Use these shorter 150mm Thermo Scientific™ Dionex™ IonPac™ AS18-Fast columns for fast runs when monitoring inorganic anions in drinking water and wastewater samples

<p><strong>Use these shorter 150mm Thermo Scientific™ Dionex™ IonPac™ AS18-Fast columns for fast runs when monitoring inorganic anions in drinking water and wastewater samples for compliance with U.S. EPA Methods 300.0 (A) and 300.1. Dionex IonPac AS18 columns are high capacity hydroxide-selective anion-exchange columns. Having the same selectivity as the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2054"><strong>Dionex IonPac AS18 column</strong></a><strong>, the shorter format significantly reduces run times of common inorganic anions and low molecular weight organic acids in diverse sample matrices including drinking water, wastewater, leachates, foods, beverages, and pharmaceutical preparations.</strong></p><h5><strong>Analysis of Common Inorganic Anions and Low-Molecular Weight Organic Acids in Diverse Matrices</strong></h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Determination of low levels of inorganic anions in complex matrices using large-loop injections</li><li>Superior retention and quantification of fluoride, acetate, and formate</li><li>Fast separation of the common inorganic anions in 5 min in simple matrices using 150mm column</li><li>High efficiency, fast analysis use the 150mm column for increased sample throughput</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5><strong>Recommended for Inorganic Anions in Diverse Sample Matrices</strong></h5><ul><li>Source water and drinking water, municipal and industrial wastewater</li><li>Industrial cooling water and waste water, acid rain</li><li>Foods and beverages, anionic counterions in pharmaceutical preparations</li></ul><h5><strong>Multiple Formats for Application Flexibility</strong></h5><p>The shorter 150mm Dionex IonPac AS18-Fast columns produce faster runs of relatively clean matrices compared to the longer 250mm columns and are available in three formats with guard columns:</p><ul><li>4x150mm standard bore AS18-Fast columns with 4x30mm guard columns</li><li>2x150mm microbore AS18-Fast columns with 2x30mm guard columns</li><li>0.4x150mm capillary AS18-Fast columns with 0.4x35mm guard columns</li></ul><h5><strong>Capillary Columns Reduce Operating Costs from Lower Eluent Requirements</strong></h5><p>Capillary columns provide significantly reduced operating and waste disposal costs through eluent conservation. Packed with the same material, the Dionex IonPac AS18-Fast capillary columns provide the same performance as the standard bore and microbore counterparts. Operating costs are reduced because the capillary system operates at only 1% of the eluent flow rate of the standard bore system. Capillary columns are used with the Thermo Scientific™ Dionex™ ICS-4000 and ICS-5000+ Capillary systems.</p><h5><strong>Need Higher Resolution or Faster Separations?</strong></h5><p>If you need higher resolution separations of more complex sample matrices, refer to the longer 250mm Dionex™ IonPac™ AS18 Hydroxide-Selective Anion-Exchange column<br>For fastest, highest resolution separations of relatively cleaner sample matrices, refer to the small particle Dionex™ IonPac™ AS18-4µm Hydroxide-Selective Anion-Exchange column. Use of 4µm columns requires a high-pressure IC system.</p><h4><strong>Specifications</strong></h4><ul><li><strong>Anion Exchange Capacity:</strong> 171 μeq</li><li><strong>Crosslinking: </strong>55% DVB</li><li><strong>Column Capacity:</strong> 171 μeq</li><li><strong>Column Chemistry:</strong> Hydroxide</li><li><strong>For Use With (Application):</strong> Anion Exchange</li><li><strong>Ion Exchange Group: </strong>Alkanol Quaternary Ammonium Ion</li><li><strong>Max. Pressure:</strong> 4000 psi (275 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> IonPac AS18-Fast</li><li><strong>Format:</strong> Standard Bore</li><li><strong>Packing Material: </strong>Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS18-Fast-4μm IC Columns

Attain the optimal combination of chromatographic speed and resolution using the new Thermo Scientific™ Dionex™ IonPac™ AS18-Fast-4μm anion-exchange column.

<p><strong>Attain the optimal combination of chromatographic speed and resolution using the new Thermo Scientific™ Dionex™ IonPac™ AS18-Fast-4μm anion-exchange column. This high-capacity, high-efficiency column provides excellent resolution of inorganic anions in diverse sample matrices. This is the hydroxide-selective column of choice for fastest compliance monitoring of inorganic anions in drinking water and wastewater samples in accordance with U.S. EPA Methods 300.0 (A) and 300.1. Compared to the Thermo Scientific™ Dionex™ IonPac™ AS18-Fast column, the new Dionex IonPac AS18-Fast-4μm anion-exchange column uses smaller resin particles for more efficient peaks resulting in faster run times, more accurate peak integration, and more reliable results.</strong></p><h5><strong>Fastest Separation of Common Inorganic Anions with Excellent Resolution</strong></h5><p>Through the use of smaller resin particles and a shorter column format, this column offers the highest peak efficiency and best resolution of common inorganic anions for fast analysis of environmental waters.</p><h5><strong>Analysis of Common Inorganic Anions and Low Molecular Weight Organic Acids in Diverse Matrices</strong></h5><ul><li>Attain super fast isocratic separation of the common inorganic anions in less than 3 min</li><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>High peak efficiency and increased peak resolution for more consistent integration and more reliable results</li><li>Offers the same selectivity as the Dionex IonPac AS18-Fast column so applications are easily transferred to the 4μm column</li><li>Reduces run time without loss of resolution compared to the Dionex IonPac AS18-Fast column</li><li>Achieve excellent separation of inorganic anions and low-molecular weight acids in diverse sample matrices</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5><strong>Use 4μm Columns with High-Pressure IC Systems</strong></h5><p>Higher resolution is achieved through the use of smaller resin particles, which can produce a column backpressure over 3000 psi. When operating the Dionex IonPac AS18-Fast-4μm capillary column at the standard flow rate of 10μL/min, an IC system capable of operating up to 3000 psi is sufficient. However, to take advantage of the fast runs, using elevated flow rates, a high-pressure capillary IC system, such as the Thermo Scientific™ Dionex™ ICS-5000+ HPIC or the Thermo Scientific™ Dionex™ ICS-4000 HPIC is required. The Dionex ICS-5000+ HPIC system is required for standard operation of the Dionex IonPac AS18-Fast-4μm microbore and standard bore columns.</p><h5><strong>Use the Format That Fits Your Lab</strong></h5><p>Shorter 150mm AS18-Fast-4μm columns facilitate faster runs while the smaller particle size maintains a higher resolution separation and are available in 3 formats with guard columns:</p><ul><li>Use the 4x150mm standard bore column with the 4x30mm guard column</li><li>Use the 2x150mm analytical columns with the 2x30mm guard column</li><li>Use the 0.4x150mm capillary column with the 0.4x35mm guard column</li></ul><h5><strong>Capillary Columns Reduce Operating Costs from Lower Eluent Requirements</strong></h5><p>Capillary columns provide significantly reduced operating and waste disposal costs through eluent conservation. Packed with the same material, the Dionex IonPac AS18-Fast-4μm capillary columns provide the same performance as the standard bore and microbore counterparts. Operating costs are reduced because the capillary system operates at only 1% of the eluent flow rate of the standard bore system. Capillary columns are used with the Thermo Scientific™ Dionex™ ICS-4000 and ICS-5000+ Capillary systems.</p><h5><strong>Need Higher Resolution or Faster Separations?</strong></h5><ul><li>If you need higher resolution separations of more complex sample matrices, refer to the longer 250mm Dionex™ IonPac™ AS18 Hydroxide-Selective Anion-Exchange column</li><li>The shorter 150mm Dionex IonPac AS18-Fast columns produce faster runs of relatively clean matrices compared to the longer 250mm columns and operate under 3000 psi.</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Crosslinking: </strong>55% DVB</li><li><strong>Column Capacity:</strong> 174 μeq</li><li><strong>For Use With (Application):</strong> Anion Exchange</li><li><strong>Max. Pressure:</strong> 5000 psi (345 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> Super Macroporous Resin</li><li><strong>Format:</strong> Standard Bore</li></ul>

Thermo Scientific Dionex IonPac CS10 IC Columns

Choose Thermo Scientific Dionex IonPac CS10 Cation-Exchange Columns for isocratic separation of inorganic cations using hydrochloric acid (HCl) with diaminopropionic (DAP) acid eluents. 

<p><strong>Choose Thermo Scientific™ Dionex™ IonPac™ CS10 Cation-Exchange Columns for isocratic separation of inorganic cations using hydrochloric acid (HCl) with diaminopropionic (DAP) acid eluents. Well suited to determine common inorganic cations and aliphatic and aromatic amines in diverse sample matrices, including environmental waters, power plant waters treated with ammonium, morpholine, or ethanolamine; chemical additives; chemical process solutions; scrubber solutions; plating baths; and industrial solvents.</strong></p><h5><strong>Recommended Cation-Exchange Columns by Use</strong></h5><p>Since the introduction of the Dionex IonPac CS10 column, Dionex has introduced several new cation-exchange columns with advanced features. These modern columns and their recommended uses are listed below.</p><ul><li>The <strong>Dionex IonPac CS11</strong> column has selectivity similar to the Dionex IonPac CS10 column, with improved sensitivity and lower eluent consumption due to its smaller 2 mm i.d. format.</li><li>The <strong>Dionex IonPac CS12A </strong>column improves performance for fast analysis of inorganic cations and ammonium in diverse matrices.</li><li>The <strong>Dionex IonPac CS17 </strong>column is recommended for hydrophobic and polyvalent amines.</li><li>The <strong>Dionex IonPac CS19</strong> and <strong>CS19-4μm</strong> columns are recommended for polar amines including alkanolamines and methylamines and also moderately hydrophobic amines and polyvalent amines.</li><li>Compatible with organic solvents, to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5><strong>Formats Available for Application Flexibility</strong></h5><ul><li>4x250mm analytical column</li><li>4x50mm guard column</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Column Capacity:</strong> 80 μeq</li><li><strong>For Use With (Application):</strong> Cation Exchange</li><li><strong>Max. Pressure:</strong> 4000 psi (275 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> IonPac CS10</li><li><strong>Format:</strong> Standard Bore</li><li><strong>Packing Material: </strong>Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS11 IC Columns

Choose Thermo Scientific Dionex IonPac CS11 low-capacity, sulfonate-functionalized, cation-exchange column for isocratic separation of inorganic cations using HCl with DAP eluents.

<p><strong>Choose Thermo Scientific™ Dionex™ IonPac™CS11 Analytical and Guard Columns for isocratic separation of inorganic cations using hydrochloric acid (HCl) with diaminopropionic (DAP) acid eluents. This column has selectivity similar to the IonPac CS10 column, with improved sensitivity and lower eluent consumption due to its smaller 2mm I.D. format.</strong></p><p>The Dionex IonPac CS11column can be used to determine common inorganic cations and aliphatic and aromatic amines in diverse sample matrices, however, advances in cation-exchange column technology have produced better column choices for these separations.</p><h5><strong>Recommended Cation-Exchange Columns by Use</strong></h5><p>Since the introduction of the Dionex IonPac CS11 column, Dionex has introduced several new cation-exchange columns with advanced features. For example, most modern Dionex IonPac Cation Exchange columns use simple methanesulfonic acid eluents rather than DAP-HCl eluents. These columns and their recommended uses are listed below.</p><ul><li>The <strong>Dionex IonPac CS12A </strong>column improves performance for fast analysis of inorganic cations and ammonium in diverse matrices.</li><li>The <strong>Dionex IonPac CS17 </strong>column is recommended for hydrophobic and polyvalent amines.</li><li>The <strong>Dionex IonPac CS19</strong> and <strong>CS19-4μm</strong> columns are recommended for polar amines including alkanolamines and methylamines and also moderately hydrophobic amines and polyvalent amines.</li><li>Compatible with organic solvents, to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5><strong>Formats Available for Application Flexibility</strong></h5><ul><li>2x250mm analytical column</li><li>2x50mm guard column</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Crosslinking: </strong>5% DVB</li><li><strong>Column Capacity:</strong> 35 μeq</li><li><strong>For Use With (Application):</strong> Cation Exchange</li><li><strong>Max. Pressure:</strong> 4000 psi (275 bar)</li><li><strong>Solvent Compatibility:</strong> pH 0 to 14, 0 to 100% HPLC Solvents</li><li><strong>Stationary phase:</strong> IonPac CS11</li><li><strong>Format:</strong> Microbore</li><li><strong>Packing Material: </strong>Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS12 IC Columns

Obtain robust, reliable results and fast isocratic separation of common inorganic cations and alkanolamines using the Thermo Scientific Dionex IonPac CS12 Cation-Exchange Column.

<p><strong>Obtain robust, reliable results and fast isocratic separation of common inorganic cations and alkanolamines using the Thermo Scientific™ Dionex™ IonPac™ CS12 Cation-Exchange Column. This is a high-capacity, cation-exchange column designed for the fast, isocratic separation of lithium, sodium, ammonium, potassium, magnesium, and calcium using methanesulfonic or sulfuric acid eluents in diverse sample matrices. However, the newer Thermo Scientific™ Dionex™ IonPac™ CS12A column provides improved performance and is the recommended column for inorganic cation analysis.</strong></p><h5><strong>Fast Isocratic Separation of Common Inorganic Cations</strong></h5><p>The Dionex IonPac CS12 Cation-Exchange Column provides fast, isocratic separation of cations in diverse sample matrices, including drinking water, power plant waters, soil extracts, acid digests, chemical additives, chemical process solutions, scrubber solutions, and plating baths. However, the Dionex IonPac CS12A column improves performance for fast analysis of inorganic cations and ammonium in diverse matrices and is the recommend column for these applications. The columns are compatible with organic solvents, excluding alcohols, to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</p><h5><strong>Multiple Formats Available for Application Flexibility</strong></h5><ul><li>4x250mm, 2x250mm analytical columns</li><li>4x50mm, 2x50mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Crosslinking: </strong>55% DVB</li><li><strong>Column Capacity:</strong> 2.8 meq</li><li><strong>For Use With (Application):</strong> Cation Exchange</li><li><strong>Max. Pressure:</strong> 4000 psi (275 bar)</li><li><strong>Solvent Compatibility:</strong> Acidic Eluents, 0 to 100% HPLC Solvent Compatible, Alcohols Should be Avoided</li><li><strong>Stationary phase:</strong> Macroporous Resin</li><li><strong>Format:</strong> Standard Bore</li><li><strong>Packing Material: </strong>Ethylvinylbenzene/Divinylbenzene</li></ul>

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