Meeting EU Drinking Water Standards: The Critical Role of Sample Prep in Trace Contaminant Analysis

<h3><strong>Charged for Action: The Hidden Secrets of AEX Oligonucleotide Analysis</strong></h3><p><strong>Oligonucleotides—short, well-defined fragments of DNA or RNA—have become indispensable tools in modern life sciences. They underpin cutting-edge applications in molecular diagnostics, gene therapy, and pharmaceutical development. Before oligonucleotides can be confidently used in research or clinical settings, however, their quality must be rigorously assessed. Purity, sequence integrity, length distribution, and chemical modifications all play a decisive role in their performance.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg" alt="KNAUER: Oligos Made Easy - Part 2: AEX" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_2_45eee54fa0.jpg 245w," sizes="100vw" width="1534" height="711"></p><p>Among the analytical techniques available today, <strong>anion exchange chromatography (AEX)</strong> stands out as a robust and highly informative method for characterizing oligonucleotides. By exploiting their intrinsic negative charge, AEX provides detailed insight into product composition and impurity profiles that are difficult to obtain by other approaches.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6808"><strong>Part 1 of the Oligos series: A Practical Guide to Oligonucleotide Production – From Concept to Final Product</strong></a></p></blockquote><h4><strong>How Scientists Read Oligonucleotides Using Charge</strong></h4><p>At the core of AEX lies a simple but powerful principle: oligonucleotides carry a negatively charged phosphate backbone. This charge increases in a predictable way with strand length and, to a lesser extent, sequence composition. Anion exchange chromatography uses this property to separate oligonucleotides based on differences in charge strength and interaction with a positively charged stationary phase.</p><p>As a result, AEX has become one of the most widely used analytical tools for evaluating oligonucleotide quality. It allows scientists to distinguish full-length products from truncated species, degradation products, or closely related variants—often with single-nucleotide resolution.</p><h4><strong>Why Ion Exchange Works: Binding, Retention, and Release</strong></h4><p>Ion exchange chromatography (IEX) relies on electrostatic interactions between analytes and a charged stationary phase. In the case of oligonucleotides, <strong>anion exchange</strong> is used, where negatively charged molecules interact with positively charged functional groups on the resin—most commonly quaternary amines.</p><p>The system consists of two main components:</p><ul><li><strong>Stationary phase:</strong> A positively charged resin that binds anionic analytes.</li><li><strong>Mobile phase:</strong> An aqueous buffer system, typically combined with a salt gradient, that controls both pH and elution strength.</li></ul><p>Retention in AEX is governed primarily by charge. Molecules with weaker overall charge interact less strongly with the stationary phase and elute earlier, while more highly charged oligonucleotides bind more tightly and require stronger elution conditions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 1 IEX overview including elution order dependency on analyte charge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_1_IEX_overview_including_elution_order_dependency_on_analyte_charge_3419ad3075.jpg 245w," sizes="100vw" width="1583" height="654"></p><h4><strong>The Five-Step Workflow of Ion Exchange Chromatography</strong></h4><p>AEX separations generally follow a well-established sequence of steps:</p><ol><li><strong>Column equilibration</strong><br>The column is conditioned with the starting buffer until the baseline and pH are stable. This ensures that all charged sites on the resin are ready for interaction.</li><li><strong>Sample loading</strong><br>Samples, prepared in the starting buffer, are introduced under conditions that promote binding of the target oligonucleotides while minimizing retention of unwanted impurities.</li><li><strong>Washing</strong><br>The column is washed with the starting buffer to remove uncharged or weakly interacting components. The baseline stabilizes as these species are flushed away.</li><li><strong>Elution</strong><br>Bound oligonucleotides are released using a salt or pH gradient. Increasing ionic strength introduces competing ions that displace the analytes from the resin. Weakly bound species elute first; strongly charged oligonucleotides elute later.</li><li><strong>Regeneration and re-equilibration</strong><br>A high-salt buffer removes any remaining bound material. The column is then returned to starting conditions in preparation for the next analysis.</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 2  Five steps of IEX procedure (in blue), outlined using an example chromatogram (in red)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_2_Five_steps_of_IEX_procedure_in_blue_outlined_using_an_example_chromatogram_in_red_38dd70b1b1.jpg 245w," sizes="100vw" width="1583" height="674"></p><h4><strong>Why AEX Is Especially Effective for Oligonucleotides</strong></h4><p>The repeating phosphate backbone of oligonucleotides gives rise to a strong and uniform anionic character across a wide pH range (typically pH 7–9). This makes oligonucleotides exceptionally well suited for anion exchange separations.</p><p>Key factors influencing AEX behavior include:</p><ul><li><strong>Charge density:</strong> Longer oligonucleotides carry more negative charges and therefore exhibit stronger retention.</li><li><strong>Resin chemistry:</strong> Strong and weak anion exchangers differ in functional groups and pH stability, influencing selectivity and robustness.</li><li><strong>Buffer composition:</strong> The choice of buffering ions and salt gradients directly affects elution strength and resolution.</li></ul><p>Salt gradients—commonly based on chloride ions—compete with the oligonucleotide backbone for binding sites on the resin. By carefully tuning gradient slope and composition, analysts can achieve highly reproducible and finely resolved separations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 3 Ionic interactions and pH influence on Anion Exchange Chromatography (AEX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_3_Ionic_interactions_and_p_H_influence_on_Anion_Exchange_Chromatography_AEX_612e231ba4.jpg 245w," sizes="100vw" width="1547" height="593"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 4 AEX buffer selection and gradient strategy (chromatogram with red buffer gradient curve)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_4_AEX_buffer_selection_and_gradient_strategy_chromatogram_with_red_buffer_gradient_curve_53fd1bb11b.jpg 245w," sizes="100vw" width="1600" height="327"></p><h4><strong>AEX as the Gold Standard for Oligonucleotide Separation</strong></h4><p>Anion exchange chromatography has become the method of choice for both analytical and preparative oligonucleotide workflows. Its advantages include:</p><ul><li><strong>High resolving power:</strong> Closely related impurities, including n–1 or n–2 species, can often be separated and quantified.</li><li><strong>Predictable retention behavior:</strong> In many cases, retention time correlates linearly with oligonucleotide length, simplifying identification.</li><li><strong>Compatibility with modified oligonucleotides:</strong> Even chemically modified sequences retain their anionic nature, allowing AEX to resolve both products and related impurities.</li><li><strong>Excellent control via gradient elution:</strong> Salt gradients provide precise tuning of selectivity and resolution.</li></ul><p>Typically, shorter or degraded oligonucleotides elute at lower ionic strength, while full-length products with higher charge density appear later in the chromatogram.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg" alt="KNAUER: Oligos Made Easy - Part 2 AEX: Figure 5 AEX Advantages and Challenges." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Oligos_Made_Easy_Part_2_AEX_Figure_5_AEX_Advantages_and_Challenges_7835521e34.jpg 245w," sizes="100vw" width="1535" height="707"></p><h4><strong>Final Perspective: Mastering AEX with Confidence</strong></h4><p>Anion exchange chromatography may appear complex at first, but with thoughtful optimization of pH, buffer composition, and gradient conditions, it becomes a highly precise and reliable tool for oligonucleotide analysis. When properly applied, AEX delivers sharp peaks, excellent resolution, and robust performance—even for challenging sequences and modifications.</p><p>For laboratories developing or refining oligonucleotide workflows, AEX offers both analytical depth and operational confidence.</p><blockquote><p>If you would like to discuss AEX method development or optimization for oligonucleotides, feel free to contact us at <strong>sales@knauer.net</strong>. More insights into practical oligonucleotide analysis will follow in our <i>“Oligos Made Easy”</i> series.</p><p>For technical questions or in-depth discussion, the author can be reached at <strong>kindler@knauer.net</strong></p></blockquote>

Oligos Made Easy - Part 2: AEX

<p><strong>Although modern agriculture needs to be based on accurate real-time data on soil, plant, and environmental conditions, affordable, sufficiently sensitive, and robust monitoring devices for this purpose are currently missing. According to scientists, low-cost sensors based on new smart materials and printing technologies offer a suitable solution. The results of multidisciplinary research thus far and proposals for the development of these devices have been presented by researchers from Czechia, Great Britain, Spain, and the USA in a review article in the prestigious journal </strong><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1"><i><strong>Nature Communications</strong></i></a><strong>.</strong></p><p>“<i>Sensor technologies for monitoring plant health are still in their infancy. Only simple sensors capable of monitoring basic parameters such as pH, soil moisture, or temperature are commonly available on the market. However, if farmers are to face current challenges, including climate change, and ensure sufficient food for humanity, they need much more effective tools that will enable them to monitor, for example, various pathogens, including bacteria and fungi. In our opinion, a suitable solution is a combination of new smart materials and printing for the production of inexpensive, durable, and scalable materials</i>,” said the article’s first author, <strong>David Panáček</strong> from CATRIN, who worked on the study during his internship at Imperial College London.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152"></p><p>Sensors for monitoring plant health, for example, lag behind similar devices used in human medicine. According to the authors, advances in materials science, which will enable the development of scalable sensor technologies, play a key role in this potential shift. “<i>Printing techniques, including inkjet printing, screen printing, aerosol printing, 3D printing, and direct laser writing, offer flexible ways to produce flexible sensors, large-area sensors, and sensors integrated directly into plants. The review article summarizes recent advances in printable low-dimensional materials for agricultural sensors, analyzes their physico-chemical properties in relation to sensor performance, and discusses key challenges and future opportunities requiring interdisciplinary integration</i>,” said one of the corresponding authors, <strong>Michal Otyepka</strong>.</p><p>The research brought together materials scientists, chemists, biologists, sensing experts, and printing technology specialists. Materials research and the use of graphene-based smart materials were led by scientists from CATRIN at Palacký University and VŠB-Technical University of Ostrava. Plant biologists from CATRIN contributed their knowledge of plant development, their responses to stress conditions, and the monitoring of their properties. Researchers from Imperial College London took care of the electronics, while representatives from<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/36"><strong> CEITEC – VUT</strong></a> focused on printing technologies. The team also included leading experts in sensing from the Catalan Institute of Nanoscience and Nanotechnology in Barcelona, and Joseph Wang of the University of California San Diego, the “father of sensing and electrochemistry,” also contributed his extensive knowledge.</p><p>“<i>This is a groundbreaking study on this topic, which has managed to attract some truly big names in their respective fields. Last but not least, the study demonstrates that interdisciplinarity at CATRIN gives rise to completely new and promising research topics, such as plant sensing and its use for studying plant-environment interactions and smart agriculture,</i>” added another corresponding author, <strong>Nuria De Diego</strong>.</p>

Current sensors are not good enough. Scientists propose a new way to monitor plant health

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The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Thermo Scientific Transcend Multichannel UHPLC Systems

Thermo Scientific Transcend Multichannel UHPLC Systems are advanced LC-MS systems with a multichannel UHPLC architecture that increase analytical productivity and maximize mass spectrometer utilization without compromising data quality.

<p><strong>Thermo Scientific™ Transcend™ Multichannel UHPLC Systems are advanced LC-MS platforms designed for laboratories that demand higher throughput, improved efficiency, and stronger return on investment. Their multichannel UHPLC architecture connects up to four fully independent LC channels to a single mass spectrometer, dramatically increasing system utilization without compromising data quality.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_8_5f824e5e08.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: The Transcend LX systems feature either 2 or 4 (shown) completely independent LC channels." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_8_5f824e5e08.jpg 245w," sizes="100vw" width="955" height="404"></p><h3><strong>Key benefits</strong></h3><ul><li>Significantly increased LC-MS throughput</li><li>Maximized mass spectrometer utilization</li><li>Maintained sensitivity, selectivity, and robustness</li><li>Reduced operating costs and analysis time</li><li>Scalable configurations tailored to laboratory needs</li></ul><h3><strong>Multichannel UHPLC architecture</strong></h3><p>Conventional single-channel LC-MS systems process samples sequentially, leaving the mass spectrometer idle during injection, column washing, and equilibration.<br>Transcend systems overcome this limitation by <strong>intelligently interleaving injections from multiple LC channels</strong>, delivering data to the mass spectrometer only during relevant retention time windows and enabling substantial productivity gains.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_5_ab4093366d.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Injections are interleaved to maximize throughput and mass spectrometer use." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_5_ab4093366d.jpg 169w," sizes="100vw" width="831" height="764"></p><h3><strong>Vanquish UHPLC platform</strong></h3><p><strong>Thermo Scientific™ Transcend™ Multichannel UHPLC Systems</strong> are built on proven <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=40&amp;manufacturerItems=3&amp;search=vanquish"><strong>Thermo Scientific Vanquish UHPLC</strong></a> technology. The Transcend multichannel architecture integrates up to four independent Vanquish-based UHPLC channels into a single LC-MS platform.</p><p><strong>The Vanquish UHPLC platform provides:</strong></p><ul><li>high mechanical and operational robustness</li><li>reproducible long-term performance</li><li>precise gradient formation and stable flow control suitable for multichannel operation</li><li>flexible pump configurations (binary or quaternary) tailored to application requirements</li></ul><p>By combining the Transcend multichannel concept with Vanquish UHPLC technology, laboratories can achieve high throughput without compromising chromatographic performance, sensitivity, or system reliability.</p><h3><strong>System configurations</strong></h3><ul><li><strong>Transcend LX and VLX</strong><br>Designed for high-throughput LC-MS workflows without on-line sample cleanup<ul><li>2- and 4-channel configurations</li><li>Fully independent LC channels</li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_1567f69a93.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend LX UHPLC Systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_1567f69a93.jpg 245w," sizes="100vw" width="968" height="500"></p><ul><li><strong>Transcend TLX</strong><br>Designed for workflows requiring automated on-line sample cleanup<ul><li>1-, 2-, and 4-channel configurations</li><li>Integrated TurboFlow™ technology</li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_2_8ac2e32016.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend TLX UHPLC Systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_2_8ac2e32016.jpg 245w," sizes="100vw" width="1674" height="523"></p><p>Each LC channel operates independently, allowing identical methods to run in parallel or multiple methods to be combined within a single system.</p><h3><strong>On-line sample cleanup with TurboFlow™ technology (TLX)</strong></h3><p><strong>TurboFlow™ technology</strong> enables rapid on-line removal of matrix interferences directly within the LC-MS system, resulting in:</p><ul><li><strong>Reduced or eliminated </strong>manual sample preparation</li><li><strong>Direct injection</strong> of complex biological and environmental samples</li><li><strong>Improved sensitivity and reproducibility</strong></li><li><strong>Increased method robustness and simplified workflows</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_3_efccaa3928.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: On-line sample cleanup with TurboFlow™ technology (TLX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_3_efccaa3928.jpg 245w," sizes="100vw" width="1105" height="556"></p><h3><strong>System control and software</strong></h3><p>All system functions are managed by <strong>Thermo Scientific™ Aria™ MX software</strong>, providing:</p><ul><li>Control of pumps, valves, gradients, and injection scheduling</li><li>Intuitive multichannel method setup</li><li>Parallel execution of up to four methods</li><li>A user-friendly graphical interface for complex LC-MS workflows</li></ul><p>Aria MX software is fully compatible with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Thermo Scientific™ Xcalibur™</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>Thermo Scientific™ TraceFinder™</strong></a> software.</p><h3><strong>Mass spectrometer compatibility</strong></h3><p>Transcend systems are designed as a flexible LC-MS platform compatible with a broad range of <strong>Thermo Fisher Scientific</strong> mass spectrometers, including:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=tsq"><strong>TSQ triple quadrupole systems</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3&amp;search=orbitrap"><strong>High-resolution Orbitrap instruments</strong></a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_4_fc2c09672b.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend TLX-2 system with a TSQ Altis Plus triple quadrupole mass spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_4_fc2c09672b.jpg 245w," sizes="100vw" width="1178" height="646"></p><h3><strong>Typical application areas</strong></h3><ul><li>Clinical research and bioanalysis</li><li>Pharmaceutical development and quality control</li><li>Toxicology</li><li>Environmental analysis</li><li>High-throughput screening workflows</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_6_db70763211.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Retention time (A) and peak area (B) reproducibility of a high-throughput targeted proteomics assay for quantifying SARS-CoV-2 peptides in clinical research samples across five days. The Transcend TLX-4 UHPLC system was used for on-line sample clean-up and analysis of 500 respiratory tract swab samples per day. (Cardozo, K.H.M., Lebkuchen, A., Okai, G.G. et al. Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts. Nat Commun 11, 6201 (2020))" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_6_db70763211.jpg 245w," sizes="100vw" width="1489" height="862"></p>

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Workflows based on intelligent data acquisition methods leverage new levels of instrument performance to deliver high confidence, and high throughput.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp" alt="Thermo Fisher Scientific: Ion path and key components of the Orbitrap Exploris 480 mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp 245w," sizes="100vw" width="950" height="410"></p><div><h4><strong>How does the Orbitrap Exploris 480 MS enable greater data insights faster?</strong></h4></div><div><p>See what makes the Orbitrap Exploris 480 MS stand out, how it can empower all users to obtain the highest quality results and deepest insights with the least amount of effort; see how our breakthrough is now your breakthrough.</p></div><ul><li><strong>Next-Generation Instrument Design</strong></li><li><strong>Targeted Protein Quantitation Workflows with SureQuant IS</strong></li><li><strong>Advancing Accuracy, and Precision in Quantitative Proteomics through Multiplexing</strong></li><li><strong>Sub 1-ppm Mass Accuracy as Standard</strong></li><li><strong>Improved Performance through Instrument Enhancements</strong></li><li><strong>Intelligence-Driven Instrument Set-Up, Control and Data Acquisition</strong></li><li><strong>Visualize the Orbitrap Exploris Data Acquisition Modes</strong></li></ul><h4><strong>Optional features to maximize performance</strong></h4><p>Maximize performance and flexibility to expand experimental capabilities of the Orbitrap Exploris 480 mass spectrometer with multiple hardware and software options, allowing you to see more, quantify more, deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Enhance your Experimental Performance with the FAIMS Pro Duo interface</strong></li><li><strong>Comprehensive and confident biotherapeutic characterization</strong></li></ul><div data-uw-styling-context="true"><h4><strong>Data analysis made easy</strong></h4></div><div data-uw-styling-context="true"><p data-uw-styling-context="true">From complex proteomic challenges, quantitation with SureQuant and TMT multiplexing, through to complete biotherapeutic characterization, data analysis doesn’t have to be the bottleneck to accessing deeper insights into your high-quality MS data. 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Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer

Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.

<div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</strong></p><p>Deliver on your objectives with performance to drive discovery and identification, plus receive the quantitative precision and accuracy you need to confidently scale up and achieve impact. With operational simplicity through intelligent data acquisition and processing, discover your fast track to confident results regardless of sample complexity, the depth of insights required or the presence of unknown compounds.</p><h4><strong>Application capabilities through instrument versatility</strong></h4><p>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Confident and comprehensive proteomic analyses</strong></li><li><strong>Translational proteomics: Scaling translational discoveries into reliable clinical applications</strong></li><li><strong>Comprehensive biotherapeutic characterization: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Intact native mass analysis: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Metabolomics workflows: One solution for all metabolics workflows&nbsp;</strong></li><li><strong>Clinical research: Translate qualitative and quantitative assays into future clinical applications</strong></li><li><strong>Food/beverage and environmental analyses: Fast-track to results with confidence&nbsp;</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg" alt="Thermo Fisher Scientific: a) Quantitative experimental design for the analysis of a control and three knockout (KO) strains. b) The orthogonality of the FAIMS Pro interface shows improved peptide coverage when using a range of different CVs. c) Intensity ranking across five orders of quantitative dynamic range for the peptide spectrum matches provided by Proteome Discoverer software. d) Quantitative ratios for each of the samples, highlighting the relative abundance of the KO proteins." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg 245w," sizes="100vw" width="1000" height="543"></p><div><h4><strong>Key benefits of the Orbitrap Exploris 240 mass spectrometer</strong></h4></div><div><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, with sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p></div><h5><strong>Everyday experimental flexibility</strong></h5><p>Discover workhorse versatility from confident proteomic and small-molecule identification and quantitation to biopharmaceutical characterization and in-depth sample-profiling.</p><h5><strong>Faster path to confident insights</strong></h5><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, such as sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p><h5><strong>Reliable, robust, and maintainable</strong></h5><p>Meet an exceptional system every day, one with versatility and operational simplicity, but that doesn’t compromise robustness and reliability so you can be confident in its ability to perform on long-term studies.</p><h5><strong>Focus on driving results with faster setup</strong></h5><p>Fully integrated instrument control, setup, and data processing, helps you focus on delivering actionable results while single-system calibrations and pre-defined method templates drive productivity.</p><blockquote><h5><strong>Top reasons to choose Orbitrap Exploris 240 MS over Q-TOF instrumentation</strong></h5><p>Others claim to set new standards in proteomics. Is Protein ID without quantitation sufficient for shotgun proteomics to provide biological insights? Meet the Orbitrap Exploris 240 mass spectrometer – with leading quantitative performance, sensitivity and versatility, designed to meet your needs.</p><p>Trust us to deliver technology innovations that are foundations of reliable workflows and solutions, along with publishable and actionable results.</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/products-and-services/promotions/industrial/10-reasons-choose-orbitrap-exploris-over-qtof.html"><span><strong>Learn more</strong></span></a></li></ul></blockquote><h4><strong>Data Analysis with connectivity to drive productivity</strong></h4><p>From complex proteomic challenges, complete biotherapeutic characterization, or small-molecule discovery to everyday testing, data analysis is your gateway to accessing deeper insights into your high-quality MS and MS2 data. Despite the numerous workflows involved, there are flexible analysis tools for simple, confident interpretation of your data to streamline research and facilitate rapid decision making.</p><ul><li><strong>Flexibly identify and quantify proteins based on your workflow</strong></li><li><strong>Biopharmaceutical characterization with BioPharma Finder software</strong></li><li><strong>Streamline your small-molecule qualitative and quantitative assays</strong></li><li><strong>Small-molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using Thermo Scientific TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul></div></div>

Thermo Scientific Orbitrap Exploris 120 Mass Spectrometer

With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.

<p><strong>The proven Thermo Scientific Orbitrap technology in the Thermo Scientific Orbitrap Exploris 120 mass spectrometer accelerates your route to qualitative and quantitative confidence for both method development and everyday testing purposes. With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.</strong></p><h4><strong>Key benefits of the Orbitrap Exploris 120 mass spectrometer&nbsp;</strong></h4><h5><strong>Confidently perform high-throughput qualitative and quantitative analysis</strong></h5><p>Spend less time questioning your results with the unique ability of Orbitrap high-resolution, accurate-mass spectrometers (HRAM) to provide accurate results and reduce false positives or negatives. Confidently resolve ions of interest from interfering ions with high mass resolution up to 120,000 at m/z 200 for both method development and everyday testing analyses.</p><h5><strong>Keep your laboratory running seamlessly with the new standard in instrument ruggedness</strong></h5><p>Maximize return on your investment with capabilities that minimize downtime. Perform a single, stable calibration for the entire mass range from m/z 40-3000. With an improved scan rate up to 22 Hz, maximize your compound coverage with confidence. The ability to do both positive and negative mode switching ensures you analyze twice as many analytes in the same sample.</p><h5><strong>Focus on driving results with faster method set-up</strong></h5><p>Empower high-resolution MS users by giving them the ability to analyze samples using ready-to-run method templates. Minimize time spent on software training for Thermo Scientific MS users with a common software user interface for data acquisition.</p><h4><strong>How the Orbitrap Exploris 120 MS works</strong></h4><p>Discover how the Orbitrap Exploris 120 MS instrument enables you to prioritize your time on making critical decisions which impact the future of you or your client's organization. The latest instrument capabilities have been designed with the sole purpose of putting you on the fast path to accurate, reportable results. Leave the lab at the end of the day feeling productive and accomplished.</p><ul><li><strong>Uncover and quantify more suspect analytes</strong></li><li><strong>Sub-ppm mass accuracy as standard</strong></li><li><strong>System to system consistency</strong></li><li><strong>Robust performance</strong></li><li><strong>Maximize compound coverage with faster scan rates&nbsp;</strong></li><li><strong>Analyze samples twice as fast with rapid polarity switching&nbsp;</strong></li><li><strong>Intelligence-driven instrument setup, control and data acquisition&nbsp;</strong></li><li><strong>Quantitation: Which scan modes do I use on the instrument?</strong></li><li><strong>Take a video tour&nbsp;</strong></li></ul><div><h4><strong>Data analysis software: Streamline small molecule qualitative and quantitative assays</strong></h4></div><div><p>Connecting small molecule unknown identification and characterization through to screening and quantitation doesn’t just stop at data acquisition across multiple platforms. Now that you have acquired comprehensive, high-quality MS and MS<sup>2</sup> data, you need to identify and characterize unknowns and transfer discovery knowledge through to every day testing.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg" alt="Thermo Fisher Scientific: Which data analysis software is right for you?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg 213w," sizes="100vw" width="1385" height="1016"></p><p>Our connected data processing software ecosystem streamlines interpretation of your high-confidence discovery data through powerful Thermo Scientific Compound Discoverer software with direct access to the world’s largest LC-MS<sup data-uw-styling-context="true">n</sup> reference spectral library, Thermo Scientific&nbsp;mzCloud, or through utilization of offline or proprietary libraries. These libraries act as your knowledge repository and allow direct transfer through to everyday screening and quantitation using Thermo Scientific&nbsp;TraceFinder software.</p><ul><li><strong>mzCloud Mass Spectral Library</strong></li><li><strong>Small molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul><h4><strong>Common applications for Orbitrap Exploris 120 Mass Spectrometer</strong></h4><p>To perform method development and everyday testing with confidence, you need a liquid chromatography mass spectrometry (LC-MS) workflow solution that is relevant to your laboratory’s goals. The Orbitrap Exploris 120 MS instrument can be used for a variety of applications, including clinical research, environmental and food safety, forensic toxicology, and pharmaceutical analysis.</p><ul><li><strong>Clinical Research</strong></li><li><strong>Forensic Toxicology</strong></li><li><strong>Drug Screening and Confirmation</strong></li><li><strong>Environmental Emerging Contaminants</strong></li><li><strong>Pesticide Residues Analysis</strong></li><li><strong>Veterinary Drugs Residues Analysis</strong></li><li><strong>Pharmaceutical applications</strong></li></ul></div>

Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer

Overcome quantitative workflow challenges with the TSQ Altis Plus MS, which ensures superior speed, sensitivity, and precision for low-level detection in complex matrices.

<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Altis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3><strong>Ultimate quantitative performance made possible</strong></h3><p>Overcome the most demanding quantitative workflow challenges. With superior <strong>acquisition speeds, enhanced sensitivity, prototypical selectivity</strong>, and <strong>exceptional robustness</strong>, the <strong>TSQ Altis Plus mass spectrometer </strong>delivers unprecedented accuracy and precision <strong>for low-level compound detection</strong> and <strong>quantitation in complex matrices </strong>that redefines ultimate instrument performance.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt7" comp-id="A1"><div><h3 style="text-align:left;"><strong>Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity&nbsp;</strong></h3><p>Greater than <strong>6 orders</strong> of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as <strong>0.3 milliseconds — 5 millisecond</strong> polarity switching maximizes productivity in fewer experiments.</p><p>Where data confidence is required, the instrumental features on the TSQ Altis Plus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>High-throughput screening and quantitation</strong></h3><p>Innovations in the ion source, mass analyzer, active <strong>Q2 collision cell</strong>, and <strong>RF electronics </strong>offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and<strong> 600 SRMs/second</strong>, <strong>1000’s of compounds</strong> can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. <strong>Thermo Scientific Chromeleon Chromatographic Data System</strong> (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. <strong>Direct method transfer </strong>from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Database integration</strong></h3><p>Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of <strong>experimental libraries </strong>created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in <strong>Thermo Scientific TraceFinder software</strong> can be directly imported into the instrument method editor, streamlining large-scale study creation.</p><p>Discovery experiments, however, may not contain all compounds targeted in a study. Integration with <strong>Thermo Scientific mzCloud databases</strong> enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.</p></div></div></div></div></div></div></div></div>

Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System

Perform basic anion or cation analyses reliably with Dionex™ Aquion™ IC system bundles that include hardware, software, and consumables for easy ordering.

<h4><strong>Reliable, budget-friendly ion chromatography for routine anion and cation analysis</strong></h4><p>Simplify ion analysis in your laboratory with the <strong>Dionex™ Aquion™ IC system</strong>, a compact and easy-to-operate platform designed for routine applications in <strong>environmental, food safety, and academic labs</strong>. Ideal for budget-conscious operations, the Aquion system delivers dependable performance, quick startup, and low operating costs.</p><h3><strong>Key system features</strong></h3><ul><li><strong>Chemically inert PEEK flow path</strong></li><li><strong>Serial dual-piston pump</strong><ul><li>Flow rate: 0.01–5.0 mL/min</li><li>Pressure: up to 5000 psi</li></ul></li><li><strong>High-pressure pulse dampener</strong></li><li><strong>Electrically actuated, PEEK, 6-port Rheodyne injection valve</strong></li><li><strong>Conductivity detection with digital signal processing</strong><ul><li>Range: 0–15,000 μS</li><li>Temperature-controlled conductivity cell for signal stability</li></ul></li><li><strong>Support for electrolytic or chemical suppressors</strong></li><li><strong>Optional column heater</strong></li><li><strong>Built-in inline vacuum degasser</strong></li></ul><h3><strong>Benefits of electrolytic suppression</strong></h3><ul><li>Lower background conductivity and reduced detection limits</li><li>Faster system startup</li><li>Superior sensitivity for both anion and cation analysis</li><li>No need for manual regenerant preparation</li></ul><h3><strong>Optimized detection with conductivity</strong></h3><p>The Aquion system is optimized for conductivity detection using a <strong>thermostated high-performance cell</strong> that ensures stability against ambient temperature fluctuations. Digital signal control offers a wide dynamic range for simultaneous detection of analytes with varying concentrations.</p><h3><strong>Seamless control with Chromeleon™ CDS software</strong></h3><p>Included in every system bundle, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</strong></a> software provides intuitive instrument control, automated workflows, and streamlined data handling:</p><ul><li><strong>eWorkflows</strong>: auto-load instrument conditions and processing templates</li><li><strong>Calibration Wizard</strong>: step-by-step guidance for method setup and quantification</li><li><strong>Wellness Trending</strong>: monitor system performance over time for predictive maintenance</li></ul><h3><strong>Anion and Cation System Bundles</strong></h3><p>Each bundle includes everything needed to get started:</p><h4><strong>Included in all system bundles:</strong></h4><ul><li>Dionex Aquion IC System with power cable</li><li>Dionex Aquion Analysis Kit (anion or cation specific)</li><li>Chromeleon SE software and license</li><li>3-year warranty (parts-only coverage in years 2 and 3)<br>→ Optional extended warranty available including labor and travel in years 2 and 3</li></ul><h4><strong>Anion Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac AG22 (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac AS22 (4 × 250 mm) analytical column</strong></li><li><strong>Dionex AERS 500 Carbonate (4 mm) suppressor</strong></li><li><strong>Combined Seven Anion Standard II</strong><br><i>Note: Eluent concentrate must be ordered separately.</i></li></ul><h4><strong>Cation Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac CG12A (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac CS12A (4 × 250 mm) analytical column</strong></li><li><strong>Dionex CDRS 600 (4 mm) suppressor</strong><br><i>Note: Eluent concentrate and standards must be ordered separately.</i></li></ul><h3><strong>Why choose Dionex Aquion?</strong></h3><ul><li>Proven IC platform with straightforward operation</li><li>Reliable results and stable performance</li><li>Full compatibility with standard and microbore column formats (2–5 mm)</li><li>Low cost of ownership with high-quality support and service</li><li>Ideal entry point for labs new to ion chromatography</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/thumbnail_Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></p>

Thermo Scientific Dionex Integrion HPIC System 

Achieve versatile and efficient separations that meet your routine ion analysis demands with the reliable Thermo Scientific Dionex Integrion HPIC system. 

<div><div id="container-9240b945f2"><div><div id="title-b4d119a2b1"><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Dionex Integrion HPIC System: An easy solution for routine analysis</strong></h3></div></div><div><div id="container-2c24fcced5"><div><div id="text-1819779492"><p><strong>Achieve versatile and efficient separations that meet your routine ion analysis demands with the reliable Thermo Scientific Dionex Integrion HPIC system. Its high-pressure ion chromatography (HPIC) capabilities enable faster analysis without compromising data quality. The Dionex Integrion&nbsp;HPIC system is designed for routine&nbsp;ion chromatography (IC) applications for water, food and beverage, biofuels and pharmaceutical analysis.</strong></p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Integrion_Iontovy_Chromatograf_2_7a7f2ce86a/Thermo-Dionex-Integrion-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Integrion_Iontovy_Chromatograf_2_7a7f2ce86a/thumbnail_Thermo-Dionex-Integrion-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div></div></div><div><div id="container-ee4e409cf5"><div><div id="sectiontitle-d7eca6bc0f"><h3><strong>Highlights</strong></h3></div></div><div><div id="container-94710c6880"><div><div><div id="container-006293a352"><div><div><div id="text-328176320"><h4><strong>Simple plumbing layout</strong></h4><p><strong>The plumbing layout </strong>of this high-pressure ion chromatography system is based on a logical flow path for <strong>easy component access</strong> in a compact platform with a small physical footprint.</p></div></div></div></div></div><div><div id="container-9133f3a75a"><div><div><div id="text-1491634964"><h4><strong>Inert, reliable components</strong></h4><p><strong>Inert, nonmetallic PEEK components</strong> throughout the <strong>Dionex Integrion HPIC system </strong>ensure <strong>compatibility with corrosive eluents and analyses free from metal contamination.</strong> Easy-to-install<strong> IC PEEK Viper fittings</strong> have <strong>low dead volume</strong> and require no special training or tools.</p></div></div></div></div></div><div><div id="container-1d936b69ba"><div><div><div id="text-644579526"><h4><strong>Wide range of IC columns</strong></h4><p>The Dionex Integrion HPIC system is<strong> compatible with a wide variety of column sizes,</strong> including<strong> smaller-particle-size 4 µm columns for HPIC capabilities, </strong>which provide faster run times and better resolution, to meet the requirements of your applications. &nbsp;</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Integrion_Iontovy_Chromatograf_3_bf2f665361/Thermo-Dionex-Integrion-Iontovy-Chromatograf-3.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Integrion_Iontovy_Chromatograf_3_bf2f665361/thumbnail_Thermo-Dionex-Integrion-Iontovy-Chromatograf-3.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div></div><div><div id="container-f643098693"><div><div><div id="text-1278873072"><h4><strong>Automated Eluent Generation (EG)</strong></h4><p>Optional <strong>Reagent-Free Ion Chromatography</strong> with Eluent Generation (RFIC-EG) combines<strong> automated eluent generators and electrolytically regenerated suppressors</strong> to create eluents and regenerants.</p></div></div></div></div></div></div></div></div><div><div id="container-1021b10e17"><div><div><div id="container-a6d8f5fdb8"><div><div><div id="text-1022646706"><h4><strong>Flexible detector options</strong></h4><p>The Dionex Integrion HPIC system allows for easy, swappable integration with either a <strong>conductivity detector</strong> <strong>(CD)</strong> or an <strong>electrochemical detector (ED)</strong>. The system is also compatible with<strong> various external detectors</strong>, including a <strong>mass spectrometer (MS) </strong>or a<strong> variable wavelength detector (VWD).</strong></p></div></div></div></div></div></div></div></div><div><div id="container-cd507ea43e"><div><div><div id="container-3bdbc48a4f"><div><div><div id="text-1802479128"><h4><strong>CDS Software</strong></h4><p>The Dionex Integrion HPIC system comes with the easy-to-use <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon Chromatography Data System (CDS)</strong></a><strong>.</strong> This software platform provides powerful control and data processing for IC and offers eWorkflows that make all our essential applications easily accessible.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Dionex_Integrion_Iontovy_Chromatograf_a_ICS_4000_c7b3adbeea/Pragolab-Thermo-Dionex-Integrion-Iontovy-Chromatograf-a-ICS-4000.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Dionex_Integrion_Iontovy_Chromatograf_a_ICS_4000_c7b3adbeea/thumbnail_Pragolab-Thermo-Dionex-Integrion-Iontovy-Chromatograf-a-ICS-4000.jpg 236w," sizes="100vw" width="965" height="638"></p></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific Dionex ICS-6000 HPIC System

The modular Thermo Scientific Dionex ICS-6000 HPIC system is a highly configurable ion chromatography (IC) system with high pressure capabilities.

<h3><strong>Dionex ICS-6000 HPIC System: Run different methods simultaneously</strong></h3><p><strong>The modular Thermo Scientific Dionex ICS-6000 HPIC system is a highly configurable ion chromatography (IC) system with high pressure capabilities. It enables you to develop and run different methods for a single sample or for different samples simultaneously. The robust design of this system enables operation at up to 5000 psi and produces consistent, reliable results. As a top-of-the-line ion chromatography system, the Dionex ICS-6000 HPIC system is designed to adapt to the needs of users and push the boundaries of what is possible in ion analysis.</strong></p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_ICS_6000_Iontovy_Chromatograf_3_cd832a923f/Thermo-Dionex-ICS-6000-Iontovy-Chromatograf-3.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_ICS_6000_Iontovy_Chromatograf_3_cd832a923f/thumbnail_Thermo-Dionex-ICS-6000-Iontovy-Chromatograf-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Highlights</strong></h3><h4><strong>Flexible configurations</strong></h4><p>Dionex ICS-6000 HPIC systems<strong> come in a variety of configurations</strong>, with the ability operate <strong>as a single- or dual-channel system</strong> to run samples concurrently. This high-pressure IC system can address a full range of IC applications, from <strong>2-D IC</strong> for trace-level analysis to<strong> high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) </strong>for complex carbohydrate analysis.</p><h4><strong>Wide range of IC columns</strong></h4><p>The Dionex ICS-6000 HPIC system is compatible with<strong> 4 μm-particle-size IC columns,</strong> which are available in <strong>150 or 250 mm lengths.</strong> The 150 mm-length columns decrease run times while maintaining chromatographic resolution. The 250 mm-length columns offer improved peak resolution.</p><h4><strong>Automated Eluent Generation (EG)</strong></h4><p>For unmatched method reproducibility and accuracy, the system can electrolytically generate <strong>high-purity hydroxide, carbonate, bicarbonate, or methanesulfonic acid (MSA) eluents </strong>when provided with a source of high-purity deionized water. Using the <strong>Dual EGC mode</strong>, the Dionex ICS-6000 HPIC system can <strong>also generate potassium hydroxide/potassium methanesulfonate (KOH/KMSA) eluents </strong>for complex carbohydrate analysis.</p><figure class="image"><img style="aspect-ratio:1246/940;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_66f622c7f9.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: Feutin alditol oligosaccharide analysis using (a) manually prepared eluents (NaOH/NaOAc) (b) Dual EGC mode (KOH/KMSA) with 1 mm column format (c) Dual EGC mode (KOH/KMSA) with 0.4 mm column format." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_66f622c7f9.jpg 206w," sizes="100vw" width="1246" height="940"></figure><h4><strong>Versatile detection capabilities</strong></h4><p>The system is<strong> </strong>compatible with a wide variety of detectors, including <strong>suppressed conductivity, electrochemical, UV-Vis absorbance, inductively coupled plasma mass spectrometry (ICP-MS), and mass spectrometry (MS).</strong></p><h4><strong>Mass spectrometry compatible</strong></h4><p>The Dionex ICS-6000 HPIC system is the<strong> ideal IC system to work in tandem with mass spectrometry, </strong>as it can used for a wide variety of sample analyses. From single quadrupole to high resolution accurate mass (HRAM) <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=Orbitrap"><strong>Thermo Scientific Orbitrap mass spectrometers</strong></a>, IC-MS analysis provides improved selectivity and higher sensitivity.</p><figure class="image"><img style="aspect-ratio:1245/682;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_3_ecfef0173d.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: HRAM MS/MS fragments facilitate identification of unknown compounds. IC, combined with HRAM mass spectrometry, is an ideal solution for component identification in non-targeted and unknown workflows. In this figure, identification of lithium-ion battery failure analysis products using HRAM MS/MS offers four-decimal-point accuracy to distinguish between species. The unique fragmentation signature enhances that confidence." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_3_ecfef0173d.jpg 245w," sizes="100vw" width="1245" height="682"></figure><figure class="image"><img style="aspect-ratio:1362/727;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_2_64749e2b9d.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: Targeted MS/MS analysis enables quantitation of molecules in a wide variety of matrices. IC, combined with triple quadrupole mass spectrometry, is an ideal solution for resolving molecules that are often difficult to separate from a matrix using conventional liquid chromatography techniques. In this chromatogram, glyphosate in drinking water is detected at a level of 5 ng/L. The linearity of the assay allows quantitation over 3 orders of magnitude, from 5 ng/L to 1000 ng/L, enabling a wide detection range without having to dilute samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_2_64749e2b9d.jpg 245w," sizes="100vw" width="1362" height="727"></figure><h4><strong>CDS Software</strong></h4><p>The Dionex ICS-6000 HPIC system comes with the<strong> easy-to-use Thermo Scientific Chromeleon Chromatography Data System (CDS)</strong>. This software provides powerful control and data processing for IC and offers eWorkflows that make all our essential applications easily accessible. Additionally,<strong> the Chromeleon CDS can control mass spectrometry systems, enabling seamless IC-MS analyses.</strong></p>

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