<h5><strong>Tasty beer starts with knowing what’s in your hops. Explore how online SPE makes bitter acid analysis in hops faster and more reliable.</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_326238593f.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_326238593f.jpeg 245w," sizes="100vw" width="1024" height="512"></p><h3><strong>How can you detect bitter acid profiles quickly, reliably, and more sustainably?</strong></h3><p>For craft brewers and beer lovers alike, a refreshing experience is all about flavor.</p><p>So how can you achieve the desired bitterness in your beer? The answer is not just about the recipe. Finding the right flavor profile starts with the bitter acids present in the starting hops material.</p><div><div><p>Hops (the heart of your favorite beer) are the source of the brew’s distinctive flavor tied to bitterness and aroma.</p><p>At the molecular level, bitterness is driven by <a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0308814622016338">α- and β-bitter acids</a>, like humulones and lupulones, whose concentrations determine the final sensory profile of the beer (<strong>Figure 1</strong>).</p><p>Accurately characterizing these compounds in each batch allows brewers to unlock the full potential of every variety of hops.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 1. General chemical structure of hop bitter acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_2_6435757c03.jpeg 222w," sizes="100vw" width="700" height="493"></p><p>While conventional analytical methods rely on long, manual sample preparation steps and hazardous solvents, laboratories now strive for greener and more efficient workflows.</p><p>And moving from manual to online sample preparation is one of the easiest ways your lab can reduce waste and — most importantly — improve reliability with automation.</p><h3><strong>Key takeaways</strong></h3><ul><li>Online SPE reduces hands-on work, shortens turnaround time, and supports more sustainable methods by cutting solvent use and eliminating single-use cartridges.</li><li>Automated UHPLC workflows are easier for new users to execute, offering more reproducible quantifications of α- and β-bitter acids in hops.</li><li>Accurate bitter acid profiles help brewers distinguish hop varieties and control flavor with confidence.</li></ul><h3><strong>Comparing offline vs. online solid phase extraction for bitter acid HPLC analysis</strong></h3><p>If you’ve spent long hours in the lab preparing samples for hops analysis, you’re not alone.</p><p>Manual sample preparation often takes the most time in hops analysis, an area where online <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/chromatography-learning-center/chromatography-consumables/sample-prep.html">solid phase extraction</a> (SPE) can make a real difference. Here’s why.</p><p>Manual SPE has a lot of manual steps. Extraction. Cartridge loading. Washing. Elution. And sometimes solvent exchange or reduction. All before your actual analysis begins. This labor-intensive workflow can take up to an hour and depends strongly on operator skillsets, making reproducibility a challenge for new hires.</p><h3><strong>Online SPE analysis provides key benefits like:</strong></h3><ul><li>Hands-off workflow free of cartridges, manifolds, or vacuum steps.</li><li>Column washing and re-equilibration occur in parallel with separation.</li><li>SPE step is complete in just two minutes.</li><li>Minimizes operator-dependent variability.</li><li>Uses less than 8 mL of solvent.</li></ul><p>Let’s explore what this technique looks like in practice.</p><h3><strong>Online SPE for analyzing α- and β-bitter acids in hops standard solutions.</strong></h3><p>Changing your sample preparation from manual to automated isn’t complicated. With the right tools you can fully integrate online SPE with your UHPLC system (<strong>Figure 2</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 2. Schematic workflow for the determination of bitter acids in hops. The process involves clean up and instrumental analysis using the Thermo Scientific Vanquish Online SPE UHPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_3_4fb14243b4.jpeg 245w," sizes="100vw" width="700" height="323"></p><h3><strong>The process for analyzing a hops standard solution is straightforward:</strong></h3><ol><li>First, extract hop samples with ethanol (a greener alternative to toluene or diethyl ether in conventional methods).</li><li>Inject the extract directly into your instrument for analysis. Bitter acids retain<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1970"><strong> on the SPE column</strong></a> while matrix interferences that can comprise quantitation are removed.</li><li>Next, backflush the SPE column to transfer the analytes to the<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/423"><strong> analytical column </strong></a>for separation. While this separation is taking place, the SPE column is washed and re-equilibrated in parallel, keeping the total run time to 15 minutes, with the separation of all six major bitter acids in a single analysis (<strong>Figure 3</strong>).</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 3. UV chromatogram of hop bitter acids in standard solution (1-cohumulone, 2-humulone, 3-adhumulone, 4-colupulone, 5-lupulone, 6-adlupulone)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_4_1e47405e3c.jpeg 245w," sizes="100vw" width="700" height="347"></p><h3><strong>Online SPE for analyzing α- and β-bitter acids in real hops samples</strong></h3><p>Analytical labs need methods that are accurate and reliable for brewers to develop distinct and reproducible flavor profiles across batches.</p><p>To assess the applicability of online SPE UHPLC methods for hops analysis, we analyzed bitter acid profiles from four species — Sultana, Barbe Rouge, Azacca, and Sabro.</p><p>The concentration of α-acids dominated all samples, while each hops species exhibited distinct profiles in terms of α-acid and β-acid content, making them suitable for different brewing strategies (<strong>Figure 4</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg" alt="Thermo Fisher Scientific: How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors: Figure 4. Bitter acid profiles in four different hop species, error bars display SD (n=6). To check method consistency, we measured each hops extract six times. Variation between measurements was low, with relative standard deviation below 3.5 % across all hops species." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_How_Bitter_Acid_Analysis_Helps_Brewers_Better_Control_Beer_Flavors_5_3a179217db.jpeg 245w," sizes="100vw" width="700" height="410"></p><ul><li>For testing labs, this process translates into a workflow that is easy to run, fast, and delivers reliable results without added complexity.</li><li>For craft brewers, reliability means clear, trustworthy insights into hops bitter acid profiles, for better hop selection and more precise control of bitterness and flavor in your beer.</li></ul><h3><strong>From carefully procured samples to tasty sips</strong></h3><p>Efficient UHPLC workflows support faster results, less solvent use, and reliable bitterness data for brewers. And online SPE turns those advantages into practical, day-to-day benefits for brewers and labs alike.</p><ul><li>Less hands-on skills required for lab analysts</li><li>Faster results from labs to brewers</li><li>A more sustainable way to work</li><li>Clear insights into hops flavor</li></ul><p>To learn more about the method and see the full application data, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cn_004238_hplc_vanquish_online_spe_bitter_acids_hops_cn004238_na_en_587a5d300b.pdf"><strong>check out our application note today</strong></a>.</p><h3><strong>FAQs</strong></h3><div><div><h5><strong>What are the key compounds in hops analyzed by HPLC?</strong></h5><p>Bitter acids, namely α-acids and β-acids, especially the six major bitter acids (humulones and lupulones) that define hop bitterness and are required for quality control and brewing decisions.</p></div><div><h5><strong>What column types are recommended for hop acid separations?</strong></h5><p>Classical C18 Silica columns are ideal for bitter acids separation. UHPLC compatible columns with particle size ≤ 2 µm boost analysis with higher flow rate, thus shorter analysis time and solvent consumption.</p></div><div><h5><strong>What’s the best workflow for hops analysis?</strong></h5><p>A typical workflow for hop analysis consists of three main steps: extraction of the target compounds, clean-up of co-extracted matrix components, and instrumental analysis by HPLC or UHPLC. To keep this workflow efficient and reproducible, you should minimize manual handling and add in automation when possible. Integrating online SPE into your LC instrument allows sample clean-up to run automatically, reducing hands-on time, solvent use, and variability while delivering faster, more reliable results.</p></div></div><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#UHPLC #Automation</p></blockquote></div></div>

How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors

<p><strong>In the week of June 29, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Insights from an IC specialist: To be suppressed or not suppressed?</strong></h5><ul><li>Tu, 30.6.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6310">Registration</a></li></ul><p>Join Thermo Fisher’s Ask the Experts session to learn how suppressor technology impacts ion chromatography performance, sensitivity, reliability, maintenance, and troubleshooting.</p><h5><strong>2. SCIEX: Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery</strong></h5><ul><li>Tu, 30.6.2026 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6311">Registration</a></li></ul><p>Discover how ZenoTOF high-resolution mass spectrometry is accelerating single-cell proteomics and plasma biomarker discovery through enhanced sensitivity, throughput, and automation.</p><h5><strong>3. Agilent Technologies: Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres</strong></h5><ul><li>Tu, 30.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6052">Registration</a></li></ul><p>This webinar will discuss diffuse transmission and reflection UV/VIS measurements, including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer.</p><h5><strong>4. Waters Corporation: Informatics series #33 Tips, Tricks and Best Practices</strong></h5><ul><li>Th, 2.7.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6315">Registration</a></li></ul><p>This interactive session revisits essential features, shortcuts, and practical techniques in Empower software that can streamline everyday laboratory work and reduce unnecessary effort.</p><h5><strong>5. Waters Corporation: Unlocking Therapeutic Peptide Characterisation (GLP-1RAs) with Cyclic IMS</strong></h5><ul><li>Th, 2.7.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6313">Registration</a></li></ul><p>Discover how cyclic ion mobility spectrometry (cyclic IMS) improves characterization of GLP-1 analogues and therapeutic peptides, supporting development, quality control, and regulatory submissions.</p><h5><strong>6. Agilent Technologies: Spectral Flow Cytometry Masterclass - Session 1</strong></h5><ul><li>Fr, 3.7.2026 07:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6316">Registration</a></li></ul><p>Learn how full-spectrum flow cytometry enables high-dimensional cell analysis. Explore spectral flow technology, experimental design, and applications in immunology, oncology, and vaccine research.</p>

Webinars LabRulezLCMS Week 27/2026

<p><strong>The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;</strong></p><p>There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607"></p><p>A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;</p><h4><strong>Evaluation of measurement procedure performance&nbsp;</strong></h4><p>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;</p><ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"></p><h4><strong>Characterisation of candidate reference materials&nbsp;</strong></h4><p>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;</p><ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4><strong>Other ILCs&nbsp;</strong></h4><p>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).</p>

Interlaboratory comparisons other than proficiency testing

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Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry

The Xevo® G2-XS QTof combines StepWaveTM ion optics with the XS Collision Cell, providing a significant increase in sensitivity with no reduction in selectivity.

<h4><strong>eXtreme Sensitivity, eXtraordinary Selectivity, eXceptional Solutions</strong></h4><div><p><strong>For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.</strong></p><ul><li>Maximum robustness with no compromise in performance</li><li>Class-leading real-world quantitative sensitivity</li><li>Highest quality, most comprehensive qualitative information</li><li>Flexibility to adapt to changing needs</li><li>Accessible to experts and non-experts alike</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_1_b9f8dd32be/Waters-Xevo-G2-XS-QTof-Quadrupole-Time-of-Flight-Mass-Spectrometry-1.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_1_b9f8dd32be/thumbnail_Waters-Xevo-G2-XS-QTof-Quadrupole-Time-of-Flight-Mass-Spectrometry-1.jpg 173w," sizes="100vw" width="1099" height="991"></p><h3><strong>Overview</strong></h3><div><h4><strong>Maximum robustness with no compromise in performance</strong></h4><p>The trend for increasing complexity of both samples and studies can result in difficulty obtaining high quality data for every component of interest while maintaining optimum performance throughout the analysis.</p><p>The <strong>Xevo® G2-XS QTof</strong> combines <strong>StepWave<sup>TM</sup> ion optics</strong> with the <strong>XS Collision Cell</strong>, providing a significant increase in sensitivity with no reduction in selectivity.&nbsp; During long analyses, critical hardware components stay clean for longer, so results are more reproducible and the laboratory stays productive.</p><p>Meaningful information is obtained for a greater number of components across a larger population of samples than ever before, giving a more complete picture for improved understanding and more confident decision making.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_437f84bacd.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry: Maximum robustness with no compromise in performance." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_437f84bacd.jpg 224w," sizes="100vw" width="900" height="628"></p><div><h4><strong>Class-leading real-world quantitative sensitivity</strong></h4><p>In targeted quantitative analysis, the greatest challenge is to detect and quantify components of interest down to the lowest possible levels, often in the presence of interferences from complex matrix.&nbsp; Large variation in the concentrations of different components further adds to this challenge.</p><p>The <strong>Xevo G2-XS QTof</strong> combines sensitivity and selectivity with the mass accuracy, dynamic range and speed provided by <strong>QuanTofTM technology</strong> and the enhanced quantitative capability of <strong>Tof-MRM data acquisition</strong>.&nbsp; The end result is class-leading quantitative performance in real everyday laboratory conditions, demonstrated by limits of detection and quantification superior to anything achieved before with high resolution MS.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_2_d805c7aa49.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry: Class-leading real-world quantitative sensitivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_2_d805c7aa49.jpg 245w," sizes="100vw" width="900" height="312"></p><div><h4><strong>Highest quality, most comprehensive qualitative information</strong></h4><p>In addition to accurate quantitative profiles, complete understanding of a sample requires detailed and comprehensive qualitative information.</p><p><strong>MS<sup>E</sup></strong> is a simple but powerful approach that delivers accurate mass precursor and fragment ion data for every detectable component, whether chromatographically resolved or not.&nbsp; This represents the ultimate in qualitative information, and because the approach is un-targeted, the data can be interrogated again later as scientific questions evolve.</p><p><strong>FastDDA</strong> is an automated, targeted data acquisition method that provides rapid, intelligent accurate mass MS/MS capability for confirmation of known compounds or characterization of unknowns, for situations where only true MS/MS data will suffice.</p><h4><strong>Flexibility to adapt to changing needs</strong></h4><div><p>The growing emphasis on efficiency and productivity in the laboratory demands analytical systems that are not only robust and reliable, but that also have the flexibility to accomplish a wide variety of tasks today, with future-proofing for the innovations of tomorrow.&nbsp;</p><p><strong>Waters’ Universal Ion Source Architecture</strong> enables the use of a single analytical platform for many different applications and molecule types, as well as providing the option to add new functionality as requirements and priorities change.&nbsp; All source options are designed to be quickly interchangeable and ready to use within minutes, maximizing versatility and minimizing downtime.</p><div><h3><strong>Accessible to experts and non-experts alike</strong></h3><p>Traditionally the ability to achieve and maintain optimum performance from such a powerful analytical system would require a level of knowledge and experience held only by expert users.</p><p>The <strong>Xevo G2-XS QTof</strong> features <strong>IntelliStartTM technology</strong>, an intuitive user interface that automates routine tasks and ensures reproducible data of the highest quality, ensuring the full capability of the system is accessible to all.</p><p><strong>IntelliStart enables essential functions to be carried out automatically:</strong></p><ul><li>MS resolution and calibration checks</li><li>Simple setup of diverse experiments</li><li>Scheduled LC-MS system checks</li><li>Continuous system monitoring</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_3_279cf35277.jpg" alt="Waters Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry: Accessible to experts and non-experts alike." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G2_XS_Q_Tof_Quadrupole_Time_of_Flight_Mass_Spectrometry_3_279cf35277.jpg 136w," sizes="100vw" width="900" height="1038"></p></div></div></div></div></div></div>

Waters ACQUITY PREMIER UPLC System

Get the highest limits of detection, more consistent results, and better recovery, so you can see what you couldn’t before.

<p class="cke-user_style-important"><strong>Redefining separation science. Again.</strong></p><p data-pm-slice="1 3 []"><strong>The most significant innovation in separation science since we introduced UPLC™ in 2004, the ACQUITY™ Premier Solution reduces variability associated with metal-sensitive analytes - without time-consuming tasks like system and column passivation. By giving you greater confidence in your results, minimizing your risk, and increasing efficiency, you will have more time to generate meaningful data and focus on your next scientific breakthrough.</strong></p><h5><strong>With the ACQUITY Premier Solution you can:</strong></h5><ul data-spread="false"><li>Increase confidence in every result</li><li>Minimize risk of undetected analytes</li><li>Get to the right answer – faster</li></ul><h3><span><strong>Stop looking and start seeing</strong></span></h3><p data-pm-slice="1 3 []"><span>The ACQUITY Premier Solution enables your lab to make informed decisions and reduce risk with stronger analytical capabilities to detect more of your sample components from the very beginning. Get the highest limits of detection, more consistent results, and better recovery, so you can see what you couldn’t before.</span></p><h5><span><strong>The ACQUITY Premier Solution can help you:</strong></span></h5><ul data-spread="false"><li>Decrease time-to-result</li><li>Reduce time on method development</li><li>Increase overall efficiency in the laboratory</li></ul><figure class="image"><img style="aspect-ratio:1148/1223;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_2_50afcbba6d.jpg" alt="Waters ACQUITY PREMIER Solution: The ACQUITY Premier Solution consists of the ACQUITY Premier System, ACQUITY Premier Columns, and QuanRecovery™ Vials and Plates with MaxPeak™ HPS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_2_50afcbba6d.jpg 147w," sizes="100vw" width="1148" height="1223"></figure><h3><span><strong>MaxPeak High Performance Surfaces Technology</strong></span></h3><p>The ACQUITY Premier Solution is designed with MaxPeak High Performance Surfaces (HPS) Technology, which offers improvements in separation and detection of metal-sensitive analytes. By mitigating non-specific binding, the ACQUITY Premier Solution provides:</p><ul data-spread="false"><li>Dramatic improvements in RP and HILIC applications for organic acids, organophosphates, oligonucleotides, peptides, glycans, and phospholipids</li><li>Increased sensitivity reducing risk of undetected analytes</li><li>Increased efficiency by eliminating time-consuming system and column passivation</li><li>Greater reproducibility and increased confidence in results</li></ul><figure class="image"><img style="aspect-ratio:1183/1177;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_3_ca85533e85.jpg" alt="Waters ACQUITY PREMIER Solution: ACQUITY Premier Solution performance without time-consuming passivation – analysis of insulin receptor – doubly phosphorylated peptide (TRDIpYETDpYYRK)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_3_ca85533e85.jpg 157w," sizes="100vw" width="1183" height="1177"></figure><h3><strong>Holistic solutions for optimal performance</strong></h3><p>A true measure of excellence for Waters is in orchestrating consistent instrument and chemistry optimization, enabling you to fine-tune your system to your specific analytical need, rapidly change between applications, and consistently maintain a high level of confidence in every result.</p><p>The outcome is better quality data faster and improved system-to-system and column-to-column reproducibility, allowing methods to be transferred between analysts, instruments, and laboratories.</p><figure class="image"><img style="aspect-ratio:1534/1271;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4e1b9e6b60.jpg" alt="Waters ACQUITY PREMIER Solution: The ACQUITY Premier Solution significantly reduces analyte/surface interaction of sensitive compounds for improved chromatographic performance in RPLC/MS-based separations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4e1b9e6b60.jpg 188w," sizes="100vw" width="1534" height="1271"></figure><h3><span><strong>Improve spectral quality and analyte identification</strong></span></h3><p><span>Obtaining high-quality mass spectrometry spectra is central to structural elucidation and analyte identification. The process of obtaining these spectra is often confounded by spectral overlap from closely eluting analytes or poor-quality MS signal due to low peak concentration. MaxPeak HPS Technology eliminates secondary interactions from metals, reducing chromatographic peak tailing. The result is more gaussian peaks, reduced chromatographic coelution, and superior spectral quality.</span></p><figure class="image"><img style="aspect-ratio:1291/1172;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg" alt="Waters ACQUITY PREMIER Solution: Improve spectral quality and analyte identification." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_4_def1e84e9a.jpg 171w," sizes="100vw" width="1291" height="1172"></figure><h3><span><strong>Global Services: Committed to your success</strong></span></h3><p data-pm-slice="1 1 []"><span>As part of the ACQUITY Premier experience, one of our applications specialists will work with you to ensure you are getting everything you need from your system. We have a flexible range of support plans to ensure you get the most out of your system:</span></p><h4><span><strong>FlexChoice™ MySystem Coverage&nbsp;</strong></span></h4><p><span>Choose the support you need – no more, no less. The Waters service team offers personalized and flexible support, maintenance, and service options to meet your unique lab requirements.</span></p><h4><span><strong>Compliance Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Simplify your process of validating, qualifying, and record-keeping with consulting services to help meet your regulatory guidelines.</span></p><h4><span><strong>Professional Services</strong></span></h4><p data-pm-slice="1 1 []"><span>Waters comprehensive suite of consultative services, software applications, and analytical business tools guide you on your path to increased efficiencies and lower costs.</span></p><h4><span><strong>FlexUp™ Technology Renewal Program</strong></span></h4><p data-pm-slice="1 1 []"><span>Benefit from ongoing seamless upgrades to our latest LC and mass spec instrumentation and software and eliminate the issues associated with older instrumentation.</span></p><p><span>*Coming soon to all regions.</span></p><h3><span><strong>Informatics: Get more from your data for more trusted decisions</strong></span></h3><p><span>Capture, manage, integrate, and analyze your LC and MS data with our informatics platforms, improving discovery and manufacturing, quality and integrity, and reducing time to market. Easily and seamlessly conduct scientific searches, integrate networks, manage compliance, and streamline operations.</span></p><h4><span><strong>Empower™ Chromatography Data System</strong></span></h4><p data-pm-slice="1 1 []"><span>Your entire laboratory operates better with Empower Software, which makes it easier than ever to run samples and produce meaningful results, all while ensuring adherence to strict compliance requirements.</span></p><h4><span><strong>MassLynx™ Software</strong></span></h4><p data-pm-slice="1 1 []"><span>Increase laboratory productivity with Waters MassLynx™ Software, which simplifies interaction with and improves your MS system with an intuitive interface, intelligent instrument control, and software features built around the focus of your analysis - the sample.</span></p><h4><span><strong>Unifi™</strong></span></h4><p data-pm-slice="1 1 []"><span>Merges LC and high-performance MS data into a single solution, providing organizations with the flexibility to deploy UNIFI-based systems within regulated and non-regulated laboratory environments.</span><br><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg" alt="Waters ACQUITY PREMIER Solution " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_PREMIER_Solution_5_2d2c9ba640.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Waters ACQUITY Advanced Polymer Chromatography (APC) System

The ACQUITY APC System Increase sample throughput and laboratory operations by obtaining accurate and repeatable sample separation up to 20 time faster than before.

<div><div><h4><strong>The highest performance for polymers and oligomers</strong></h4></div></div><div><div><p><strong>Today’s polymer scientists operate within an increasingly dynamic market space, one with a growing demand for high-performing materials, bio-material innovations, and intense competition. But the long run times of traditional chromatography polymer characterization has made keeping up with this demand a challenge for many labs.</strong></p><p>Not anymore. With the <strong>next era in polymer separation</strong>, the <strong>ACQUITY Advanced Polymer Chromatography (APC) System</strong>, you can achieve the <strong>highest resolution size-based separations</strong> for <strong>chromatographic polymer and oligomer characterization</strong>, all <strong>faster than ever</strong>. With the <strong>ACQUITY APC System</strong>, you can <strong>improve data consistency and quality</strong> with <strong>fast, daily calibration</strong>, and <strong>automate your method development</strong> with <strong>advanced system technologies</strong> – so you can <strong>innovate faster</strong> while <strong>improving lab operations.</strong></p><div><div><div><div><h3><strong>Features and Benefits</strong></h3><ul><li><strong>Accelerate your insights</strong> - Reduce laboratory turnaround times for polymer samples by getting answers to your development labs, your manufacturing operations teams, and your customers 5 to 20 times faster than traditional SEC/GPC with the ultra-low system dispersion of the ACQUITY APC System paired with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1950"><strong>ACQUITY APC Columns</strong></a>.</li><li><strong>Get the accurate data you need for informed decisions</strong> - Gain more insight into your polymer samples through compatibility with a wide range of specific detection techniques (refractive index, UV/Vis, PDA, ELS) and third-party advanced detectors like multi-angle light scattering and viscometry. Get accurate molecular weight (MW) data every day with the precise flow delivery of the isocratic solvent manager.</li><li><strong>Optimize method development, even in harsh conditions</strong> - Optimize method development via rapid and automated solvent switching and aggressive solvent compatibility, which supports the harsh separation conditions associated with polymer analyses.</li><li><strong>Improve lab efficiency with one system</strong> - Increase analytical scope and laboratory efficiency by leveraging one system to perform multiple applications, including basic liquid chromatography (LC), gradient, isocratic, reverse-phase, and gel permeation chromatography (GPC).</li><li><strong>Simplify your column management</strong> - Simplify and optimize column bank calibration through standards that are matched to column bank MW ranges. Versatile column management allows you to automatically select up to two banks of <strong>ACQUITY APC</strong> columns and up to two banks of traditional GPC columns - all housed in a stable, temperature-controlled environment.</li></ul></div></div><div><div><h4><strong>Recommended Use</strong></h4><p>Highest-resolution, size-based separations for chromatographic polymer and oligomer characterization.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_APC_System_nakonfigurovany_pro_automaticke_prepinani_jak_APC_tak_GPC_kolon_e198c774f4/Waters-ACQUITY-APC-System-nakonfigurovany-pro-automaticke-prepinani-jak-APC-tak-GPC-kolon.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_APC_System_nakonfigurovany_pro_automaticke_prepinani_jak_APC_tak_GPC_kolon_e198c774f4/thumbnail_Waters-ACQUITY-APC-System-nakonfigurovany-pro-automaticke-prepinani-jak-APC-tak-GPC-kolon.jpg 213w," sizes="100vw" width="969" height="710"></p><div><div><h3><strong>Accelerate innovation with enhanced insight</strong></h3><p>Harnessing the benefits of advanced polymer chromatography with the ACQUITY APC System means obtaining accurate and repeatable polymer and oligomer molecular weight information anywhere between<strong> 5 to 20 times faster than was possible</strong> with traditional<strong> GPC/SEC technology</strong> - so you can innovate faster while improving laboratory operations.</p><p><strong>With the ACQUITY APC System, you can:</strong></p><ul><li><strong>Reduce laboratory turnaround times for polymer samples&nbsp;</strong>by getting answers to your development labs, your manufacturing operations teams, and your customers - faster.</li><li><strong>Drive innovation</strong>&nbsp;with faster results and more information so that your entire operation can respond more rapidly by decreasing development cycle times and accelerating time to market.</li><li><strong>Streamline process monitoring</strong>&nbsp;and achieve better batch control with the agility to make timely decisions “on-the-fly” about process and synthesis optimization<strong>.</strong></li><li><strong>Significantly reduce the analysis cost per sample</strong>&nbsp;by reducing solvent consumption and waste disposal volumes.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_ca5154865a.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Accelerate your innovation with enhanced insight into polymer chemical structure with the ACQUITY APC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_ca5154865a.jpg 245w," sizes="100vw" width="1024" height="600"></p><div><div><h3><strong>Optimize method development with solvent switching and compatibility</strong></h3><p>Using the ACQUITY APC System with <strong>Polymer Quaternary Solvent Manager</strong> (p-QSM) <strong>technology </strong>provides chemists and polymer scientists with the ultimate flexibility to analyze the most complex polymer blends and additives using standard polymer chromatography, gradient polymer elution chromatography (GPEC), and reverse-phase LC with a single system.</p><p>Additional system features allow automated solvent selection of up to six different solvents. Automated column bank switching capabilities can also be paired with the rigid and solvent-resilient particles of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1950"><strong>ACQUITY APC Columns</strong></a> to achieve the world’s first truly automated solution for method development of size-based polymer separations. This supports separation of polymers in hours, instead of days.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_2_b95f96f0a2.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Repeatable analysis of poly (methyl methacrylate co ethylacrylate) using the same two running ACQUITY APC 4.6 x 150 mm Columns (450 Å and 125 Å) in series after automated switching of the solvents from THF to toluene to DMF and back to THF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_2_b95f96f0a2.jpg 245w," sizes="100vw" width="1024" height="609"></p></div></div><div><div><h3><strong>Use advanced detection for even more insights</strong></h3><p>Get the valuable decision-making information you need from a single analysis by equipping the ACQUITY APC System with advanced detectors. Combining the ACQUITY APC System with advanced detection solutions significantly increases information attainable from <strong>size-exclusion chromatography</strong> (SEC) analysis through addition of <strong>refractive index</strong> (RI), <strong>ultraviolet </strong>(UV),<strong> photodiode array </strong>(PDA), <strong>light scattering</strong> (LS), and <strong>differential viscometry</strong> (IV). Advanced detection options from <strong>Wyatt Technology</strong> are seamlessly integrated with ACQUITY APC System, enabling you to fully characterize samples to better inform the structure-property relationship of novel complex polymers.</p></div></div><div><div><h3><strong>Keep pace with your research with dedicated consumables</strong></h3><p>The ACQUITY APC System is even more powerful with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/columns/acquity-apc-columns.html"><strong>ACQUITY APC Columns</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/products/standards-and-reagents/acquity-advanced-polymer-chromatography-calibration-standards-ki.html"><strong>ACQUITY APC Calibration Standards Kits</strong></a>. The Ethylene Bridged Hybrid (BEH) Technology in ACQUITY APC Columns creates particles that ensure extreme column performance and long column lifetime under harsh operating conditions – ideal for general purpose, reversed-phase chromatography, and for method development due to extreme pH stability and applicability to the broadest range of compound classes.</p><p>With run times of less than 10 minutes, a bank of ACQUITY APC Columns can be <strong>calibrated in less than 30 minutes</strong> using ACQUITY APC Calibration Standards Kits.&nbsp;These standard kits have been matched to the MW range of ACQUITY APC Columns, generating a 10-point calibration for any bank combination in a simple dilute-and-shoot format. With daily column bank calibration, you can greatly improve data consistency to increase confidence in batch-to-batch measurements. Select the best column and calibration standards for a given application with our convenient <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/promotionDetail.htm?id=134823417">selector tool</a>.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_4_056bb6d284.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Ethylene Bridged Hybrid (BEH) Technology helps you keep up with the pace of your research with state-of-the-art reversed-phase and HILIC HPLC columns." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_4_056bb6d284.jpg 245w," sizes="100vw" width="1024" height="620"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_5_7a814e249b.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) System: Improve data and consistency with ACQUITY APC Calibration Standards." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_System_5_7a814e249b.jpg 245w," sizes="100vw" width="1024" height="591"></p></div></div></div></div></div></div></div></div></div></div>

Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer

Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows.

<h4><strong>Superior performance in your routine quantitative analyses</strong></h4><p><strong>Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows. &nbsp;With solutions for today’s needs and technologies to overcome tomorrow’s challenges, explore what the adaptable, flexible, and proven Xevo TQ-XS Tandem Quadrupole Mass Spectrometer coupled with ACQUITY UPLC can afford your laboratory’s productivity and capabilities. &nbsp;</strong></p><div><div><div><div><ul><li><strong>Expanding your efficiencies</strong>: Maximize your laboratory’s potential in high sensitivity quantitative analysis by extending your capabilities, confidently and productively</li><li><strong>Performance that’s proven</strong>: Trust the proven Xevo TQ-XS to meet the analytical demands of your challenging applications , injection after injection</li><li><strong>Digesting your data</strong>: Reduce the burden in data handling with flexible and adaptable software solutions to meet your application and quality system needs</li><li><strong>Supporting your success</strong>: Have confidence that you will exceed your analytical requirements using Waters end to end solutions with flexible service and application focused training and support</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Quantitative analysis where <strong>high sensitivity instrument performance</strong> is required (e.g.,&nbsp;to reach <strong>low level concentrations (ppt)</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: The Xevo TQ-XS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg 245w," sizes="100vw" width="1024" height="545"></p><div><div><h3><strong>Expand your analytical capabilities with enhanced sensitivity</strong></h3><p>Delivering the next step in reliable sensitivity, the <strong>Xevo TQ-XS</strong> enables your laboratory to expand your analytical capacity and productivity. Whether seeking more sensitivity to detect your analytes routinely, looking to extend your scope of analytes with increased confidence or revise your workflow to reduce time and costs, explore what <strong>Xevo TQ-XS</strong>, coupled with <strong>ACQUITY UPLC</strong> and <strong>ACQUITY Premier Systems</strong> can offer your lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Vancomycin: Xevo TQ-XS versus Xevo TQ-S. On average, the analyte area counts on Xevo TQ-XS were >10x higher than area counts on Xevo TQ-S for Vancomycin." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg 245w," sizes="100vw" width="1024" height="295"></p></div></div><div><div><h3><strong>Proven performance you can trust for your challenging analyses</strong></h3><p>Whether looking to streamline your methods or advance your laboratory’s performance, explore how <strong>Xevo TQ-XS</strong>, coupled with <strong>LC (UPLC), GC (APGC) or SFC (UPC2)</strong> can benefit your challenging applications. Trust the proven <strong>Xevo TQ-XS</strong> to meet your <strong>analytical demands</strong>, injection after injection.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Representative liraglutide LLOQ (0.5 ng/mL) chromatogram, extracted from plasma, demonstrating sensitivity and selectivity with Xevo TQ-XS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg 245w," sizes="100vw" width="1024" height="536"></p></div></div><div><div><h3><strong>Software solutions to overcome a common bottleneck</strong></h3><p>While quantitation of targeted analytes can be a routine experiment, the volume of data acquired and generated for processing, review and management can be significant. <strong>Waters</strong>’ informatics platforms offer extensive toolsets to support efficient and compliant <strong>data handling</strong> to support your <strong>21 CFR 11 and ISO 17025</strong> environments.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: With the Xevo TQ-XS System, you’ll get robust results you can trust with the most demanding sample matrices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg 234w," sizes="100vw" width="1024" height="683"></p></div></div><div><div><h3><strong>Accelerating your success with award winning service</strong></h3><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with Waters comprehensive analytical solutions with expert training (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services.html"><strong>APS</strong></a>) and flexible and cost-effective solutions to advance your business with system service <strong>(</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services/flexchoice-instrument-service-coverage.html"><strong>FlexCHOICE</strong></a>), trade-ins and technological upgrades (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/FlexUP-Technology-Renewal-Program-%7C-Upgrade-Lab-Instruments/nav.htm?cid=135071972"><strong>FlexUP</strong></a>).</p></div></div></div></div></div></div>

Waters CERTIFIED HPLC Vials

Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.

<div><div><h4><strong>Meet your analytical challenges with the right vial.</strong></h4></div></div><div><div><p><strong>The right vial.&nbsp;</strong><span><strong>A world of difference.</strong></span></p><p>Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.</p><p>All Waters sample vials are held to the tightest dimensional tolerances. Manufactured via a 2-, 3-, or 4-step certification process, we ensure that Waters Certified Vials meet and maintain specified vial dimensions, levels of cleanliness and adsorption properties from batch to batch.&nbsp;Find the right vial for your application and autosampler - use our <a target="_blank" rel="noopener noreferrer" href="https://find.waters.com/VialSelector/"><strong>Vial Selector</strong></a> to find your perfect match.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_118649175c.jpg" alt="Waters CERTIFIED Vials: Table 1. Vials for Routine and Advanced Analyses." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_118649175c.jpg 245w," sizes="100vw" width="1226" height="754"></p><h3><strong>Waters LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><ul><li>Low MS interferences from known residues &amp; polymers</li><li>For routine QC and LC-MS analysis with lower analyte concentrations from 10-100s ng/ml.</li></ul><h3><strong>Waters TruView<sup>TM</sup> LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><p><span><strong>✅&nbsp;</strong></span>Low Adsorption Test</p><div><div><ul><li>Lowest MS interferences from known residues &amp; polymers</li><li>For high-end LC-MS analysis and quantification of analytes with a concentration of below 1 ng/ml with reduced adsorption of polar analytes.</li></ul><h3><strong>Waters CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><div><div><ul><li>No UV interferences caused caused by manufacturing and packaging residues</li><li>For routine QC LC-UV analysis&nbsp;of compounds in µg/mL&nbsp;concentrations.&nbsp;</li></ul><h3><strong>MAXPEAK QuanRecovery</strong></h3><ul><li>For high recovery peptide and protein quantification workflows. Reduces sample losses due to non-specific binding (NSB) and ionic interactions.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_2_4fba532335.jpg" alt="Waters CERTIFIED Vials: Vials Shapes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_2_4fba532335.jpg 245w," sizes="100vw" width="1261" height="617"></p><div><div><h3><strong>Control data quality risks and reduce unexpected or ghost peaks</strong></h3><p>Don’t let the presence of background noise impact your results, causing data quality risks and unexpected or ghost peaks. Background noise can come from many factors.&nbsp;One of the most important factors are vial and septa cleanliness, which introduces contamination peaks. Ghost peaks are introduced by analyte degradation that can be triggered by significant pH changes in the diluent. In this chromatogram, the top shows normal behavior, and the bottom chromatogram shows ghost peaks.</p><p>Waters Certified vials are cleanliness tested so you don’t have to worry about contaminant peaks. The TruView pH Control Vials are certified to minimize and control a pH shift away from the neutral.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_4_7749301ba1.jpg" alt="Waters CERTIFIED Vials: Prevent the appearance of unexpected peaks during LC/UV analysis with Waters LC/GC Certified Vials as a control strategy." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_4_7749301ba1.jpg 245w," sizes="100vw" width="1024" height="535"></p><h3><strong>More time on development. Less on troubleshooting</strong></h3><p>Stop losing valuable development time on troubleshooting due to analyte loss from non-specific adsorption. Waters TruView pH Control LCMS Certified Vials have the lowest adsorptive losses on the market, and you can rely on them to provide consistency from batch to batch and vial to vial. This chromatogram shows a comparison of adsorptive loss of chlorhexidine in a variety of vials.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg" alt="Waters CERTIFIED Vials: Comparison of adsorptive loss of chlorhexidine acetate in a variety of vials." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg 245w," sizes="100vw" width="1024" height="633"></p><div><div><h3><strong>Ideal for demanding MS work</strong></h3><p>LCMS Certified Vials are suited for analyte concentrations in the 100s ng/mL concentration. Waters LCMS Certified Vials are tested by MS scans from 250 to 1000 <i>m/z</i> with specifications set on the total ion count and presence of clusters in the high mass range. This chromatogram shows a comparison of typical MS scans of Waters LCMS Certified Vials to vials of other sources and clean solvents.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_3_4869fbf57a.jpg" alt="Waters CERTIFIED Vials: Comparing typical MS scans of Waters LCMS Certified Vials, with vials from other sources." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_3_4869fbf57a.jpg 245w," sizes="100vw" width="1024" height="406"></p><div><div><h3><strong>Stay in control of your samples' pH</strong></h3><p>The analysis of low abundance species, pH sensitive analytes or not yet well understood compound mixtures benefit from consistent and well controlled vial surfaces. The glass surface of TruView pH Control LCMS Certified Vials minimizes pH shifts away from the neutral and thus eliminates unwanted reactions and resulting ghost peaks.&nbsp;Ghost peaks are very difficult to troubleshoot.</p><p>Waters TruView pH Control LCMS Certified vials were used to analyze two compounds, drospirenone and lovastatin. The TruView pH Control LCMS Certified Vials show little to no degradant formed over the time tested. Standard glass vials showed considerable degradant formation over the same testing time with irreproducible formation of the degradant across different vials.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_6_4dc330d849.jpg" alt="Waters CERTIFIED Vials: UV peak areas of lovastatin degradant across replicate vials and different vial types. Error bars indicate standard deviation for the replicate injection peak area." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_6_4dc330d849.jpg 245w," sizes="100vw" width="1024" height="605"></p><div><div><h3><strong>Reducing adsorption starts here</strong></h3><p>Inconsistent analytical results from small molecule analyte adsorption onto the surface of glass vials can be a problem at today’s low analyte concentrations. Some scientists have even experienced total analyte loss with samples stored in vials for an extended time. The vial chemistry, specifically the&nbsp;glass surface, is the major contributor to this problem.</p><p>Polar analytes&nbsp;may adsorb to the glass vial surface by polar-polar interaction and/or ion exchange mechanisms, thereby reducing the overall amount of sample in solution. TruView Certified LCMS Vials&nbsp;reduce this problem dramatically due to a stringent manufacturing process. The process yields a glass surface that has a lower concentration of free ions on the surface.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_8_064003b933.jpg" alt="Waters CERTIFIED Vials: Nortriptyline at 1 ppb concentration in several vials. The tall peak is the initial injection; the smaller peak (overlaid) is the four-hour injection. The first two chromatograms are competitor’s vials. The third chromatogram is for the Waters TruView LCMS Certified vial. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_8_064003b933.jpg 245w," sizes="100vw" width="1912" height="1182"></p><div><div><h3><strong>No analyte left behind</strong></h3><p>Instrument development is yielding more sensitive mass spectrometers. With more sensitive instruments, analytes can be detected at pg/mL levels. At these concentrations, understanding adsorption issues is critical for good quantitative results. We tested adsorption loss for the major manufacturers and saw high sample loss across manufacturers and clear and amber glass types – with significantly less loss with Waters TruView Autosampler Vials.</p><h4><strong>Average Analyte Loss</strong></h4><p><strong>Manufacturer: Clear Glass / Amber Glass</strong></p><ul><li><strong>Vendor A</strong>: 55% / 69%</li><li><strong>Vendor B</strong>: 25% / 25%</li><li><strong>Vendor C</strong>: 54% / 74%</li><li><strong>Vendor D</strong>: 18% / 59%</li><li><strong>Vendor E</strong>: 75% / Not tested</li><li><strong>Waters TruView LCMS Certified Vial</strong>: 1% / 6%</li></ul></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Waters QuanRecovery HPS Vials & Plates

 QuanRecovery Vials and Plates minimize sample losses from NSB and ionic interactions, ensuring greater confidence in results and improved assay repeatability.

<div><div id="title-b8cf3c562d" data-locator="title-with-text"><h3><strong>Reduce sample losses due to non-specific binding (NSB)</strong></h3></div></div><div><div id="text-c1d5077d21" data-locator="text"><p><strong>Successfully quantitating proteins and peptides with LC–MS is often more challenging than doing so for small molecules. Their large and complex structure requires a different approach to LC–MS method development and may also cause other unique problems like nonspecific adsorption (or nonspecific binding). Proteins and peptides in solution tend to stick to the surfaces they encounter.</strong></p><p>Autosampler-ready QuanRecovery Vials and Plates with MaxPeak High Performance Surfaces (HPS)&nbsp;are designed to enable scientists like you to meet recovery, sensitivity and reproducibility challenges in LC-MS peptide and protein quantification. By reducing sample losses from non-specific binding (NSB) and ionic interactions, QuanRecovery Vials and Plates provide your lab greater confidence in analytical results and fewer long-term assay repeatability problems.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Quan_Recovery_HPS_Vials_and_Plates_Quan_Recovery_Vials_and_Plates_with_Max_Peak_HPS_ed65a9e3fe.jpg" alt="Waters QuanRecovery HPS Vials &amp; Plates: QuanRecovery Vials &amp; Plates with MaxPeak HPS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Quan_Recovery_HPS_Vials_and_Plates_Quan_Recovery_Vials_and_Plates_with_Max_Peak_HPS_ed65a9e3fe.jpg 234w," sizes="100vw" width="1024" height="682"></p><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-b5ef0a0cdd" data-locator="text"><div><div id="text-62116091dc" data-locator="text"><h3 data-locator="modal-title"><strong>Improved LC-MS analysis of peptides and proteins</strong></h3><p>It can be difficult to predict peptide losses due to non-specific binding and ionic interactions, as losses can be dependent on many characteristics, including pI and hydrophobicity. Demonstrated here are the recovery of four different peptides.&nbsp;The recovery of desmopressin is not affected by the sample container, while glucagon, insulin, and melittin suffer varying losses due to non-specific binding and ionic interactions in the glass and standard polypropylene containers.&nbsp;</p><p>Only QuanRecovery Vials and Plates with MaxPeak HPS protect these peptides from loss, enabling you to achieve higher recovery and improved repeatability.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Quan_Recovery_vialky_a_platicka_pro_lepsi_analyzy_proteinu_a_peptidu_caa551b7f1/Waters-QuanRecovery-vialky-a-platicka-pro-lepsi-analyzy-proteinu-a-peptidu_l.webp" alt="Waters QuanRecovery HPS Vials &amp; Plates: A comparison of the recovery of four peptides prepared in a typical LC-MS diluent and stored in various sample containers." width="1074" height="466"></p></div></div></div></div></div></div></div></div></div></div><div><div id="text-455dc5902f" data-locator="text"><h3 data-locator="modal-title"><strong>Enhanced recovery and sensitivity at high and low sample concentrations</strong></h3><p>Biomolecule sample losses are a problem at low concentrations. However, non-specific binding and ionic interactions can also cause losses at higher concentrations. Such losses not only negatively impact the assay sensitivity, they also compromise the reproducibility, precision, and accuracy of the analysis. QuanRecovery Vials and Plates with MaxPeak HPS protect your sample, ensuring improved analytical results.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Quan_Recovery_HPS_Vials_and_Plates_Improved_recovery_and_sensitivity_at_high_and_low_sample_concentrations_with_Quan_Recovery_Plates_2816689528.jpg" alt="Waters QuanRecovery HPS Vials &amp; Plates: Improved recovery and sensitivity at high and low sample concentrations with QuanRecovery Plates." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Quan_Recovery_HPS_Vials_and_Plates_Improved_recovery_and_sensitivity_at_high_and_low_sample_concentrations_with_Quan_Recovery_Plates_2816689528.jpg 221w," sizes="100vw" width="1024" height="724"></p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-9f8f97fb02" data-locator="text"><ul><li>For large molecule LC-MS bioanalysts who need the ultimate sensitivity, reproducibility and sample stability over multiple analyses.</li><li>Improve detection limits and analysis reproducibility for peptide and protein quantification with these low adsorption plates and vials.</li><li>Designed for LC-MS analysis in autosampler ready formats with low residual volumes in 700 µL 96-well plate and 300 µL sample vial formats.</li><li>Increase analyte recovery, sensitivity and reproducibility by minimizing analyte/surface interactions that can lead to sample losses with MaxPeak High Performance Surfaces (HPS).</li><li>Suitable for workflows with ACQUITY Premier Systems and Columns.</li></ul></div></div><div><div id="text-b5ef0a0cdd" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>To minimize sample losses due to non-specific binding (NSB) and ionic interactions.</p></div></div></div></div></div></div></div></div>

Waters ACQUITY UPLC H-Class PLUS System

Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution.

<div><div><h4><strong>Performance that advances your lab</strong></h4></div></div><div><div><p><strong>Whether your goal is to rapidly develop new methods or to routinely analyze large numbers of incoming samples, the ACQUITY UPLC H-Class PLUS System can help you decrease the time to result, while increasing the depth and quality of information received from your sample analysis.</strong></p><p>With the ACQUITY UPLC H-Class PLUS System, you can improve laboratory productivity by transitioning methods to UPLC/UHPLC technology, improve the characterization of your most complex samples through enhanced resolution and leverage advanced tools to simplify and streamline your method development workflow.</p><div><div><div><div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Simplify and streamline your method development workflow. The ACQUITY H-Class PLUS Quaternary System automatically screens multiple column and eluent combinations to identify the separation conditions that provided the best chromatographic resolution. The system provides on-demand solvent blending and support for any analytical LC column, making it an ideal choice for modernizing existing or developing new methods." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_5_55c4c9e990.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div><ul><li><strong>Get the flexibility of multi-solvent blending</strong> - Blend up to nine solvents with integrated solvent-select valve with the Quaternary Solvent Manager&nbsp;</li><li><strong>Deliver precise and accurate binary solvent blending</strong> - Blend up to four solvents with integrated solvent-select valve with the Binary Solvent Manager</li><li><strong>Get high-precision injections with direct inject sampling&nbsp;</strong>- The needle-in-flow path design ensures an accurate needle seal at high pressure</li><li><strong>Get accurate temperature control across the entire column</strong> - Configurable for 1 to 6 columns with active preheating</li><li><strong>Automate the formulation of mobile phases</strong> - Significantly reduce the time you spend in the prep lab with&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"> Auto•Blend Plus </a>Technology</li><li><strong>Transfer methods more easily</strong> - Easily adjust for system volume differences when transferring methods from an alternative LC system without alteration to the method table using Gradient SmartStart </li><li><strong>Wide software support</strong> – ACQUITY UPLC H-Class PLUS System is supported by  <strong>Empower, MassLynx, UNIFI</strong>, and several 3rd party software packages</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Improving laboratory productivity by transitioning methods to UPLC technology.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: A highly reliable and robust LC-MS system without any compromise in speed, resolution, or sensitivity, especially in everyday settings. The ACQUITY H-Class PLUS Binary System combines an optimized flow path resistant to clogging, stable high-pressure gradient formation, and support for sub-2-µm to 5-µm particle columns to deliver the ideal choice for reproducible everyday LC-MS analyses with any tandem quad or Q-ToF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_6_2e9f1740ab.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div><div><div><h3><strong>Discover the UPLC difference</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS System</strong> is the next evolution of ultra-performance instrumentation, providing the <strong>high resolution</strong> of a <strong>quaternary or binary liquid chromatography (LC) system</strong>.</p><p>Achieving <strong>true UPLC performance</strong> requires that system dispersion (or extra-column band spread) be matched to the peak widths associated with narrow bore columns packed with <strong>sub-2-μm particles</strong>. While other systems might be designed for high pressure, it doesn’t mean they're designed to deliver the <strong>sharp peaks of UPLC performance</strong> and the <strong>ACQUITY UPLC H-Class PLUS System</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Comparison of the same method with the same column on a low-dispersion ACQUITY UPLC H-Class PLUS System versus a higher-dispersion UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_cd9c6e5cda.jpg 245w," sizes="100vw" width="1024" height="555"></p></div></div><div><div><h3><strong>Take your methods to the next level</strong></h3><p>Leverage the benefits of <strong>UPLC technology</strong> to improve your existing <strong>HPLC methods</strong>. By scaling your methods to UPLC, your laboratory will benefit from the combination of <strong>increased resolution, sensitivity, and speed</strong> that comes with modern small particle chemistries.</p><p>Designed to accommodate all of your LC method needs, the <strong>ACQUITY UPLC H-Class PLUS System</strong> is ideally suited to <strong>future-proof your laboratory</strong>, enabling the support of existing HPLC methods now, and provide <strong>significant productivity and cost benefit</strong> when utilized for UPLC methods.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: The USP analysis of diclazuril and organic impurities was scaled from HPLC to UHPLC to UPLC. The UPLC method resulted in a 4x reduction in run time and a 10x reduction in solvent consumption resulting in improved sample throughput and reduced cost per analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_2_97e7735374.jpg 245w," sizes="100vw" width="1024" height="613"></p></div></div><div><div><h3><strong>Discover the best method for the best results</strong></h3><p>Get the <strong>versatility</strong> to discover the best set of chromatographic conditions for your sample, providing a <strong>more robust method</strong>. The flexibility of the <strong>ACQUITY UPLC H-Class PLUS Quaternary System</strong> allows you to <strong>automatically screen important method parameters</strong>, including:</p><ul><li>Up to <strong>six columns</strong> in independently temperature-controlled compartments</li><li>pH and ionic strength with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/Auto%E2%80%A2Blend-Plus/nav.htm?cid=134623262"><strong>Auto•Blend Plus</strong></a><strong> Technology</strong></li><li><strong>Optional and integrated solvent selection valve</strong> expands access to six additional mobile phase lines&nbsp;</li><li><strong>11 unique gradient profiles</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: (A) Auto·Blend Plus method gradient table for trastuzumab pH optimization. (B) pH optimization on trastuzumab charge variants separation. Gradient: 20 mM MES buffer, 50–155 mM NaCl in 15 min." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_3_fc2b3f925b.jpg 245w," sizes="100vw" width="1024" height="622"></p></div></div><div><div><h3><strong>Deliver greater speed and precision for routine analyses</strong></h3><p>The <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> combines the <strong>proven reliability and performance</strong> of the H-Class PLUS System with the <strong>precision and lowest system volume</strong> offered by our <strong>high-pressure mixing binary solvent manager</strong>, allowing you to:</p><ul><li>Accommodate the <strong>most challenging sample matrices</strong></li><li>Tackle applications with <strong>long shallow gradients</strong></li><li><strong>Improve the throughput</strong> of your methods</li></ul><p><strong>Combine </strong>the capabilities of the <strong>ACQUITY UPLC H-Class PLUS Binary System</strong> with <strong>Waters </strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Tandem-Quadrupole-%28-Triple-Quadrupole-%29-Mass-Spectrometry/nav.htm?cid=134656172"><strong>Tandem quadruple technology</strong></a><strong> </strong>for routine quantitative UPLC-MS/MS applications, so you can confidently quantify and trace components in the most complex of samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg" alt="Waters ACQUITY UPLC H-Class PLUS System: Direct transfer without a gradient delay offers the opportunity for method improvement with the analysis time going from 5 minutes to 3 minutes representing a 40% reduction in runtime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_UPLC_H_Class_PLUS_System_4_618bbb6347.jpg 245w," sizes="100vw" width="1024" height="600"></p><h3><strong>Specifications</strong></h3><ul><li><strong>Maximum operating pressure</strong>: 15,000 psi</li><li><strong>pH range</strong>: 1–12.5 (<i><span>For specific test conditions, contact your Waters sales representative)</span></i></li><li><strong>Operating flow rate range</strong>: Up to 2.2 mL/min</li><li><strong>Sample flow path</strong>: Stainless-steel</li><li><strong>Sample carryover</strong>: ≤0.002% (Caffeine) under UV conditions</li><li><strong>Sample compartment</strong>: 4–40 °C</li><li><strong>Pump options</strong>: Binary, Quaternary</li><li><strong>Solvent conditioning</strong>: Active Pre-heating</li><li><strong>Column tracking</strong>: eCord Technology tracks column information and archives column usage</li><li><strong>Column capacity</strong>: Up to 6 columns of 150 mm length and up to 4.6 mm I.D.</li><li><strong>Maximum sample capacity</strong>: Up to 20 plates (with Sample Organizer)</li><li><strong>Detector options</strong>:&nbsp;<ul><li>PDA Detector</li><li>TUV Detector</li><li>FLR Detector</li><li>RI Detector</li><li>ELS Detector</li><li>Mass Spectrometers</li></ul></li><li><strong>External control</strong>:&nbsp;<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Empower Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635">MassLynx Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect</a></li><li>UNIFI Scientific Information System</li></ul></li><li><strong>Physical specifications</strong> <strong>(QSM or BSM, SM-FTN, CHA):</strong><ul><li>Width: 34.3 cm (13.5 in.)</li><li>Height: 71.1 cm (28.0 in.)</li><li>Depth: 71.2 cm (28.0 in.)</li></ul></li></ul></div></div></div></div></div></div></div></div>

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