At MSACL 2025, a Thermo Fisher Scientific–sponsored workshop led by Qin Fu addressed one of the most persistent challenges in proteomics: how to efficiently and reproducibly translate biomarker discoveries into clinically meaningful assays. Drawing on experience spanning academia and industry—including prior work in Jennifer Van Eyk’s lab—Fu shared practical insights into building a scalable, end-to-end biomarker discovery-to-validation pipeline.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg" alt="Thermo Fisher Scientific: Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Accelerating_Biomarker_Discovery_and_Validation_From_Discovery_to_Clinical_Utility_9558364cf2.jpg 245w," sizes="100vw" width="1024" height="512">The session highlighted how emerging mass spectrometry technologies, automation, and informatics are reshaping biomarker research—reducing complexity, improving reproducibility, and accelerating the path to clinical utility.<h3>The three tiers of biomarker assays</h3>The workshop opened with a review of the widely accepted three-tier framework that guides biomarker development from early discovery through clinical validation:<h4>Tier 3 – discovery</h4>Exploratory, untargeted workflows such as data-dependent acquisition (DDA) and data-independent acquisition (DIA). These approaches prioritize breadth, enabling the identification of large-magnitude biological changes across hundreds to thousands of analytes, typically with low-to-moderate precision and without internal standards.<h4>Tier 2 – verification</h4>Research-grade targeted assays, including parallel reaction monitoring (PRM) and multiple reaction monitoring (MRM). These methods focus on tens to hundreds of analytes, delivering improved precision and repeatability to confirm trends observed during discovery.<h4>Tier 1 – validation</h4>Clinically validated assays designed to meet rigorous quality and regulatory standards. These workflows incorporate internal standards and strict quality controls to ensure quantitative reproducibility suitable for clinical and translational use.Each tier represents a critical step toward ensuring that biomarker candidates can ultimately deliver reliable patient benefit.<h3>The central challenge: from sample to signal</h3>Reliable biomarker development depends on consistency across the entire analytical workflow—from biological sample preparation to mass spectrometry data acquisition and downstream analysis. Every step introduces potential sources of variability, and minimizing this analytical noise while preserving biological signal is essential.Automation emerged as a central theme of the workshop. Beyond improving throughput, automation fundamentally enhances reproducibility. Robotic sample preparation reduces variability associated with digestion, pipetting, and handling—enabling consistent performance across hundreds or thousands of samples, a scale that is difficult to achieve manually.<h3>Technological innovation powering a paradigm shift</h3>Recent advances in mass spectrometry are enabling researchers to bridge the gap between discovery and validation more efficiently than ever before. The workshop highlighted several Thermo Fisher Scientific platforms driving this shift:<ul><li>Thermo Scientific Orbitrap Astral mass spectrometer Optimized for discovery workflows, the Astral system delivers rapid acquisition and deep proteome coverage while maintaining high precision across large cohorts.</li><li>Thermo Scientific Stellar platform Designed for high-throughput targeted quantification, the Stellar platform supports scalable PRM workflows. Features such as PRM Conductor enable adaptive retention time tracking, which is essential for robust performance in large studies.</li><li>Thermo Scientific OptaSpray Ion Source (under evaluation) A hands-free ionization source designed to deliver consistent spray performance with simplified maintenance, supporting reproducibility across thousands of injections.</li></ul>Together, these technologies create a smoother continuum across assay tiers, shortening timelines and reducing barriers to clinical translation.<h3>Case study: Inflammatory bowel disease (IBD) cohort</h3>A key highlight of the presentation was a large-scale biomarker study in inflammatory bowel disease (IBD). The team conducted a 500-sample discovery analysis, followed by validation in a 1,000-sample cohort. Discovery was performed using the Orbitrap Astral system, while targeted validation employed the Stellar platform.This integrated approach successfully confirmed established biomarkers such as C-reactive protein (CRP) while also identifying novel protein candidates with strong translational potential. Importantly, these markers demonstrated consistency across discovery and validation data sets—underscoring the power of advanced instrumentation combined with robust workflows and informatics.<h3>From high quantity to high quality</h3>Historically, biomarker discovery has involved a tradeoff between throughput and data quality. The workshop demonstrated that this compromise is no longer necessary. By integrating automated sample preparation, optimized informatics, and next-generation mass spectrometry, researchers can now generate high-quality, high-throughput data that is both scalable and reproducible.This shift enables faster discovery while increasing confidence that candidate biomarkers are ready for downstream validation and clinical follow-up.<h3>The future of biomarker translation</h3>The workshop concluded on an optimistic note. Innovations in proteomics are fundamentally transforming biomarker development—shortening timelines, reducing costs, and accelerating the transition from discovery to clinical application.By integrating platforms such as Orbitrap Astral, Stellar, and OptaSpray, Thermo Fisher Scientific is helping advance a new era of translational biomarker science—where precision, scalability, and reliability work together to deliver meaningful clinical impact.Watch the full workshop recording to <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk">explore the data, workflows, and results behind this end-to-end approach to biomarker discovery and validation.</a><h3>Intended use disclaimer</h3>General Laboratory Equipment – Not For Diagnostic Procedures. Thermo Scientific general laboratory equipment, consumables, and software are intended for research, academic, and industrial use only. These products are not designed, validated, or approved for in vitro diagnostic or clinical use. Use of these products for diagnostic purposes may result in inaccurate results and potential health and safety risks.<h3>Resources</h3>Workshop &amp; educational content<ul><li>MSACL 2025 workshop recording: <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=ziyffQzZTwk">Accelerating Biomarker Discovery and Validation</a></li><li>Other MSACL workshop recordings coming soon</li></ul>Thermo Fisher Scientific Product Pages<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2207">Thermo Scientific TSQ Certis Mass Spectrometer</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/836">Thermo Scientific Orbitrap Astral Mass Spectrometer</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1149">Thermo Scientific Stellar Mass Spectrometer</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/B51004132">Thermo Scientific OptaSpray Ion Source</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs.html">Mass spectrometer affordability programs</a> (Refurbished MS, trade-in, financing/ leasing)</li></ul>Peer-Reviewed Literature<ul><li>Baker ES et al. <a target="_blank" rel="noopener noreferrer" href="https://europepmc.org/article/MED/22943415">Mass spectrometry for translational proteomics: progress and clinical implications.</a> Genome Medicine (2012).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/clinchem/article/62/1/198/5611803">An Empirical Approach to Signature Peptide Choice for Selected Reaction Monitoring.</a> Clinical Chemistry (2016).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/mas.21750">Automated proteomic sample preparation: The key component for high throughput and quantitative mass spectrometry analysis.</a> Mass Spectrometry Reviews (2023).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.jproteome.7b00623">Highly Reproducible Automated Proteomics Sample Preparation Workflow for Quantitative Mass Spectrometry.</a> Journal of Proteome Research (2018).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202409446">A Proteomics Pipeline for Generating Clinical Grade Biomarker Candidates from DIA-MS Discovery.</a> Angewandte Chemie International Edition (2024).</li><li>Fu Q et al. <a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/anie.202507610">Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort.</a> Angewandte Chemie International Edition (2025).</li></ul><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#Omics #BiomarkerDiscovery #MassSpectrometry #ClinicalResearch</blockquote>

Accelerating Biomarker Discovery and Validation: From Discovery to Clinical Utility

Interlaboratory comparisons (ILCs) have been used for more than a century and many important concepts are linked to them. This leaflet addresses the basic terminology of ILCs, why some colloquial terms can be misleading or misunderstood, and the importance of harmonisation.&nbsp;An ‘ILC’ is the organisation, performance and evaluation of measurements or tests on the same or similar items by two or more laboratories in accordance with predetermined conditions [1]. ILCs have a variety of overall – and detailed – objectives, the three most common [2] being:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_3_9993b9fb0f.jpg" alt="Eurachem: Let’s call a PT scheme a PT scheme" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_3_9993b9fb0f.jpg 245w," sizes="100vw" width="1516" height="472"><h4>Some comparisons have special names&nbsp;</h4>The evaluation of participant (laboratory, organisation or individual) performance is typically referred to as ‘proficiency testing’ (PT) or ‘external quality assessment’ [1]. When the main objective is evaluating the performance of, for example, a candidate standard method, the ILC is often called a ‘method performance study’ or a ‘collaborative study’ [2, 3]. The former is quite clear whereas wording such as “collaborative” and “cooperative” just stresses joint effort. A project aimed at producing a new certified reference material may involve several laboratories conducting analyses on agreed properties [4]. Not surprisingly, this work is sometimes labelled as a ‘material certification study’. Special ILCs used to demonstrate measurement capabilities of National Metrology Institutes are called ‘key comparisons’, ‘supplementary comparisons’, and ‘pilot studies’ [5].&nbsp;<h4>Some terms can be confusing&nbsp;</h4>Other terms for ILCs, including ‘ring test’, ‘round robin’ and ‘circle analysis’, are common in the literature. They have, however, been used for different objectives and different designs and may be ambiguous or understood differently by laboratory staff. The use of these terms may, for example, imply a specific way of distributing the ILC sample. ISO/IEC 17043 uses ‘sequential scheme’, for a PT where a unique item is transferred between the participants and ‘simultaneous scheme’, in which similar items from a batch are distributed simultaneously to the participants [1].&nbsp;Terms like ‘measurement audit’, ‘interlaboratory testing scheme’, ‘measurement comparison scheme’, ‘rapid performance evaluation scheme’ and ‘intercalibration’ may not correctly reflect the category of laboratory involved, or the type of work participants do during the ILC.&nbsp;When in 1994 the IUPAC defined and described three major types of ‘interlaboratory studies’, the word ‘study’ was preferred to synonyms such as ‘trial’, ‘exercise’, ‘test’, ‘evaluation’ or ‘check’ [2].<h4>Let’s try to harmonise&nbsp;</h4>Many laboratory staff are unaware of official terms related to ILCs but recognise the acronym PT and words like ‘ring test’. Ideally, we would use a common scientific language, but harmonisation is time consuming. Terms appear and disappear and definitions change. The same term can be defined differently, even in different international standards. Lack of standards and guidelines in local languages can cause confusion and contribute to spreading of less appropriate terms.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_2_820043ce8b.jpg" alt="Eurachem: Let’s call a PT scheme a PT scheme" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Let_s_call_a_PT_scheme_a_PT_scheme_2_820043ce8b.jpg 234w," sizes="100vw" width="1006" height="671">Much confusion can be avoided by clear reference to relevant standards and sectoral guides. ISO/ IEC 17043 [1] and ISO 13528 [6] contain many important concepts related to PT schemes and other ILCs. Some of these are also incorporated into ISO/IEC 17025 [7]. Additional useful, and free, tools are the Eurachem PT Guide [8] and the ISO online browsing platform [9].&nbsp;In writing guidance and instructions, remember that the term ‘interlaboratory comparison’ has a broad meaning and can be used for all cases described above. Sometimes this is clear enough for the reader. In other cases, use acknowledged terms that reflect the detailed objective of the ILC. Let’s call a PT scheme a PT scheme!

Let’s call a PT scheme a PT scheme!

The countdown is on for one of the world’s leading conferences dedicated to food analysis. The 12th International Symposium on Recent Advances in Food Analysis (RAFA 2026), taking place in Prague from 3–6 November 2026, is approaching two important milestones: the Early Bird registration deadline and the deadline for oral abstract submissions, both ending on 30 June 2026. Researchers, analysts, industry professionals, regulators, and students are encouraged to secure their participation at a reduced registration rate and take advantage of the opportunity to present their latest scientific results to the international food analysis community.RAFA 2026 will once again bring together leading experts from academia, industry, and regulatory organizations to discuss the latest developments in food safety, authenticity, contaminants, non-target screening, PFAS, microplastics, food contact materials, artificial intelligence, and advanced analytical technologies. The preliminary program already features an outstanding lineup of internationally recognized speakers addressing some of the most pressing challenges in modern food analysis and food safety.<h3>Registration</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://rafa.easyevent.eu/tickets/">Register to attend RAFA 2026!</a>Early-bird registration until 30 June, 2026</blockquote>After successful submission of your registration, you will receive by e-mail (i) an automatic confirmation of receipt indicating the total amount of payment due (either for bank transfer or for on-line payment by card), (ii) login to Member section where you can administrate your profile, submit your abstracts, and from September 2026 register for satellite events, workshops and seminars. If it will not be delivered within a few minutes after submission of your registration please contact us at RAFA2026@vscht.cz.As soon as payment of registration fee is processed, you will also receive by e-mail (iii) confirmation of payment.<h4>Registration Fees</h4><ul><li>Smart rate (Until 30 June, 2026): € 655</li><li>Regular registration (Until 30 September, 2026): € 855</li><li>Late registration (From 1 October, 2026): € 955</li><li>Student rate*&nbsp;<ul><li>Until 30 June, 2026: € 465</li><li>From 1 July, 2026: € 605</li></ul></li></ul>* The proof of student status (e.g. copy of a student identify card) is requested as an attachment of the registration form.<h5>The regular registration fee will include:</h5><ul><li>Attendance at all scientific sessions, workshops, seminars, vendor seminars and other satellite events</li><li>Access to the poster and exhibition area</li><li>Conference kit (name badge, conference bag, conference documents, certificate of participation, certificate of presentation on request)</li><li>Final programme</li><li>E-Book of Abstracts</li><li>Coffee breaks</li><li>Buffet luncheons</li><li>Welcome drink</li></ul>In the registration form you can register free of charge for the welcome drink and you can also order ticket(s) for the conference dinner (€ 85).Please note that your registration is firm when your payment has been received.<h3>Abstract submission</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://rafa.easyevent.eu/tickets/">Submit your ABSTRACT HERE!</a>In order to submit an abstract, you must first register to attend RAFA 2026. After registration you will receive an access to the Member section where you can submit your abstract(s).</blockquote>&nbsp;After successful submission of your abstract you will receive an automatic confirmation of receipt of submitted abstract via e-mail. If it will not be delivered within a few minutes after submission of your abstract please check at first your spam box-mail and then contact us at RAFA2026@vscht.cz.Please ensure that your abstract does not contain spelling, grammatical or scientific errors. Even though modifications of your submitted abstract will be allowed in the Abstract section of the Member section until the deadline for the abstract submission, please be confident on the lack of errors in your final version prior to starting the submission process.The abstract will be reproduced exactly as submitted. No proofreading will be done, although some corrections may be requested by the reviewers.If you need to withdraw your abstract, a written statement reflecting the reasons for this decision must be sent to RAFA2026@vscht.cz no later than September 30, 2026.<h4>Important notice:</h4><blockquote>1 registered participant can submit no more than 2 abstracts.</blockquote>To apply for a young scientist’s oral presentation, as an indication please respect the rule that you should be born in 1991 or later.The text of the abstract should be limited to 3000 characters including spaces. Tables and pictures are not allowed.Abstracts of oral presentations and posters will be included into the "e-Book of Abstracts" only after receipt of the conference registration fee. Any payment of the registration fee has to be received until September 30, 2026, otherwise contribution(s) will not be included into the e-Book of Abstracts and the Conference programme.<h3>Program</h3><h4>Invited Speakers</h4><h5>Food allergen risk assessment: Past, present, future</h5><ul><li>Ben Remington from Remington Consulting Group B.V., Utrecht, the Netherlands &amp; University of Nebraska, USA</li></ul>Food allergy and allergen management are global public health issues, and consumer protection depends on transparent and trustworthy labelling. While 30 years of scientific advances show that low level exposures, or reference doses, are unlikely to trigger reactions in most allergic individuals, harmonized and globally aligned regulations are still needed to promote consistent allergen risk assessment and labelling decisions. This presentation will discuss the landscape of allergen risk assessment, global policy developments, current research and future needs in the area.<h5>Unmasking hidden adulteration in honey: Strategies for detecting and characterizing honeys produced from sugar-fed colonies</h5><ul><li>Oscar Nuñez Burcio from University of Barcelona, Barcelona, Spain</li></ul>From hive to jar, not all honey tells the same story. This presentation addresses hidden adulteration associated with sugar-fed bee colonies, highlighting implications for authenticity, production practices, and the need for a more precise characterization of honey to ensure consumer trust.<h5>Analytical and toxicological methods for safety of food contact materials</h5><ul><li>Erich Leitner from Graz University of Technology, Institute of Analytical Chemistry and Food Chemistry, Graz, Austria</li></ul>Food packaging plays a critical role in protecting and preserving food throughout the supply chain. All packaging materials intended to come into contact with food must comply with strict EU safety rules. Due to increased complexity of packaging solutions, lowering legal limits and increasing numbers of target compounds, we also have to adapt the strategies used to verify and guarantee the safety of these materials.<h5>Data-driven strategies to reduce complexity in non-target HRMS analysis of food samples</h5><ul><li>Anneli Kruve from Stockholm University, Stockholm, Sweden</li></ul>LC/HRMS based non-target screening can detect hundreds to thousands of chemical features in complex food and environmental samples. Investigating all of these in detail is practically impossible, so which ones to focus on? Novel computational tools developed in computational mass spectrometry allow predicting the toxicity and concentration of the detected chemical features even if these have not yet been fully structurally elucidated. Combining these predictions enables us to focus on the chemical features possessing high risk.<h5>Role of AI in the identification of emerging food systems risks</h5><ul><li>Ákos Bernard Jóźwiak from Syreon Research Institute, Budapest, Hungary</li></ul>AI-assisted evidence synthesis – spanning curated scientific evidence, exposome data, and network analysis – is the backbone of next-generation emerging chemical food safety risk identification, enabling earlier signals and more resilient surveillance systems.<h5>Challenges of microplastics analysis in the context of food safety</h5><ul><li>Dorte Herzke from Norwegian Institute of Public Health, Oslo, Norway</li></ul>Food and food packaging are major sources of micro- and nanoplastic exposure. Plastics used in processing, storage, and packaging can release particles through heat, abrasion, and degradation. Small particles below 2 µm may cross gut barriers and carry chemicals, highlighting the need for robust and sensitive measurement methods.<h5>Never-ending analytical challenges in PFAS analysis of food</h5><ul><li>Darina Dvořáková from University of Chemistry and Technology Prague, Prague, Czechia</li></ul>Exploring and monitoring PFAS in food requires advanced strategies. Combining targeted, suspect, and non-target HRMS analysis, determination of total fluorine and sum parameters, and novel sensors provides new insights into PFAS occurrence and supports food safety monitoring.<h5>An overview of the latest scientific knowledge on process contaminants in food for appropriate risk management measures</h5><ul><li>Thierry Delatour from Nestlé Research, Lausanne, Switzerland.</li></ul>Recent scientific findings related to acrylamide and furans formation, occurrence and analytical methods in food provide important insights for risk management.

Deadline for RAFA 2026 Early Registration and Oral Abstract Submission is approaching

Article

Events

Academy

Science and research

Video

RAFA provides an overview of contemporary trends in ANALYTICAL & BIOANALYTICAL STRATEGIES IN FOOD QUALITY AND SAFETY CONTROL and discusses CHALLENGES / NOVEL APPROACHES IN FOOD AND NATURAL PRODUCTS ANALYSIS.

Recent Advances in Food Analysis (RAFA)

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Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Thermo Scientific Dionex IonPac AS10 IC Columns

Analyze trace-levels of inorganic anions and organic acids using isocratic or gradient methods with the Thermo Scientific™ Dionex™ IonPac™ AS10 IC Column.

Analyze trace-levels of inorganic anions and organic acids using isocratic or gradient methods with the Thermo Scientific™ Dionex™ IonPac™ AS10 IC Column. Its high capacity permits the analysis of trace-level analytes in high-ionic-strength matrices. Use the Dionex IonPac AS10 column for the analysis of inorganic anions in high nitrate samples.<h5>Superior Chromatographic Performance in High Nitrate Samples</h5><ul><li>Excellent resolution of weakly retained low-molecular-weight aliphatic acids</li><li>Selectivity and high capacity for analysis of trace-level analytes in high-ionic-strength matrices</li><li>Strongly retains nitrate for high-resolution analysis of trace anions in nitric acid and nitrate salts</li></ul><h5>For Best Results</h5><ul><li>Use a Dionex eluent generator for simplified eluent preparation for applications using less than 100mN hydroxide</li><li>Use the Thermo Scientific™ Dionex™ Anion Self-Regenerating Suppressor (ASRS™ 300) with the Dionex IonPac AS10 column for continuous suppression of traditional eluents and more concentrated eluents up to 200mM NaOH</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 55% DVB</li><li>Column Capacity: 170 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Separation of Inorganic Anions and Organic Acids</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS10</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li><li>pH: 0 to 14</li></ul>

Thermo Scientific Dionex IonPac AS11 IC Columns

Resolve a large number of inorganic anions and organic acids in approximately 15 minutes with the Thermo Scientific Dionex IonPac AS11 Analytical & Guard Column. 

Resolve a large number of inorganic anions and organic acids in approximately 15 minutes with the Thermo Scientific™ Dionex™ IonPac™ AS11 Analytical &amp; Guard Column. The Dionex IonPac AS11 is a relatively low-capacity column designed for fast gradient screening of inorganic anions and organic acid anions in simple sample matrices such as from foods, beverages, chemical process solutions, wastewaters, brines, and power plant waters.<h5>Superior Chromatographic Performance:</h5><ul><li>Facilitates rapid analysis of organic acids and inorganic anions in well-characterized samples</li><li>Ideal for highly charged anions, including polyphosphates and polycarboxylates</li><li>Resolves organic acids and inorganic anions in complex sample matrices</li><li>Shortens analysis time and speeds throughput</li></ul><h4>Specifications</h4><ul><li>Anion Exchange Capacity: 45 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 45 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Analysis of Inorganic and Organic Acid Anions</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS11</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li><li>pH: 0 to 14</li></ul>

Thermo Scientific Dionex IonPac AS12A IC Columns

Thermo Scientific Dionex IonPac AS12A Analytical and Guard Columns resolve trace chloride and sulfate in high-carbonate samples

Separate inorganic anions and oxyhalides, such as chlorite and bromate, in environmental samples. The Thermo Scientific™ Dionex™ IonPac™ AS12A Analytical and Guard Columns resolve trace chloride and sulfate in high-carbonate samples and meet or exceed the requirements of U.S EPA Methods 300.0 (A) and (B). However, the advanced, high-capacity IonPac AS23 Carbonate Eluent Anion-Exchange column is recommended for determination of oxyhalides and inorganic anions, such as trace bromate, in ozonated drinking water.<h5>Fast Isocratic Separation of Inorganic Anions and Oxyhalides in Diverse Matrices</h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A) and (B)</li><li>Separation of common inorganic anions and oxyhalides including chlorite, bromate and chlorate in less than 12 minutes</li><li>Superior retention and quantification of fluoride</li><li>Trace analysis of chloride and sulfate in high-carbonate samples</li><li>Solvent compatibility permits easy column cleanup after the analysis of samples with hydrophobic components.</li></ul><h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x200mm, 2x200mm analytical columns</li><li>4x50mm, 2x50mm guard columns</li><li>Longer 200mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4>Specifications</h4><ul><li>Anion Exchange Capacity: 52 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 52 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>For Use With (Application): Separation of Inorganic Anions</li><li>Ion Exchange Group: Alkyl Quaternary Ammonium</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS12A</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS11-HC IC Columns

Resolve a large number of inorganic anions and organic acid anions in complex matrices with the Thermo Scientific Dionex IonPac AS11-HC Capillary, Analytical & Guard Column.

Resolve a large number of inorganic anions and organic acid anions in complex matrices with the Thermo Scientific™ Dionex™ IonPac™ AS11-HC Capillary, Analytical &amp; Guard Column. Complex sample matrices such as chemical wastewater effluents and fermentation broth solutions contain a variety of inorganic anions and organic acids. With the high-capacity Dionex IonPac AS11-HC column, you can inject higher concentration samples without column overloading or peak broadening.The Dionex IonPac AS11-HC column was specifically designed to resolve analytes in a single run using a hydroxide gradient. The high-capacity column delivers improved separation for monovalent carboxylic acids including: quinate, lactate, acetate, propionate, formate, and butyrate.<h5>High Capacity for Higher Resolution</h5><ul><li>Requires longer retention times, but with higher resolution</li><li>Facilitates rapid analysis of organic acids and anions in well-characterized samples</li><li>Ideal for organic acids and anions in complex sample matrices or uncharacterized samples</li><li>Recommended for monovalent and divalent organic acids</li></ul><h5>Reduce Operating Costs With Lower Eluent Requirements</h5>The new Dionex IonPac AS11-HC Capillary column is packed with the same material as the equivalent standard bore and microbore versions (providing the same performance as a 4mm and 2mm column) using only 1% of the eluent flow rate, which helps reduce operating costs.Use the Thermo Scientific™ Dionex™ IonPac™ ICE-AS1 or ICE-AS6 columns for organic acids in high-ionic-strength samples.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 290 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 290 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS11-HC</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS14 IC Columns

Deliver excellent results for fast isocratic separations of inorganic anions in diverse matrices with the Thermo Scientific Dionex IonPac AS14 Carbon Eluent Anion-Exchange Column.

Deliver excellent results for fast isocratic separations of inorganic anions in diverse matrices with the Thermo Scientific™ Dionex™ IonPac™ AS14 Carbon Eluent Anion-Exchange Column. This universal column for the separation of inorganic anions delivers improved peak resolution and retention of fluoride in applications performed previously with the Dionex IonPac AS4A, AS4A-SC and AS12A columns, however, the Dionex IonPac AS22 Carbonate Eluent Anion-Exchange column, an advanced carbonate eluent column, is recommended for fast analysis of inorganic anions.<h5>Fast Separation of Inorganic Anions in Diverse Matrices</h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Separation of common inorganic anions in 13 min in drinking water, wastewater, food &amp; beverages, scrubber solutions, and other diverse sample matrices</li><li>Superior retention and quantification of fluoride, glycolate, acetate, and formate</li><li>Compatible with a sodium tetraborate gradient to optimize difficult separations</li><li>Solvent compatibility permits easy column cleanup after the analysis of samples with hydrophobic components.</li></ul><h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x250mm, 2x250mm analytical columns</li><li>4x50mm, 2x50mm guard columns</li><li>Longer 25mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul>Note: Use with the Dionex IonPac AS14 Eluent Concentrate for simple, accurate eluent preparation.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 65 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 65 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>For Use With (Application): Analysis of Fluorides and Other Inorganic Anions</li><li>Ion Exchange Group: Alkyl Quaternary Ammonium</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 2 to 12, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS14</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li><li>pH: 2 to 12</li></ul>

Thermo Scientific Dionex IonPac AS14A IC Columns

Thermo Scientific Dionex IonPac AS14A IC Column is high capacity anion-exchange column for fast isocratic separation of inorganic anions in environmental matrices

Deliver fast isocratic separation of inorganic anions from diverse and complex matrices such as drinking water, wastewater, foods and beverages, and scrubber solutions with the Thermo Scientific™ Dionex™ IonPac™ AS14A Carbon Eluent Anion-Exchange Column. The Dionex IonPac AS14A column meets or exceeds the requirements of U.S EPA Method 300.0 (A). However, the Dionex IonPac AS22 Carbonate Eluent Anion-Exchange column, an advanced carbonate eluent column, is recommended for fast analysis of inorganic anions. For the fastest separation of inorganic anions using a carbonate/bicarbonate eluent, the Dionex IonPac AS22-Fast column is recommended.<h5>Fast Separation of Inorganic Anions in Diverse Matrices</h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Separation of common inorganic anions in 8 min (3 x 150mm format) or 13 min (4 x 250mm format) in diverse sample matrices</li><li>Superior retention and quantification of fluoride</li><li>Compatible with sodium or potassium hydroxide gradient to optimize difficult separations</li><li>Solvent compatibility permits easy column cleanup after the analysis of samples with hydrophobic components.</li></ul><h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x250mm, 3x150mm analytical columns</li><li>4x50mm, 3x30mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Shorter 150mm columns produce faster runs of relatively clean matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul>Note: Use with the Dionex IonPac AS14 Eluent Concentrate and the Combined Seven Anion Standard for simple, accurate eluent preparation.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 65 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 120 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkyl Quaternary Ammonium</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 2 to 11, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS14A</li><li>Format: Standard Bore</li><li>pH: 2 to 11</li></ul>

Thermo Scientific Dionex IonPac AS15 IC Columns

Determine trace-level concentrations of inorganic anions and low-molecular-weight organic acids in high-purity water matrices with the Thermo Scientific Dionex IonPac AS15 Capillary, Analytical & Guard Columns.

Determine trace-level concentrations of inorganic anions and low-molecular-weight organic acids in high-purity water matrices with the Thermo Scientific™ Dionex™ IonPac™ AS15 Capillary, Analytical &amp; Guard Columns. Specifically designed for analysis of trace anions in high-purity water matrices used by the semiconductor and power generation industries, the column delivers high sensitivity and superior resolution of early-eluting anions (e.g., fluoride, glycolate, acetate, and formate). The column is optimized for selective at an operating temperature of 30°C, and it is ideal for use with large-loop injections.<h5>Available in Multiple Formats</h5><ul><li>Dionex IonPac AS15-5μm (3x150mm) column for high efficiency, fast analysis (15 min)</li><li>Dionex IonPac AS15-9μm (2x250mm, 4x250mm, and 0.4x250mm) columns for higher-capacity applications</li><li>Dionex IonPac AS15 capillary column (0.4x250mm) delivers the performance of the standard bore version but requires only 1% of the eluent flow rate, which helps reduce operating costs</li></ul><h5>For Best Performance</h5><ul><li>Use the Thermo Scientific™ Dionex™ IonPac™ AC15 Concentrator column for ultratrace (part per trillion) analyses</li><li>Use a Dionex eluent generator for simplified eluent preparation</li><li>Use the Thermo Scientific™ Dionex™ Anion Self-Regenerating Suppressor (ASRS™ 300) or the Thermo Scientific™ Dionex™ Anion Capillary Electrolytic Suppressor (ACES™ 300) with the Dionex IonPac AS15 column for eluent suppression</li></ul><h4>Specifications</h4><ul><li>Anion Exchange Capacity: 225 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 225 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS15</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS16 IC Columns

Measure trace perchlorate and other highly polarizable anions quickly and accurately in a variety of water matrices with the Thermo Scientific Dionex IonPac AS16 IC Columns.

Measure trace perchlorate and other highly polarizable anions quickly and accurately in a variety of water matrices with the Thermo Scientific™ Dionex™ IonPac™ AS16 IC Columns . This column simplifies the determination of polarizable anions, including thiosulfate, iodide, thiocyanate, and perchlorate using an isocratic hydroxide eluent. It is ideally suited for determination of trace perchlorate in drinking water in accordance with U.S. EPA Methods 314.0 and 314.1 (Primary Method).<h5>Designed for Simple, Sensitive Analysis</h5><ul><li>Easily measure trace concentrations of perchlorate in drinking water, surface water, and ground water matrices using a large-loop injection</li><li>Separate hydrophobic anions (iodide, thiocyanate, and thiosulfate) in less than 20 min</li><li>Ideal for polyvalent anions, including polyphosphates and polycarboxylates</li><li>Ultralow hydrophobicity allows fast analysis of polarizable anions</li><li>Can be used in the second dimension of the 2D-IC method for the analysis of trace perchlorate (sub ppb) in drinking water</li></ul><h5>Available in Multiple Formats</h5><ul><li>Standard bore (4x250mm) and microbore (2x250mm) formats</li></ul><h4>Specifications</h4><ul><li>Anion Exchange Capacity: 170 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 170 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS16</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS17-C IC Columns

Quickly determine common inorganic anions in high-purity water matrices with the Thermo Scientific Dionex IonPac AS17-C column. 

Quickly determine common inorganic anions in high-purity water matrices with the Thermo Scientific™ Dionex IonPac AS17-C column. This low-capacity column is optimized for fast gradient separation of inorganic anions in simple sample matrices. It is also ideal for fast gradient separation of sulfur species, including sulfite, sulfate, and thiosulfate. The Dionex IonPac AS17C column is the recommended replacement for all Dionex IonPac AS17 column anion applications.<h5>Make Gradient Separations as Easy as Isocratic Runs</h5>The Dionex IonPac AS17-C column is designed to be used in conjunction with the Dionex Eluent Generator. The Dionex Eluent Generator automatically produces potassium hydroxide eluents from water, making gradient separations as easy as isocratic runs. Using the Dionex Eluent Generator under gradient conditions, common inorganic anions can easily be separated in a variety of sample matrices including high purity water, drinking water, wastewater, process streams, and scrubber solutions.<h5>Achieve Superior Chromatographic Performance</h5><ul><li>Fast gradient separation of inorganic anions in high purity water matrices</li><li>Easy suppression of hydroxide eluent to a very low background with the Thermo Scientific™ Dionex™ Anion Self-Regenerating Suppressor (ASRS™ 300) for trace level determinations (including fluoride) even with a large loop injection</li><li>Superior retention and quantification of fluoride, acetate, propionate, and formate</li><li>Meets performance requirements specified in U.S. EPA Method 300.0 (A)</li><li>Operates at ambient or elevated temperatures</li><li>Column selectivity is optimized for operating temperature of 30°C to ensure reproducible results</li><li>Compatible with Reagent-Free™ Ion Chromatography (RFIC™) systems</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, or for effective column clean-up</li></ul>Note: The Thermo Scientific™ Dionex™ IonPac™ AS18 column is the recommended hydroxide-selective column for determination of common anions in diverse sample matrices.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 30 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 30 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS17-C</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS4A-SC IC Columns

For fast, isocratic separation of inorganic anions in environmental waters, the Thermo Scientific Dionex IonPac AS4A-SC column was the preferred column for many years. 

For fast, isocratic separation of inorganic anions in environmental waters, the Thermo Scientific™ Dionex™ IonPac™ AS4A-SC column was the preferred column for many years. It was first introduced in 1984 and is the specified column in U.S. EPA Method 300.0 (A). However, the advanced, high-capacity Dionex IonPac AS22 Carbonate Eluent Anion-Exchange column is recommended for fast analysis of inorganic anions in diverse matrices when using carbonate eluents.<h5>Fast Isocratic Separation of Inorganic Anions in Simple Matrices</h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Methods 300.0 (A)</li><li>Separation of common inorganic anions in 10 minutes in water, food and beverages, and other diverse sample matrices</li><li>Compatible with sodium tetraborate gradient to optimize difficult separations</li><li>Solvent compatibility for easy column cleanup after the analysis of samples with hydrophobic components</li></ul><h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4×250mm, 2x250mm analytical columns</li><li>4×50mm, 2x50mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul>Note: Use with the Dionex IonPac AS4A Eluent Concentrate for simple, accurate eluent preparation.<h4>Specifications</h4><ul><li>Column Capacity: 20 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>Crosslinking: 0.5% DVB</li><li>For Use With (Application): Separation of Inorganic Anions, Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS4A-SC</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

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