EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

<div><div>Researchers led by <a target="_blank" rel="noopener noreferrer" href="https://kudova.group.uochb.cz/en">Eva Kudová</a> from IOCB Prague and Jitka Viktorová from UCT Prague have identified new androstane-based steroid derivatives that can significantly improve the effectiveness of existing antibiotics against multidrug-resistant Staphylococcus aureus.</div></div><div>The team screened dozens of natural steroidal hormones and synthetic derivatives to see whether they could block bacterial efflux pumps – mechanisms that bacteria use to eject antibiotics and survive treatment. Two compounds emerged as particularly promising: they inhibited efflux pumps and lowered the effective doses of antibiotics such as ciprofloxacin and erythromycin.Further analysis showed that one of the compounds also suppressed genes linked to bacterial virulence. Another key finding is that the most active molecules are non-toxic to human immune cells and showed no detectable endocrine activity, suggesting a favorable safety profile.These findings support the idea that rationally designed steroid-based molecules could act as antibiotic adjuvants, helping existing drugs overcome bacterial resistance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg" alt="IOCB Prague: Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg 222w," sizes="100vw" width="1258" height="886"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0223523426001613?via%3Dihub">Steroidal hormones and neurosteroids - novel therapeutic strategies in bacterial infections: Design, synthesis, and biological evaluation</a></h4>Daniela Brdová, Bára Křížkovská, Jan Špaček, Zdeněk Míchal, Eva Jablonská, Ondřej Strnad, Hana Chodounská, Eszter Szánti-Pintér, Marina Morozovová, Václav Hanžl, Jan Tkadlec, Martijn Riool, Jan Lipov, Jitka Viktorová, Eva Kudová&nbsp;Eur. J. Med. Chem., 2026, 308, 118716<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.ejmech.2026.118716">https://doi.org/10.1016/j.ejmech.2026.118716</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>The global rise of antibiotic resistance necessitates novel therapeutic strategies for infectious diseases. Inhibition of bacterial efflux pumps, which contribute to multidrug resistance, represents a promising approach to restore or even increase the efficacy of existing antibiotics. Using fluorescence-based ethidium bromide accumulation, broth microdilution, and checkerboard assays, we evaluated 26 endogenous steroidal hormones and neurosteroids, along with 30 synthetic derivatives, for their ability to enhance antibiotic susceptibility in multidrug-resistant Staphylococcus aureus. Structure-activity relationship analysis identified compounds 13 and 16 as lead candidates, exhibiting strong efflux pump inhibition and marked reductions in the minimum inhibitory concentrations of ciprofloxacin and erythromycin. Both compounds showed additive effects in checkerboard assays. Modifications at C-3 (polar substitution) and C-17 (3α,5β-stereochemistry and nonpolar substitution) were essential for potent efflux inhibition and sensitization, although these modifications were not additive when combined. Transcriptome analysis further revealed that compound 13 significantly downregulated S. aureus virulence-associated genes when administered alone or in combination with antibiotics. Cytotoxicity assessment in human peripheral blood mononuclear cells and receptor transactivation assays for estrogen, androgen, and progesterone receptors indicated that the most active derivatives were non-toxic and lacked detectable endocrine activity, suggesting a favorable safety profile. Overall, these findings support the concept that rationally designed andostane-based steroidal scaffolds can function as competitive bacterial efflux pump inhibitors and serve as potential antibiotic adjuvants to mitigate efflux-mediated resistance.<h4>Instrumentation</h4><h5>Structural characterization</h5><ul><li>AVANCE III 400 MHz NMR spectrometer (Bruker)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=LTQ+Orbitrap+XL">LTQ Orbitrap XL HRMS</a> (Thermo Fisher Scientific, ESI)</li></ul></div>

Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections

Metformin is currently the first-line oral drug of choice for the treatment of type 2 diabetes. It reduces glucose production in the liver, improves tissue sensitivity to insulin, and does not cause weight gain or hypoglycemia, which sets it apart from some other antidiabetic drugs. Moreover, its long-term beneficial effects on the risk of cardiovascular complications and mortality in people with type 2 diabetes have been well established. Researchers from the Institute of Physiology CAS (IPHYS) have identified a new group of blood metabolites that could help physicians objectively monitor whether patients with type 2 diabetes are taking their metformin as prescribed.<h4>New biomarkers for metformin use</h4>A team led by Tomáš Čajka from the Laboratory of Translational Metabolism at IPHYS analyzed plasma samples from 637 patients with type 2 diabetes treated with metformin and 143 non-diabetic controls using advanced metabolomics and lipidomics. Among 614 detected metabolites, they identified five from the group of N-lactoyl-amino acids (e.g. N‑lactoyl-phenylalanine), which had previously been seen as unknown signals due to missing reference spectra in databases. The levels of these metabolites in the blood closely reflected the plasma concentrations of metformin. In patients with the highest metformin exposure, the concentrations of these metabolites were up to 7.2 times higher than in controls.<h4>A sensitive “fingerprint” of the drug’s effect</h4>N-Lactoyl-amino acids are formed in cells by combining lactate and amino acids, thus reflecting the metformin-induced changes in cellular energy metabolism. “Importantly, even though they occur in plasma only at nanomolar concentrations, they reliably distinguish patients who take metformin regularly from those who take it irregularly or not at all,” emphasizes T. Čajka.<h4>Metabolomics in practice and international collaboration</h4>The study also provides a detailed description of broader metabolic changes in type 2 diabetes, including increases in lactate, organic acids, and branched-chain amino acids, as well as extensive remodelling of the lipid profile. In addition to T. Čajka’s team, collaborators from the Institute for Clinical and Experimental Medicine in Prague and the West Coast Metabolomics Center (University of California, Davis) also participated in the study.The results demonstrate that advanced metabolomics approaches developed at IPHYS within the CarDia project can find highly practical applications both in clinical studies and in personalized monitoring of treatment in patients with diabetes.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.70205">Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes</a></h4>Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin HaluzikClin Pharmacol Ther, 119: 1057-1069<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/cpt.70205">https://doi.org/10.1002/cpt.70205</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites. Patients were stratified by plasma metformin into sub-therapeutic, therapeutic, and supra-therapeutic groups, and associations were evaluated by multiple linear regression and composite metabolite ranking. Five previously unannotated features were structurally identified as N-lactoyl-amino acids, whose levels correlated strongly with plasma metformin (ρ = 0.42–0.55, P &lt; 0.0001) and increased up to 7.2-fold in the supra-therapeutic group (&gt; 2000 ng/mL). While N-lactoyl-amino acids were consistently detected in the nanomolar range, they still displayed robust and dose-dependent associations with metformin. Broader metabolic changes in T2D included elevated lactate, organic acids, and branched-chain amino acids, together with reduced urea cycle metabolites. Lipidomics showed increases in saturated triacylglycerols and diacylglycerols and decreases in cholesteryl esters, sphingomyelins, and phospholipids. These findings establish N-lactoyl-amino acids as robust, dose-responsive plasma biomarkers of metformin exposure. Despite being up to four orders of magnitude less abundant than their amino acid precursors, they sensitively reflect mitochondrial lactate overflow and pharmacodynamic adaptation, offering objective assessment of adherence.

New blood biomarkers reveal how faithfully diabetes patients take metformin

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Watrex SPR-200 Solvent saver

Watrex SPR-200 Solvent Recycler is designed to save up to 90% of mobile phase during isocratic HPLC.

This Solvent Recycler saves up to 90% of mobile phase by redirection of the pure solvent to the solvent reservoir during the isocratic HPLC. The stand alone device is powered by 5 V DC from power adapter or from computer USB port. Working parameters (Threshold and Delay) are easily set on the display using a membrane keyboard.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SPR_200_Solvent_saver_I_Nputs_694d991f2c.jpg" alt="Watrex: Watrex SPR-200 Solvent saver - INputs">The SPR-220™ Solvent Recycler continuously monitors the output signal of the chromatography detector and displays its current value on the built-in display. A highresolution analog-to-digital converter provides data for further evaluation in the built-in processor. If the input signal level exceeds a preset value (Threshold), the SPR-200 will redirect the flow to the waste.When the signal drops, the solvent recycler waits for the transport delay and then switches the mobile phase back to the reservoir. An autosampler injection marker connected to the SPR-200 ZERO input can be used to zero the input signal at the time of injection.<h3>FEATURES</h3><ul><li>Stand alone operation</li><li>Detachable valve</li><li>Possibility of manual Waste/Recycle switching</li></ul><h3>TECHNICAL SPECIFICATION</h3><ul><li>Detector compatibility: compatible with any HPLC detector</li><li>Connection: 1/16″ O.D. tubing, 1/4″-28 flat bottom fittings</li><li>Maximum pressure: 30 p.s.i./0,2 MPa</li><li>Wetted material: PEEK, PTFE</li><li>Input range: +/- 1 V or +/- 100 mV, user selectable</li><li>Computer connection: μUSB</li><li>TTL/contact closure input: configurable (ZERO, start, valve position)</li><li>Power: 5V DC/&lt;100 mA (power supply or computer USB port)</li><li>User interface: large character LCD alphanumeric display + membrane keypad</li></ul><h3>Ordering information:</h3><h5>PN/Component:</h5><ul><li>SPR200-001 SPR-200 Solvent Recycler, PEEK version (Price 1 250 € ex VAT)</li><li>SPR200-002 SPR-200 Solvent Recycler, PTFE version (Price 1 250 € ex VAT)</li></ul>You can also visit this product on the <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=SPR-200+Solvent&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty">Watrex website</a>.

SIELC Alltesta Cromite HPLC Analyzer

Compact and cloud-connected, the Cromite™ HPLC System delivers precise UV/Vis analysis with innovative single-ended column technology—ideal for research, QC, and education labs.

The Cromite™ HPLC System from SIELC Technologies is a compact, high-performance liquid chromatography platform engineered for research, teaching, and routine quality control. It combines professional analytical performance with intuitive operation in a lightweight, space-saving design.Designed for academic institutions, research laboratories, and QC environments in pharmaceuticals, food science, and environmental analysis, Cromite™ delivers reliable separations without the complexity of conventional full-scale systems. Its automated single-vial injection, isocratic syringe pump, and UV/Vis detection enable accurate analysis of compounds such as caffeine, vitamins, food dyes, environmental contaminants, and active pharmaceutical ingredients.Cloud-enabled control software allows users to create methods, run analyses, review chromatograms, and share data remotely from virtually any device. This connectivity makes Cromite™ well suited for distributed teams, teaching environments, and flexible laboratory setups.A key innovation is SIELC’s proprietary Single-Ended HPLC Column technology (up to 150 mm length). This design eliminates tubing and fittings, minimizes dead volume, and enables tool-free column replacement, reducing setup time and the risk of leaks. Each system is supplied with a single-ended column of choice and all essential accessories for immediate operation.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SIELC_Alltesta_Cromite_HPLC_analyzator_285f593640.jpg" alt="SIELC: Alltesta Cromite HPLC analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SIELC_Alltesta_Cromite_HPLC_analyzator_285f593640.jpg 234w," sizes="100vw" width="1536" height="1024"><h4>Key Features</h4><ul><li>Compact and Lightweight Design: Weighing only 1.45 kg and measuring 115 × 190 × 115 mm, Cromite™ fits easily into space-limited labs and classrooms.</li><li>Automated Injection: Single-vial automated injection simplifies operation and improves reproducibility.</li><li>Isocratic Syringe Pump: Flow rates from 0.1 to 4.0 mL/min with pressures up to 4000 psi ensure effective separation of complex mixtures.</li><li>UV/Vis Detection<ul><li>Standard wavelengths: 275, 460, 520, 630 nm</li><li>Custom configuration: any four wavelengths starting from 235 nm</li><li>Low noise (&lt;0.05 mAU) and 20 Hz detection rate support reliable quantification.</li></ul></li><li>Cloud-Based Software: Wi-Fi, Ethernet, and mobile connectivity enable remote method development, data analysis, and collaboration.</li><li>Single-Ended Column Technology<ul><li>Zero dead volume design</li><li>No tubing or fittings</li><li>Tool-free replacement</li><li>Supports 4.6, 3.2, and 2.1 mm ID columns up to 150 mm length</li></ul></li></ul><blockquote>We offer a special 15% discount for schools.</blockquote><h4>Examples of Alltesta™-based methods</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://chrom.app/share/#/samples/12579/injection/22619?t=3f67e3c308cc479085c836cc682e8f1a">HPLC Method of Analysis of Ascorbic Acid</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://chrom.app/share/#/samples/12533/injection/22589/?t=43cad31c0e924440a18874658565c3db">HPLC Method of Analysis of Theobromine, Theophylline, Caffeine and C7</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://chrom.app/share/#/samples/12411/injection/22415/?t=0c93f4eb855c43aebcfd4c3b1fd55ce9">HPLC Method of Analysys of Aspirine</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/HPLC_Method_for_Analysis_of_Phenylephrine_Hydrochloride_1_in_Equate_Nasal_Spray_on_Primesep_100_Column_02f2983c25.pdf">HPLC Method for Analysis of Phenylephrine Hydrochloride 1% in Equate – Nasal Spray</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/HPLC_Method_for_Analysis_of_Rockstar_Zero_Carbs_Energy_Drink_with_Caffeine_and_Taurine_on_Primesep_100_Column_c87a85a0b4.pdf">HPLC Method for Analysis of Rockstar Zero Carbs Energy Drink with Caffeine and Taurine</a></li></ul><h4>Specifications</h4><ul><li>Injection: Automatic, 1 vial</li><li>Pump: Syringe, isocratic</li><li>Flow Rate: 0.1–4.0 mL/min</li><li>Maximum Pressure: 4000 psi</li><li>Noise Level: &lt;0.05 mAU</li><li>Detection Rate: 20 Hz</li><li>Wavelengths (standard): 275, 460, 520, 630 nm</li><li>Wavelengths (custom): Any four starting from 235 nm</li><li>Supported Columns: Single-Ended HPLC Columns (4.6, 3.2, 2.1 mm ID)</li><li>Column Length: ≤150 mm</li><li>Connectivity: Wi-Fi, Ethernet, Mobile network</li><li>Power Supply: 100–240 V, 50–60 Hz</li><li>Operating Temperature: 0–40 °C</li><li>Dimensions (W × H × L): 115 × 190 × 115 mm</li><li>Weight: 1.45 kg</li></ul><h4>Typical Applications</h4><ul><li>Pharmaceutical Analysis – API identification, formulation testing, and stability studies</li><li>Environmental Testing – Detection of contaminants in water and soil</li><li>Food &amp; Beverage – Analysis of vitamins, additives, and preservatives</li><li>Academic Laboratories – Hands-on chromatographic training and research</li><li>Materials &amp; Chemical Research – Evaluation of additives, catalysts, and specialty chemicals</li></ul><blockquote>For pricing information, please contact: <a>alltesta@sielc.com</a></blockquote>

Thermo Scientific Vanquish Core HPLC System

The Vanquish Core HPLC systems provide exceptional analytical precision, detector sensitivity, and operational simplicity to enable unprecedented reliability and robustness.

Thermo Scientific™ Vanquish™ Neo UHPLC System

Take advantage of outstanding performance and productivity for all LC-MS workflows with nano-, capillary, and microflow using the Thermo Scientific™ Vanquish™ Neo UHPLC system.

ECOM L3320 HPLC Autosampler

An automatic autosampler with excellent accuracy and linearity of sample injection. Innovated needle design reduces sample contamination and µl pick-up mode achieves zero sample loss.

Autosampler L3320 is an automatic autosampler with excellent accuracy and linearity of sample injection. Innovated needle design significantly reduces sample residue contamination. µl pick-up mode achieves zero sample loss.The autosampler is designed as a&nbsp;standalone unit.The user-friendly unit features computer control and shows information about the actual status on the unit display. Automated self-checking simplifies the usage of the autosampler, there is no need for calibration or needle position setting.Rheodyne valve secures the reliable operation of the device.The unit is supported by the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity&nbsp;software</a>.<h4>Parameters</h4><ul><li>Communication: RS232,USB</li><li>Syringe volume: Standard 250μl; 100μl optional</li><li>Reproducibility: Full loop injection: RSD≤0.3%, Partial loopfill injection: RSD≤0.5%, μl pickup injection: RSD≤1%</li><li>Control:&nbsp;PC (Clarity SW)</li><li>Loop volumes: Standard 100μl; 10μl, 20μl and 50μl optional</li><li>Injection Volume: Full loop injection = loop volume, Partial loop injection = ½ of loop volume, μl pickup injection = (loop volume – 3 x needle volume)/2</li><li>Sample Capacity: 2 standard 48-vial tray (1.5ml vials)</li><li>Pressure limit: 6000 PSI</li><li>Cross Contamination: &lt; 0.02% after programmed needle wash</li><li>Weight: 17kg</li><li>Dimensions W x H x D: 453 x 359 x 244 mm (17.8 x 14.1 x 9.6”)</li><li>Linearity: 0.9999</li><li>Power supply: 100-240VAC, 50-60Hz, 110W&nbsp;</li></ul>

Waters Alliance iS HPLC System

Waters™ delivers a reliable partner for QC labs. The Alliance™ iS HPLC System enhances efficiency, reduces errors, and simplifies workflows - your new essential lab ally.

<h3>The Alliance iS HPLC System didn’t start in our lab.</h3>It started in yours.Pharmaceutical Quality Control (QC) labs face relentless demand to do more with less amid higher staff turnover, growing levels of sample complexity, and the drive to reduce errors.With regulatory scrutiny and faster time to market fueling these intense demands, the need for simplicity has never been greater.Waters™ understands the challenges you face and is ready to deliver a true ally for your laboratory. With capabilities developed specifically for the QC laboratory, the Alliance™ iS HPLC System will quickly become your favorite ally.<ul style="list-style-type:disc;"><li>Intuitively prevents up to 40% of common errors*</li><li>Provides fast, simple guidance at the point of need</li><li>Boosts productivity and capacity through effective resource utilization and error-free operation</li><li>Drives workflow efficiencies and quality improvements</li><li>Improves data integrity</li></ul>*Based on Waters’ market research in 2022, surveying 56 global Pharma QC labs running &gt;25 systems<h3>Common challenges facing the QC lab</h3>What you are telling us<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_cc30c5f925.jpg" alt="Waters Alliance iS HPLC System - What you are telling us" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_cc30c5f925.jpg 245w," sizes="100vw" width="2038" height="1132"><h3>Meet your new lab ally</h3>Intuitive and reliable, the Alliance iS HPLC System is designed to work seamlessly with Empower™ Software and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720007883en_41b7055d98/720007883en.pdf">eConnect™ Column Tag Technology</a>, unlocking unique features and functionality that eliminate the need to choose between simplicity, efficiency, and quality.<h3>Step-change the performance of your lab</h3>Achieve First Time Quality (FTQ) with the Alliance iS HPLC SystemThe Alliance iS HPLC System supports FTQ by reducing the risk of common errors and improving the reliability of analytical measurements. Your lab can reduce reagents and consumables waste, and automated system checks help to meet critical error reduction KPIs. The increase in operational efficiency and productivity will save time and money and boost the capacity of your lab.**With ease of use at the heart of the user experience, the Alliance iS HPLC System identifies potential errors earlier, reducing the number of retests and failure investigations. This supports a Quality culture resulting not only in safer products critical to human health and well-being, but also an improved working environment, directly impacting employee retention and motivation.****vs the Alliance HPLC System<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_2_44577b6737.jpg" alt="Waters Alliance iS HPLC System with bottles connected." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_2_44577b6737.jpg 234w," sizes="100vw" width="1024" height="682"><h3>The System: intuitively simple</h3><h5>System Status Lighting and Solvent Tubing Clips&nbsp;</h5>Status lighting provides you with a clear visual indication of the system status (in use, idle etc), while the color-coded solvent tubing clips ensure the tubing remains organized to enable tracing from instrument to the solvent bottle flags.<h5>Made for Empower</h5>Waters Empower Software Suite helps your entire laboratory operate better, with the industry’s most advanced data acquisition, management, processing, analytics, and reporting capabilities. Empower Software provides you an environment where your records are traceable, so you always have full control of your most critical asset - your data.<h5>waters_connect™ System Monitoring&nbsp;</h5>Maximize lab productivity - utilize resources more effectively with real-time lab management from anywhere, anytime. System Monitoring provides intuitive and centralized access to detailed Empower Software instrument information via the waters_connect Cloud Platform, without compromising security or compliance.<h5>Intelligent Method Translator App&nbsp;</h5>Working with Empower Software, the iMTA enables you to create an Alliance iS HPLC System Instrument Method directly from a Waters or other third-party LC system. Basic chromatographic conditions are automatically transferred for you, and the new Empower instrument method can be reported, providing traceability to the original method for compliance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_with_bottles_connected_and_the_doors_open_ff4184918a.jpg" alt="Waters Alliance iS HPLC System with bottles connected and the doors open." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_with_bottles_connected_and_the_doors_open_ff4184918a.jpg 234w," sizes="100vw" width="1024" height="682"><h3>Say ‘hi’ to your lab ally</h3><h5>Intuitive touchscreen&nbsp;</h5>An easy-to-use, advanced touchscreen integrates with Empower Software and provides easy-to-follow steps. Pre-run checks for common errors such as missing vials, incorrect column, and qualification/preventative maintenance requirements enable you to catch these mistakes before they result in a sample analysis failure, preventing re-runs.<h5>Help at your fingertips&nbsp;</h5>The Alliance iS HPLC System support journey delivers smart on-board technology that digitally brings you straight to the information you need at the new Waters Help Center. Train and troubleshoot with ease, knowing that Waters will support you at every stage.<h5>Smart column capabilities&nbsp;</h5>Ensure complete column traceability and facilitate post-run troubleshooting with the eConnect HPLC Columns. Ready-to-use from the box, eConnect columns are securely fitted with an NFC-enabled eConnect device tag, ensuring they are always automatically identified, verified, and tracked by the system. These second-generation smart columns propel today’s QC laboratory toward an entirely digital platform and away from manual logbooks.<h3>Enjoy stress-free analysis</h3>The Alliance iS HPLC System keeps you and your lab stress-free and running smoothly with an intuitive touchscreen that supports the productivity and efficiency of your lab.<ul><li>Start your day easily with a system guided start-up.</li><li>Pre-run checks to minimize sample analysis failures due to human error.</li><li>When issues arise, Alliance iS HPLC System provides you with information about what needs attention.</li><li>Guided workflows provide step-by-step guidance on how to resolve common issues.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_2_0e64835283.jpg" alt="Waters Alliance iS HPLC System - Enjoy stress-free analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_2_0e64835283.jpg 204w," sizes="100vw" width="1388" height="1063"><h3>Built to perform, time after time</h3><h4>Intuitive innovation</h4>Developed with the singular goal of providing innovation that solves the problems that matter in the QC lab, the Alliance iS HPLC System includes a range of new and unique features.&nbsp;<ul><li>New electronics to enable the Alliance iS HPLC System smart features (including advanced touchscreen, eConnect Column Tag Technology, and unparalleled interactivity with Empower Software)</li><li>Redesigned check valves and mixer for increased performance and robustness</li><li>Faster detector warm-up time and reduced drift to ensure you’re up and running quickly, for as long as your analysis requires</li><li>Robust performance when operating at the extremes of the Column Heater Cooler and Sample Manager temperature ranges</li><li>Class leading carryover performance and injection precision</li></ul><figure class="image"><img style="aspect-ratio:1561/740;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_3_9aab20fd13.jpg" alt="Waters Alliance iS HPLC System - Overlay of 42 injections of gradient performance mix over 44 hours demonstrated RT repeatability of 0.5% RSD on the Alliance iS HPLC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_3_9aab20fd13.jpg 245w," sizes="100vw" width="1561" height="740"></figure><h3>Alliance iS HPLC System gives you so much more</h3>Unlock new potential with Empower SoftwareThe Alliance iS HPLC System works exclusively with our <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008057en_af76145fe7/720008057en.pdf">Empower Software</a> version 3 Feature Release 4 or later, with fully enabled and differentiated features, starting with eConnect Technology. Empower Software elevates your quality, your business, and your lab.<ul style="list-style-type:disc;"><li>Intuitive method matching</li><li>Bi-directional touchscreen interactivity</li><li>Column tracking and history</li><li>Enhanced instrument traceability</li><li>Pre-run checks</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_4_430a084194.jpg" alt="Waters Alliance iS HPLC System gives you so much more." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_4_430a084194.jpg 245w," sizes="100vw" width="1385" height="674"><h3>Help at your fingertips</h3>From onscreen to onsite, we’re there for you.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_5_df4f1467ed.jpg" alt="Waters Alliance iS HPLC System - From onscreen to onsite, we’re there for you." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_5_df4f1467ed.jpg 245w," sizes="100vw" width="1550" height="910">Maintain peak performance, minimize unexpected downtime, and ensure regulatory compliance of your AllianceTM iS HPLC System by partnering with Waters Service. Waters FlexCHOICETM Full-Service Plan for Regulated Laboratories includes:<ul style="list-style-type:disc;"><li>Yearly Waters Performance Maintenance</li><li>Priority* remote and onsite service including all parts, labor and travel</li><li>Full suite of compliance services</li><li>Discounts on future hardware upgrades and user training</li><li>Optional coverage available:<ul><li>Additional Performance Maintenance visits</li><li>Two business day on-site response time**</li></ul></li></ul>Priority over non-contract customers **May not be available in all areas<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_first_system_designed_for_Empower_the_Alliance_i_S_HPLC_System_features_intuitive_simplicity_built_specifically_for_QC_laboratories_112259fad6.jpg" alt="Waters Alliance iS HPLC System - The first system designed for Empower, the Alliance iS HPLC System features intuitive simplicity built specifically for QC laboratories." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_first_system_designed_for_Empower_the_Alliance_i_S_HPLC_System_features_intuitive_simplicity_built_specifically_for_QC_laboratories_112259fad6.jpg 234w," sizes="100vw" width="1024" height="682">

Thermo Scientific Vanquish Duo UHPLC Systems

A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance.

<h3>Optimize your productivity</h3>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;At the same time, advancements and innovations are needed to improve operational efficiency and performance. How do you accomplish this? It’s easy with the Thermo Scientific™ Vanquish™ High-throughput LC systems built for enhanced productivity. Vanquish High-throughput LC systems combine individual Vanquish components and software wizards to deliver increased throughput or detector utilization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"><h3>Two flow paths for maximized productivity</h3>Your laboratory may be facing increased pressure to improve working efficiency and deal with limiting resources, such as budget, space, or manpower. Vanquish High-throughput LC systems are designed to overcome these limitations by providing multiple flow paths for parallelization of specific stages of the LC run.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"><h4>Unique dual technology</h4>The Vanquish platform contains two unique dual modules. Vanquish dual pumps merge two individual, low pressure mixing pumps in one housing enabling separate eluents and gradients for each pump.Vanquish dual split samplers possess two independently controlled injection units including separate injection valves and injection needles. Used in Dual LC and LC-MS workflows only, this enables high throughput and extensive sample characterization workflows.<h3>Two configurations to best serve your needs</h3>Vanquish High-throughput workflows are configured with Thermo Scientific™ Vanquish™ Core system, Thermo Scientific™ Vanquish™ Flex system or Thermo Scientific™ Vanquish™ Horizon system modules. Both workflows make use of two pumps to increase instrument productivity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"><h4>Vanquish Duo UHPLC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li>Sampler: Dual split sampler</li><li>Detector: Two out of the complete detector portfolio</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4>Vanquish Tandem LC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li>Sampler: Split sampler</li><li>Detector: One out of the complete detector portfolio and/or one mass spectrometer</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3>Vanquish Duo UHPLC systems</h3>A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance. The unique Vanquish Duo UHPLC system will:<ul><li>Improve return on investment by reducing cost per sample</li><li>Increase sample throughput without changing validated methods</li><li>Increase capacity without sacrificing bench space</li><li>Accelerate your method development process</li><li>Analyze the same set of samples with multiple methods, reducing sample preparation time and maximizing sample knowledge</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg 245w," sizes="100vw" width="1678" height="512"><h4>What can you do with a Vanquish Duo UHPLC system?</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: What can you do with a Vanquish Duo UHPLC system?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg 245w," sizes="100vw" width="1604" height="658"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two independent assays run simultaneously from a single sample on one LC instrument to deepen your sample knowledge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg 245w," sizes="100vw" width="1372" height="385"><h4>Complete control with just a few clicks</h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a> delivers industry-leading ease-of-use for the Vanquish Duo system. Independently control the two channels of the Vanquish Duo system from a single interface with full traceability of all actions that is 21 CFR Part 11 compliant.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Easy-to-use and intuitive system control of the Dual LC workflow within Chromeleon CDS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg 245w," sizes="100vw" width="1190" height="632"><h3>See the Vanquish Duo UHPLC system</h3>The Vanquish Duo UHPLC system has been built to utilize a wide range of analytical detectors, including mass spectrometry (MS), diode array detection (DAD), charged aerosol detection (CAD), variable wavelength detection (VWD), and fluorescence detection (FLD).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: See the Vanquish Duo UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg 174w," sizes="100vw" width="939" height="841"><h5>1. Vanquish Solvent Monitor</h5>Use the Vanquish Solvent Monitor to increase your regulatory compliance, productivity, and safety of your laboratory. That device guarantees that your HPLC systems will never run dry and the waste will not spill over during your analysis, reducing loss of valuable measurement time and sample material.<h5>2. Vanquish User Interface</h5>With the Vanquish User Interface, you are the master of your LC instrument. The display always shows you the key parameters of your instrument such as flow and pressure and guides you in a visual step-by-step video tutorial through key maintenance tasks.<h5>3. Versatile detection capabilities</h5>Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitate multiple detector methodologies. Vanquish Duo UHPLC systems can be used with any two detectors out of the broad detector portfolio including MS, DAD, VWD, FLD and CAD.<h5>4. Compatible with your software infrastructure</h5>A Vanquish Duo UHPLC system can be operated in various software environments including the latest Chromeleon software feature release, Chromeleon CDS long-term, and extended support version and Waters Empower.<h5>5. Versatile column management</h5>Greater column capacity (two 30 cm columns or a greater number of shorter columns per compartment), plus class-leading temperature range and temperature stability.<h5>6. Delivering powerful separations</h5>Run samples with two similar or different columns to increase throughput or maximize output. Setup with optional second compartment for independent column temperatures.<h5>7. Easier operation</h5>Patented tool-free Thermo Scientific™ Viper™ Fingertight Fittings with near-zero dead volume operation and ergonomic design.<h5>8. Unique Thermo Scientific™ SmartInject technology</h5>Superior retention time precision and enhanced column protection with intelligent SmartInject technology on both flow paths.<h5>9. Two proprietary injection valves</h5>Two separate injection valves with no shared fluidics allowing full application flexibility, including individual eluents, wash liquids and loop sizes.<h5>10. Easier sample handling</h5>Automated barcode reader to eliminate tedious rack configuration.<h5>11. Higher sample capacity</h5>High sample capacity is standard (four plates versus two plates on industry average). Increase capacity further with the optional Thermo Scientific™ Vanquish™ Charger module.<h5>12. Accurate flow for more data confidence</h5>The flow is delivered by a dual pump offering two truly individual devices in a single housing with ternary gradient proportioning.<h5>13. Simple maintenance</h5>Module maintenance is reduced to a minimum and can be worked on without instrument de-stacking, plus smart light bars on the front of the system provide instant system status update.<h5>14. Keep the lab tidy</h5>The built-in drawer stores accessories, related documents, or any other useful material for the system.<h3>Thermo Scientific LC portfolio overview</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660">

Thermo Scientific Vanquish FLEX UHPLC System

Whether you are analyzing innovative biotherapeutics or novel chemical medicines, method development with Thermo Scientific™ Vanquish™ Flex™ UHPLC system has never been easier.

Thermo Scientific Vanquish Horizon UHPLC System

Designed with innovative technology and fine detail, the Vanquish Horizon UHPLC delivers outstanding precision, sensitivity, and simplicity for unmatched performance and robustness.

ARC Solvere Universal HPLC Detector

The Solvere™ is a new LC detector that brings the benefits of the Flame Ionization Detector (FID) to LC. 
Using ARC’s expertise in catalysis and reactor design, a novel method was developed for removing volatile compounds, which allows for the use of both aqueous and organic solvents with the detector. 
Non-volatile components in the sample stream are transformed into the gas phase, converted to methane, and then detected by the FID with a linear range of five orders of magnitude.
ARC Solvere is designed for quantitation of compounds where GC ends with a range up to large 1M+ Da molecules. In addition, Solvere works with a myriad of mobile phases, additives, and gradients, with unprecedented linear range, uniformity and robustness.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ARC_Koncept_detekce_pomoci_HPLC_FID_detektoru_Solvere_1090d61827/ARC-Koncept-detekce-pomoci-HPLC-FID-detektoru-Solvere.jpg" alt="ARC: The concept of HPLC - FID detector Solvere"/>
<h3>Why is it important?</h3>
<ul>
<li>Mobile phases are effectively separated from non-volatile analytes</li>
<li>Analytes are converted into methane for universal FID detection</li>
<li>Compatible with gradients and organic solvents</li>
<li>A variety of molecules such as proteins, peptides, and sugars give a universal carbon response</li>
</ul>
<blockquote>
FOR USE WITH ANY LC MODEL
</blockquote>
<h3>Benefits of the Solvere</h3>
<ul>
<li>Analyte response independent of mobile phase composition</li>
<li>Conversion of analytes to methane for universal FID response</li>
<li>5 orders of magnitude range</li>
<li>~10 ppm LOD</li>
<li>Standalone and automated</li>
</ul>
<h3>Solvere - Universal FID for HPLC</h3>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ARC_Ukazka_detekce_Sacharozy_pomoci_Solvere_detektoru_pro_HPLC_21106ae2ae/ARC-Ukazka-detekce-Sacharozy-pomoci-Solvere-detektoru-pro-HPLC.jpg" alt="ARC: Example of Sacharose Analysis Using Solvere Detector for HPLC"/>

Products focused on HPLC - page 6

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