KNAUER AZURA Autosampler AS 6.1L

The KNAUER AZURA® AS 6.1L is a high-performance autosampler designed for automated sample injection in HPLC/UHPLC systems, offering high capacity, precision, and flexibility for both routine and high-throughput applications.

The autosampler supports:

• up to 768 sample positions (microtiter plates)
• up to 108 standard 1.5 mL vials

A highly effective internal and external needle wash system minimizes carryover to extremely low levels. The system is also fast, with a complete injection cycle taking less than one minute, including needle washing.

Three injection modes are supported:

• full loop filling (highest precision)
• partial loop filling (variable volumes)
• µl pickup (loss-free injection of small volumes)

The integrated ILD™ (Intermediate Loop Decompression) valve ensures accurate high-pressure injections without sample dilution and reduces pressure spikes, protecting the column.

Key Features

• Autosampler for HPLC/UHPLC systems
• Up to 768 sample positions
• Up to 108 vials (1.5 mL)
• Ultra-low carryover (< 0.0003%)
• Fast injection cycle (< 1 min)
• 3 injection modes (full loop, partial loop, µl pickup)
• ILD™ technology for high-pressure injection
• PASA™ (pressure-assisted sample aspiration)
• Optional sample cooling (4–40 °C)
• Missing vial/plate detection
• Supports precolumn derivatization

Technical Specifications

Sample Injection

• Injection volume range: 0.1 µl – 10 mL
• Precision:
  • Full loop: < 0.3% RSD
  • Partial loop: < 0.5% RSD
  • µl pickup: < 1.0% RSD
• Accuracy: 0.2 µl (250 µl syringe)

Performance

• Carryover:
  • < 0.0015% (standard)
  • < 0.0003% (extended wash)
• Injections per vial: max. 9
• Cycle time:
  • 7 s (same vial)
  • 14 s (different vials)
  • < 60 s total

Capacity & Compatibility

• Microtiter plates: ANSI SLAS standard
• Max vial/plate height: 47 mm

Additional Features

• Headspace pressure (bubble prevention)
• Precolumn derivatization
• Sample tray cooling (optional, 4–40 °C)
• Vial detection sensor

Materials

• ETFE, PTFE, stainless steel, glass, Vespel
• Wide chemical compatibility

Control & Communication

• LAN / Ethernet
• Analog inputs
• TTL inputs (start, stop, freeze)
• Relay output (alarm, marker)

Operating Conditions

• Temperature: 10–40 °C
• Humidity: 20–80%