News from LabRulezLCMS Library - Week 15, 2026

<p><strong>Traditional protein purification workflows in many laboratories still rely on ultracentrifugation and long incubation steps. These approaches often involve multi-step protocols, extended processing times, and the use of specialized equipment. As a result, workflows can become complex, time-consuming, and prone to variability.</strong></p><p>Magnetic bead-based protein purification offers a faster, simpler, and more efficient alternative by enabling selective capture and rapid magnetic separation.</p><h3><strong>Limitations of Conventional Protein Cleanup Methods</strong></h3><p><strong>In standard laboratory workflows, protein cleanup typically involves:</strong></p><ul><li>Multiple processing steps</li><li>Centrifugation and column equilibration</li><li>Dependence on specialized instrumentation</li><li>Long processing times</li></ul><p><strong>These factors introduce several challenges:</strong></p><ul><li>Increased complexity of workflows</li><li>Variability between runs, reducing reproducibility</li><li>Risk of sample loss during transfers, especially for small sample volumes or scarce targets</li><li>Limited throughput due to manual handling</li></ul><h3><strong>Principle of Magnetic Bead-Based Purification</strong></h3><p>Magnetic beads enable selective protein capture through surface functionalization.</p><p>Each bead is coated with <strong>streptavidin</strong>, allowing the attachment of a <strong>biotinylated ligand</strong>. This ligand can be selected based on the target analyte and may include:</p><ul><li>Antibodies</li><li>Aptamers</li><li>Antigen fragments</li></ul><p>This functionalization step provides the beads with the specificity required to bind the target analyte.</p><h3><strong>Materials and Key Components</strong></h3><h4><strong>Magnetic Beads</strong></h4><ul><li>Streptavidin-coated surface</li><li>Functionalized with biotinylated ligands</li></ul><h3><strong>Ligands</strong></h3><ul><li>Selected for target specificity</li><li>Attached to beads prior to purification</li></ul><h3><strong>Step-by-Step Procedure</strong></h3><h4><strong>1. Bead Activation</strong></h4><p>Load the biotinylated ligand onto the streptavidin-coated magnetic beads to confer specificity.</p><h4><strong>2. Washing</strong></h4><p>Remove impurities after ligand loading to prepare the beads for interaction with the sample.</p><h4><strong>3. Incubation with Sample</strong></h4><p>Incubate the functionalized beads with the sample to allow binding between the ligand and the target analyte.</p><h4><strong>4. Magnetic Separation</strong></h4><p>Place the sample on a magnet:</p><ul><li>Magnetic beads (with bound analyte) are attracted to the vessel wall</li><li>The liquid phase can be separated easily</li></ul><h4><strong>5. Washing</strong></h4><p>Wash the beads while they remain immobilized by the magnetic field to remove:</p><ul><li>Weak interactions</li><li>Non-specific binding</li></ul><h4><strong>6. Elution</strong></h4><p>Add an elution solvent to release the purified analyte from the beads.</p><h3><strong>Downstream Applications</strong></h3><p>After elution, the purified sample is ready for further analysis, including:</p><ul><li>LC-MS</li><li>Western blot</li><li>ELISA</li><li>Activity assays</li></ul><h4><strong>Advantages of Magnetic Bead-Based Workflows</strong></h4><p>Magnetic bead-based purification offers several key benefits:</p><h4><strong>Speed and Simplicity</strong></h4><ul><li>No centrifugation required</li><li>No complex instrumentation needed</li></ul><h4><strong>Improved Reproducibility</strong></h4><ul><li>Consistent magnetic separation</li><li>Reduced variability between runs</li></ul><h4><strong>Reduced Sample Loss</strong></h4><ul><li>Fewer transfer steps</li><li>Suitable for small or scarce samples</li></ul><h4><strong>Scalability and Throughput</strong></h4><ul><li>Compatible with automation</li><li>Supports microplate formats:<ul><li>96-well plates</li><li>384-well plates</li></ul></li></ul><h3><strong>Biozen™ Magnetic Beads Features</strong></h3><p>Phenomenex <strong>Biozen™ magnetic beads</strong> incorporate several design features:</p><ul><li><strong>Hydrophilic co-polymer surface</strong><ul><li>Reduces non-specific hydrophobic interactions</li></ul></li><li><strong>Biotinylated BSA spacer</strong><ul><li>Acts as a linker to streptavidin</li><li>Helps orient capture ligands</li></ul></li><li><strong>Monodispersed capture ligands</strong><ul><li>Optimized binding capacity</li></ul></li></ul><p>These features contribute to:</p><ul><li>Reduced non-specific binding</li><li>Improved capture consistency</li><li>Cleaner eluates</li></ul><h3><strong>When to Use Magnetic Beads</strong></h3><p>Magnetic bead-based purification is particularly suitable when:</p><ul><li>Sample volumes are small</li><li>Fast turnaround is required</li><li>Minimal equipment is preferred</li><li>High-throughput workflows are needed</li></ul><h3><strong>Conclusion</strong></h3><p>Magnetic bead-based protein purification simplifies traditional workflows by eliminating centrifugation and reducing complexity. Through selective capture and efficient magnetic separation, it enables faster processing, improved reproducibility, and compatibility with high-throughput and automated systems.</p>

Magnetic Bead-Based Protein Purification: A Faster and More Efficient Workflow

Microplastics and Nanomaterials: Understanding Emerging Contaminants in Environmental Testing

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<p><strong>In recent years, glucagon-like peptide-1 receptor (GLP-1R) agonists have gained significant attention because of their effectiveness to treat obesity and type 2 diabetes. The global market for GLP-1 analogues is projected to grow rapidly, reaching $260 billion by 2034. Developing sensitive bioanalytical assays to determine pharmacokinetics and toxicokinetics is crucial for advancing these medications.&nbsp;</strong></p><p>Traditionally, the plasma concentration of GLP-1 analogs was measured by ligand binding assay, which requires time to develop antibody and lack selectivity and specificity. Liquid chromatography-mass spectrometry (LC/MS), which is used for sequence identification of GLP-1 receptor agonists, has emerged as an alternative methodology to precise quantify these molecules in biological matrix because of its superior sensitivity, wide dynamic range, and high specificity. Here we present an automated workflow, which combines automation and LC/MS technologies, to quantify GLP-1 analog drug in human plasma by using an Agilent 1290 Infinity II Bio LC and an Agilent 6495D triple quadrupole system (Figure 1). Our results indicate that this automated LC/MS workflow can enhance assay sensitivity by five times compared to traditional organic solvent precipitation.&nbsp;</p><p>This workflow can be used for quantitative analysis of GLP-1 therapeutics without the need to have specific antibody while providing excellent sensitivity, high specificity and fast method development, which will play a crucial role in drug discovery and development.</p><blockquote><p><strong>Presenter: </strong>Xi Qiu, PhD (LC-MS Application Scientist, Agilent Technologies, Inc.)</p><p>Xi Qiu is application scientist at Agilent, he has extensive experience using LC-MS for large molecules analysis including protein, protein conjugates, peptide, and oligos. He earned his Ph.D. degree from the department of Pharmacognosy and Medicinal Chemistry at University of Illinois at Chicago focusing on benefits and safety of botanical dietary supplements and herbal-drug interactions. After graduation, he did his postdoc training at Pfizer and Bristol Myers Squibb where he worked on drug transporters protein expression analysis in tissues as well as drug induced liver injury mechanism. He then worked for two major contract research organizations leading their large molecule LC-MS group performing protein, protein conjugates, peptide, and oligos pharmacokinetics/toxicokinetics analysis under GLP/regulated environment. Prior to joining Agilent, he worked at Johnson and Johnson where he focused on large molecule quantification using LC-MS at intact and peptide level.</p></blockquote>

Agilent Technologies: Comprehensive workflow for Automated Sample Cleanup and Sensitive Quantitation of Glucagon-like peptide-1 (GLP-1) Analogs from Plasma

Comprehensive workflow for Automated Sample Cleanup and Sensitive Quantitation of Glucagon-like peptide-1 (GLP-1) Analogs from Plasma

Discover automated LC/MS approach for GLP-1 bioanalysis with Agilent, delivering higher sensitivity, specificity, and assay development without antibodies.

Automated Sample Cleanup & Sensitive Quantitation of GLP-1

<div><h4><strong>Navigating Challenges and Opportunities for Environmental Testing Labs Under the Revised EU Water Framework Directive</strong></h4><p><strong>The European Commission’s proposed updates to the Water Framework, Groundwater, and Environmental Quality Standards Directives are bringing new responsibilities and opportunities for environmental testing labs. With expanded pollutant lists - including PFAS, pharmaceuticals, and pesticide metabolites - and stricter monitoring and reporting requirements, the landscape of water analysis is rapidly evolving.</strong></p><p>Join the 4th Waters Environmental Webinar Series to explore how your lab can navigate these challenges and turn regulatory change into opportunity.</p><p>Register for free and partner with us to shape the future of European water quality.</p><h5><strong>Why Attend</strong></h5><p>Stay ahead of new EU regulatory demands with insights from leading experts. Gain practical guidance, share experiences with peers, and prepare your lab for the next generation of water quality standards.</p><h5><strong>Highlights</strong></h5><ul><li>New pollutant categories and analytical challenges</li><li>Updates to monitoring protocols and reporting</li><li>Innovative methods to meet revised Environmental Quality Standards</li><li>Strategic guidance for compliance and adaptation</li></ul><p><strong>Lead the change in water analysis—stay ahead, stay compliant, and make a real impact.</strong></p><h4><strong>EPISODE 2: PFAS in the Environment: A Deep Dive into Analysis, Regulation, and Real-World Data</strong></h4><h4><strong>What you Will Learn</strong></h4><ul><li>How to maintain sub-ng/L LOQs in water samples with direct injection</li><li>How an extended number of PFAS and Relevant Potency Factors in the upcoming EU Water Framework Directive can be addressed</li></ul><blockquote><p><strong>Presenter:</strong> Jana Kováčová (PFAS Lead for Continental Europe, ALS Czech Republic)</p><p>Jana Kováčová is an analytical chemist with over 15 years of experience in method development and validation. She earned her MSc and PhD from the University of Chemistry and Technology, Prague (UCT Prague), where she specialized in analytical methods for pesticide residue determination in water and food matrices of both plant and animal origin.</p><p>In 2020, Jana joined ALS Czech Republic as a Validation Specialist within the environmental analytical innovations group, later transitioning to a full-time focus on PFAS (per- and polyfluoroalkyl substances) analytics. In 2022, she was appointed Supervisor of the PFAS Section.</p><p>Currently, Jana serves as the PFAS Lead for Continental Europe. In this role, she coordinates ALS’s PFAS analytical activities across the region, acting as a key technical representative for PFAS topics. She supports laboratories and clients with strategic guidance and data interpretation, aligns testing approaches across multiple sites, and ensures consistent, high-quality delivery. To stay at the forefront of the field, Jana closely monitors legislative updates and emerging trends, sharing her expertise through client webinars, seminars, and presentations at scientific conferences</p><p><strong>Presenter: </strong>Sara Beverly (Principal Sales Application Chemist, Waters)</p><p>In her current position, Sara is a Principal Sales Application Chemist specializing in food and environmental LC-MS/MS based applications within the Waters UK and Ireland demo laboratory. Sara has worked in F&amp;E analysis with various research interests including the development of both multi-residue HRMS screening and targeted LC/GC MS based methods for the past 25 years in both the government and private sectors. Prior to joining Waters Sara was employed as a Lead Scientist at the Food and Environment Research Agency (FERA, Defra, UK) for 14 years. Sara has participated in EU Food and Veterinary Office (FVO) audit inspections, was an expert on behalf of the International Atomic Energy Agency (IAEA) and a member of the EuroResidue conference scientific committee.</p><p><strong>Presenter: </strong>Claudia Rathmann (Principal F&amp;E Market Development Manager, Waters Corporation)</p><p>Experienced and passionate analytical science professional with over 20 years of technical and strategic expertise in food and environmental applications. Currently serving as Principal Market Development Manager at Waters Corporation, Claudia specializes in connecting customers with product management to deliver innovative solutions for complex analytical challenges. With a strong scientific foundation and a proven track record in both technical and marketing roles, Claudia bridges the gap between customer needs and product innovation across the EMEA region.</p></blockquote></div>

PFAS in the Environment: A Deep Dive into Analysis, Regulation, and Real-World Data

Explore PFAS analysis, regulation, and real-world data under the revised EU Water Framework Directive in Episode 2 of the Waters Environmental Webinar Series.

PFAS in Environment: Analysis, Regulation

<p><strong>Join us for Part 1 of our three-part Single-Cell Proteomics Webinar Series, designed to guide researchers through the technologies, workflows, and analytical strategies enabling deeper biological insights at single cell resolution. This introductory session provides a comprehensive overview of the end-to-end workflow and establishes the foundation for the more advanced topics that will follow in subsequent webinars.</strong></p><p>In this session, we will <strong>walk through the complete single-cell proteomics workflow</strong>, from initial sample preparation to liquid chromatography, mass spectrometry, and data analysis. Attendees will see how each component contributes to data quality, sensitivity, and scalability, and how Thermo Fisher Scientific’s integrated portfolio is purpose-built to support high-confidence single-cell protein quantification.</p><h4><strong>Why attend?</strong></h4><p>Participants will gain a clear understanding of:</p><ul><li>How each step in the workflow influences overall data quality and biological interpretation.</li><li>The latest technologies and best practices for generating reproducible, high-sensitivity single-cell proteomics data.</li><li>How Thermo Fisher Scientific’s tools work together seamlessly to deliver actionable insights.</li></ul><p>The session will conclude with a live Q&amp;A, providing participants the opportunity to engage directly with the speaker.</p><p>Whether you are establishing a single-cell proteomics workflow for the first time or looking to optimize an existing platform, this foundational session will equip you with the knowledge needed to navigate the full process with confidence.</p><blockquote><p><span><strong>Presenter:</strong> Bernard Delanghe (Scientific Lead, Proteomics Workflow Applications, Thermo Fisher Scientific)</span></p><p><span>Bernard Delanghe specializes in single-cell proteomics workflows, bringing together advanced mass spectrometry and data analysis approaches. With over 20 years of experience in mass spectrometry and bioinformatics, Bernard is based in Bremen, Germany and has held multiple leadership roles across proteomics hardware and software. He was recognized with the 2018 European Proteomics Association Industry Award for his contributions to Thermo Scientific™ Proteome Discoverer™ software.</span></p></blockquote>

Thermo Fisher Scientific: Single-cell proteomics

Optimizing Every Step: An End-to-End Workflow for High-Confidence Single-Cell Proteomics

Single-cell proteomics webinar: end-to-end workflow from sample prep to LC-MS and data analysis using Thermo Fisher Scientific solutions. Live Q&A included.

Workflow for High-Confidence Single-Cell Proteomics

<p><strong>In Part 2 of our three-part Single-Cell Proteomics Master Class Series, we move beyond foundational workflows to explore real-world applications led by experts actively advancing the field. Featuring Ryan Kelly, PhD (Brigham Young University) and Sarah Sipe, PhD (Parallel Squared Technology Institute), this session highlights how single-cell proteomics is being applied in practice to address complex biological questions.</strong></p><p>Drawing from their own research and facility experience, our guest speakers will share practical case studies, challenges, and strategies for maximizing data quality, throughput, and biological insight—providing attendees with actionable takeaways they can apply immediately.</p><h4><strong>Why attend?</strong></h4><p>Participants will walk away with:</p><ul><li>A clearer picture of real-world challenges and solutions when implementing single-cell proteomics.</li><li>Proven strategies used by experts to maximize data quality, throughput, and interpretation.</li><li>Inspiring examples of how single-cell proteomics is enabling breakthroughs in biology and disease research.</li><li>Practical takeaways that can be applied immediately in your own lab or workflow development.</li><li>An opportunity to engage with the experts in a live Q&amp;A.</li></ul><p>Whether you are preparing to launch a single-cell proteomics program or looking for ways to accelerate ongoing studies, this session provides actionable knowledge from researchers who are already driving innovation in the field.</p><blockquote><p><span><strong>Presenter:</strong> </span>Ryan Kelly, PhD (Professor, Brigham Young University)</p><p>Ryan Kelly is a professor in the Department of Chemistry and Biochemistry at Brigham Young University. His recent research efforts have focused on single-cell and spatial proteomics, which have involved tailoring sample preparation, separations, ionization and mass spectrometry acquisition for low-input samples.</p><p><span><strong>Presenter:</strong>&nbsp;</span>Sarah Sipe, PhD (Head of Mass Spectrometry, Parallel Squared Technology Institute)</p><p>Sarah is a mass spectrometrist with 10 years of experience spanning analysis of primary explosives and drugs to proteins and viruses. Now, Sarah is the Head of Mass Spectrometry at Parallel Squared Technology Institute, where she is pushing the limits of current technologies for total characterization of the single cell proteome.</p><p><strong>Moderator:</strong> Bernard Delanghe (Scientific Lead, Proteomics Workflow Applications, Thermo Fisher Scientific)</p><p>Bernard Delanghe specializes in single-cell proteomics workflows, bringing together advanced mass spectrometry and data analysis approaches. With over 20 years of experience in mass spectrometry and bioinformatics, Bernard is based in Bremen, Germany and has held multiple leadership roles across proteomics hardware and software. He was recognized with the 2018 European Proteomics Association Industry Award for his contributions to Thermo Scientific™ Proteome Discoverer™ software.</p></blockquote>

Real-World Breakthroughs: Expert-Led Applications in Single-Cell Proteomics

Single-cell proteomics webinar Part 2: real-world case studies, expert strategies and practical tips to improve data quality, throughput and biological insight.

Expert-Led Applications in Single-Cell Proteomics

<h4><strong>Food Safety Webinar Series: When Food Meets the Lab</strong></h4><p><strong>Food testing in the region still revolves around “legacy” contaminants that decide release, rejection, and recall discussions - veterinary drug residues, pesticide residues and fumigants, and toxic elements including species-sensitive forms, in different food matrices. This 3-part series is built for audiences where regulatory expectations reference Codex-based frameworks, country-specific legislative guidelines, and import/export-market requirements that influence testing scope, reporting limits, and confirmation criteria. Each webinar focuses on the analytical factors that drive outcomes: matrix effects and co-extractives, trace-level quantitation, transition/ion-ratio checks, interference control, and reportable result logic.</strong></p><p>Keynote expert speakers will set the regulatory context, give a glimpse of the current trends, and future implications. Agilent workflow segments map these needs to sample preparation nuances, LC-MS/MS for multi-class residues, GC-MS/MS and headspace GC for residue/fumigant markers, and ICP-MS plus LC-ICP-MS for heavy metals and speciation, including QC structures and data review patterns used in high-throughput labs, to name a few.</p><h5><strong>Webinar Series Details</strong></h5><ul><li>Register once to attend the complete 3-part series</li><li>Submit your questions beforehand</li><li>Access recorded sessions anytime within one year</li><li>Certificate of attendance will be provided to all attendees</li></ul><h4><strong>Part 1: Veterinary Drugs Edition</strong></h4><p>Veterinary drug residue monitoring increasingly demands broad coverage across classes (β-lactams, sulfonamides, tetracyclines, quinolones, macrolides, nitroimidazoles, chloramphenicol-type compounds and others) at low reporting levels in seafood, dairy and meat matrices. Regulatory context spans Codex-oriented residue frameworks and national controls such as residue provisions under EU and FSSAI, with additional buyer-driven lists and decision rules influencing what labs must report. This session also focuses on the LC-MS/MS methods for multi-class screening and confirmation.</p><blockquote><p><strong>Presenter: </strong>Dr. Niladri Sekhar Chatterjee (Senior Scientist, ICAR-CIFT, Kochi, India)</p><p><strong>Presenter:&nbsp;</strong>Dr. Prasanth Joseph (Application Engineer, LC/MS, Agilent Technologies, India)</p></blockquote>

Agilent Technologies: Food Safety Webinar Series: When Food Meets the Lab

Veterinary Drugs Edition

Veterinary drug residues webinar: LC-MS/MS screening and confirmation in seafood, dairy and meat under Codex, EU and FSSAI regulations.

<p><strong>The end-to-end sample journey represents a structured and traceable pathway that ensures every sample is managed with accuracy, integrity, and compliance from the moment an analysis request is raised to the secure archival of data. This comprehensive approach enables laboratories to deliver reliable results while maintaining operational efficiency and regulatory confidence.</strong></p><h4><strong>Why is this webinar a must‑attend?</strong></h4><p>Join us for this insightful webinar where you’ll explore essential elements of the Digital &amp; Automated Lab, including:</p><ul><li>Efficient management of analysis requests and sample registration, integrated with inventory management.</li><li>Streamlined processes for sample receipt and verification.</li><li>Automation in sample preparation and end‑to‑end sample tracking within chromatography workflows.</li><li>Comprehensive data handling from acquisition and review to reporting, storage, and archiving.</li></ul><p>By overseeing the sample journey from the initial analysis request through to final archival, you ensure complete traceability, stronger data integrity, and improved operational performance. This structured lifecycle not only reinforces compliance and quality standards but also builds stakeholder confidence by guaranteeing that every sample is handled with accuracy and accountability.</p><p>Register now and learn how to turn your scattered digital lab workflows into a connected, holistic, and automated lab ecosystem.</p><blockquote><p><strong>Presenter: </strong>Dr. Nirmal Thakker (Technical Application Support Specialist - Chromatography, Dissolution &amp; Lab Informatics, Agilent Technologies)</p><p>Dr. Nirmal has done his PhD in quality assurance and pharmacy and his master's in pharmacy from the University of Pune. He has more than 15 years of overall industrial experience working in analytical research &amp; development for renowned multinational pharma companies like Glenmark, Torrent, and Piramal. He has also worked with Spinco Biotech as an application specialist for LC. Presently, he is working with Agilent Technologies as a technical application support specialist for chromatography, dissolution, and lab informatics. He has expertise in chromatography, QbD, method transfer, and mass spectrometry.</p><p><strong>Presenter: </strong>Mr. Amit Ghate (Application Specialist - Lab Informatics, Agilent Technologies)</p><p>Amit Ghate is currently working as Lab Informatics Application Specialist at Agilent Technologies. Amit comes from analytical software background where he has an in-depth knowledge of variety of software like Chromatography Data Systems, Data Management, LIMS, Electronic Lab Notebook, databases, reports and Compliance. Prior to joining Agilent, Amit worked with Persistent Systems Ltd as a Project Manager for software support and services. He has done his Masters in Bioinformatics from University of Pune. His main areas of interest is in providing workflow solutions and enabling digital transformation of labs.</p></blockquote>

Agilent Technologies: Automation at the Next Level: Never Lose Track of Your Sample

Automation at the Next Level: Never Lose Track of Your Sample

Webinar on digital lab automation, covering end-to-end sample tracking, chromatography workflows, data integrity, and compliance.

Automation: Never Lose Track of Your Sample

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Ion Chromatography (IC) is a critical analytical technique for ensuring drug product safety through accurate and reliable nitrite analysis. This webinar explores how IC is applied across pharmaceutical workflows to quantify nitrite in water, excipients, and finished drug products—supporting effective monitoring and control of nitrosamine impurity risk during manufacturing and storage.</strong></p><p>Attendees will learn how streamlined IC workflows, combined with conductivity, UV-Vis, and mass spectrometry detection, enable sensitive and robust nitrite quantification. The session highlights analytical capabilities, best practices, and practical considerations for implementing IC methods that enhance data confidence, support regulatory compliance, and improve overall product quality.</p><blockquote><p><strong>Presenter: </strong>Chanakya Thaker (Product Applications Specialist, Thermo Fisher Scientific)</p><p>Chanakya Thaker is a Product Applications Scientist within the IC/SP Applications Development team at the Ion Chromatography and Sample Preparation (ICSP) Business Unit, based in Mumbai, India.</p><p>With over 15 years of extensive experience in Ion Chromatography (IC) and Sample Preparation (SP), Chanakya brings deep technical expertise and leadership to his role. He began his career with Dionex, which later became part of Thermo Fisher Scientific, as an Applications Specialist. Over the years, he has successfully advanced into roles that include managing applications teams and overseeing laboratory operations for the IC/SP portfolio at the Center of Excellence in Mumbai.</p><p>He holds a Master of Science in Analytical Chemistry from the University of Mumbai and an MBA in Marketing from ITM Vocational University, Vadodara. In recognition of his contributions to life sciences, he has been awarded an Honorary Doctorate in Life Sciences by the CCU Institute, Florida.</p><p>Chanakya is passionate about advancing analytical technologies, mentoring teams, and driving customer success through innovative solutions. His work continues to support Thermo Fisher Scientific’s mission of enabling customers to make the world healthier, cleaner, and safer.</p><p><strong>Moderator:</strong> Lizzie Gallagher Cagney (Vertical Marketing Manager, Pharma and BioPharma, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: IC Nitrite Analysis: Streamlined Workflows for Reliable Quantification

IC Nitrite Analysis: Streamlined Workflows for Reliable Quantification

This webinar explores how IC is applied across pharmaceutical workflows to quantify nitrite in water, excipients, and finished drug products

IC Nitrite Analysis

<p><strong>Lipid nanoparticle (LNP) payloads are the top choice when it comes to delivering a wide range of nucleic acid therapeutics, like RNA and plasmid DNA (pDNA). But when it comes to characterizing LNPs, assays for size, payload quantification and encapsulation efficiency (EE%) are split up in different steps that slow down any workflow. This split‑assay approach adds complexity, from increased pipetting steps to surfactants that alter pDNA structure and reduce reproducibility and sample throughput. As LNP programs scale up, researchers need simpler, faster LNP characterization in an EE% method that works with any nucleic acid payload.</strong></p><p>In this SelectScience® webinar, Dr. Kevin Lance, Director of Product Management at Unchained Labs, will present new data showing how Stunner AF measures EE% for both RNA‑ and pDNA‑containing LNPs without surfactants, and will demonstrate how avoiding surfactant‑driven particle disruption creates a platform EE% assay that also allows simultaneous reads on size and aggregation from the same measurement. You will learn how to integrate Stunner AF into RNA‑ and pDNA‑LNP screening, formulation optimization, and QC workflows to capture more LNP data in far less time.</p><h4><strong>Key learning objectives:</strong></h4><ul><li>Learn how to characterize size, payload amount, and encapsulation efficiency in a single, one-instrument assay.</li><li>Understand the challenges with pDNA payloads and what steps to take to overcome them.</li><li>Explore the challenges and latest approaches in UV/Vis quantification of LNPs and their payloads.</li><li>Understand how surfactant‑free EE% measurements preserve particle integrity for both RNA‑ and pDNA‑LNPs.</li><li>Learn how to streamline high‑throughput LNP screening with up to 44 samples plus standards on a single 96‑well plate.</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>Formulation and analytical scientists developing and optimizing biologic drug products – including conjugated LNPs, novel formulations, stability studies, excipient screening, and biophysical characterization.</li><li>Process development teams translating early formulations into scalable, manufacturable processes.</li></ul><h4><strong>Certificate of attendance</strong></h4><p>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.</p><p>If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.</p><h4><strong>Webinar details</strong></h4><ul><li><strong>Cost:</strong> Free to attend</li><li><strong>Location:</strong> Online</li><li><strong>Duration: </strong>60 minutes</li></ul><p><i>Registration is required to secure your place. If you register but cannot attend live, you will receive a link to the on‑demand recording once it becomes available.</i></p><blockquote><p><strong>Presenter: </strong>Dr. Kevin Lance (Director, Product Management, Unchained Labs)</p><p>Dr. Kevin Lance covers the Stunner portfolio globally at Unchained Labs. His expertise includes biophysical characterization of proteins, nucleic acids, viral vectors, and LNPs. Prior to Unchained Labs, his research experience covered the fields of sustained antibody delivery and nanotechnology. He earned his Ph.D. in Bioengineering from the joint UC Berkeley – UCSF Bioengineering Graduate Program.&nbsp;</p><p><strong>Moderator: </strong>Olivia Long (Editorial Team, SelectScience)</p></blockquote>

SelectScience: Supercharge LNP EE% and size characterization on Stunner AF

Supercharge LNP EE% and size characterization on Stunner AF

Streamline RNA and pDNA LNP characterization with surfactant-free EE% measurement, size and aggregation in one assay using Stunner AF.

<h4><strong>The Problem</strong></h4><p>Lab automation promises speed and scale, but too often it operates without intelligence. Researchers must translate scientific intent into rigid workflows, scripts, and parameters — requiring deep expertise and constant manual intervention. As experiments grow more complex, automation becomes harder to adapt, forcing scientists to rely on guesswork and slowing iteration.</p><h4><strong>The Solution</strong></h4><p>Stuntman brings native AI into automation to fundamentally change how experiments are run. With built-in intelligence, Stuntman allows researchers to describe their intent in plain language and have experiments designed, executed and analyzed end-to-end. Stuntman creates workflows, runs experiments, logs results, and hands data back for AI-driven interpretation – guiding experiments forward with clarity, adaptability, and purpose.</p><h4><strong>The Proof</strong></h4><p>In this webinar, see how Stuntman turns ideas into executable experiments across pharma, biopharma, materials, energy, consumer goods workflows, and more. Learn how Stuntman’s built-in AI enables experiment design, automated execution and rapid iteration — all on a single, integrated platform.</p><h4><strong>Key Learning Objectives:</strong></h4><ul><li>Understand why traditional lab automation struggles to scale with experimental complexity and where intelligence is missing.</li><li>See how Stuntman embeds native AI into automation workflows to translate scientific intent into executable experiments.</li><li>Learn how a fully integrated platform connects experiment design, execution, data logging, and AI-driven iteration across industries.</li></ul><blockquote><p><strong>Presenter: </strong>Ruja Shrestha (Product Manager, Unchained Labs)</p><p><strong>Presenter:&nbsp;</strong>Sara Kobilka (Contributing Editor, C&amp;EN Media Group)</p></blockquote>

C&EN: Explode into AI-driven Automation with Stuntman

Explode into AI-driven Automation with Stuntman

AI-powered lab automation with Stuntman—design, execute, and iterate experiments end-to-end on one integrated platform.

<h4><strong>Are you interested in automating your NGS workflow but don’t operate a high throughput laboratory?</strong></h4><p><strong>Join our upcoming webinar for an introduction to the Agilent Magnis, a fully automated NGS library preparation instrument that processes up to 8 samples per run with minimal hands on time.</strong></p><p>In the webinar we will share real-life experience using the Agilent Magnis system for automated NGS library preparation in a clinical diagnostics laboratory.</p><p>After a short introduction to the University Hospital Osijek and its molecular testing activities, the talk outlines the clinical and operational context of routine NGS testing. It will highlight the transition from manual to automated workflows, showing how the Magnis system improves efficiency, reproducibility, standardization, and hands-on time.</p><p>Practical diagnostic examples demonstrate how Magnis enables reliable and consistent NGS library preparation under real clinical conditions, offering guidance for laboratories considering automation.</p><h5><strong>What to Expect</strong></h5><ul><li><strong>Product Overview:</strong> Our Product Manager will provide a concise introduction to the Magnis system and its capabilities.</li><li><strong>Real World User Experiences: </strong>Hear directly from customers who have integrated the Magnis into their workflows.&nbsp;</li><li>How a large laboratory in South Africa increased efficiency and reproducibility.</li><li>How a Molecular Pathology lab in Croatia achieved a smooth and confident start in NGS.</li></ul><blockquote><p><strong>Presenter: </strong>Dr. Martin Judex (Channel Partner Manager DGG, Agilent Technologies)</p><p>After studying Biology at the University of Regensburg in Germany, Martin earned his PhD at the University Hospital Regensburg, where he focused on gene expression studies in samples from patients with rheumatoid arthritis. He continued this research as a postdoctoral fellow in San Diego, USA, and later in Munich, Germany, before beginning his sales career at Stratagene.</p><p>When Stratagene was acquired by Agilent, Martin advanced through several sales positions within the company. He currently serves as Channel Partner Manager for Eastern European countries—initially for Genomics, and since 2024 also for Pathology.</p><p><strong>Presenter:&nbsp;</strong>Matt Wang (Product Manager, Agilent Technologies)</p><p>Matt Wang is a Senior Product Manager at Agilent Technologies, where he drives product strategy for next‑generation sequencing (NGS) automation. He leads system architecture and workflow integration for the Magnis NGS Prep System and oversees its global deployment, including expansion into developing markets and OEM partnerships in Greater China. His expertise spans FDA medical device compliance, clinical LDT verification and validation, and integration of LIMS and cybersecurity requirements.</p><p>Matt holds an MBA from the University of California, Irvine, and a bachelor’s degree in Bioengineering from the University of California, San Diego.</p><p><strong>Presenter:&nbsp;</strong>Roberto Pereira, PhD (Senior Field Application Scientist, Diagnostech, South Africa)</p><p>Roberto completed his PhD in Molecular Medicine at the University of the Witwatersrand’s HIV Pathogenesis Research Unit in South Africa, where his research focused on HIV–immune system interactions and HIV vaccine development. His PhD work involved the expression, characterisation and immunogenicity testing of an HIV vaccine immunogen in a non-human primate model. He joined Diagnostech as a Field Application Scientist in 2021, supporting their Pathology portfolio for several years before moving over to the Molecular team to support their NGS customer base. In this role, he continues to grow his expertise in molecular technologies, with a particular focus on next-generation sequencing workflows and applications.</p><p><strong>Presenter:&nbsp;</strong>Jasmina Rajc, MD,PhD (Department Head, Pathology and Forensic medicine, University Hospital Osijek, Croatia)</p><p>Jasminais a specialist in pathological anatomy with extensive clinical and academic experience. She is currently the Head of the Department of Pathology and Forensic Medicine at University Hospital Osijek and an Assistant Professor at the Faculty of Medicine, Josip Juraj Strossmayer University of Osijek in Croatia. Her professional interests include oncopathology, molecular diagnostics, and the evolving role of pathologists in comprehensive genomic profiling. She is actively involved in clinical and scientific research, including national and international studies.</p></blockquote>

Agilent Technologies: Improve Your NGS Workflow With The Magnis

Improve Your NGS Workflow With The Magnis

In the webinar we will share real-life experience using the Agilent Magnis system for automated NGS library preparation in a clinical diagnostics laboratory.

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