<div><div><div><p><strong>Our immune system is incredibly powerful: among other things, it can recognize and destroy cancer cells. But tumors can be just as effective at avoiding detection – they build “invisibility shields” to protect themselves from attack.</strong></p></div></div><div><p>One breakthrough in cancer therapy has been immune checkpoint inhibitors (ICIs), drugs that reactivate immune T cells and help them fight tumors again. However, only about 20–50% of patients respond well to this treatment. Researchers are therefore seeking alternative therapeutic strategies. A small and well-known molecule called adenosine plays a key role in these efforts.</p><p>When tumor cells are stressed or dying, they release ATP, which is normally a signal that something is wrong in the tissue. But in the tumor microenvironment, ATP gets rapidly broken down by two enzymes, CD39 and CD73. Released adenosine acts like a chemical “calm-down” signal, binds to immune cells (T cells, NK cells, and others), and tells them to slow down, reducing their ability to kill cancer cells. Targeting CD73 therefore represents a promising strategy for developing new cancer treatments.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="IOCB Prague: Development of potent inhibitors to boost the immune system's ability to fight cancer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363"></p><p>At IOCB Prague, interdisciplinary teams led by Jan Řezáč, Jan Konvalinka, and Michal Hocek used a newly developed high-throughput screening method to test over 5,000 compounds, identifying two ribonucleoside derivatives as promising CD73 inhibitors.</p><p>The scientists then improved the compounds’ activity by carefully modifying the ribonucleoside scaffold with bulky (het)aryl groups. Further optimization improved the pharmacokinetic properties of these compounds, yielding inhibitors with low clearance, long half-life, high solubility, and strong selectivity over related enzymes such as CD39.</p><p>In cellular experiments, the compounds reduced adenosine production in cancer cells, restored T cell activation, and showed no toxicity toward human fibroblasts. The most active compound showed a single-digit picomolar inhibition constant (Ki).</p><p>These findings establish a strong foundation for further in vivo efficacy and combination studies, which will explore the therapeutic potential of this novel inhibitor class.</p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707"><strong>Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates</strong></a></h4><p>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal Hocek</p><p><i><span><strong>ACS Pharmacol. Transl. Sci.</strong></span></i><strong> </strong><span><strong>2026, 9, 1, 191–213</strong></span></p><p><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>CD73 generates immunosuppressive adenosine in the tumor microenvironment and is a promising target for cancer immunotherapy. We have designed and systematically studied diverse 2-substituted 7-deazapurine ribonucleoside 5′-<i>O</i>-bisphosphonates bearing a variety of (het)aryl groups at position 6 and discovered their highly potent and selective CD73 inhibition activity. The most active compounds (with single-digit picomolar <i>K</i><sub>i</sub>) contained bicyclic (het)aryl groups at position 6 in combination with chlorine at position 2. Further optimization of pharmacokinetic properties identified inhibitors with low clearance, long half-life, high solubility, and excellent selectivity over CD39 and NTPDase3. They effectively suppressed adenosine formation in MDA-MB-231 cells, rescued CD8<sup>+</sup> T cell activation, and were nontoxic to human fibroblasts. Overall, their profile compares favorably with <strong>AB680</strong>, a CD73 inhibitor currently in phase I/II clinical trials.</p></div>

Development of potent inhibitors to boost the immune system's ability to fight cancer

<p><strong>In the week of April 13, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Agilent Technologies: The Journey of Safer Science through Safer Labs</strong></h5><ul><li>Tu, 14.4.2026 07:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6104">Registration</a></li></ul><p>Agilent Safer Labs webinar highlights best practices in lab safety, including handling, storage, and instrumentation, helping professionals build safer, more efficient laboratory environments.</p><h5><strong>2. Phenomenex: Strategies to Mitigate Sporadic PFAS Contamination in Analytical Workflows</strong></h5><ul><li>We, 15.4.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6095">Registration</a></li></ul><p>Discover how PFAS contamination enters LC-MS workflows and learn practical strategies to identify sources, prevent false positives, and ensure reliable PFAS analysis.</p><h5><strong>3. SCIEX: Tracking irrigation-related contaminants in water and soils (QTOF-MS)</strong></h5><ul><li>We, 15.4.2026 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6033">Registration</a></li></ul><p>Join this webinar to hear about benefits of ZenoTOF 7600 system for the analysis of pharmaceuticals and pesticides in wastewater, soils and crops.</p><h5><strong>4. Thermo Fisher Scientific: Imaging and top-down analysis of intact protein complexes in tissue</strong></h5><ul><li>Th, 16.4.2026 12:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6059">Registration</a></li></ul><p>Join this webinar to hear about latest methods and advances for probing intact protein complexes in tissue using in situ native mass spectrometry.</p><h5><strong>5. C&amp;EN: Precision Lab Solutions for High-End Optics and Coatings</strong></h5><ul><li>Th, 16.4.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6096">Registration</a></li></ul><p>Join this presentation and open discussion with industry-leading experts Patrick Muller and Kieran Evans – leaders in UV/Vis and IR analytical methods and testing techniques.</p><h5><strong>6. Agilent Technologies: Accelerating GLP-1 Analog Impurity Profiling with the Agilent Pro IQ Plus Followed by Detailed Sequence Analysis using Electron Capture Dissociation</strong></h5><ul><li>Th, 16.4.2026 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5997">Registration</a></li></ul><p>Accelerate GLP-1 impurity profiling with single quad screening and LC/Q-TOF ExD analysis. Learn how ECD improves sequence confirmation and modification localization.</p><h5><strong>7. Agilent Technologies: Quantifying GLP-1 Peptides in Plasma: Bioanalytical Workflows for PK and Development</strong></h5><ul><li>Fr, 17.4.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5944">Registration</a></li></ul><p>Peptide 360 Episode 3 webinar on LC-MS bioanalysis of GLP-1 peptides in plasma for PK studies and development decisions.</p>

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<p><strong>This study introduces atmospheric solids analysis probe high-resolution tandem mass spectrometry with cyclic ion mobility as a novel approach for characterizing Asian lacquers. Applied to 27 historical samples from Japan, China, Vietnam, and Myanmar, the method enabled classification by geographic origin based on phenol and benzenediol derivatives.</strong></p><p>In addition to lacquer identification, the technique simultaneously detected pigments such as arsenic sulfides and associated resins, providing comprehensive chemical insight. This approach expands analytical capabilities for cultural heritage studies, supporting restoration, conservation, and art historical research.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572"><strong>Characterization of Asian lacquers by atmospheric solids analysis probe high resolution tandem mass spectrometry coupled with cyclic ion mobility separation</strong></a></h4><p>Vojtěch Zemek, Radek Ryšánek, Petra Krejčí, Lukáš Kučera, Jana Nádvorníková, Adéla Tůmová, Helena Heroldová, Adriana Stříbrná, Petr Bednář</p><p>Journal of Cultural Heritage, 77, 2026, 187-196</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.culher.2025.11.012">https://doi.org/10.1016/j.culher.2025.11.012</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><div><p>In recent years, an expansion of ambient pressure ionization mass spectrometry in various areas is observed [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0024"><span>24</span></a>,<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0025"><span>25</span></a>]. Atmospheric solids analysis probe mass spectrometry (ASAP-MS) is a powerful technique for direct analysis of even very complex samples, such as polymers [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0026"><span>26</span></a>], foods [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0027"><span>27</span></a>], or petrochemical sources and products [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0024"><span>24</span></a>]. ASAP ionization technique is a modification of atmospheric pressure chemical modification (APCI). In conventional arrangement, the sample is attached to a sampling probe tip (a standard melting point capillary is inserted into powder or liquid sample that sticks to its surface) and the probe is consequently placed into the ion source (commonly adapted ESI or APCI source). The analytes are released into the gas phase using hot gas (nitrogen) and ionized in the corona discharge. The formed ions (quasimolecular ions, radical cations or radical anions) are then transferred to the evacuated part of mass spectrometer [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0024"><span>24</span></a>,<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0025"><span>25</span></a>,<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0028"><span>28</span></a>]. Note that especially at higher vaporization temperatures a portion of the analytes is pyrolyzed and a mixture of parent ions and pyrolysis product ions is commonly observed in the ASAP-MS spectra [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0029"><span>29</span></a>]. The main feature of this direct MS mode is a fast detection of the formed products (including those with a higher mass and perhaps a shorter lifetime). In contrast, due to chromatographic separation in py-GC/MS, only relatively stable and volatile products are detected (the chromatographic step provides an additional selectivity here). In addition, electron impact ionization produces significantly different spectra profiles compared to the atmospheric pressure chemical ionization ongoing in the ASAP source. Both techniques are to a certain extent complementary [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0024"><span>24</span></a>,<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0025"><span>25</span></a>,<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0030"><span>30</span></a>].</p><p>There is a direct possibility of coupling mass spectrometry with ion mobility spectrometry (IMS) to significantly improve the selectivity of analysis (and, to certain extent, to compensate the advantage of the chromatographic step in py-GC/MS while maintaining the direct MS analysis speed). During an ion mobility spectrometry experiment, ions of analytes are flying through the ion mobility cell (e.g., a drift tube or a closed-loop path within a traveling wave ion guide in case of the cyclic ion mobility cell) filled with buffer gas (e.g. helium). In this process, ions collide with the buffer gas. These collisions slow down the ions differently based on their size, shape and charge. Ion mobility spectrometry therefore allows separation of the present analytes in the gas phase according to their collision cross sections (CCS). It also allows separation of isomeric compounds and filtration of the matrix signals, resulting in a higher quality of the MS and MS/MS spectra [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0031"><span>[31]</span></a>, <a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0032"><span>[32]</span></a>, <a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0033"><span>[33]</span></a>].</p><p>ASAP-MS has a high potential for the study of protective and decorative layers on the surfaces of historical objects. To the best of our knowledge, however, ASAP-MS and ASAP-IMS-MS have never been used for characterization of lacquers. This paper deals with the development of ASAP-MS method for characterization of Asian lacquers and its application for classification of oriental historical objects.</p><h4><strong>3. Material and methods</strong></h4><h5><strong>3.3. Instrumentation and experimental setup</strong></h5><p>Analyses were performed using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/202"><strong>Waters Cyclic IMS high resolution tandem mass spectrometer</strong></a> with an integrated cyclic ion mobility cell and atmospheric solids analysis probe (ASAP) used as ion source (Waters, Milford, MA, USA). Samples (∼ 0.1–0.5 mg) were inserted into a melting point capillary (G119/32, manufacturer SAMCO, United Kingdom) through an in-lab radially drilled hole (hole diameter: approx. 1 mm; distance from the bottom end approximately 5 mm). Solution of 2′,4′,6′-trihydroxyacetophenone monohydrate (THAP) in acetone was used as a standard for lock mass correction (<i>c</i> = 1 mg.ml<sup>-1</sup>). The m/z values were calculated as the means from three repeated measurements of appropriate samples. Approx. 1 μl of standard was deposited onto the capillary using a small pipette tip. Following experimental parameters were used: desolvation temperature of 600 °C, source temperature of 100 °C, corona “current” mode (corona current 2.0 μA), cone voltage of 30 V, source offset of 10 V, cone gas flow of 30 l/min, desolvation gas flow of 500 l/min, nebulizer gas pressure of 6 bar and reference capillary voltage of 2.5 kV. As for the ion mobility separation setup, a cyclic ion mobility cell was used in the following sequence: 1. Inject (10 ms), 2. Separate (37 ms), 3. Inject to Pre-Store (0.50 ms), 4. Eject (0.50 ms), 5. Reinject from Pre-Store (0.63 ms), 6. Eject and Acquire (13.20 ms). TW static height was 11 V, TW ramp start height was 15 V and TW ramp end height was 35 V. Acquisition time was 3 min for the MS scan and 1 min for the MS/MS scan used for identification of analytes. In the MS/MS mode, collision energy 30 V was used for pentadecyl and heptadecylcatechols, 35 V for phenols substituted with (CH<sub>2</sub>)<sub>10</sub>C<sub>6</sub>H<sub>5</sub> and 40 V for catechols substituted with (CH<sub>2</sub>)<sub>12</sub>C<sub>6</sub>H<sub>5</sub> and phenols substituted with CH<sub>2</sub>CO(CH<sub>2</sub>)<sub>10</sub>C<sub>6</sub>H<sub>5</sub>, respectively. Scan time 1 s was used for both scans. At the end of each working day, sample V was measured for confirmation that the instrument measured consistently. Values of m/z were calculated by MassLynx software (version 4.2, SCN 1016) after lock mass correction using the signal of protonated molecule of THAP. Theoretical mass of particular analyte was used for lock mass correction in the MS/MS spectra. Centroid top at 80 % and areas of peaks were used for accurate mass and intensity of signals calculation. The maximal accepted difference from theoretical mass (dtm) of signals was 10 mDa. Peak areas were used to compare the abundance of identified analytes among particular samples. Mobilograms from cyclic ion mobility experiments were produced by DriftScope v2.9 software. In mobilograms, spectra were generated by integration at Full Width at Half Maximum (FWHM) of peaks at drift time 1.72 ms.</p><h4><strong>4. Results and discussion</strong></h4><h5><strong>4.1. Utilization of ASAP-MS</strong></h5><p>In the ASAP-MS spectra of the studied lacquers, signals of a several compounds were observed (<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#fig0002"><span>Fig. 2</span></a>). Signals of radical cations as well as protonated molecules of identified analytes were easily visible. Usually a slightly higher abundance of cation radicals compared to protonated molecules was observed (spectra of all samples are listed in Supplementary material B). The processes observed in the ASAP-MS spectra involve the release of alkyl phenol/alkyl catechol monomer(s) and cleavages of alkyl chain(s) after the carbon linked to the phenol/catechol ring (i.e. cleavage after the first, second and third alkyl carbons) and elimination of water either from polymer or released monomers (the pyrolytic/collision-induced fragmentation processes are discussed below in detail). The analysis of provided samples revealed the most important markers of specific types of lacquers.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Journal_of_Cultural_Heritage_77_2026_187_196_Fig_2_Spectra_of_lacquers_prepared_from_Toxicodendron_vernicifluum_Toxicodendron_succedaneum_and_Gluta_usitata_samples_U_V_and_B_0200c24c06.jpg" alt="Journal of Cultural Heritage, 77, 2026, 187-196: Fig. 2. Spectra of lacquers prepared from Toxicodendron vernicifluum, Toxicodendron succedaneum and Gluta usitata (samples U, V and B)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Journal_of_Cultural_Heritage_77_2026_187_196_Fig_2_Spectra_of_lacquers_prepared_from_Toxicodendron_vernicifluum_Toxicodendron_succedaneum_and_Gluta_usitata_samples_U_V_and_B_0200c24c06.jpg 245w," sizes="100vw" width="2750" height="1269"></p><h5><strong>4.1.4. Study of MS/MS spectra of characteristic markers</strong></h5><p>For all the standard materials, the most important markers were subjected to fragmentation after the collision induced dissociation (CID) in the Trap collision cell of the mass spectrometer (MS/MS experiments; all fragmentation spectra and observed diagnostic fragments including differences from theoretical masses are given in Supplementary material B).</p><p>Signals of fragments with an intensity higher than the specified percentage of well known fragments arising from studied compounds were investigated and identified. Diagnostic fragments are given in Table B.2, Supplementary material B. The threshold signal was set for different compounds. For heptadecyl- and pentadecylcatechols, the threshold signal was defined as 5 % of the signal of dihydroxytropylium that is always an integral component of their collision spectra. For heptadecenyl- and pentadecenylcatechols the threshold signal was 2.5 % of dihydroxytropylium. For pentadecatrienyl catechol it was 100 % of dihydroxytropylium while for dodecylphenylcatechol it was 1 % of dihydroxytropylium. In case of 1-(3-hydroxyphenyl)-12-phenyldodecan-2-one, the threshold signal was defined as 17 % of the signal of hydroxyphenylethan-2-one. Finally, for 10-decylphenylphenol and 12-dodecylphenylphenol, 50 % of the signal of methylphenol was used as the threshold signal. These fragments were used for confirmation of the presence of lacquer compounds in routine measurements (at least one MS/MS spectrum was measured in each sample). The threshold signals were suggested and set in order to reach a sufficient yield of diagnostic fragments for unambiguous identification of individual markers. These signals are intended to be used in long term measurement in practice.</p><div><p>Fragmentation of heptadecylcatechols with 0-3 double bonds (<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#fig0003"><span>Fig. 3</span></a>a-d) is similar to that of pentadecylcatechols with same number of double bonds. In all cases, the signals of the characteristic fragments are well separated from the signals of the matrix.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Journal_of_Cultural_Heritage_77_2026_187_196_Fig_3_Fragmentation_spectra_of_heptadecylcatechols_possessing_0_3_double_bonds_6149330bc3.jpg" alt="Journal of Cultural Heritage, 77, 2026, 187-196: Fig. 3. Fragmentation spectra of heptadecylcatechols possessing 0-3 double bonds, (MS/MS; m/z of parent ions are: a) 342.2559, b) 344.2715, c) 346.2872, d) 348.3028)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Journal_of_Cultural_Heritage_77_2026_187_196_Fig_3_Fragmentation_spectra_of_heptadecylcatechols_possessing_0_3_double_bonds_6149330bc3.jpg 232w," sizes="100vw" width="3000" height="2017"></p><h5><strong>4.2. Principal component analysis</strong></h5><p>Excellent separation of particular types of Asian lacquers in Score Plot (<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#fig0005"><span>Fig. 5</span></a>a-d) was obtained by Principal Component Analysis based on the benzenediol and phenol derivatives described above. The Score Plot contains a set of 20 samples obtained from the Náprstek Museum Prague as well as other samples (BBI, BBO, SBI, SBO, U, V and B) in which lacquer compounds were detected (<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#tbl0002"><span>Table 2</span></a>). Note that in three other samples from The Náprstek Museum Prague, the lacquer compounds were not found at all.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Journal_of_Cultural_Heritage_77_2026_187_196_Fig_5_Score_plot_and_bi_plot_from_PCA_analysis_of_lacquers_taken_from_historic_objects_df82e0592a.jpg" alt="Journal of Cultural Heritage, 77, 2026, 187-196: Fig. 5. Score plot and bi-plot from PCA analysis of lacquers taken from historic objects, a. whole Score PCA plot, b. zoom of the T. succedaneum area, c. zoom of the T. vernicifluum area, d. zoom of the G. usitata area, e. whole PCA bi-plot, f. zoom of the T. succedaneum area in the PCA bi-plot, g. zoom of the T. vernicifluum area in the PCA bi-plot, h. zoom of the G. usitata area in the PCA bi-plot." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Journal_of_Cultural_Heritage_77_2026_187_196_Fig_5_Score_plot_and_bi_plot_from_PCA_analysis_of_lacquers_taken_from_historic_objects_df82e0592a.jpg 156w," sizes="100vw" width="3000" height="2994"></p><p>The significance of suggested markers for the studied lacquers across the whole data matrix was confirmed. The effect of particular markers is reflected in related bi-plots (<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#fig0005"><span>Fig. 5</span></a>e-h). Qualitatively, the results are in accordance with the former study obtained by py-GC/MS [<a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S1296207425002572#bib0001"><span>1</span></a>]. Since both cation-radicals and protonated molecules are formed in ASAP source with significant yield of both ion forms, their sum is an input into the data matrix for each substance (e.g., for pentadecenyl catechol, where the input is the sum of intensities I<sub>(m/z</sub> <sub>=</sub> <sub>318)</sub>+ <i>I</i><sub>(m/z</sub> <sub>=</sub> <sub>319)</sub>), see PCA matrix in Supplementary material C. Measured m/z values of the analyzed compounds are in good agreement with the theoretical values calculated for specific elemental compositions (noted differences from the theoretical mass, dtm is in all cases less than or equal to 10 mDa).</p><h4><strong>5. Conclusion</strong></h4><p>The combination of atmospheric solids analysis probe with high resolution tandem mass spectrometry proved to be a fast and effective tool for analysis of historical Asian lacquer objects, their resolution and classification. The developed method is based on profiling of phenol and benezenediols derivatives. The fragmentation of alkylphenols and alkylbenzene diols after collision activated dissociation in Trap and Transfer collision cells was described. Scission of alkyl chains and elimination of water represent the main fragmentation processes important for identification. Cyclic ion mobility separation appeared to be a useful tool for “cleaning” of signals of the lacquer ions from the matrix signals allowing their better identification from the fragmentation spectra. Moreover, ASAP-MS and MS/MS allowed detection of diterpenic resins, triterpenic resins and arsenic sulphide pigments present along with Asian lacquers. Principal Component Analysis provided complete separation of samples into three clusters of Asian lacquers in Score Plot. A simple classification approach based on direct comparison of newly suggested classification parameters (CPs) allows reliable differentiation of lacquer samples according to their provenance. The developed method is now implemented in routine controls of lacquered objects and could be applied to the analysis of resins and ambers obtained from archaeological findings.</p></div></div>

Characterization of Asian lacquers by atmospheric solids analysis probe high resolution tandem mass spectrometry coupled with cyclic ion mobility separation

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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<p><strong>Effective sample preparation for food safety analysis should efficiently and selectively remove interferences to ensure accurate and consistent data. Additionally, it should aim to process as many samples as possible at minimal cost.</strong></p><p>Preparing samples for food safety analysis can often be cumbersome, but it doesn't have to be. In this webinar, we'll explore straightforward passthrough options for food sample cleanup. &nbsp;We'll provide examples of simple, innovative sample preparation solutions for analyzing mycotoxins, PFAS, pesticides, veterinary drugs, and PAHs across various food samples.</p><blockquote><p><strong>Presenter:</strong> Golnar Javadi (Application Engineer, Agilent Technologies, Inc.)</p><p>Golnar Javadi is an applications engineer providing online applications assistance and technical support for LC columns and supplies, Sample Preparation products, and Spectroscopy supplies.</p><p>Before joining Varian and then Agilent, Golnar worked in the pharmaceutical and nutraceutical industries on method development and quality control. She also taught college level chemistry courses for a few years.</p><p>Golnar then joined Varian as a technical support specialist, providing customers with method development assistance and technical support on Sample Preparation (SPE, SLE, and Filtration), HPLC, GC, ToxiLab and DAT. After the Varian-Agilent merger, Golnar joined Agilent Technologies as an Applications Engineer. She provides technical support to customers on Sample Preparation products, Liquid Chromatography columns, and Spectroscopy supplies.</p></blockquote>

Agilent Technologies: Becoming a Better Chromatographer - Educational Webinar Series

Sample Preparation for Food Safety Analysis

We'll provide examples of innovative sample preparation solutions for analyzing mycotoxins, PFAS, pesticides, veterinary drugs, and PAHs

<p><strong>What should you do when standard equipment falls short for your dissolution test?</strong></p><p>Join us for an insightful panel discussion with experts on the increasing development and acceptance of nonstandard accessories for dissolution testing. From small-volume accessories to Apex vessels and enhancer cells, we'll update you on the latest advancements in this field and provide tips on how to effectively use them in your lab.</p><blockquote><p><strong>Presenter:</strong> Karen Krauel-Göllner, PhD (Product Manager Dissolution, Agilent Technologies, Inc.)</p><p>Karen Krauel-Göllner is a registered pharmacist and holds a PhD in Pharmacy from the University of Otago, New Zealand. Karen has worked in various roles in the field of pharmaceutical development. For the last 10 years she has been working at Agilent Technologies and currently holds a position as product manager for dissolution systems.</p><p><strong>Presenter:</strong> Ken Boda (Dissolution Product Specialist, Agilent Technologies, Inc.)</p><p>Ken joined Varian (now Agilent) in 2005 as an applications engineer and is now a dissolution product specialist. Prior to working at Agilent, he worked in pharma specializing in dissolution testing and method development. As a dissolution product specialist, Ken works with customers in determining the best systems for their needs and optimizing their workflows. He has also helped educate customers on dissolution science through webinars, the Dissolution Discussion Group, LinkedIn, and other channels.</p><p><strong>Presenter: </strong>Bryan Crist (President, DissoAssist Consulting, Wilmington, NC, USA)</p><p>Bryan has been the president of DissoAssist Consulting based in Wilmington, NC, USA since 2021. He provides consulting, coaching, and training services for dissolution and drug release in the pharmaceutical industry. Bryan is also an active member on various USP Expert Committees. Previously, Bryan was a scientific affairs manager with Agilent Technologies located in Cary, North Carolina, USA. From 1997 to 2021, he focused on providing method and technical application support for dissolution and drug release testing in the pharmaceutical industry as well as working with VanKel, Varian, and eventually Agilent. Prior to 1997, Bryan supervised and managed pharmaceutical laboratories and performed analytical testing with Bristol-Myers Squibb, Merck, AAI, and Abbott Laboratories until he joined the dissolution equipment manufacturer VanKel.</p><p><strong>Presenter: </strong>Vivian Gray (Founder VA Gray Consulting; Managing Director of Dissolution Technologies)</p><p>Vivian has spent the last 40+ years involved in all aspects of dissolution testing and evaluating new dissolution technology. At the United States Pharmacopeia, she enjoyed a long career serving first as a bench chemist, supervisor, and lastly as a liaison to various expert USP committees. In 1997, Vivian joined the DuPont-Merck Pharmaceuticals Company Analytical Research and Development Section as the head of the Dissolution Group. In 2002, she formed her own consulting business, V. A. Gray Consulting, Inc., in dissolution testing and related areas. In June 2003, she became managing director of Dissolution Technologies, a peer-reviewed journal dealing specifically with dissolution testing issues.</p></blockquote>

Agilent Technologies: Navigating Small-Volume and Specialty Accessories

Navigating Small-Volume and Specialty Accessories

Join this webinar as we explore the latest regulations on automation 

<div><p><strong>High resolution mass spectrometry is being asked to step up and achieve the levels of sensitivity akin to that of tandem quadrupole mass spectrometry. The question is…can it deliver? During this session we’ll look at the acquisition and processing of Tof MRM on the Xevo MRT MS. The system incorporates multi-reflecting time-of-flight technology that achieves excellent levels of sensitivity over a wide dynamic range, ideal for qualitative and quantitative applications. We’ll assess the results in the MS Quan Application, part of the waters_connect Software Solution, for efficient data processing and data review. And yes – the Xevo MRT MS can deliver</strong></p><h5><strong>Who Should Attend:</strong></h5><ul><li>Learn about the operation of the novel Xevo MRT MS technology and see it in Action!</li><li>Discover how the system integrates into MS Quan Application for streamlined data processing and review of Tof MRM data sets&nbsp;</li><li>Assess the levels of performance with the detection of low level analytes over a wide dynamic range, ideal for targeted (and untargeted) applications &nbsp;</li></ul><p><i>The session will conclude with a live Q&amp;A where members of the Waters Xevo MRT team will be on hand to answer all of your questions.&nbsp;</i></p><blockquote><p><strong>Presenter:</strong> Matt Daly PhD (Senior Applications Chemist - Xevo MRT Program, Waters Corporation)</p><p>Matthew Daly joined Waters in September 2022 and is currently working as a Senior Scientist in the Xevo MRT Science Team. Matthew’s main focus and area of expertise lies in LC-MS discovery bottom-up proteomics using high-resolution mass spectrometry with a particular interest in biomarker discovery and translation through to targeted applications.</p><p>Matthew obtained a BSc Hons from Swansea University in Biochemistry and Genetics before completing a MSc by Research in Nanotechnology at the same institution. After a brief time in industry developing food allergen ELISAs, Matthew returned to academia to complete his PhD in Biochemistry at the University of Manchester where he developed a targeted mass spectrometry method to detect and quantify gluten in foods.</p></blockquote></div>

Waters Corporation: XEVO MRT in Action - Demo Series

Enhanced Sensitivity and Selectivity with Tof MRM

Discover if Xevo MRT MS with Tof MRM can rival triple quad sensitivity. Learn how it integrates with MS Quan for accurate, streamlined quant analysis.

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join a global community of scientists, innovators, and industry leaders at the forefront of analytical chemistry. Now in its 5th year, the SelectScience® Virtual Analytical Science Summit explores the latest technologies, trends, and breakthroughs driving progress across a wide range of scientific disciplines.</strong></p><p>From accelerating drug discovery and development to ensuring safety in food and beverage, monitoring environmental health, and advancing materials science, this year’s program will showcase the power of analytical chemistry to solve real-world challenges.</p><h5><strong>Why attend?</strong></h5><ul><li>Keep up with cutting-edge developments from expert speakers</li><li>Access the latest written guides, posters, technical papers and more in our resource hubs</li><li>Discover new technology launches and innovations</li><li>Ask the experts – live Q&amp;As with guest speakers and manufacturers</li></ul><h5><strong>Example past presentation topics include:</strong></h5><ul><li><strong>Maximizing information recovery with LC-IM-MS in DMPK and omics studies</strong>&nbsp;<ul><li>Prof. Ian Wilson, Imperial College London</li></ul></li><li><strong>Greener nanocatalyst for the detection and degradation of "forever chemicals" PFAS&nbsp;</strong><ul><li>Dr. Omowunmi 'Wunmi' Sadik, Distinguished Professor of Chemistry and Environmental Science at the New Jersey Institute of Technology</li></ul></li><li><strong>Accelerating phenotyping with structural mass spectrometry in drug discovery and synthetic biology</strong>&nbsp;<ul><li>Prof. John McLean, Associate Professor of Chemistry at Vanderbilt University</li></ul></li><li><strong>Harmonizing science and sustainability: The pivotal role of green chemistry in mass spectroscopy&nbsp;</strong><ul><li>Prof. Shivani N Jani, Assistant Professor, Smt S. M. Shah Pharmacy College</li></ul></li></ul><h3><strong>Agenda</strong></h3><h5><strong>11:30 (BST) Opening address</strong></h5><h5><strong>11:45 – 12:45 (BST) New perspectives in halogenated contaminant analysis using GC–Ion mobility–MS</strong></h5><ul><li>Prof. Guthier Eppe, Director of the Mass Spectrometry Laboratory, University of Liège</li></ul><h5><strong>12:45 – 13:30 (BST) Revolutionize drug discovery with high throughput mass spectrometry and automated pipetting</strong></h5><ul><li>Dr. Christian Klinner, Analytik JenaGmbH+Co. KG, Dr. Arndt Asperger, Bruker Daltonics GmbH &amp; Co. KG, and Amanda Weaver, Biodesix</li></ul><h5><strong>13:30 – 14:15 (BST) Developing sustainable Gas Chromatography (GC) methods</strong></h5><ul><li>Dr. Diane Turner, Director, Owner, and Senior Consultant, Anthias Consulting Limited</li></ul><h5><strong>14:15 – 15:00 (BST) Sustainable science: Essential lab products for a greener tomorrow</strong></h5><ul><li>Kate Morgan, Product Marketing Manager, and Marielle Schink, Business Partner Sustainability, Sartorius</li></ul><h5><strong>15:00 – 15:45 (BST) Enantiomer separations using ion mobility-mass spectrometry</strong></h5><ul><li>Prof. John McLean, Vanderbilt University</li></ul><h5><strong>15:45 – 16:30 (BST) Incorporating ultrashort-chain compounds into the comprehensive analysis of PFAS</strong></h5><ul><li>Dr. Shun-Hsin Liang, Senior Principal Scientist, LC Solutions, Restek Corporation</li></ul><h5><strong>16:30 – 17:15 (BST) Investigating the impact of volatile compounds on the flavor profiles of foods and drinks</strong></h5><ul><li>Prof. Kieran Kilcawley, Principal Research Officer, Teagasc Food Research Centre and Adjunct Professor, University College Cork and Technological University Dublin</li></ul><h5><strong>17:15 – 18:00 (BST) Emerging contaminants for food and packaging</strong></h5><ul><li>Lauren Stainback and Patricia Atkins, ZeptoMetrix</li></ul><blockquote><p><strong>Presenter: </strong>Prof. Ian Wilson (Visiting Professor, Imperial College London)</p><p><strong>Presenter: </strong>Prof. John A. McLean (Stevenson Professor of Chemistry, Vanderbilt University)</p><p><strong>Presenter: </strong>Dr. Diane Turner (Director, Owner, and Senior Consultant, Anthias Consulting Limited)</p><p><strong>Presenter: </strong>Prof. Jonathan Sweedler (Professor, Department of Chemistry, University of Illinois)</p><p><strong>Presenter: </strong>Dr. Omowunmi 'Wunmi' Sadik (Distinguished Professor of Chemistry and Environmental Science at the New Jersey Institute of Technology)</p><p><strong>Moderator:</strong> Cameron Smith-Craig (Pharma and Applied Sciences Editor, SelectScience)</p></blockquote></div></div></div>

SelectScience: SelectScience Analytical Science Summit

SelectScience Analytical Science Summit

Discover cutting-edge analytical chemistry at the 5th Virtual Analytical Science Summit with expert talks, new tech, and live Q&As.

<p><strong>Method screening, development, and validation are time-consuming. With an ever-increasing demand on automating processes to increase efficiency and free up a scientist’s time, there are numerous tools which can be used to help produce robust methods faster.</strong></p><p>Waters Empower Chromatography Data System (CDS) provides features to support a lifecycle management approach and improve outcomes. In this session, <strong>we will explore:</strong></p><ul><li>Empower Method Developer application</li><li>Empower Sample Set Generator</li><li>Scoring Report</li><li>MS Peak Tracking and Peak Purity</li><li>Waters eCord- and eConnect-enabled Columns</li><li>Empower Method Validation Manager</li><li>Third-Party AQbD software</li><li>Reporting Control Charts for tracking and data trending</li></ul><p>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about using Empower Software.</p><blockquote><p><strong>Presenter: </strong>Neil Lander (Principal Product Manager, Informatics, Waters Corporation)</p><p>Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.</p></blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About Tools to Support an Enhanced Approach to Analytical Procedure Development Following ICH Q14 and ICH Q2(R2)

Empower Tips: Ask Me Anything About Tools to Support an Enhanced Approach to Analytical Procedure Development Following ICH Q14 and ICH Q2(R2)

Discover how Empower CDS automates method development and validation. Boost efficiency with tools for lifecycle management and robust workflows.

Ask Me Anything: Empower Tools for ICH Q14 & Q2(R2)

<p><strong>Join Metrohm DropSens as they provide a comprehensive overview of different multi-analysis configurations used in electrochemistry for sensor development through practical case studies, experimental design considerations, and recent advances enabling high-throughput and real-time electrochemical analysis.</strong></p><h5><strong>Key learnings of this webinar:</strong></h5><ul><li>How <strong>multi-analysis approaches</strong> enhance data quality and sensor optimization</li><li>Instrumentation and configuration strategies for research and prototyping</li><li>Real-world examples of multi-analysis electrochemical sensors</li></ul><p>This session is designed for researchers aiming to <strong>accelerate sensor development </strong>by leveraging the power of using multi-analysis configurations.</p><p>Register now to understand how strategic use of multi-analysis techniques can refine and advance your sensor research!</p>

Metrohm: Multi-Analysis Approaches for Electrochemical Sensor Optimization

Multi-Analysis Approaches for Electrochemical Sensor Optimization

Discover how multi-analysis configurations improve electrochemical sensor research, data quality, and prototyping strategies in this Metrohm DropSens webinar.

Approaches for Electrochemical Sensor Optimization

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Food safety testing laboratories are under growing pressure to do more with less. As testing volumes surge, labs must deliver accurate and regulatory compliant results, while navigating staffing shortages and limited resources. These challenges are further compounded by increasing sample sizes and throughput demands.</strong></p><p>In this webinar, meet with Dr. Salman Zeitouni and Jani Holopainen to explore real-world examples of how automation is driving transformation in food safety testing laboratories. See how labs are leveraging automated solutions to enhance accuracy and efficiency, reduce human error, and build resilient testing capabilities.</p><h5><strong>Key learning objectives</strong></h5><ul><li>Explore the drivers behind automation of molecular workflows in food safety testing laboratories</li><li>Understand key considerations and common challenges in adopting lab automation</li><li>Discover real-world examples of successful automation implementation in microbiology labs</li><li>Gain insight into how automated molecular workflows can support lab scalability, traceability, and long-term resilience to build a future lab today.</li></ul><h5><strong>Who should attend?</strong></h5><ul><li>Laboratory professionals, including food microbiologists, lab managers, and technical service directors.</li><li>Quality, safety, and regulatory leaders, such as quality managers, operations directors, and compliance professionals.</li></ul><h5><strong>Certificate of attendance</strong></h5><ul><li>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.</li><li>If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.</li></ul><blockquote><p><strong>Presenter: </strong>Jani Holopainen (R&amp;D and Operations Director, Microbiology, Thermo Fisher Scientific)</p><p>With nearly two decades in the food and beverage industry, Jani Holopainen brings extensive knowledge and diverse experience to the field of food safety testing. As Director of R&amp;D and Operations at Thermo Fisher Scientific, he leads innovation across molecular solutions, with a focus on streamlining workflows for strategic laboratory operations.</p><p><strong>Presenter:&nbsp;</strong>Dr. Salman Zeitouni (Global Product Manager for Molecular Solutions, Thermo Fisher Scientific)</p><p>As the Global Product Manager for Molecular Solutions at Thermo Fisher Scientific, Dr. Salman Zeitouni drives the development and launch of innovative PCR-based workflows for food safety testing. He combines insights into industry challenges, regulatory trends, and cutting-edge technologies to deliver solutions that enhance efficiency and reliability in modern food labs.</p><p><strong>Moderator:</strong> Olivia Long (Editorial Team, SelectScience)</p></blockquote></div></div></div>

SelectScience: Reaching new heights in food safety testing using automated PCR workflows

Reaching new heights in food safety testing using automated PCR workflows

Webinar on lab automation in food safety testing. See how automated workflows enhance accuracy, reduce errors, and build scalable, resilient labs.

Food safety testing using automated PCR workflows

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Listened as expert speakers highlighted improved workflow solutions that benefit the study of post-translational modifications (PTMs), including phosphorylation and histone modifications, as well as advancements in spatial proteomics analysis using label-free quantitation strategies. These innovations are enhancing the precision and site localization of PTM analysis and spatial resolution for proteomics, providing valuable insights into cellular processes and protein functions. This session offered an in-depth look at how these improved workflows are advancing research in molecular biology and biochemistry.&nbsp;</strong></p><h5><strong>Learning points:</strong></h5><ul><li>How to build end-to-end PTM workflows that increase coverage and site localization (phosphorylation, histone marks) via orthogonal enrichment, optimized LC, complementary fragmentation (e.g., HCD/ETD/EThcD), and rigorous localization scoring.&nbsp;</li><li>How to set up label-free quantitation (LFQ) for PTM and spatial studies—using calibration/spike-ins, QC replicates, normalization, and CV tracking—to deliver reproducible, decision-ready data.&nbsp;</li><li>How to choose between capture-based and direct-injection LC-MS approaches for PTM and spatial experiments, understanding trade-offs in depth, throughput, unique-protein yield, and reproducibility.&nbsp;</li></ul><h5><strong>Who should attend:</strong></h5><ul><li><strong>Proteomics &amp; PTM Researchers:</strong> Scientists studying phosphorylation or histone modifications who need higher confidence in site-specific calls and robust quantitation.&nbsp;</li><li><strong>Spatial Proteomics / Spatial Biology Scientists: </strong>Teams mapping protein/PTM distributions in tissues using label-free strategies and seeking better spatial resolution with trustworthy quantitation.&nbsp;</li><li><strong>Method Developers, Analytical Chemists &amp; Data Analysts:</strong> Professionals benchmarking workflows and building LFQ pipelines with strong QC, normalization, and reporting practices.&nbsp;</li></ul><p>If you cannot attend this webinar please register to receive a link to the On Demand version the following day.&nbsp;</p><blockquote><p><strong>Presenter: </strong>Benjamin Garcia Ph.D. (Professor, Washington University in St. Louis)</p><p><strong>Presenter: </strong>Emma Lundberg Ph.D. (Associate Professor, Stanford University)<br><br><strong>Presenter: </strong>Joshua Coon Ph.D. (Professor, University of Wisconsin-Madison)<br><br><strong>Presenter: </strong>Brett Larsen (Senior Vertical Marketing Manager, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: ASMS 2025 Proteomics Workshop

Innovative solutions for expanded PTM and spatial analysis

Explore optimized PTM and spatial proteomics workflows with LFQ strategies, boosting precision, reproducibility, and insight into protein functions.

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Discovery advancements in structural biology applications, including charge detection approaches including Direct Mass technology mode, protein cross-linking, and hydrogen-deuterium exchange (HDX). These technologies provide complementary information about the structure of proteins and RNA molecules, offering insights into their functional states. This session delved into how these innovative methods are enhancing our understanding of molecular structures, contributing to more accurate models of protein and RNA behavior, and driving progress in fields such as biochemistry and molecular biology.&nbsp;</strong></p><h5><strong>Learning points:</strong></h5><ul><li>How native/charge-detection (Direct Mass) MS determines accurate mass and stoichiometry of intact protein complexes and other large macromolecules.&nbsp;</li><li>How hydrogen–deuterium exchange (HDX-MS) maps conformational dynamics and ligand binding using rapid quench/online digestion for sensitive, high-throughput analysis.&nbsp;</li><li>How cross-linking MS provides distance restraints to define intra-/inter-protein contacts and improve structural models alongside cryo-EM/X-ray.&nbsp;</li></ul><h5><strong>Who should attend:</strong></h5><ul><li>Structural biologists and biochemists seeking complementary tools to cryo-EM/X-ray for dynamic or membrane proteins and RNA.&nbsp;</li><li>Mass spectrometry method developers implementing native MS/Direct Mass, HDX-MS, and cross-linking workflows with strong QC.&nbsp;</li><li>Drug discovery and computational biology teams needing reliable protein–ligand interaction and conformational insights to guide design.&nbsp;</li></ul><p>If you cannot attend this webinar please register to receive a link to the On Demand version the following day.&nbsp;</p><blockquote><p><strong>Presenter: </strong>Weijing Liu Ph.D. (Vertical Marketing Manager, Thermo Fisher Scientific)</p><p><strong>Presenter:&nbsp;</strong>Malvina Papanastasiou (Group Leader, Broad Institute)<br><br><strong>Presenter:&nbsp;</strong>Varun Gadkari Ph.D. (Assistant Professor, University of Minnesota)</p><p><strong>Presenter:&nbsp;</strong>Philip Lössl (Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin)</p></blockquote></div></div></div>

Thermo Fisher Scientific: ASMS 2025 Workshops

Fresh solutions to elucidate the structure-function relationship of macromolecules

Explore Direct Mass, HDX, and cross-linking MS for structural biology—powerful tools to study protein/RNA dynamics, interactions, and functional states.

Fresh Solutions for Macromolecule Structure–Function

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>This is the second webinar of a two-part series.</strong></p><p>This webinar will showcase new advancements in the analysis of N-nitrosamines in pharmaceutical products. This session will emphasize the importance of sensitive analytical techniques to ensure product safety.</p><h5><strong>Key Highlights:</strong></h5><ul><li><strong>Automated microextraction methods:</strong> Discover how automated microextraction methods can streamline your analytical processes</li><li><strong>Machine learning approaches:</strong> Learn about the integration of machine learning techniques to enhance analytical accuracy and efficiency</li><li><strong>Bayesian optimization</strong>: See how Bayesian optimization can significantly reduce the time and number of experiments needed for method development</li></ul><p>With these innovations, analytical workflows become faster, more efficient, and more sustainable. Don't miss this opportunity to stay ahead in the field of pharmaceutical analysis.</p><blockquote><p><strong>Presenter: </strong>Giorgio Blom (Associate Principal Scientist, AstraZeneca)</p><p>Giorgio Blom is an Associate Principal Scientist in Trace Analysis at AstraZeneca in the UK, working in Pharmaceutical Technology and Development. He leads AstraZeneca's global Trace Analysis Expert Working Group. His work encompasses the development of novel methods to enable accurate and reliable quantitation of nitrosamines and their precursors to low parts per billion levels in drug substance, drug product, and excipients, with a focus on automation and QBD principles. As part of his role, Giorgio works with various industry groups to define best-practice procedures for trace analysis within the pharmaceutical industry and influence future practices. Giorgio obtained his degree in Chemistry with a major in Forensic Science from Avans University in the Netherlands and obtained his PhD in the field of Forensic Taphonomy.</p><p><strong>Presenter:&nbsp;</strong>Amy Moore (Analytical Scientist, AstraZeneca)</p><p>Amy Moore is an Analytical Scientist at AstraZeneca, contributing to drug development projects through automated workflows, chromatography, mass spectrometry, and ICP techniques. She began with a placement year at AstraZeneca Macclesfield, where she focused on LC and GC method development, 2D NMR characterization, trace analysis, and laboratory automation. After joining Chemical Development as a graduate, Amy progressed to the Trace and Mass Spectrometry Team, expanding her expertise in robotic automation and advanced analytical technologies to improve the efficiency and accuracy of pharmaceutical analysis to low parts per billion levels across AstraZeneca's drug portfolio. Amy completed her MSci in Chemistry with a year in industry at the University of Liverpool.</p><p><strong>Moderator:</strong> Jon Bardsley (Market Development Manager, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Optimizing N-Nitrosamine Detection: Automated Microextraction & Machine Learning

Optimizing N-Nitrosamine Detection: Automated Microextraction & Machine Learning

This webinar will showcase new advancements in the analysis of N-nitrosamines in pharmaceutical products. 

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