We are pleased to invite you to our upcoming free online webinar on June 11, 2026 focused on one of the most pressing challenges in environmental monitoring and water quality management — PFAS (Per- and Polyfluoroalkyl Substances).As regulatory frameworks continue to evolve and compliance deadlines approach, laboratories, water utilities, and environmental professionals need robust, reliable, and cutting-edge analytical solutions to stay ahead.<blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://events.teams.microsoft.com/event/91d97003-fe33-4dca-b80b-160d9f8a5655@485ca04e-6f74-4050-9764-cdb4bfa89c25">Registration HERE</a></blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_analyzy_PFAS_a9e4a87fbc.jpg" alt="ALS: Advanced PFAS Analytical Services " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_analyzy_PFAS_a9e4a87fbc.jpg 245w," sizes="100vw" width="600" height="336"><h4>🎤 Our Speaker</h4>The webinar will be hosted by Jana Kováčová, Ph.D., PFAS Regional Lead for Continental Europe Environmental Division, who has dedicated the last several years to the field of PFAS analysis and determination in ALS laboratories. Jana is a recognized expert in PFAS environmental analytics and will share practical insights and the latest developments in analytical strategies to help your organization achieve and maintain compliance.<h4>🎯 What You Will Learn</h4><ul><li>Latest regulatory developments and compliance requirements for PFAS in water, including EU Drinking Water Directive 2020/2184 and its implications for water suppliers and laboratories.</li><li>Regulatory updates for surface water and groundwater — what's new and what to expect next.</li><li>Overview of advanced analytical strategies for PFAS detection and quantification in water matrices and how we analyse PFAS samples.</li><li>Key analytical challenges associated with PFAS testing — from ultra-trace detection to matrix interferences and contamination control.</li><li>The critical importance of using tested sampling containers and sample preservation to ensure reliable results.</li><li>Illustrative examples of results from real-world PFAS water analyses.</li><li>How ALS can support your needs with accredited PFAS testing services.</li></ul><h4>👥 Who Should Attend</h4>This webinar is designed for our clients, professionals, laboratory and technical staff, scientists, as well as anyone with an interest in analytical chemistry who wants to better understand the occurrence of these "forever chemicals" in the environment. &nbsp;<h4>💬 Q&amp;A Session</h4>There will be a live Q&amp;A session at the end of the webinar. You are welcome to submit your questions in advance during registration or ask them live on the day.<h4>📅 Additional Webinar Info:</h4><ul><li>Platform: Microsoft Teams (online)</li><li>Time: 10:00 CEST</li><li>Language: English</li><li>Duration: approx. 45 - 60 minutes (incl. Q&amp;A) Extras: If you are unable to attend on the day, please register and we will provide you with the recording of the webinar.</li></ul><h4>🔬 About ALS Environmental</h4>ALS is a global leader in environmental testing and analytical services, providing accredited PFAS analysis to clients across Europe and beyond. Our dedicated PFAS experts help clients navigate the complex regulatory landscape with confidence.<blockquote>For further information, please contact us on: marketing.cz@alsglobal.com</blockquote>We look forward to welcoming you to this important discussion on PFAS compliance in water.

Invitation to the ALS Webinar PFAS in Water 2026: Achieving Compliance through Advanced Analytical Strategies

News from LabRulezLCMS Library - Week 23, 2026

Solvent switching is the process of changing the solvent contained within a liquid chromatography (LC) column. This procedure must be performed carefully to avoid irreversible damage to the column.The topic originates from a common customer question:<blockquote>“My column arrived in hexane, but I need to use it with water and acetonitrile. How do I switch the solvents in the column?”</blockquote>This article explains the solvent switching process, how to determine the solvent currently inside a column, how to select an appropriate transition solvent, and why proper solvent switching is essential.<h2>Step 1: Determine the Shipping Solvent</h2>Before changing solvents, it is important to know which solvent or mobile phase is already present in the column.This information can typically be found in:<ul><li>The column care guide</li><li>The Certificate of Quality Assurance (CQA)</li></ul><h4>Using the Column Care Guide</h4>The column care guide is usually available on the manufacturer's website under the specific column brand.<ul><li>In the Shipping Solvent section, users can identify the solvent in which each phase is supplied.</li><li>The Mobile Phase Compatibility section can be used to determine whether the phase has any mobile-phase limitations beyond pH restrictions.</li></ul><h4>Using the Certificate of Quality Assurance (CQA)</h4>The CQA also provides useful information.Under the Test Conditions section, the mobile phases used to test the column are listed.<ul><li>In the example shown in the video, a Luna column was tested using:<ul><li>75% acetonitrile</li><li>25% water</li></ul></li></ul>The testing conditions are often the same as the shipping solvent conditions, although this is not always the case.If uncertainty remains, the recommendation is to contact the column manufacturer directly.<h3>Step 2: Check Solvent Miscibility</h3>Once the shipping solvent is known, the next step is to verify whether it is miscible with the mobile phases used in the analytical method.A solvent miscibility chart can be used for this purpose.<h4>Water and Immiscible Solvents</h4>The video highlights that water is immiscible with several commonly used LC solvents, including:<ul><li>Hexane</li><li>Dichloromethane (DCM)</li><li>Heptane</li></ul>These solvents are commonly used under normal-phase conditions.<h4>Isopropanol as a Transition Solvent</h4>The video identifies isopropanol (IPA) as a solvent that is miscible with all LC solvents shown in the chart.Because of this property, IPA is commonly used as an intermediate or transition solvent when switching between:<ul><li>Water and hexane</li><li>Water and heptane</li></ul><h3>Step 3: Perform the Solvent Switching Procedure</h3>After selecting an appropriate transition solvent, the solvent exchange can begin.The procedure described in the video consists of the following steps:<h4>1. Flush with the Transition Solvent</h4>Flush the column with the selected transition solvent for:<ul><li>30–60 column volumes</li></ul><h4>2. Flush with the Pure Starting Solvent</h4>After the transition solvent, flush the column with:<ul><li>10 column volumes of the pure starting solvent</li></ul><h4>3. Equilibrate with the Method Mobile Phase</h4>Finally, equilibrate the column using the mobile phases required for the analytical method.<h3>Example Solvent Switching Protocol</h3>The video provides the following example.<h5>Initial Column Solvent</h5><ul><li>The column arrives packed in:<ul><li>99% hexane</li><li>1% acetonitrile</li></ul></li></ul><h5>Transition Solvent</h5><ul><li>Use:<ul><li>Isopropanol (IPA)</li></ul></li><li>Flush the column with IPA for:<ul><li>30–60 column volumes</li></ul></li></ul><h5>Intermediate Step</h5><ul><li>Flush with:<ul><li>10 column volumes of acetonitrile</li></ul></li></ul><h5>Final Equilibration</h5><ul><li>Equilibrate with one of the following:<ul><li>50% acetonitrile / 50% water</li><li>50% acetonitrile / 50% buffered water</li></ul></li></ul><h3>Why Proper Solvent Switching Is Important</h3>The video emphasizes that improper solvent switching can cause irreversible column damage.Potential issues include:<h4>Formation of Voids and Pockets</h4>Immiscible solvent transitions can create:<ul><li>Pockets within the packed bed</li><li>Voids at the column inlet</li></ul>These defects can permanently damage column performance.<h4>Salt Precipitation</h4>If buffered mobile phases are involved and pure solvents are not used appropriately during the transition, salts may precipitate from solution.<h4>Damage to Pressure-Sensitive Polymer Media</h4>Pressure-sensitive polymer-based media may burst during improper solvent transitions.<h4>Stripping of Coated Phases</h4>Columns containing coated stationary phases or coated ligands may experience removal of these coatings during unsuitable solvent changes.<h3>Irreversibility of Column Damage</h3>According to the video, once damage caused by immiscible solvent exposure occurs, it is extremely difficult—if not impossible—to reverse.For this reason, solvent changes should always be performed through an appropriate intermediate solvent whenever required.<h3>Conclusion</h3>Successful solvent switching begins with identifying the solvent in which the column was shipped. The miscibility between the shipping solvent and the intended mobile phases must then be evaluated. When immiscible solvents are involved, an appropriate transition solvent such as isopropanol should be used.Following a controlled sequence of flushing, intermediate solvent exchange, and equilibration helps prevent permanent column damage and ensures safe operation of the chromatographic column.

Solvent Switching in Liquid Chromatography Columns: How to Change Column Solvents Safely

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For more than 40 years, ALS has provided testing and technical solutions to clients all over the world in a wide range of industries. We have built our global reputation by embracing the latest technologies and innovative methodologies to deliver high quality testing services to clients. ALS is able to leverage a multifaceted international team while remaining agile enough to provide local expertise and personalized solutions to every one of our clients.

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Waters Corporation

Join us for the fourth SELECT SERIES MRT in Action deminar. In this installment of our series, we will show new levels of imaging clarity and confidence being obtained with MRT, at speeds that realize useful improvements in throughput.
In our applications demo lab we will show the simplicity of changing between MALDI and DESI XS modes, both available on the MRT instrument. We will also highlight new imaging workflows, enabled by micro apps, developed to extract meaningful information quickly.
The session will conclude with a live Q&amp;A where Emmanuelle Claude, Wei Rao and other members of the team, who will be on hand to answer all of your questions. 
Why Should You Attend?
<ul>
<li>Discover how the characteristics of the MRT aid mass spectrometry imaging workflows</li>
<li>Learn how the different imaging modes work to extend imaging coverage</li>
<li>Understand how MRT imaging data is processed through various workflows</li>
</ul>
<blockquote>
Presenter: Emmanuelle Claude (Consulting Scientist, Waters Corporation)
</blockquote>
<blockquote>
Emmanuelle Claude started at Waters Corporation in October 2000 as an Applications Chemist in the Proteomics and Genomics Marketing group, developing automated Peptide Mass Fingerprint (PMF) MS methods using a MALDI-TOF mass spectrometer. Over the years she developed several methods in the proteomics analytical space using MALDI TOF and naturally moved in starting the development of Mass Spectrometry Imaging (MSI) at Waters corporation over 15 years ago.
</blockquote>
<blockquote>
She has been involved with hardware and software R&amp;D to ensure that the solutions are fit-for-purpose for the MSI community and beyond. She has worked extensively with the main MSI leaders in Europe and the US such as Prof Heeren in the Netherlands, Prof Clench, Prof Takats and Bunch in the UK and Prof Caprioli in the US. She has been a Principal Scientist since 2014 and became a Consulting scientist in 2021. Emmanuelle is managing the MS imaging application team at Waters, who are involved in developing new applications and methods for imaging by both MALDI and DESI mass spectrometry.
</blockquote>
<blockquote>
Presenter: Wei Rao (Principal Applications Chemist, Waters Corporation)
</blockquote>
<blockquote>
Wei Rao is currently working as a Principal Applications Chemist in the European Applications Laboratory at Waters Wilmslow, focusing on MS imaging and ambient MS with the DESI XS platform. He has more than 12 years of ambient MS imaging experience, and has worked in various posts in the UK, US, China, and many countries within the APAC region, bringing with him a unique global perspective to the field.
</blockquote>

Accelerated Imaging Clarity

In our applications demo lab we will show the simplicity of changing between MALDI and DESI XS modes, both available on the MRT instrument.

Join us for this webinar series to learn and hear from experts in the field about major advancements, optimizations, and innovations of analytical technology to take your oligonucleotide analysis to the next level.
From sample to results, the analysis of oligonucleotide therapeutics requires robust and accurate analytical characterization to confirm identity, and to determine purity, quality, and strength.
Through our external and internal expert speakers’ testimonials, you will have the chance to discover our complete workflow solutions and get a full understanding of new advancements and optimization techniques for each step of the workflow.
Learning points
<ul>
<li>Discover new LC-MS methods for oligonucleotide and RNA analysis.
</li>
<li>Understand practical improvements and innovations in nucleic acid separations using oligonucleotide DNAPac columns.
</li>
<li>Find out how BioPharma Finder™ Software can support your oligonucleotide analysis.
</li>
</ul>
Who should attend?
<ul>
<li>Biopharmaceutical Research Scientists
</li>
<li>Analytical Scientists from Biopharma companies working on or interested in oligonucleotide-based therapies.
</li>
<li>PhD students in any field of biotherapeutic drug development
</li>
<li>Scientists looking to advance knowledge of oligonucleotide analysis.
</li>
</ul>
<blockquote>
Presenter: Dr. Christina Jayne Vanhinsbergh (Senior Scientist, Oligonucleotides, AstraZeneca)
</blockquote>
<blockquote>
Dr. Christina Jayne Vanhinsbergh is a senior scientist working within the pharmaceutical industry with a focus on therapeutic oligonucleotides and other new modality drugs. Her background is in the analysis of biomolecules, such as proteins and nucleic acids, and her PhD research centred on the development of multidimensional chromatographic methods interfaced with MS detection. Christina was a postdoctoral researcher at The University of Sheffield, developing LC–MS-based analytical methods for the analysis of alkylated nucleic acids and mRNA therapeutics. She has collaborated with multiple industrial partners, and advocates for networking and development opportunities for early career scientists as a committee member of the Chromatographic Society, UK.
</blockquote>
<blockquote>
Presenter: Aude Croguennec (Moderator, Regional Marketing Manager, Thermo Fisher Scientific)
</blockquote>

Thermo Scientific: Advancements & Optimization of Analytical Technology for Oligonucleotide Analysis - Webinar 2

Advancements & Optimization of Analytical Technology for Oligonucleotide Analysis - Webinar 2

Major advancements, optimizations, and innovations of analytical technology to take your oligonucleotide analysis to the next level.

Advancements & Optimization of Analytical Technology

Join us as we uncover how Evosep One empowers researchers to investigate the proteomic landscapes within single cells, paving the way for new discoveries and innovative therapeutic approaches.
<blockquote>
Presenter: Zilu Ye (Researcher at Olsen Group, Novo Nordisk Foundation Center for Protein Research)
</blockquote>
<blockquote>
Presenter: Nicolai Bache (Head of Applications at Evosep)
</blockquote>

Single cell proteomics

How to investigate the proteomic landscapes within single cells, paving the way for new discoveries and innovative therapeutic approaches.

In this virtual Ask Me Anything session we are offering you a chance to delve into the fascinating world of PFAS (Per- and Polyfluoroalkyl Substances).
We are honored to present Dr. Carol Kwiatkowski, a distinguished science and policy senior associate from Green Science Policy, as our esteemed guest.
Dr. Kwiatkowski will be your guide, providing expert insights and answering all your questions about PFAS. From its profound health and environmental concerns to the ever-evolving landscape of regulations, restrictions, and detection techniques. No question is off limits! 
During this session, you can expect to:
<ul>
<li>Engage in a Live Q&amp;A: Seize the opportunity to directly interact with Dr. Kwiatkowski, posing your most thought-provoking questions, and receive real-time, well-informed answers.
</li>
<li>Gain Expert Perspectives: Immerse yourself in a vibrant exchange of ideas, as Dr. Kwiatkowski shares her profound insights on questions posed by fellow participants.
</li>
</ul>
<blockquote>
Presenter: Dr. Carol Kwiatkowski (Adjunct Assistant Professor, North Carolina State University)
</blockquote>

Technology Networks: Ask Me Anything: PFAS

Ask Me Anything: PFAS

Delve into the fascinating world of PFAS.

Join us for a live presentation highlighting the uses of the Xevo G3 QTof mass spectrometer in a case study of biosimilar mAb characterization at intact, subunit, and peptide level.
<blockquote>
Presenter: Samantha Ippoliti (Principle Scientist, Discovery &amp; Development- Biopharma, Waters Corporation)
</blockquote>
<blockquote>
Sam joined Waters (Milford, MA) in 2018 and has worked on a variety of applications for LC-MS based biopharmaceutical characterization, including peptide mapping analysis and method development, and intact/subunit analysis via reversed phase (RP) and ion exchange (IEX) -MS. Prior to joining Waters, she was part of the LC-MS characterization group supporting a biopharmaceutical developability assessment group at Novartis in Cambridge, MA. Sam acquired a BS-MS in Chemistry from Northeastern University in 2012.
</blockquote>

Waters Corporation: Robust Multi-Level LC-MS Workflows for Biosimilar Comparability Assessment

Robust Multi-Level LC-MS Workflows for Biosimilar Comparability Assessment

Uses of the Xevo G3 QTof mass spectrometer in a case study of biosimilar mAb characterization at intact, subunit, and peptide level.

Robust Multi-Level LC-MS Workflows  for Biosimilars

Ion Mobility (IM) advancements in Software, Data Bases, AI and Machine learning are quickly improving capabilities to make unknown identifications, separate and ID isomers, as well as improve workflows associated with metabolomics, lipidomics, PFAS, and qual-quant screening.
In addition, IM measurements are significantly improved with HRdm High Resolution Demultiplexing. This is the first commercial IM instrument to enable the simultaneous combination of high drift resolution, while at the same time achieving all four of the following measurement capabilities: broad mass range in a single injection, multiplexing to increase sensitivity, compatibility with fast chromatographic acquisition rates , and highest precision in CCS measurements. For more accurate CCS predictions, the better precision in the CCS training set improves AI machine learning SW. This can significantly reduce the number of potential candidate structures to select from when making unknown identifications.
<blockquote>
Presenter: Carrie McDonough, PhD (Carnegie Mellon University)
</blockquote>

Agilent Technologies: Towards more Comprehensive Characterization of PFAS Exposure using Ion Mobility and High-Resolution Mass Spectrometry

Towards more Comprehensive Characterization of PFAS Exposure using Ion Mobility and High-Resolution Mass Spectrometry

Towards more Comprehensive Characterization of PFAS Exposure using Ion Mobility and High-Resolution Mass Spectrometry.

Characterization of PFAS Exposure using IM and HRMS

This online event is aimed at those working within academia and pharmaceutical drug development, who want to hear from experts across their field. Focus will be given to the latest advances in small molecule drug discovery and development, biopharma and biotechnology.
This online symposium will cover:
<ul>
<li>Accelerating drug discovery through AI
</li>
<li>Molecular dynamics simulations for novel drug targets
</li>
<li>Allosteric small-molecule activation of PI 3-kinase for cardioprotection and neuroregeneration
</li>
<li>Analytical solutions for challenging nitrosamine quantitation using LC-MS
</li>
<li>Screening in organoids and complex 3D assays using high-content imaging
</li>
<li>Paucity of novel oncology targets
</li>
<li>An interactive Ask-Me-Anything session where you can pose your questions to thought leadership experts at the forefront of biopharmaceutical commerce
</li>
</ul>
<h3>Agenda Day 2</h3>
<h5>16:00 – 16:30 Screening in Organoids &amp; Complex 3D Assays Using High Content Imaging</h5>
<ul>
<li>Speaker: Michiel Fokkelman, PhD</li>
</ul>
<h5>16:30 – 16:40 Networking Break</h5>
<h5>16:40 – 17:00 Enhancing Safety and Quality Assurance in Cell Based Therapies and ATMPS: The Power of Rapid NAT-Based Mycoplasma Detection</h5>
<ul>
<li>Speaker: Michael Brewer</li>
</ul>
<h5>17:00 – 17:10 Networking Break</h5>
<h5>17:10 – 18:00 Call to Action: Critical Need to Address the Paucity of Novel Oncology Targets</h5>
<ul>
<li>Speaker: Brian D. Lamon, PhD</li>
</ul>
<h5>18:00 – 18:10 Networking Break</h5>
<h5>18:10 – 18:30 Target Discovery and Validation with Arrayed Cell Libraries</h5>
<ul>
<li>Speaker: Alexander Brown, PhD</li>
</ul>
<h5>18:30 – 18:40 Networking Break</h5>
<h5>18:40 – 19:30 To Improve the Selectivity and Sensitivity of Chimeric T-Cell Receptor for Treating Solid Tumours</h5>
<ul>
<li>Speaker: Chun Wu, PhD</li>
</ul>
<blockquote>
Presenter: Joshua Smith, PhD (Global Lead for Industry Partnerships, IBM Research)
</blockquote>
<blockquote>
Presenter: Dr. Chun Wu (Associate Professor, Departments of Chemistry &amp; Biochemistry and the Biological Biomedical Sciences – Rowan University)
</blockquote>
<blockquote>
Presenter: Dr. Bart Vanhaesebroeck (Professor, Cancer Institute, University College London)
</blockquote>
<blockquote>
Presenter: Dr. Grace Gong (Research Fellow, Cancer Institute, University College London)
</blockquote>
<blockquote>
Presenter: David Pardoe (SVP Global Molecular Architects, Evotec)
</blockquote>
<blockquote>
Presenter: Carla Marchioro (VP Scientific Director Global Molecular Architects, Evotec)
</blockquote>
<blockquote>
Presenter: Jack Steed (Senior Technical Marketing Specialist, Sciex)
</blockquote>
<blockquote>
Presenter: Michael Brewer (Director, Global Principal Consultant, Regulatory, BioProduction, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Presenter: Michiel Fokkelman, PhD (Head of High Throughput Screening, Crown Bioscience Netherlands)
</blockquote>
<blockquote>
Presenter: Brian Lamon, PhD (Senior Vice President, Chief Business Officer and Head of BioPharma Business Development, Caris Life Sciences)
</blockquote>
<blockquote>
Presenter: Alexander Brown, PhD (Associate Director ECLIPSE Development, Synthego)
</blockquote>
<blockquote>
Presenter: Mike Ward (Global Head of Life Sciences &amp; Healthcare Thought Leadership, Clarivate plc)
</blockquote>

LabRulez/AI: Advances in Drug Discovery & Development 2023

Advances in Drug Discovery & Development 2023 (Day 2)

The latest advances in small molecule drug discovery and development, biopharma and biotechnology.

Advances in Drug Discovery & Development 2023 (Day 1)

<h4>Accelerate time to outcome and achieve efficiency in your laboratory</h4>
Contaminations can enter the food-chain at various stages. This has led to more rigorous regulations for the testing of contaminants in exported, imported, and domestic food and beverages.
In this webinar series, we will discuss how our latest solutions meet industry demands, such as high throughput, enhanced sensitivity requirements, increased accuracy, and compliance.
<h4>Episode 2: Solving challenges in the determination of pyrrolizidine alkaloids via LC-MS/MS and LC-IM-HRMS</h4>
With the increasing demand for food and more rigorous regulations, there is more pressure for laboratories to operate efficient, sensitive, and selective analysis methods.
Amongst various food toxins, analysis of plant alkaloids is a prerequisite nowadays. This of course, presents multiple challenges for testing laboratories.
During this session we will discuss:
<ul>
<li>Can critical pairs of isomers of Pyrrolizidine alkaloids be chromatographically separated?
</li>
<li>What efficient clean-up strategies can be utilized to remove matrix co-extractives?
</li>
<li>Can techniques like ion mobility be utilized to separate isomers?
</li>
</ul>
Join us for the food safety webinar series, where you can gain insights from industry experts and ask your questions in our live Q&amp;A session. We are really looking forward to discussing this topic further with you.
<blockquote>
Presenter: Nicola Dreolin (Senior Scientist and Product Manager, Waters Corporation)
</blockquote>
<blockquote>
Nicola Dreolin is a Senior Scientist and Product Manager at Waters. Nicola is specialised in method development for a variety of applications in food, environmental and life sciences. During the past five years, he was involved in different research projects regarding metabolomics, ion mobility and direct-mass spectrometry. Before joining Waters, Nicola worked as an Analytical Scientist at Elements, where he developed targeted and screening methods for the analysis of extractables and leachables, pharmaceuticals, tobacco and agrochemicals.
</blockquote>
<blockquote>
Presenter: Laura Carbonell Rozas (Postdoctoral Researcher, University of Almeria (Spain))
</blockquote>
<blockquote>
Laura Carbonell Rozas is a Postdoctoral researcher at the University of Almeria (Spain), within the research group “Analytical Chemistry of Contaminants”. Over the past seven years, Laura has been working on developing novel strategies for the determination of a wide range of food and environmental contaminants, including mycotoxins and alkaloids. In her research, Laura also pioneered the investigation of “greener” alternatives to conventional sample preparation methods. She obtained her PhD in Analytical Chemistry at the University of Granada (Spain) and she has worked with multiple international organisations, including LABERCA (France), CONICET (Argentina), and the University of Parma (Italy).
</blockquote>

Waters Corporation: Solving challenges in the determination of pyrrolizidine alkaloids via LC-MS/MS and LC-IM-HRMS

Solving challenges in the determination of pyrrolizidine alkaloids via LC-MS/MS and LC-IM-HRMS

How our latest solutions meet industry demands, such as high throughput, enhanced sensitivity requirements, increased accuracy, and compliance.

Pyrrolizidine alkaloids via LC-MS/MS and LC-IM-HRMS

Comparing MS spectra to libraries of reference spectra is one of the most widely used and successful methodologies in the identification of unknown mass spectra. Using this approach, access to an expansive, quality dataset is critical to achieving reliable results.
In this session we will introduce the latest release of the Wiley Registry® / NIST Mass Spectral Library 2023, which combines the power of two trusted MS spectral libraries to provide comprehensive compound coverage and ensure identification across multiple use cases and a wide variety of analytes.
In this session, we will also demonstrate through a series of live examples how this library can be used to successfully identify unknown spectra.
<blockquote>
Presenter: Dr. Nadia Laschuk
</blockquote>
<blockquote>
Dr. Nadia Laschuk is a Product Manager for Wiley Science Solutions, for which she manages new products and databases while supporting existing KnowItAll capabilities. Nadia previously completed her PhD in Materials Science from Ontario Tech University, where she performed research applying a wide array of instrumental techniques to analyze metal-organic coordination compounds. Nadia has since pursued cheminformatics and software, joining Wiley in 2022.
</blockquote>

Wiley: Increase the Likelihood of MS Identification with the Wiley Registry / NIST Library

Increase the Likelihood of MS Identification with the Wiley Registry / NIST Library

The latest release of the Wiley Registry® / NIST Mass Spectral Library 2023, which combines the power of two trusted MS spectral libraries.

MS Identification with the Wiley Registry / NIST Library

Learn how you can achieve confident, sensitive and reproducible AAV HCP identification.
This webinar will demonstrate approaches to overcome key challenges with AAV HCP analysis, such as the highly complex proteome background and large dynamic range which necessitate the need for high sensitivity enabling the detection and quantification of low abundant HCPs, essential for safe and efficacious production of these advanced biotherapeutics.
<h5>In this webinar you’ll learn:</h5>
<ul>
<li>How to overcome challenges in HCP analysis of AAV based gene therapies</li>
<li>How to ensure you accurately profile and quantify critical HCP contaminants in the sub ppm range</li>
<li>How the new <a href="https://lcms.cz/products/836">Thermo Scientific Orbitrap Astral Mass Spectrometer</a> can aid your HCP analysis</li>
</ul>
<blockquote>
Presenter: (Jonathan Bones, Principal Investigator, Characterization and Comparability Group, NIBRT)
</blockquote>
<blockquote>
Professor Bones obtained his BS in Analytical Science (Chemistry) and PhD in Analytical Chemistry from Dublin City University (DCU). Jonathan joined Prof. Pauline M. Rudds group at NIBRT in 2007.
</blockquote>

Chromatography & Mass Spectrometry: Host Cell Protein (HCP) Profiling and Quantitation in Gene Therapy Products with the Orbitrap Astral Mass Spectrometer

Host Cell Protein (HCP) Profiling and Quantitation in Gene Therapy Products with the Orbitrap Astral Mass Spectrometer

This webinar will demonstrate approaches to overcome key challenges with AAV HCP analysis.

LCMS webinars focusing on LC/MS - page 82