EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

<h4>Let’s begin with a simple question: what do we actually mean by high throughput?</h4>In the laboratory, high throughput usually refers to the ability to analyze tens, hundreds, or even thousands of samples per day, either across a laboratory workflow or on a single analytical system. Achieving this requires more than just a fast method. It depends on reliable instrumentation, automation, sufficient sample capacity, and smart system design that minimizes idle time between runs.In this article, we look at the key requirements for high-throughput HPLC analysis and how they are addressed in the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2371">HTQC system</a>.<h4>Speed</h4>High-throughput HPLC workflows typically rely on short methods. This includes both the chromatographic runtime and the cycle time of the injection module.With the HTQC system, fast gradient applications up to 1200 bar can be implemented using two integrated UHPLC high-pressure gradient pumps.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_1_2_HPG_pumps_of_HTQC_system_left_P_8_1_L_max_pressure_1240_bar_right_P_6_1_L_max_pressure_1000_bar_4d4873ff2f.jpg" alt="KNAUER: Fig. 1–2 HPG pumps of HTQC system, left: P 8.1L (max. pressure 1240 bar), right: P 6.1L (max. pressure 1000 bar)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_1_2_HPG_pumps_of_HTQC_system_left_P_8_1_L_max_pressure_1240_bar_right_P_6_1_L_max_pressure_1000_bar_4d4873ff2f.jpg 245w," sizes="100vw" width="1266" height="386">We will not discuss the full details of transferring classical HPLC methods to fast, high-resolution UHPLC methods here, but UHPLC implementation can dramatically reduce total analysis time.Let’s use a hypothetical example. Imagine Giorgia, a randomly chosen name, working in pharmaceutical quality control in 1998. She must have travelled back in time, because she would have been too young to work in a lab then, but the example still works. With a classical HPLC method, each sample takes approximately 75 minutes, including equilibration, analysis, and backflushing of a 250 × 4.6 mm ID column. This type of method has been common in QC laboratories around the world. During an eight-hour working day, Giorgia can analyze around six samples.Now let’s transfer the same method to UHPLC. The improvement is substantial. Analysis time, equilibration time, and backflushing time are all reduced to under six minutes per sample. Giorgia can now process around 90 samples in one working day.You may wonder why the HTQC system requires two UHPLC gradient pumps. We will come back to that shortly.The next way to increase speed is to reduce injector cycle time. Injection procedures and washing steps can sometimes take a significant amount of time. This is where the LH 8.1 liquid handler becomes important.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_3_KNAUER_LH_8_1_Liquid_Handler_77ab506ca6.webp" alt="KNAUER: Fig. 3 KNAUER LH 8.1 Liquid Handler" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_3_KNAUER_LH_8_1_Liquid_Handler_77ab506ca6.webp 129w," sizes="100vw" width="800" height="971">The LH 8.1 supports overlapped injections. This means that the next injection can already be prepared while the current analysis is still running. Necessary cleaning steps of the injection system are still maintained, but idle time is reduced.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_4_Schematic_buildup_of_injections_with_and_without_overlapped_injections_af089ba652.webp" alt="KNAUER: Fig. 4 Schematic buildup of injections with and without overlapped injections" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_4_Schematic_buildup_of_injections_with_and_without_overlapped_injections_af089ba652.webp 245w," sizes="100vw" width="1920" height="452">Let’s return to Giorgia. By using overlapped injections in her QC method, she saves about one minute per sample. This increases her capacity to approximately 105 samples per day.<h4>Sample Throughput</h4>A high-throughput system must also be able to handle and store a sufficient number of samples. Here, the LH 8.1 provides another major advantage. In the long-rail version, it can be equipped with up to three robotic coolers.With three coolers, each containing three drawers, the system can hold nine 10 × 13 sample trays. That means a total capacity of 1170 vials. The samples are also temperature controlled.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_5_6_Robotic_Cooler_with_two_10x6_trays_LH_8_1_887_version_with_two_Robotic_Coolers_855b10c2a3.jpg" alt="KNAUER: Fig. 5–6 Robotic Cooler with two 10x6 trays, LH 8.1 (887 version) with two Robotic Coolers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_5_6_Robotic_Cooler_with_two_10x6_trays_LH_8_1_887_version_with_two_Robotic_Coolers_855b10c2a3.jpg 245w," sizes="100vw" width="1262" height="503">Combined with the low eluent consumption typical of UHPLC, this large sample capacity makes it possible to extend operation from an eight-hour workday to 24-hour operation.For Giorgia and her QC lab, this changes everything again. The same UHPLC method, including overlapped injections, can now run continuously around the clock. This allows approximately 320 samples to be processed per day.Is that enough? Maybe not. As the blog title suggests: we just can’t get enough.<h4>Automation</h4>In addition to a standard 6-port, 2-position injection valve, the HTQC system includes an additional valve. This special column-switching and backflushing valve enables two columns to be operated alternately within a single UHPLC system.While one column is used for analysis, the second column can be backflushed and equilibrated in the reverse flow direction at the same time. This is particularly useful for reducing matrix effects, which are often encountered in QC laboratories when complex sample matrices are analyzed. It also helps reduce overall method runtime.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_7_Exemplary_flow_scheme_of_special_column_switching_valve_d837a71117.webp" alt="KNAUER: Fig. 7 Exemplary flow scheme of special column switching valve" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_7_Exemplary_flow_scheme_of_special_column_switching_valve_d837a71117.webp 127w," sizes="100vw" width="735" height="905"><h4>Parallel Processing</h4>Remember the earlier question: why does the system use two UHPLC gradient pumps?The reason is now clear. The second gradient pump is required to backflush one column while the other column is connected to the analytical flow path through the special switching valve.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_8_Schematic_illustration_of_column_cleaning_equilibration_and_analysis_with_special_backflush_valve_eae2e6f705.webp" alt="KNAUER: Fig. 8 Schematic illustration of column cleaning, equilibration and analysis with special backflush valve" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_8_Schematic_illustration_of_column_cleaning_equilibration_and_analysis_with_special_backflush_valve_eae2e6f705.webp 245w," sizes="100vw" width="1920" height="281">Giorgia immediately ordered a second UHPLC pump and the special valve for her QC lab. She now has a complete HTQC system and is very pleased with the result.Why? Let’s calculate it one final time. With all automation features in place, Giorgia can clean one column while the other column analyzes a sample. This enables her to process an impressive 600 samples per day.Compared with the classical HPLC method she used in 1998, the daily sample throughput has increased from six samples to 600 samples. That is a 100-fold increase.<h4>Summary</h4>We started with a question, so let’s end with one too: what steps increased the throughput?First, the method was scaled down from classical HPLC to a fast UHPLC approach. Then, a second pump and a special column-switching and backflushing valve were added to the UHPLC setup. Together with the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1454">LH 8.1 liquid handler</a> and its exceptional sample capacity, the HTQC system becomes a flexible and powerful configuration for high-throughput analysis.The system can also be coupled to nearly any detector used in HPLC. Because of its ability to operate at very high speed, it is especially well suited for mass spectrometric methods.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Fig_9_Complete_flow_scheme_of_HTQC_system_with_highlighted_system_components_edef36cb42.webp" alt="KNAUER: Fig. 9 Complete flow scheme of HTQC system with highlighted system components" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Fig_9_Complete_flow_scheme_of_HTQC_system_with_highlighted_system_components_edef36cb42.webp 161w," sizes="100vw" width="800" height="775"><blockquote>For further information on this topic, please contact our authors: kramer@knauer.net, m.myrach@knauer.net</blockquote>

Introducing Our System Solution for High Throughput Quality Control – HTQC

News from LabRulezLCMS Library - Week 19, 2026

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

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Waters Corporation

<div><h4>Navigating Challenges and Opportunities for Environmental Testing Labs Under the Revised EU Water Framework Directive</h4>The European Commission’s proposed updates to the Water Framework, Groundwater, and Environmental Quality Standards Directives are bringing new responsibilities and opportunities for environmental testing labs. With expanded pollutant lists - including PFAS, pharmaceuticals, and pesticide metabolites - and stricter monitoring and reporting requirements, the landscape of water analysis is rapidly evolving.Join the 4th Waters Environmental Webinar Series to explore how your lab can navigate these challenges and turn regulatory change into opportunity.Register for free and partner with us to shape the future of European water quality.<h5>Why Attend</h5>Stay ahead of new EU regulatory demands with insights from leading experts. Gain practical guidance, share experiences with peers, and prepare your lab for the next generation of water quality standards.<h5>Highlights</h5><ul><li>New pollutant categories and analytical challenges</li><li>Updates to monitoring protocols and reporting</li><li>Innovative methods to meet revised Environmental Quality Standards</li><li>Strategic guidance for compliance and adaptation</li></ul>Lead the change in water analysis—stay ahead, stay compliant, and make a real impact.<h4>EPISODE 5: Add a New Dimension - MS Imaging for Environmental Analysis</h4><h4>What you Will Learn</h4><ul><li>What is MS imaging?</li><li>Key benefits of Desorption Electro Spray Ionisation (DESI) for environmental analysis</li><li>Practical insights and emerging applications</li></ul><blockquote>Speaker: Emmanuelle Claude (Consulting Scientist, Waters Corporation)</blockquote></div>

Add a New Dimension - MS Imaging for Environmental Analysis

Learn about MS imaging and discover key benefits of Desorption Electro Spray Ionisation (DESI) for environmental analysis.

MS Imaging for Environmental Analysis

<h3>A five-part webinar series unlocking advanced insights across the Peptide therapeutics workflows</h3>Peptide therapeutics are reshaping modern medicine, with GLP-1 receptor agonists driving rapid advances in metabolic disease treatment. As peptide and GLP-1 programs scale, scientists face increasing pressure to generate data that is accurate, defensible, and decision-ready across development stages.Peptide 360 is designed to guide scientists through this complexity, following the peptide workflow from sequence insight to confident development decisions.<h5>Who Should Attend?</h5>This series is designed for scientists and technical leaders working in peptide and GLP-1 discovery and development, analytical development, characterization, Bioanalysis, DMPK, translational research, CMC, QA/QC, and regulatory-facing analytical roles<h5>How the Series Works?</h5><ul><li>Register once for the full series</li><li>Pre-submit questions for live expert responses</li><li>Access recordings anytime after each session</li><li>Certificate of attendance provided</li></ul><h4>Episode 4: Accelerating LC/MS Impurity Screening Followed by ECD-Based Sequence Analysis for GLP-1 Analogs</h4>As GLP-1 analogs increase in structural complexity, efficient impurity profiling requires both speed and structural clarity. This session presents a staged LC/MS-based workflow that enables rapid impurity screening to identify candidates requiring deeper investigation, followed by targeted ECD-based sequence analysis for detailed structural insight. By separating fit-for-purpose screening from high-resolution characterization, the workflow reduces unnecessary analytical complexity and shortens the path from detection to interpretation.Attendees will learn how electron capture dissociation (ECD) preserves labile modifications, enabling precise localization and confident sequence confirmation. The session highlights how tiered impurity strategies support timely, data-driven decisions during GLP-1 development.<blockquote>Presenter: Rachel Franklin (Application Development Scientist, Agilent Technologies, Inc.)Presenter:&nbsp;Ashish Pargaonkar, Ph.D. (Biopharma Applications Specialist, Agilent Technologies, Inc.)</blockquote>

Agilent Technologies: Peptide 360: Mastering the Invisible from Sequence to Confidence

Accelerating LC/MS Impurity Screening Followed by ECD-Based Sequence Analysis for GLP-1 Analogs

Peptide 360 Episode 4 webinar on LC/MS impurity screening and ECD sequence analysis for GLP-1 analog characterization.

Accelerating LC/MS Impurity Screening for GLP-1 Analogs

Glucagon-like peptide-1 (GLP-1) receptor agonists—including Semaglutide, Exenatide, and Tirzepatide—are synthetic peptide therapeutics widely used in the management of type 2 diabetes and obesity. Due to their structural complexity and susceptibility to degradation and related impurities, robust analytical methods are essential for quality control and regulatory compliance.&nbsp;This presentation highlights two orthogonal chromatographic approaches for impurity profiling: reversed-phase liquid chromatography (RPLC) and hydrophilic interaction chromatography (HILIC). We will discuss method development strategies to optimize separation performance, including considerations for gradient design, column chemistry, temperature control, and mobile phase composition. These insights aim to support analysts in achieving high-resolution separations and reliable impurity characterization of GLP-1 analogs.<blockquote>Presenter: Andrea Ngai (BioPharma Technical Specialist, Agilent Technologies, Inc.)Andrea Ngai holds a B.S. and M.S. in Biology from San Francisco State University and brings over 15 years of experience in analytical chemistry and chromatography. She has supported both biotech and biopharma organizations, developing LC-MS methods for the characterization of complex biotherapeutics and industrial enzymes. Currently, Andrea serves as a BioPharma Technical Specialist at Agilent Technologies, where she helps customers optimize analytical and preparative workflows for large molecule therapeutics</blockquote>

Agilent Technologies: Impurity Characterization of GLP-1 Receptor Agonists via RPLC and HILIC

Impurity Characterization of GLP-1 Receptor Agonists via RPLC and HILIC

RPLC and HILIC approaches for GLP-1 impurity analysis—method development, optimization, and robust peptide characterization.

Impurity Characterization of GLP-1 via RPLC and HILIC

MS Imaging Group presents "Raising the Bar: Quality Assurance and Data Integrity in MALDI MSI"<blockquote>Presenter: Dr. Caitlin Tressler (Assistant Professor, Department of Radiology and Oncology, Johns Hopkins)Presenter: Amin Jarrahi (PhD Candidate in Biomedical Engineering, University of Tennessee, Knoxville)Moderator: Dr. Jessica MooreModerator: Dr. Colleen Crouch</blockquote>

US HUPO: Raising the Bar: Quality Assurance and Data Integrity in MALDI MSI

Raising the Bar: Quality Assurance and Data Integrity in MALDI MSI

Webinar on QA and data integrity in MALDI MSI. Learn best practices for reliable imaging workflows and reproducible spatial omics data.

Quality Assurance and Data Integrity in MALDI MSI

Microplastics are increasingly detected across the environment and even within the human body, raising urgent questions about their sources, exposure pathways, and health implications.In this webinar, we will explore complementary analytical solutions for comprehensive microplastics characterization.Discover how FTIR and Raman spectroscopy enable reliable particle identification and imaging—covering sizes from millimeters down to a few microns—while high-resolution mass spectrometry techniques such as pyrolysis GC-HRMS and LC-based workflows provide sensitive detection and quantification of polymers and plastic-related chemicals in complex environmental and biological matrices.From particle-level identification to advanced chemical fingerprinting and exposure assessment, learn how Thermo Fisher Scientific technologies support micro- and nanoplastics analysis across research, environmental monitoring, and human biomonitoring applications.<blockquote>Speaker: Dr. Kuanliang Shao (Postdoctoral Fellow, Department of Environmental Health Comprehensive Laboratory for Untargeted Exposome Science | Emory University) will share how Py-GC-HRMS is enabling population-level biomonitoring of MNPs in human tissues and its integration into exposomics frameworks.Speaker:&nbsp;Dr. Wang Rui (Business Development Manager, Chemical Analysis | Thermo Fisher Scientific) will provide an overview of FTIR and Raman spectroscopy solutions for microplastics identification, highlighting how technologies ranging from point-and-shoot systems to advanced imaging platforms enable reliable analysis across diverse environmental samples and particle sizes, from millimeters down to a few microns.</blockquote>

Thermo Fisher Scientific: Uncovering Microplastics: Identification, Quantification, and Exposure Assessment

Uncovering Microplastics: Identification, Quantification, and Exposure Assessment

In this webinar, we will explore complementary analytical solutions for comprehensive microplastics characterization.

Microplastics Identification, Quantification

Compliance with IC methods US EPA 300.1 Parts A and B, ISO 10304 Parts 1 and 4, or US EPA 557 can make efficient monitoring of environmental waters a challenge. Selecting the right column technology is key, whether you are working with carbonate or hydroxide eluents.In our upcoming webinar, we focus on a new generation of high-capacity anion exchange columns. We will show how innovative column chemistry enables lowest detection limits and improved robustness against complex matrices for fully compliant analysis of environmental waters.Two complementary analytical strategies for the analysis of common anions and oxyhalides are presented in the webinar: The carbonate-based eluent approach with the new Metrosep A Supp 20 column and the hydroxide-selective approach with the Metrosep A Supp 21 column. Both strategies enable performing US EPA 300.1 Parts A and B and ISO 10304 Parts 1 and 4, respectively, in one single run.We will also show how automated hydroxide eluent production provides for highly precise and reproducible analyses with ultra‑low baselines, supporting demanding applications such as the determination of haloacetic acids (HAA) according to US EPA 557.<h4>Key learnings of this webinar</h4><ul><li>Understand how high-capacity IC columns improve robustness, accuracy, and reproducibility of your IC analysis of environmental waters</li><li>Learn how EPA 300.1 Parts A and B and ISO 10304 Parts 1 and 4, respectively, can be resolved in a single run&nbsp;</li><li>Discover the advantages of automated eluent generation combined with hydroxide-selective columns, such as the Metrosep A Supp 19 column, for haloacetic acid analysis (US EPA 557)</li><li>Explore how the right choice of columns and eluent strategies can optimize your workflows and increase laboratory efficiency and data quality</li></ul><h4>Who should attend?</h4><ul><li>Water utility operators who need robust and reliable analytical techniques to guarantee the safety of drinking water</li><li>Lab managers responsible for their lab’s compliance with the standards and regulations for the analysis of environmental waters</li><li>Scientists, researchers, and analytical method developers who need to stay up to date on state-of-the-art methods for ion chromatography</li><li>Laboratory staff and managers interested in a reliable, cost- and time-efficient analysis technique for their monitoring of environmental waters</li></ul><blockquote>Presenter: Dr. Vincent Diederich (Product Manager Ion Chromatography Columns, Metrohm International Headquarters)Vincent Diederich received his MSc in Chemical and Bioengineering at the ETH Zurich in Switzerland and stayed there for a PhD in Chemical Engineering where he gained a deep understanding of polymer reaction engineering. Since 2015, he has worked at Metrohm International Headquarters focusing on column and method development for ion chromatography, initially as a Column Production Specialist and now as Product Manager for ion chromatography columns.</blockquote>

Metrohm: Environmental waters: A new generation of high-capacity IC columns makes analysis more efficient

Environmental waters: A new generation of high-capacity IC columns makes analysis more efficient

Discover advanced IC column strategies for EPA and ISO water analysis, improving sensitivity, robustness, and efficiency in environmental monitoring workflows.

High-capacity IC columns for water analysis

<h3>Bringing laboratory automation to life with Andrew+ and OneLab</h3>This webinar series explores how Andrew+ automated liquid handling and OneLab workflow software support consistent, traceable and efficient laboratory operations. Through application‑focused episodes, you will see how automation can be successfully integrated into everyday laboratory workflows, from method development to routine and regulated environments, supported by customer experiences and testimonials.<h4>Episode 1 – Proteomics Workflows</h4><h5>Overview</h5>Automation plays a key role in modern proteomics, where reproducibility and consistency are essential. In this episode, we explore how automated liquid handling supports robust, scalable sample preparation workflows while reducing manual variability across studies, with insights shared directly from proteomics laboratories using automation in practice.<h5>Key highlights</h5><ul><li>Apply automation across proteomics workflows including digestion, desalting, peptide quantification and normalization</li><li>Reduce batch effects and improve reproducibility in long-term and large-scale studies</li><li>Support evolving proteomics methods with flexible, reliable automation Speakers</li></ul><h5>Customer testimonials:</h5>Imperial College London – National Phenome Centre<ul><li>A leading UK-based academic research centre specialising in large-scale, high‑throughput proteomics and multi‑omics studies. In this episode, the team shares how automated liquid handling has been integrated into routine proteomics sample preparation workflows — from protein assays and digestion to desalting, peptide quantification and sample normalisation — enabling highly reproducible results while significantly reducing batch variation across long-term studies.</li></ul>MRC Laboratory of Medical Sciences<ul><li>A biomedical research institute focused on understanding the molecular basis of human disease, with strong expertise in proteomics and metabolomics. The laboratory provides insight into how automation supports attention‑intensive workflows such as concentration normalisation and solid phase extraction (SPE), helping to improve consistency, usability and throughput in proteomics sample preparation.</li></ul>University of Leicester – Van Geest Multiomics Facility<ul><li>A university-based multiomics facility supporting large‑scale clinical and translational research projects. In this episode, the facility explains how automated liquid handling has transformed proteomics workflows for large cohort studies, enabling scalable, flexible sample preparation while minimising batch effects and supporting highly reproducible biomarker research.</li></ul>Reserve Your Spot Today!

Transform Your Daily Lab Operations with Automation - Proteomics Workflows

Learn how automation enhances proteomics workflows, improving reproducibility, reducing batch effects, and enabling scalable sample preparation.

Transform Daily Lab Operations with Automation - Proteomics

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Regulatory expectations around nitrosamines continue to evolve, placing increasing pressure on analytical workflows to deliver both accuracy and flexibility. Join our upcoming webinar with AbbVie to see how advanced LC-MS tools can help you confidently quantify known nitrosamines and uncover unknown impurities, saving valuable time and resources.<h4>What you’ll learn:</h4><ul><li>Confident annotation &amp; accurate quantification: Leverage the SQUAD approach to precisely identify and quantify targeted nitrosamines using authentic standards and calibration curves.</li><li>Simultaneous targeted &amp; untargeted analysis: Perform comprehensive screening in a single run—detect known compounds while uncovering unexpected impurities without additional injections.</li><li>Overcoming unknown nitrosamine challenges: Optimize your LC-MS methods to improve confidence in identifying unknown nitrosamines and meet regulatory expectations.</li></ul><blockquote>Presenter: Jessica Hoskins, PhD (Principal Research Scientist I, Predictive Stability and Structure Elucidation)Jessica is a Principal Research Scientist at AbbVie where she and her team focus on Predictive Stability and Structure Elucidation to understand degradation pathways and other potential stability limiting attributes for new synthetic molecule drug substances and drug products. She has a PhD in Organic Chemistry from Tulane University with Scott Grayson, where she first became interested in mass spectrometry for polymers. Prior to joining AbbVie, she was an Adolf Martens Postdoctoral Fellow at the Federal Institute for Materials Research and Testing (BAM) in Berlin, Germany, and worked as an analytical chemist at Stepan Company in the surfactant and polymer industry.Presenter:&nbsp;Sebastien Morin (Sr Manager, Business Development, Thermo Scientific)Sebastien is a Senior Manager, Business Development at Thermo Fisher Scientific where he partners closely with Pharma and Biopharma Companies to address analytical challenges. He holds a M. SC. in Organic Chemistry from Universite de Montreal. Prior to joining Thermo Fisher Scientific, he was a Research Associate, Medicinal Chemistry for Boehringer Ingelheim, advancing virology research.</blockquote></div></div></div>

Thermo Fisher Scientific: Keeping Up with Evolving Regulatory Requirements: Addressing Analytical Challenges for Known and Unknown Nitrosamines

Keeping Up with Evolving Regulatory Requirements: Addressing Analytical Challenges for Known and Unknown Nitrosamines

Join our webinar to see how advanced LC-MS tools can help you confidently quantify known nitrosamines and uncover unknown impurities.

Analytical Challenges for Known and Unknown Nitrosamines

<h4>Advanced Size Variant Analysis of Antibodies and ADCs Using SEC Techniques</h4>Size‑exclusion chromatography (SEC) is essential for analyzing aggregates, monomers, and fragments in biotherapeutic proteins, but traditional methods often require extensive optimization due to non‑desired ionic and hydrophobic interactions. Learn how these innovations improve resolution, reduce eluent complexity, support SEC-MALS, SEC-MS, 2D Protein A -,SEC workflows, and deliver robust, out-of-the-box performance across a wide range of protein modalities.<ul><li>Review SEC fundamentals and smart column selection</li><li>Build robust, platform-ready SEC methods for mAbs</li><li>Leverage advanced MALS and MS detectors for deeper insight</li><li>Direct analysis of mAb HMWS in cell-culture with 2D Protein A- SEC</li></ul>This webinar is designed for Scientists in Biopharma, CXOs, Academic, Government performing SEC-based protein separations.<blockquote>Speaker: Stephan M. Koza, Ph.D. (Senior Principal Scientist, Waters Corporation)Stephan Koza has worked at Waters Corporation for over 10 years and has a primary focus on the use of LC, LC-MS, and sample preparation chemistries and columns for the analysis of biomolecules.Prior to joining Waters, he had nearly twenty years of experience with biopharmaceutical characterization and analytical method development with Genetics Institute, Wyeth, and Pfizer.Stephan received his doctorate in analytical chemistry at the University of New Hampshire.Speaker:&nbsp;Bill Warren (Principal Consultant Product Manager, Waters Corporation)Bill joined Waters in 1986 as a senior applications chemist involved with the research and development of HPLC, FPLC, and Capillary Electrophoresis applications for the analysis and purification of proteins, peptides, and nucleic acids.Bill currently is a Principal Consultant Product Manager whose responsibilities involve assisting in the development and commercialization of innovative reagents and chromatography-based technologies for the separation, purification, and characterization of biological moleculesSpeaker:&nbsp;Udayabagya (Bud) Halim (Sr. Product Marketing Analyst, Waters Corporation)Bud Halimis a senior marketing analyst at Waters | Wyatt Technology with a PhD in physical chemistry from UCLA.He began his career teaching biochemistry and chemistry and contributing to laboratory manuals before transitioning into the scientific instrumentation industry as an applications scientist.At Waters, he supports researchers in the characterization of peptides, biologics, lipid nanoparticles (LNPs), and viral vectors.</blockquote>

Size variant analysis of antibodies and ADCs using SEC, SEC-MALS, SEC-MS, and 2D Protein A-SEC Methods

Review SEC fundamentals and smart column selection

Size variant analysis of antibodies and ADCs

Biotherapeutic stability is essential for ensuring product quality, safety, and efficacy. In this webinar, discover how forced degradation studies combined with intact and subunit icIEF-UV/MS workflows provide deeper insights into charge variants and degradation pathways. Learn how integrating icIEF with UV and mass spectrometry enhances analytical confidence and supports robust biopharmaceutical characterization.<h4>Key highlights</h4><ul><li>Understand how the icIEF-UV/MS method works to identify charge variants in 30 minutes</li><li>Discover how it has been applied to the analysis of an intact and the sub units of a stressed monoclonal antibody</li><li>Find out how the Biologics Explorer software aids data visualisation in both intact and subunit analysis</li></ul><blockquote>Speaker: Dr. Stephen Lock, Senior Market Development Manager, SCIEX</blockquote>

SCIEX: Assessing biotherapeutic stability through forced degradation using intact and subunit icIEF-UV/MS workflows

Assessing biotherapeutic stability through forced degradation using intact and subunit icIEF-UV/MS workflows

Join this webinar to learn icIEF-UV/MS workflows for biotherapeutic stability, charge variant analysis, and monoclonal antibody characterization.

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EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

News from LabRulezLCMS Library - Week 19, 2026

Introducing Our System Solution for High Throughput Quality Control – HTQC