When every peptide bond matters, fragmentation is where discovery begins. The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958">Thermo Scientific Orbitrap Excedion Pro mass spectrometer</a> brings EASY-ETD and HCD together on a single, ultra-high-performance Orbitrap platform—delivering clarity across proteomics, biopharma, and structural biology.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_79614cedcf.jpg 245w," sizes="100vw" width="1024" height="512"><h3>Two fragmentation technologies, one hybrid advantage</h3><h4>EASY-ETD — gentle by design, powerful by nature</h4>EASY-ETD transfers electrons to peptide/protein ions, breaking the backbone while preserving labile PTMs and fragile linkages, generating c- and z-ions ideal for confident site localization. Especially valuable for: phosphorylation, glycosylation, deamidation, isomer discrimination (Asp/IsoAsp; Leu/IsoLeu), and ADC linker–payload integrity.<h5>Example — isomer discrimination with diagnostic ions</h5>In a UHPLC-HRAM ddMS² peptide-mapping experiment on NISTmAb, EThcD (EASY-ETD + supplemental HCD) produced the ETD-diagnostic c+57 and z–57 ions and unambiguously identified isoAsp in a 23-aa, 3+ deamidated peptide present at 0.18%, with &lt;8 ppm mass error for both signatures (Figure 1). This shows how electron-based fragmentation retains the information needed to resolve subtle isomerization that collision-only methods can miss.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 1: EASY-ETD/EThcD reveals isoAsp with signature ions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_2_9750198ab6.jpg 245w," sizes="100vw" width="1024" height="550">EThcD full-MS² spectrum from a NISTmAb tryptic peptide-mapping run. Zoom-in panels highlight z6–57 and c17+57 confirming isoAsp at 0.18% with &lt;8 ppm error.<h4>HCD — High-Energy Confidence for every workflow</h4>HCD generates rich b- and y-ion spectra for robust sequencing and quantitative reproducibility. With the Excedion Pro’s ultra-high-field Orbitrap (MS² up to 70 Hz) and—on the BioPharma edition—an extended mass range to m/z 12,000, HCD supports full sequence coverage, consistent DIA/DDA quantitation, and confident identification of oxidation, deamidation, and truncation variants. Together, EASY-ETD and HCD provide orthogonal fragmentation—comprehensive coverage and high-confidence confirmation in one analysis.<h3>Why combine EASY-ETD and HCD?</h3><ul><li>PTM localization: EASY-ETD preserves fragile sites; HCD confirms sequence context.</li><li>ADC characterization: EASY-ETD keeps linker–payload intact; HCD supports quant and variant checks.</li><li>Isomer detection: EASY-ETD resolves Asp/IsoAsp; HCD adds complementary evidence.</li><li>Quant proteomics: EASY-ETD maintains structural integrity; HCD delivers reproducible intensity.</li><li>Throughput: Electron-driven fragmentation + fast collision MS² (up to 70 Hz).</li></ul><h3>Applications that push the limits</h3><h4>Biopharma Characterization</h4><ul><li>Map DARs and conjugation sites in ADCs with confidence</li><li>Detect low-level PTMs impacting efficacy</li><li>Combine native intact MS and EThcD mapping for complete characterization</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg" alt="Thermo Fisher Scientific: Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation: Figure 2. EThcD maps ADC conjugation without cleaving the payload." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Fragment_Smarter_See_Deeper_How_the_Orbitrap_Excedion_Pro_Unlocks_EASY_ETD_and_HCD_Fragmentation_3_04122d5bda.jpg 245w," sizes="100vw" width="1024" height="372">EThcD MS² spectrum of ADYEK(188-MCC-DM1)HK (light chain, z=3). Colored arrows mark c and z fragments used to localize the conjugation site at K188; complementary y/c ions provide sequence context. Data acquired on the Orbitrap Excedion Pro BioPharma platform.<h4>Advanced proteomics</h4><ul><li>Expand sequence coverage in complex proteomes with complementary ion types</li><li>Support Hybrid-DIA for accurate quantitation with fewer false positives</li><li>Profile labile PTMs that collision-only methods may miss</li></ul><h4>Structural biology &amp; HDX-MS</h4><ul><li>Preserve H/D labeling and delicate interactions</li><li>Enable low-flow DIA-HDX with high sensitivity and throughput</li></ul><h3>Hardware that makes it possible</h3><ul><li>OptaMax Plus Ion Source — enhanced spray stability and ease of use</li><li>Advanced Quadrupole Technology (AQT) — ultra-selective precursor isolation</li><li>Ion-Routing Multipole (IRM) — HCD, ETD, and EThcD in a single module</li><li>Electrodynamic Ion Funnel (EDIF) — optimized transmission for labile compounds</li><li>Ultra-high-field Orbitrap analyzer — high mass accuracy and throughput; BioPharma edition supports m/z 12,000</li></ul><h3>Answering the “How” behind advanced fragmentation</h3><ul><li>How does EASY-ETD improve peptide analysis vs standard ETD? Optimized ion routing with optional supplemental activation (EThcD) yields efficient electron transfer and improved sequence coverage—especially for labile or larger peptides. &nbsp;</li><li>Can HCD and EASY-ETD be used in one workflow? Yes—EThcD provides complementary c/z and b/y information in a single MS² event, ideal for PTM localization and conjugation analysis. &nbsp;</li><li>What’s the benefit for biopharma labs? More insight per sample. EASY-ETD localizes modifications or conjugation sites while HCD supports robust quantitation—accelerating analytical development and QC.</li></ul><h3>From complexity to confidence</h3>The Orbitrap Excedion Pro lets scientists choose the right fragmentation energy for every molecule—uncovering fine-structure detail without sacrificing throughput. From intact ADCs to complex proteomes, EASY-ETD + HCD deliver the most complete view of molecular structure available on a hybrid Orbitrap platform.Learn more about <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958">Orbitrap Excedion Pro Mass Spectrometers</a><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#OrbitrapExcedionPro #Orbitrap #MassSpectrometry</blockquote>

Fragment Smarter, See Deeper: How the Orbitrap Excedion Pro Unlocks EASY-ETD and HCD Fragmentation

A quick reminder that an important ISC2026 deadline is just around the corner - now is the time to act! Register and complete your payment on time to secure the best rate. Authors of oral presentations are kindly requested to complete their payment to ensure their contributions are included in the program.<blockquote><ul><li>Early-bird registration &amp; payment deadline: May 15, 2026</li><li>Payment deadline for authors of oral presentations: May 15, 2026</li></ul></blockquote><h3>REGISTRATION</h3><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal">Register NOW and do not miss the deadline</a></blockquote><h4>REGISTRATION FEES in EUR including VAT&nbsp;</h4><h5>Early-Bird Registration (until 15 May 2026)</h5><ul><li>Industry: 850</li><li>Academic, Government: 650</li><li>Student*: 290</li><li>Student* + 3 short courses: 390</li><li>Short Courses**: 190</li><li>Accompanying Persons: 190</li><li>Gala Dinner: 100</li></ul><h5>Late Registration (until 25 August 2026)</h5><ul><li>Industry: 1,000</li><li>Academic, Government: 780</li><li>Student*: 340</li><li>Student* + 3 short courses: -</li><li>Short Courses**: 230</li><li>Accompanying Persons: 190</li><li>Gala Dinner: 100</li></ul><h5>Onsite Registration (from 26 August 2026)</h5><ul><li>Industry: 1,150</li><li>Academic, Government: 890</li><li>Student*: 390</li><li>Student* + 3 short courses: -</li><li>Short Courses**: 270</li><li>Accompanying Persons: 190</li><li>Gala Dinner: 100</li></ul>*The student fee applies only to full-time students. This does not include individuals who are employed and pursuing a PhD or other degree part-time. Participants registering under this category are required to upload a valid proof of full time student status (e.g., confirmation from the university or a student ID) directly in the registration form.**The price covers up to 3 short courses for a single flat rate.All the above fees are in EUR and include a local VAT of 21 %.<h5>FULL REGISTRATION FEES INCLUDE:&nbsp;</h5><ul><li>Access to oral and poster sessions&nbsp;</li><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li><li>Electronic Book of Abstracts&nbsp;</li><li>Prague public transportation pass&nbsp;</li></ul><h5>ACCOMPANYING PERSON FEES INCLUDE:&nbsp;</h5><ul><li>Access to the exhibition hall&nbsp;</li><li>Welcome Reception on Sunday, 6 September 2026&nbsp;</li><li>Scheduled lunches and coffee breaks as per the programme&nbsp;</li></ul>The accompanying persons do not have access to the scientific programme.&nbsp;<h4>Short Courses - New Addition</h4>Our short course program continues to grow! In addition to the existing courses, we’ve added a new course on LC-MS data analysis using mzmine, offering even more hands-on learning opportunities.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/short-courses/">Explore all available courses on the website.</a></blockquote><h4>Exhibition &amp; Sponsorship Opportunities</h4>The ISC 2026 exhibition is filling up, but a few final spots are still available for companies interested in showcasing their products and connecting with the community.<h4>Stay Updated</h4>The ISC 2026 website is regularly updated with the latest information on the program, speakers, and symposium activities - make sure to check it out.Don’t miss these key deadlines - we’re looking forward to seeing you at ISC 2026 in Prague!Best regards,The ISC 2026 Organizing Committee

ISC 2026 Early-Bird Registration & Payment Deadline

We are pleased to announce the following awards that will be presented at RIVA 2026.<h4>MARCEL GOLAY AWARD</h4>The Marcel Golay award was instituted in honor of Marcel Jules Eduard Golay, the inventor of capillary columns.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISCC_Marcel_Golay_db4a8f5e32.jpg" alt="ISCC &amp; GCxGC Symposium: Marcel Jules Eduard Golay " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISCC_Marcel_Golay_db4a8f5e32.jpg 164w," sizes="100vw" width="246" height="234">Dr. Golay, one of the pioneers of gas chromatography, introduced the theory of dispersion in open tubular columns (capillary columns) and demonstrated their efficacy at the second International Symposium on Gas Chromatography in 1958. Dr. Golay joined PerkinElmer in 1962 as a senior scientist, and invented the Golay infrared sensor, which at the time was the most sensitive infrared sensor available.Golay’s invention helped establish PerkinElmer as a major source of infrared technology. He also extended the theory of preparative columns and examined the properties of various chromatography sampling systems. The open tubular gas chromatography column is the most popular analytical gas chromatography column in use today. Dr. Golay worked as was a senior scientist at PerkinElmer up until his death in 1989. The Marcel Golay award is presented to a scientist in recognition of a lifetime of achievement in capillary chromatography.Carlo Bicchi is Full Professor at the Faculty of Pharmacy of the University of Turin since 1990. His research focuses on the development of advanced analytical technologies for the study of biologically active specialized metabolites in plant matrices, including essential oils, terpenoids, phenolic compounds, and alkaloids, as well as on aroma profiling and fingerprinting of major industrial food crops such as coffee, cocoa, hazelnuts, olive oil, and tea. His work encompasses all aspects of sample preparation, advanced chromatographic techniques, and chemometric methods for profiling and fingerprinting. Prof. Bicchi has actively promoted the development of analytical sciences through international collaboration, mentoring, and participation in scientific boards, conferences, and editorial activities.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Carlo_Bicchi_a0672a9dbb.jpg" alt="ISCC &amp; GCxGC Symposium: Carlo Bicchi" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Carlo_Bicchi_a0672a9dbb.jpg 156w," sizes="100vw" width="285" height="285"><h4>GIORGIO NOTA AWARD</h4>The Giorgio Nota Award was instituted in honor of Giorgio Nota, who first introduced open tubular LC.The Giorgio Nota award is presented to a scientist in recognition of a lifetime of achievement in capillary liquid chromatography.The Giorgio Nota Award 2026 is sponsored by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/325">Waters</a>.Fernando Mauro Lanças is a full Professor at the Institute of Chemistry of the University of São Paulo at São Carlos, Brazil, where he &nbsp;founded and currently coordinates the Chromatography Laboratory. His commitment to promoting and disseminating the culture of chromatography in Latin America, as founder of the Latin American Congress of Chromatography (COLACRO), the Brazilian Symposium on Chromatography (SIMCRO), and the International Institute of Chromatography (IIC), has made it possible to build a lasting bridge between Latin America and the rest of the world, fostering scientific collaboration, advancing research excellence, and strengthening the global chromatographic community. His primary research interest is currently focused on the complete miniaturization and automation of sustainable sample preparation – chromatography – mass spectrometry techniques and the practical implementation of the Unified Chromatography concept.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Fernando_Mauro_Lancas_e1e0ff9e6a.jpg" alt="ISCC &amp; GCxGC Symposium: Fernando Mauro Lanças" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Fernando_Mauro_Lancas_e1e0ff9e6a.jpg 156w," sizes="100vw" width="285" height="285"><h4>GC×GC LIFETIME ACHIEVEMENT AWARD</h4>The award honors an experienced GC×GC scientist who has made significant contributions to the field.The Scientific Achievement Award &nbsp;was instituted in 2011 and recognizes GC×GC scientists who have 15 or more years of continuous contributions in the field.The 2026 GC×GC Lifetime Achievement Award is sponsored by SepSolve Analytical, Markes International and LECO.Prof. James Harynuk is currently a Full Professor at the University of Alberta, Canada. His research focuses on developing advanced analytical tools to tackle challenges such as complex samples, faster analysis times, and lower detection limits. He specializes in multidimensional gas-phase separations, including GC×GC, heart-cut GC (GC-GC), and advanced data handling tools. Applications of his work span health research, metabolite profiling, forensic science, petrochemicals, and environmental science.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_James_Harynuk_c40ab9f6cc.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. James Harynuk" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_James_Harynuk_c40ab9f6cc.jpg 156w," sizes="100vw" width="285" height="285">Christopher Reddy is senior scientist at the Department of Marine Chemistry and Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. Reddy received his B.S. degree in chemistry from Rhode Island College and his Ph.D. in chemical oceanography from the Graduate School of Oceanography at the University of Rhode Island. His research focuses on the environmental fate of organic pollutants in the ocean, often using advanced analytical techniques such as GC×GC and compound-specific isotope analysis. Drawing on lessons from past pollution, he works to design safer, more environmentally friendly materials.&nbsp; Robert K. Nelson is an organic geochemist invece di research specialist in the Department of Marine Chemistry &amp; Geochemistry at the Woods Hole Oceanographic Institution in Woods Hole, Massachusetts. He earned a B.A. in biology from Central Connecticut State University and he later expanded his scientific training through additional coursework in organic chemistry at the University of Massachusetts Dartmouth and in physical chemistry at Northeastern University, strengthening his expertise in chemistry as applied to environmental sciences. With an extensive career in organic geochemistry and environmental analysis, Nelson is widely recognized for his contributions to the study of petroleum hydrocarbons and anthropogenic contaminants in the marine environment.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg" alt="ISCC &amp; GCxGC Symposium: Christopher Reddy, Robert K. Nelson" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Christopher_Reddy_Robert_K_Nelson_d676d3a17d.jpg 234w," sizes="100vw" width="768" height="512"><h4>JOHN PHILLIPS AWARD</h4>Comprehensive two-dimensional gas chromatograpy, or GC×GC, was invented by the late Professor John Bruce Phillips of Southern Illinois University at Carbondale and his then graduate student, Dr. Zaiyou Liu. The Phillips Prize will be awarded every other year to individuals who have made outstanding contributions to the field of GC×GC analysis. The Phillips Award first given in 2004 recognizes individuals who have typically worked in the GC×GC field for less than 10 years but have demonstrated good leadership through their scientific peer-reviewed work.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Professor_John_Bruce_Phillips_51b92b40d4.jpg" alt="ISCC &amp; GCxGC Symposium: Professor John Bruce Phillips" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Professor_John_Bruce_Phillips_51b92b40d4.jpg 157w," sizes="100vw" width="200" height="199">The 2026 John Phillips Award sponsored by LECO consists of a cash prize and a scroll with the winner’s name.Dr. Meriem Gaida obtained Ph.D. in Analytical Chemistry from the University of Liège (Belgium) in August 2023, specializing in separation science with expertise in GC×GC-ToFMS. Her research focused on advanced analytical strategies for complex chemical profiling and data interpretation, and she further expanded her expertise as a visiting researcher at the University of Washington (USA). After completing her doctorate, she joined SepSolve Analytical Ltd. (UK) as an Applications Specialist, where she developed and optimized customized GC×GC-ToFMS solutions for industrial and academic clients, providing technical support, method development, and training. In September 2024, she moved to LUZI AG (Switzerland), where she currently serves as Product Safety Science Manager, overseeing regulatory compliance, safety assessments of fragrance ingredients, and product safety documentation in line with European regulations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Dr_Meriem_Gaida_fa7cd655a2.jpg" alt="ISCC &amp; GCxGC Symposium: Dr. Meriem Gaida" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Dr_Meriem_Gaida_fa7cd655a2.jpg 156w," sizes="100vw" width="400" height="400"> Petr Vozka is an Associate Professor of Chemistry and Biochemistry at California State University, Los Angeles, where he directs the Complex Chemical Composition Analysis Laboratory (C3AL). He earned a B.S. in Chemistry and Chemical Technologies, and an M.S. in Chemistry and Technology of Fuels and Environment from the University of Chemistry and Technology, Prague, followed by a Ph.D. from Purdue University focused on analytical chemistry of liquid transportation fuels. His research group develops and applies advanced separation and detection strategies, especially comprehensive two-dimensional gas chromatography (GC×GC) coupled with mass spectrometry, to resolve and quantify highly complex mixtures that challenge conventional methods. Application areas include alternative and sustainable fuels, microplastics and related environmental matrices, and forensic analyses such as chemical imaging of fingerprints.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Petr_Vozka_952f1c6248.jpg" alt="ISCC &amp; GCxGC Symposium: Petr Vozka" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Petr_Vozka_952f1c6248.jpg 186w," sizes="100vw" width="768" height="644"><h4>Fritz Pregl Medal of the Austrian Society of Analytical Chemistry awarded to Prof. Christian Huber</h4>The Fritz Pregl award of the Austrian Society of Analytical Chemistry (ASAC) was established in 1955. Since then, it is awarded at irregular intervals primarily at national and international scientific events and symposia.The medal’s namesake, Friedrich Michael Raimund PREGL, received the Nobel Prize in Chemistry in 1923 for his groundbreaking work in the field of microchemical methods, which are closely linked to microanalytical applications. Fritz Pregl is the doyen of Austrian analysts. In his honor, the ASAC established the Pregl Medal, which is awarded to individuals who have made significant and outstanding contributions in the field of analytical chemistry, particularly organic trace analysis.Prof. Christian Huber is currently professor of chemistry for biosciences at the Paris Lodron University in Salzburg, Austria. After finishing his masters and Ph.D. at the university of Innsbruck he continued as an assistant professor at this university.In 1996 Prof. Huber spent several months researching at Yale university in the group of Prof. Csaba Horvath. A year later he was appointed Associate Professor in Innsbruck. From 2002 he held the position of Professor of Analytical Chemistry at the Department of Chemistry, Division of Instrumental Analysis and Bioanalysis, Saarland University, Saarbrücken, Germany. From there he moved to Salzburg in 2008. Prof. Huber is a worldwide known researcher with a strong focus on separation sciences in particular for the analysis of large bio-molecules. According to Google Scholar his work has been cited more than 13500 times with an h-index of 63. In recognition of his contributions to HPLC and HPLC-MS, Prof. Huber will receive the Pregl Award Medal from the Austrian Society of Analytical Chemistry.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Prof_Christian_Huber_31e539d0d9.jpg" alt="ISCC &amp; GCxGC Symposium: Prof. Christian Huber" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Prof_Christian_Huber_31e539d0d9.jpg 156w," sizes="100vw" width="285" height="285">

Awards at the 44th International Symposium on Capillary Chromatography and 21st GCxGC Symposium

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

ISCC & GC×GC Symposium bring together global experts to discuss advances in capillary and multidimensional chromatography, mass spectrometry, and analytical technologies for complex sample analysis.

International Symposium on Capillary Chromatography (ISCC) and GCxGC Symposium

Metrohm

Merck

Phenomenex

SCIEX

Waters Corporation

<div><h4>Unlock the Power of the Latest Empower CDS Releases</h4>Since the base release of Empower Chromatography Data System (CDS) in 2010, we have gone through 36 version updates. These updates have included new features, enhancements to existing functionality, and numerous updates across multiple areas - from instrument support to infrastructure technology.In this webinar we will focus on new features and updates in recent releases impacting compliance, an extremely important topic for many of you.<h5>What you’ll understand by the end</h5><ul><li>Risks of using outdated software</li><li>Support status of various Empower Software versions</li><li>Security enhancements to Empower CDS</li><li>Recent updates in USP calculations</li><li>Risk reduction of potential bias in the laboratory</li><li>Streamline the lab with Multi Angle Light Scattering and monitoring application</li></ul><h5>Who should attend</h5><ul><li>This webinar is designed for Lab Managers, Empower System Administrators, Quality, Quality IT, and Lab Personnel.</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about Empower Software.<blockquote>Presenter: Neil Lander (Senior Principal Product Manager, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Senior Principal Product Manager focusing on Informatics solutions.He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives.</blockquote></div>

Waters Corporation: Empower Tips: Ask Me Anything About Updates in Empower Software to Advance Your Compliance

Empower Tips: Ask Me Anything About Updates in Empower Software to Advance Your Compliance

Webinar on recent Empower CDS releases, covering compliance updates, security enhancements, and laboratory risk reduction strategies.

Updates in Empower Software to Advance Compliance

Antibody-drug conjugates (ADCs) require robust characterization of key quality attributes—especially the drug-to-antibody ratio (DAR)—to support confident decisions in discovery, development, and manufacturing.In this webinar, we’ll present an automated, high-throughput intact ADC workflow using LC-MS under native conditions on the Thermo Scientific Orbitrap Exploris 240 mass spectrometer, fully integrated within Thermo Scientific Chromeleon CDS.You’ll see how a single, unified platform can bring together data acquisition, automated intact deconvolution, DAR calculation, and reporting—reducing manual handoffs and analyst intervention while improving consistency and throughput. Whether you are scaling ADC characterization, standardizing DAR reporting, or looking to streamline intact analysis, this session will highlight a practical, end-to-end approach designed for efficient routine use.<h4>Key learning objectives:</h4><ul><li>Why intact ADC analysis (native LC–MS) is valuable for monitoring ADC heterogeneity and DAR-related attributes</li><li>How high-resolution mass spectrometry (HRMS) supports confident intact mass measurements for ADC characterization</li><li>What an end-to-end Chromeleon CDS workflow looks like—from instrument control to automated processing and reporting</li><li>How automated intact deconvolution enables rapid, consistent interpretation of intact ADC datasets</li><li>Approaches to automated DAR calculation and standardized reporting to support high-throughput workflows and data integrity</li></ul><h4>Who should attend?</h4><ul><li>ADC analytical characterization scientists in biopharma/biotech (discovery through late-stage)</li><li>LC-MS / HRMS users developing or running intact protein and ADC methods</li><li>CMC, process development, and QC teams interested in scalable DAR characterization workflows</li><li>Lab automation and informatics professionals focused on integrating acquisition, processing, and reporting</li><li>Chromeleon CDS users looking to expand into integrated intact deconvolution and reporting</li></ul>Cannot attend the broadcast on May 6? Please register to automatically receive the link to the recording.<blockquote>Speaker: Dr. Ulrik H. Mistarz (Application Scientist, Thermo Fisher Scientific)Dr. Ulrik Mistarz is a Senior Application Scientist at Thermo Fisher Scientific in Copenhagen, Denmark. He supports a broad range of LC-MS applications with a focus on developing novel workflows for characterization of oligonucleotides, therapeutic proteins, as well as different antibody formats.He has a strong interest in improving the throughput and automation of analytical workflows through developing new LC-MS as well as software workflows.Ulrik Mistarz has a PhD from The Department of Pharmacy at the University of Copenhagen and has more than 10 years of experience with pharma/biopharma characterization and analytics. This includes positions in both pharmaceutical and biotech companies working on LC-MS and HPLC application development.</blockquote>

Thermo Fisher Scientific: Integrated LC-MS CDS workflow for automated ADC and DAR analysis

Integrated LC-MS CDS workflow for automated ADC and DAR analysis

Webinar, will present automated intact ADC workflow using LC-MS under native conditions on the Thermo Scientific Orbitrap Exploris 240

LC-MS CDS workflow for automated ADC and DAR analysis

Antibody-drug conjugates (ADCs) represent a rapidly growing class of biotherapeutics that combine the specificity of monoclonal antibodies with the cytotoxic potency of small molecule drugs. Comprehensive characterization of ADCs is critical for ensuring product quality, efficacy, and safety, requiring advanced analytical techniques capable of resolving their inherent structural complexity and heterogeneity.This webinar presents state-of-the-art liquid chromatography-mass spectrometry (LC-MS) approaches for ADC characterization. The first half focuses on recent advances in reversed-phase LC-MS analysis, highlighting improvements in separation efficiency and detection sensitivity. Application examples will demonstrate the determination of low concentration impurities and variants, the effects of mobile phase and mobile phase modifiers on chromatographic performance, and the performance gains to the method by utilizing unique column geometries (1.5 mm I.D.).The second half explores native ADC analysis by hydrophobic interaction chromatography (HIC). Modern HIC stationary phases, combined with targeted mobile‑phase engineering, demonstrate high‑resolution, reproducible DAR separations across multiple ADC modalities, including improved resolution of high‑DAR and low‑abundance species. This state-of-the-art stationary phase was used to develop an HIC workflow using ammonium tartrate to achieve ammonium‑sulfate‑like performance and enabling rapid, MS‑compatible, and PAT‑ready ADC characterization.Attendees will gain practical insights into selecting appropriate LC-MS methodologies for their ADC characterization needs and understanding the complementary nature of reversed-phase and hydrophobic interaction chromatography.<h4>During this webinar, you will:</h4><ul><li>Discover the latest advancements in reversed-phase liquid chromatography-mass spectrometry (LC-MS) for the effective characterization of antibody-drug conjugates (ADCs), focusing on improved separation efficiency and detection sensitivity.</li><li>Learn about practical applications of LC-MS in identifying low concentration impurities and variants, including the impact of mobile phase components on chromatographic performance.</li><li>Explore innovative techniques in hydrophobic interaction chromatography (HIC) for native ADC analysis, emphasizing high-resolution and reproducible drug-to-antibody ratio (DAR) separations.</li><li>Gain an understanding about the development of a streamlined HIC workflow utilizing ammonium tartrate, which enhances ADC characterization efficiency while maintaining compatibility with mass spectrometry and process analytical technology (PAT).</li></ul><blockquote>Presenter: Andrea Krumm (Product Manager, Analytical Columns, Tosoh Bioscience GmbH)Andrea Krumm studied biotechnology before gaining a PhD in Cell and Cancer Biology. After four years as an applications specialist for optical analytical devices used in academic and pharmaceutical research, she joined Tosoh Bioscience GmbH in 2020 as a product manager for analytical columns. Andrea is responsible for gathering customer requirements, application areas and addressing these with new and existing products of the analytical columns line.Presenter: Cory E. Muraco (Senior Global Product Manager, Large Molecule HPLC, MilliporeSigma, the life science business of Merck KGaA, Darmstadt, Germany)Cory E. Muraco is the Senior Global Product Manager for Large Molecule HPLC Columns at MilliporeSigma, the life science business of Merck KGaA, Darmstadt, Germany. After finishing his graduate studies at Youngstown State University (Youngstown, Ohio, USA), Cory started his career at MilliporeSigma in 2013. After holding several roles in both R&amp;D and Marketing functions across the past decade, in 2026, Cory assumed his current role as the Large Molecule HPLC Columns Product Manager where he is tasked with designing, developing, and executing the marketing and R&amp;D strategies around MilliporeSigma’s biomolecule HPLC columns. Cory is the author of several manuscripts appearing in trade magazines and has delivered over 100 presentations at international conferences, round table symposia, and at various pharmaceutical and biopharmaceutical companies.</blockquote>

Tosoh Bioscience: Recent Advances in Chromatographic Approaches in Characterizing Antibody-Drug Conjugates

Recent Advances in Chromatographic Approaches in Characterizing Antibody-Drug Conjugates

Discover LC-MS and HIC methods for ADC characterization, including DAR analysis, impurity detection, and high-resolution separations for biopharma workflows.

Chromatographic Characterizing Antibody-Drug Conjugates

In the second webinar of the Small Molecules, Big Impact series, Ken Berthelette will demonstrate how Waters™ solutions and MaxPeak Premier Columns can be applied to improve LC discovery and early development workflows.This webinar will focus on applied case studies in early drug research development and demonstrate how enhanced surface technology can deliver improved sensitivity and peak shape for acidic analytes, helping teams generate higher-quality data earlier in development process. By focusing on specific applications of method development, this session will highlight how through intelligent column selection and process introduction, development workflows can be streamlined to generate the highest quality data possible.<h4>Who should attend</h4><ul><li>Analytical scientists who support early development workflows.</li></ul><h4>Why you should attend</h4><ul><li>Gain a clearer understanding of how MaxPeak Premier Columns can enhance LC workflows through improved sensitivity, peak shape, and robustness for acidic analytes.</li><li>Access resources and tools that enable independent exploration and evaluation of MaxPeak Premier technology within your own laboratory workflows.</li></ul><h4>What you will walk away with</h4><ul><li>A better understanding of MaxPeak Premier technology to gain the advantage in your research</li><li>Insights into how MaxPeak Premier Columns can improve their separations</li><li>Access to resources to support your own research to stay better informed.</li></ul><blockquote>Speaker: Kenneth Berthelette (Principal Scientist, Waters Corporation)Ken earned his Bachelor of Science in Professional Chemistry from Bridgewater State University in Bridgewater, Massachusetts in 2010.He joined Waters Corporation in March 2012, where he contributed to multiple product launches as part of the Research and Development team. In 2021, Ken transitioned into a role supporting Chemistry Aftermarket initiatives.With a strong focus on applications and customer education, he has delivered numerous seminars and webinars covering topics such as method development, method modernization and transfer, HILIC separation techniques, and LC system troubleshooting.</blockquote>

Improving Sensitivity and Throughput in Early Drug Development with Inert LC Technologies

Learn how MaxPeak Premier Columns enhance LC workflows, improving sensitivity and peak shape for acidic analytes in early drug development.

Early Drug Development with Inert LC

Compliance with IC methods US EPA 300.1 Parts A and B, ISO 10304 Parts 1 and 4, or US EPA 557 can make efficient monitoring of environmental waters a challenge. Selecting the right column technology is key, whether you are working with carbonate or hydroxide eluents.In our upcoming webinar, we focus on a new generation of high-capacity anion exchange columns. We will show how innovative column chemistry enables lowest detection limits and improved robustness against complex matrices for fully compliant analysis of environmental waters.Two complementary analytical strategies for the analysis of common anions and oxyhalides are presented in the webinar: The carbonate-based eluent approach with the new Metrosep A Supp 20 column and the hydroxide-selective approach with the Metrosep A Supp 21 column. Both strategies enable performing US EPA 300.1 Parts A and B and ISO 10304 Parts 1 and 4, respectively, in one single run.We will also show how automated hydroxide eluent production provides for highly precise and reproducible analyses with ultra‑low baselines, supporting demanding applications such as the determination of haloacetic acids (HAA) according to US EPA 557.<h4>Key learnings of this webinar</h4><ul><li>Understand how high-capacity IC columns improve robustness, accuracy, and reproducibility of your IC analysis of environmental waters</li><li>Learn how EPA 300.1 Parts A and B and ISO 10304 Parts 1 and 4, respectively, can be resolved in a single run&nbsp;</li><li>Discover the advantages of automated eluent generation combined with hydroxide-selective columns, such as the Metrosep A Supp 19 column, for haloacetic acid analysis (US EPA 557)</li><li>Explore how the right choice of columns and eluent strategies can optimize your workflows and increase laboratory efficiency and data quality</li></ul><h4>Who should attend?</h4><ul><li>Water utility operators who need robust and reliable analytical techniques to guarantee the safety of drinking water</li><li>Lab managers responsible for their lab’s compliance with the standards and regulations for the analysis of environmental waters</li><li>Scientists, researchers, and analytical method developers who need to stay up to date on state-of-the-art methods for ion chromatography</li><li>Laboratory staff and managers interested in a reliable, cost- and time-efficient analysis technique for their monitoring of environmental waters</li></ul><blockquote>Presenter: Dr. Vincent Diederich (Product Manager Ion Chromatography Columns, Metrohm International Headquarters)Vincent Diederich received his MSc in Chemical and Bioengineering at the ETH Zurich in Switzerland and stayed there for a PhD in Chemical Engineering where he gained a deep understanding of polymer reaction engineering. Since 2015, he has worked at Metrohm International Headquarters focusing on column and method development for ion chromatography, initially as a Column Production Specialist and now as Product Manager for ion chromatography columns.</blockquote>

Metrohm: Environmental waters: A new generation of high-capacity IC columns makes analysis more efficient

Environmental waters: A new generation of high-capacity IC columns makes analysis more efficient

Discover advanced IC column strategies for EPA and ISO water analysis, improving sensitivity, robustness, and efficiency in environmental monitoring workflows.

High-capacity IC columns for water analysis

Electrogenerated Chemiluminescence (ECL) has rapidly become one of the most powerful analytical techniques for applications requiring extreme sensitivity, specificity, and quantitative performance. In this webinar, we will explore what makes ECL a unique technique for sensor development providing key hints and examples.We will begin by introducing the core principles behind the ECL mechanism, including its advantages over traditional methods. We will then move on to discuss specific case studies.To bridge science with practical implementation, we will demonstrate how advanced ECL instrumentation streamlines workflows, improves sensitivity and reproducibility, and expands the range of possible applications. This includes an overview of our instrumental solutions, highlighting their ease of use, performance benefits, and integration into routine analytical environments.<h4>By the end of the session, participants will gain:</h4><ul><li>A clear understanding of the fundamentals and advantages of ECL</li><li>Insights into cutting-edge applications in different fields driving innovation in industry and academia</li><li>Practical examples showing how ECL enables highly sensitive and selective detection</li><li>A preview of instrumental platforms designed to optimize ECL performance</li><li>Guidance on choosing the right systems and configurations for specific analytical needs</li></ul>This webinar is ideal for researchers in sensor development that are looking for electrochemical techniques to improve the sensitivity on their concrete application.&nbsp;<blockquote>Presenter: Ibáñez Martínez, David (Spectroelectrochemistry Manager, Metrohm Dropsens)PhD in Chemistry (2015, University of Burgos, Spain), with expertise in the development of novel devices for time-resolved Raman spectroelectrochemistry, applied to the study of various systems such as carbon nanotubes, metal nanoparticles, conducting polymers, graphene, DNA bases, and liquid–liquid interfaces. Postdoctoral researcher (2015–2017, University of Burgos, Spain), focused on the electrochemical fabrication of Janus materials and their characterization using UV/Vis and NIR spectroelectrochemistry. Product Specialist in Spectroelectrochemistry at Metrohm DropSens S.L.U. (2018–2022) for the development of new applications and spectroelectrochemical devices. Spectroelectrochemistry Manager at Metrohm DropSens S.L.U. (2023–present), leading the development and innovation of fully-integrated spectroelectrochemical and electrochemiluminescence instrumentation.</blockquote>

Metrohm: Electrochemiluminescence: The technique that should be on your radar for sensor development

Electrochemiluminescence: The technique that should be on your radar for sensor development

In this webinar, we will explore what makes ECL a unique technique for sensor development providing key hints and examples.

Electrochemiluminescence

<h3>Bringing laboratory automation to life with Andrew+ and OneLab</h3>This webinar series explores how Andrew+ automated liquid handling and OneLab workflow software support consistent, traceable and efficient laboratory operations. Through application‑focused episodes, you will see how automation can be successfully integrated into everyday laboratory workflows, from method development to routine and regulated environments, supported by customer experiences and testimonials.<h4>Episode 1 – Proteomics Workflows</h4><h5>Overview</h5>Automation plays a key role in modern proteomics, where reproducibility and consistency are essential. In this episode, we explore how automated liquid handling supports robust, scalable sample preparation workflows while reducing manual variability across studies, with insights shared directly from proteomics laboratories using automation in practice.<h5>Key highlights</h5><ul><li>Apply automation across proteomics workflows including digestion, desalting, peptide quantification and normalization</li><li>Reduce batch effects and improve reproducibility in long-term and large-scale studies</li><li>Support evolving proteomics methods with flexible, reliable automation Speakers</li></ul><h5>Customer testimonials:</h5>Imperial College London – National Phenome Centre<ul><li>A leading UK-based academic research centre specialising in large-scale, high‑throughput proteomics and multi‑omics studies. In this episode, the team shares how automated liquid handling has been integrated into routine proteomics sample preparation workflows — from protein assays and digestion to desalting, peptide quantification and sample normalisation — enabling highly reproducible results while significantly reducing batch variation across long-term studies.</li></ul>MRC Laboratory of Medical Sciences<ul><li>A biomedical research institute focused on understanding the molecular basis of human disease, with strong expertise in proteomics and metabolomics. The laboratory provides insight into how automation supports attention‑intensive workflows such as concentration normalisation and solid phase extraction (SPE), helping to improve consistency, usability and throughput in proteomics sample preparation.</li></ul>University of Leicester – Van Geest Multiomics Facility<ul><li>A university-based multiomics facility supporting large‑scale clinical and translational research projects. In this episode, the facility explains how automated liquid handling has transformed proteomics workflows for large cohort studies, enabling scalable, flexible sample preparation while minimising batch effects and supporting highly reproducible biomarker research.</li></ul>Reserve Your Spot Today!

Transform Your Daily Lab Operations with Automation - Proteomics Workflows

Learn how automation enhances proteomics workflows, improving reproducibility, reducing batch effects, and enabling scalable sample preparation.

Transform Daily Lab Operations with Automation - Proteomics

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Regulatory expectations around nitrosamines continue to evolve, placing increasing pressure on analytical workflows to deliver both accuracy and flexibility. Join our upcoming webinar with AbbVie to see how advanced LC-MS tools can help you confidently quantify known nitrosamines and uncover unknown impurities, saving valuable time and resources.<h4>What you’ll learn:</h4><ul><li>Confident annotation &amp; accurate quantification: Leverage the SQUAD approach to precisely identify and quantify targeted nitrosamines using authentic standards and calibration curves.</li><li>Simultaneous targeted &amp; untargeted analysis: Perform comprehensive screening in a single run—detect known compounds while uncovering unexpected impurities without additional injections.</li><li>Overcoming unknown nitrosamine challenges: Optimize your LC-MS methods to improve confidence in identifying unknown nitrosamines and meet regulatory expectations.</li></ul><blockquote>Presenter: Jessica Hoskins, PhD (Principal Research Scientist I, Predictive Stability and Structure Elucidation)Jessica is a Principal Research Scientist at AbbVie where she and her team focus on Predictive Stability and Structure Elucidation to understand degradation pathways and other potential stability limiting attributes for new synthetic molecule drug substances and drug products. She has a PhD in Organic Chemistry from Tulane University with Scott Grayson, where she first became interested in mass spectrometry for polymers. Prior to joining AbbVie, she was an Adolf Martens Postdoctoral Fellow at the Federal Institute for Materials Research and Testing (BAM) in Berlin, Germany, and worked as an analytical chemist at Stepan Company in the surfactant and polymer industry.Presenter:&nbsp;Sebastien Morin (Sr Manager, Business Development, Thermo Scientific)Sebastien is a Senior Manager, Business Development at Thermo Fisher Scientific where he partners closely with Pharma and Biopharma Companies to address analytical challenges. He holds a M. SC. in Organic Chemistry from Universite de Montreal. Prior to joining Thermo Fisher Scientific, he was a Research Associate, Medicinal Chemistry for Boehringer Ingelheim, advancing virology research.</blockquote></div></div></div>

Thermo Fisher Scientific: Keeping Up with Evolving Regulatory Requirements: Addressing Analytical Challenges for Known and Unknown Nitrosamines

Keeping Up with Evolving Regulatory Requirements: Addressing Analytical Challenges for Known and Unknown Nitrosamines

Join our webinar to see how advanced LC-MS tools can help you confidently quantify known nitrosamines and uncover unknown impurities.

Analytical Challenges for Known and Unknown Nitrosamines

<h4>Key Learning Points</h4><ul><li>Understand how to prepare your LC/LC-MS system for startup with essential checks, solvent verification, and secure connections.</li><li>Follow clear, step-by-step guidance for LC startup and shutdown procedures (system agnostic guidance).</li><li>Learn best practices for properly cleaning and storing columns, both on and off the system, to maximize lifetime and performance.</li></ul><h4>Who Should Attend</h4><ul><li>The session is aimed at LC and LC‑MS users, especially those newer to the techniques, who want a clear, system‑agnostic protocol to protect columns and instruments during start‑up and shut‑down.</li></ul><blockquote>Speaker: Duilio Romanello (Senior Technical Specialist, Phenomenex)Duilio Romanello earned his MSc in Pharmaceutical Chemistry and Technology from the University of Bologna. He joined Phenomenex in 2008 as an Inside Technical Sales Consultant, later leading GC/SPE and Env/Food teams in Italy. Since 2016, he has been Account Manager for Southern Italy and GC Specialist. In 2023, he became Senior Technical Specialist for Phenomenex’s Technical team supporting scientists globally with method development, troubleshooting, and application support.</blockquote>

Phenomenex: How To Start Up and Shut Down LC and LC-MS Instruments

How To Start Up and Shut Down LC and LC-MS Instruments

Join this webinar to learn LC/LC-MS startup, shutdown, and column care best practices to improve performance, reliability, and instrument longevity.

Start Up and Shut Down LC and LC-MS Instruments

Biotherapeutic stability is essential for ensuring product quality, safety, and efficacy. In this webinar, discover how forced degradation studies combined with intact and subunit icIEF-UV/MS workflows provide deeper insights into charge variants and degradation pathways. Learn how integrating icIEF with UV and mass spectrometry enhances analytical confidence and supports robust biopharmaceutical characterization.<h4>Key highlights</h4><ul><li>Understand how the icIEF-UV/MS method works to identify charge variants in 30 minutes</li><li>Discover how it has been applied to the analysis of an intact and the sub units of a stressed monoclonal antibody</li><li>Find out how the Biologics Explorer software aids data visualisation in both intact and subunit analysis</li></ul><blockquote>Speaker: Dr. Stephen Lock, Senior Market Development Manager, SCIEX</blockquote>

SCIEX: Assessing biotherapeutic stability through forced degradation using intact and subunit icIEF-UV/MS workflows

Assessing biotherapeutic stability through forced degradation using intact and subunit icIEF-UV/MS workflows

Join this webinar to learn icIEF-UV/MS workflows for biotherapeutic stability, charge variant analysis, and monoclonal antibody characterization.

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