In 2025, the 16th workshop will be hosted in person in Liege, Belgium. The workshop will be shared between key speaker presentations, flash presentations, poster presentations, and focus group discussions on the challenges and the futures of the field. The workshop is dedicated to all multidimensional techniques.
We hope to see you there!
<blockquote>
<h5>The content and recordings of lectures from previous years</h5>
</blockquote>
<blockquote>
💡 <a href="https://gcms.labrulez.com/events/436">15th Multidimensional Chromatography Workshop (MDCW)</a>
</blockquote>
<blockquote>
💡 <a href="https://gcms.labrulez.com/events/437">14th Multidimensional Chromatography Workshop (MDCW)</a>
</blockquote>
<blockquote>
💡 <a href="https://www.youtube.com/playlist?list=PLg-M6fM-05MrGrDggkl_UKzzcHPWPmssh">LabRulez YouTube channel: The Multidimensional Chromatography (MDC) Workshop playlist</a> with recorded presentations
</blockquote>
<h3>Registration - 2025</h3>
Follow the link below to the registration page. A copy of your responses will be sent to you after you complete the form. 
<h4>👉 <a href="https://docs.google.com/forms/d/e/1FAIpQLScTLhjK50mD79vkYhbHag2YnymyA1YcsRTQxhn9g2kg72Qe6Q/viewform">Registration - 2025</a></h4>
The registration deadline is January 1st, 2025.
<h3>Key Dates</h3>
<ul>
<li>May 1, 2024: <a href="(https://docs.google.com/forms/d/e/1FAIpQLScTLhjK50mD79vkYhbHag2YnymyA1YcsRTQxhn9g2kg72Qe6Q/viewform)">Registration</a> and <a href="http://www.multidimensionalchromatography.com/abstract-submission.html">abstract submission</a> open</li>
<li>June 1, 2024: Sponsorship agreement deadline</li>
<li>August 30, 2024: Deadline for <a href="http://www.multidimensionalchromatography.com/abstract-submission.html">abstract submission</a></li>
<li>September 15, 2024: Notification of abstract acceptances</li>
<li>October 30, 2024: Preliminary program release</li>
<li>November 30, 2024: Deadline for last minute posters</li>
<li>December 31st, 2024: Deadline to book conference hotel at special rate</li>
<li>January 1, 2025: Registration deadline and final program release</li>
<li>February 2, 2025: Short Course (registration details forthcoming)</li>
<li>February 3-5, 2025: Conference dates</li>
</ul>
<h3>Abstract Submission - 2025</h3>
Abstracts to be considered for an oral presentation must be submitted by Aug 30, 2024 for consideration. Poster abstracts can be submitted before Aug 30, 2024 for inclusion in the preliminary program. Additional last minute posters will be accepted until November 30, 2024 for the final program.
<h4>👉 <a href="https://auth.oxfordabstracts.com/?redirect=/stages/32056/submitter">SUBMIT ABSTRACT HERE</a></h4>
<h4>Presentation guidelines</h4>
Poster
<ul>
<li>Please note: As presenting author, it is your responsibility to print and bring your poster with you. We do not offer printing services for posters nor do we accept mailed posters.</li>
<li>Please bring your poster in hard copy with you to the conference. All posters should be set up prior to the poster session (during registration or on breaks). </li>
<li>Posters should be prepared in A0 vertical format (or 36&quot; wide by 48&quot; tall).</li>
<li>Poster presenters must be present at their poster during the poster session. There will be further times available for viewing posters during breaks and authors can optionally stand with their posters during coffee breaks if they so wish.</li>
</ul>
Oral
<ul>
<li>Prepare your presentation as Powerpoint or PDF document </li>
<li>Use the following file name format: LASTNAME_PRESENTATIONCODE</li>
<li>Use a 16:9 slide format for optimal display. Presentations in 4:3 will also be accommodated.</li>
<li>You will have the possibility to use a headset or a portable microphone.</li>
<li>You will have a laser pointer with a slide change button. </li>
<li>Make sure to keep a couple of minutes for questions within your allocated time.</li>
<li>Prior to your session, please check in and introduce yourself to the conference or session chairs.</li>
<li>You will be asked to upload your file in advance. Please check your email for instructions to upload your presentation by the deadline instructed. Typically we require the presentation at least 1 week before the conference start date.</li>
</ul>
<h3>Program</h3>
The Preliminary Program, Guidebook, and the Abstract book can be downloaded below when available. The Guidebook contains the program and all other pertinent conference information.
<ul>
<li>Preliminary Program</li>
<li>Final Guidebook</li>
<li>Abstract Book</li>
</ul>
<h4>Keynote Speakers 2025</h4>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Keynote_Speakers_2025_Dr_Karine_Faure_Dr_Patrik_Petersson_Dr_Pascal_Cardinael_Dr_Thomas_Dutriez_3f133fd4d2.jpg" alt="MDCW: Keynote Speakers 2025: (left to right) Dr. Karine Faure, Dr. Patrik Petersson, Dr. Pascal Cardinael, Dr. Thomas Dutriez."/>
<h5>Dr. Karine Faure</h5>
<ul>
<li>Senior Scientist, Institute of Analytical Sciences, CNRS University Lyon</li>
</ul>
Title of Keynote Lecture: Introducing Supercritical Fluid Chromatography in the Community of Multidimensional Chromatography
Karine Faure received her MSc in Chemical Engineering from Ecole Ingénieur Toulouse, France and her PhD in Analytical Chemistry from University College Cork, Ireland. Passionate about separation sciences, she has worked over the course of her career on electrophoresis, miniaturised liquid chromatography, preparative chromatography and multidimensional liquid chromatography. She authored 43 publications and 5 book chapters. Her research focuses on the development of multidimensional techniques using liquid chromatography and supercritical fluid chromatography for the non-targeted analysis of natural products and renewable materials. 
<h5>Dr. Patrik Petersson</h5>
<ul>
<li>Principal Scientist, Ferring Pharmaceuticals</li>
</ul>
Title of Keynote Lecture: Application of 2D-LC-MS for analysis of pharmaceutical peptides
Patrik Petersson is a Principal Scientist at Ferring Pharmaceuticals in Copenhagen, Denmark. He has been working within the pharmaceutical industry with the development of analytical separation methods for 29 years within research as well as all phases of development.  During the time within industry the link to the academia has been maintained through collaborations, teaching and supervision of MSc/PhD students.  This has resulted in 71 publications and 31 oral presentations at national/international conferences.  The majority related to chromatography but also capillary electrophoresis and modelling/chemometrics.
<h5>Dr. Pascal Cardinael</h5>
<ul>
<li>Professor, University of Rouen Normandy</li>
</ul>
Title of Keynote Lecture: How to design microcolumns for comprehensive GC
Pascal Cardinael obtained his Ph.D. degree in Analytical Chemistry in 2000 from the University of Rouen (France). In 2002, he became a Lecturer at the Laboratory of Separative Methods and Sciences UR3333 at the University of Rouen Normandy, and was appointed Professor of Analytical Chemistry in 2011. He has been managing the Laboratory since 2022. The Laboratory focuses on the development of new stationary phases and miniaturized columns for Gas Chromatography and High Performance Liquid Chromatography for space exploration missions and on-site monitoring. All practical and fundamental aspects of comprehensive two-dimensional Gas Chromatography are also studied, including miniaturization, modulator technology, retention modeling, and coupling with high-resolution mass spectrometry.
<h5>Dr. Thomas Dutriez</h5>
<ul>
<li>Senior Manager, PSS Labs CoE, Givaudan International</li>
</ul>
Title of Keynote Lecture: GC×GC-MS - Fragrance Allergens - The Olympic Gold Standard
Thomas Dutriez obtained his Ph.D. degree in Analytical Chemistry in 2010 from the University of Paris (France) and IFP Energies nouvelles. He then continued his career as a scientist in gas chromatography and mass spectrometry at DSM (Netherlands), during which his work on comprehensive two-dimensional gas chromatography was awarded by the John B. Phillips award in 2013. In 2014, he joined Givaudan International (Switzerland) to establish the analytical laboratory dedicated to quantifying regulated substances in fragrance ingredients. Currently, he leads the Product Safety Sciences Laboratories at Givaudan International, a center of Excellence dedicated to conducting regulatory analytical and environmental studies at a global level to address the growing regulatory requirements.
<h4>Guided Discussion Groups 2024</h4>
<h5>Advantages and Limitations of GC×GC in Government and Industrial Laboratories</h5>
<ul>
<li>Haleigh Boswell (Chevron Technology Center)</li>
<li>Sarah Prebihalo (U.S. Food and Drug Administration)</li>
</ul>
Comprehensive gas chromatography (GC×GC) is a common technique used in government and industrial laboratories; however, it has struggled to gain widespread acceptance due to perceived complexity and a lack of standardized and validated methods. Furthermore, the technique is not directly comparable to historical data sets and previously used analytical techniques. Overcoming these challenges and limitations in non-academic laboratories is a critical aspect of research by experts and advanced GC×GC users. Advanced users must be vocal advocates, highlighting the advantages of GC×GC in cases where the additional separation data can be advantageous. By addressing the benefits and limitations of this technique, this discussion will aim to address how we may elevate GC×GC in industrial and government laboratories, including, but not limited to, the role of obtaining employment in these sectors, allowing for further integration into the GC×GC community.
<h5>Preliminary Results in the Development of a System Performance Standard Reference Test Mixture for Comprehensive Two-Dimensional Gas Chromatography</h5>
<ul>
<li>Jean-Marie D. Dimandja (FDA/ORA)</li>
<li>Pierre-Hugues Stefanuto (University of Liege)</li>
</ul>
GC×GC system performance is influenced by many parameters, including modulator type, column set, detection method, and data processing software. This discussion will be focused on the development of a standard test mixture that can be used to compare GC×GC system performance across instruments and laboratories. 
<h3>Focus Groups 2025</h3>
If you are interested in hosting a focus group in 2025, please email us to express interest at multidimensionalchromatography@gmail.com
<h3>Organizing Committee</h3>
<ul>
<li><h5>Katelynn Perrault (William &amp; Mary, Assistant Professor)</h5>
</li>
<li><h5>Pierre-Hugues Stefanuto (University of Liège, Senior Scientist)</h5>
</li>
<li><h5>Dwight Stoll (Gustavus Adolphus College, Professor)</h5>
</li>
<li><h5>Petr Vozka (California State LA, Assistant Professor)</h5>
</li>
</ul>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_MDCW_2025_organizing_committee_9a5e9d9c05.jpg" alt="MDCW: MDCW 2025 organizing committee."/>
<h3>Sponsors 2025</h3>
<blockquote>
<h4>GOLD SPONSORS</h4>
</blockquote>
<blockquote>
<h4><a href="https://gcms.labrulez.com/library?mainauthorItems=24">LECO</a></h4>
</blockquote>
<blockquote>
<h4><a href="https://gcms.labrulez.com/library?mainauthorItems=23">JEOL</a></h4>
</blockquote>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_MDCW_2025_Gold_Sponsors_97685a5688.jpg" alt="MDCW: MDCW 2025 Gold Sponsors."/>
<blockquote>
<h4>SILVER SPONSORS SPONSORS</h4>
</blockquote>
<blockquote>
<h4>SpectralWorks</h4>
</blockquote>
<blockquote>
<h4>GC Image</h4>
</blockquote>
<blockquote>
<h4>SepSolve Analytical</h4>
</blockquote>
<blockquote>
<h4><a href="https://gcms.labrulez.com/library?mainauthorItems=40">TRAJAN</a></h4>
</blockquote>
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_MDCW_2025_Silver_Sponsors_abe75dc6f0.jpg" alt="MDCW: MDCW 2025 Silver Sponsors."/>

16th Multidimensional Chromatography Workshop (MDCW 2025) Abstract Submission Deadline

Certified reference material of MCT oil with medium-long chain triglycerides AN-BM04 prepared by the method of addition of hemp extract and individual phytocannabinoids. Selected cannabinoids are certified.
<ul>
<li>Analytes: CBD, CBDA, Δ9-THC, Δ9-THCA-A, CBN, CBG, CBC, CBGA, CBDV, CBCA, THCV, CBL.
</li>
<li>Packaging: 3.0 ml of oil in a dark glass bottle.
</li>
<li>Use: This certified reference material is intended to provide metrological continuity, validate analytical methods and assign values to other materials of similar composition.
</li>
<li>Recommended analytical methods for the measurands: <a href="https://lcms.labrulez.com/library?instrumentationItems=27&amp;search=cannabinoids">Liquid chromatography</a>
</li>
<li>Expiration date: 2 years from the date of manufacture
</li>
</ul>
This material has been prepared in cooperation with the Metrology and Testing Laboratory at <a href="https://lcms.labrulez.com/companies/58">Department of food analysis and nutrition, University of Chemical Technology Prague</a>, accredited according to ČSN EN ISO/IEC 17025:2018, where the homogeneity and stability of the material was also tested.
More detailed information on the preparation, homogeneity testing and characterization of this CRM is provided in the certification report, which is available to interested parties upon request.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Analytika_Kanabinoidy_v_MTC_oleji_METRANAL_CRM_ff01415316.jpg" alt="Analytika: Cannabinoids in MTC oil (METRANAL - CRM)"/>
<h5>Metrological follow-up:</h5>
Metrological continuity is ensured by the use of certified calibration solutions for calibration of measurement methods (direct link to SI unit) or by parallel analysis of matrix CRMs (RM) of similar composition.
<h5>Homogeneity and stability:</h5>
Homogeneity and short-term stability have been demonstrated according to TNI guideline ISO 35.
<h5>Certified and indicative values and their uncertainties:</h5>
The certified and indicative values for each cannabinoid are given in Table 1. The overall averages of the received laboratory values were assigned the status of certified and indicative values when the following criteria were met: a certified value was derived from at least five received data sets, an indicative value from at least three received data sets. The combined uncertainties listed are dominated by the contribution of uncertainty in the characterisation of the relevant property value. The certification study was conducted at international level in the form of an inter-laboratory comparison, with the participation of laboratories with quality assured testing in the field of cannabinoid analysis.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Analytika_Tabulka_c_1_Certifikovane_a_indikativni_hodnoty_obsahu_jednotlivych_kanabinoidu_6dc4a5def4.jpg" alt="Analytical: Table 1 Certified and indicative values for the content of individual cannabinoids.jpg"/>
The CRM will be monitored for its shelf life. If there are significant changes to the reported values, Analytika, Ltd. will notify the purchaser.
<h5>Storage and instructions for use:</h5>
The CRM must be kept and stored in its original packaging at a temperature below -12 °C. The material should be analysed as delivered and should be tempered to 20 °C and rehomogenised by mechanical shaking of the contents before taking an aliquot for analysis. At low temperatures, a solid fraction may be excluded, which will dissolve again on re-extempering. In order to ensure sufficient homogeneity, the recommended minimum weight for analysis is 50 mg.

Matrix certified oil reference material for cannabinoid content

Fertilizers manufactured from the sludgy leftovers of wastewater treatment processes can contain traces of potentially hazardous organic chemicals, according to a new study by Johns Hopkins University researchers.The research, <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.est.4c02934">published today in journal Environmental Science &amp; Technology</a>, provides one of the most comprehensive looks at the chemical composition of so-called biosolids across the country and is the first step toward identifying common chemical contaminants that may need government regulation. The findings could help the U.S. Environmental Protection Agency prioritize which organic compounds to investigate further, the researchers said."We've been relatively in the dark when it comes to possible organic hazards in biosolids, and we need to know if there are any smoking guns that we're unaware of," said <a target="_blank" rel="noopener noreferrer" href="https://engineering.jhu.edu/faculty/carsten-prasse/">Carsten Prasse</a>, an assistant professor in the Department of Environmental Health and Engineering who studies environmental contaminants. "Regulators need to know what these types of fertilizers are made of to determine how they can be responsibly used."<blockquote>"We've been relatively in the dark when it comes to possible organic hazards in biosolids, and we need to know if there are any smoking guns that we're unaware of."<h5> - Carsten Prasse</h5>Assistant professor, Whiting School</blockquote>Using analytical chemistry techniques capable of identifying thousands of chemicals, Prasse and his team screened 16 samples of biosolids from wastewater treatment facilities in nine U.S. and three Canadian cities. Samples contained traces of pharmaceuticals, industrial chemicals, and a variety of fragrances. Among them were bisphenol A (BPA), commonly found in plastics, and carbamazepine, a drug used to treat epilepsy and bipolar disorder."Because there are so many compounds in biosolids, the question we had was how do we triage? How do we find the chemicals that are widespread and could potentially be problematic, that the EPA and other scientists would need to investigate before proposing regulations," Prasse said.The researchers then created lists of the chemicals found in each sample and compared them to compounds that popped up in multiple places across the country. They identified 92 compounds that were present in 80% or more of the samples.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Johns_Hopkins_University_Getty_Images_Team_aims_to_improve_safety_of_fertilizers_made_from_wastewater_sludge_461986840c.jpg" alt="Johns Hopkins University / Getty Images: Team aims to improve safety of fertilizers made from wastewater sludge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Johns_Hopkins_University_Getty_Images_Team_aims_to_improve_safety_of_fertilizers_made_from_wastewater_sludge_461986840c.jpg 234w," sizes="100vw" width="1194" height="796">The researchers then cross-referenced those 92 compounds against the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/310">EPA</a>'s <a target="_blank" rel="noopener noreferrer" href="https://www.epa.gov/comptox-tools/comptox-chemicals-dashboard">CompTox Chemical Dashboard</a>—a database that details the properties, hazards, and potential risks of thousands of chemicals. The dashboard helped the team identify which chemicals were most likely to pose threats to human health or the environment."We're not saying that these compounds pose a risk right now, because we haven't done a formal risk assessment," said <a target="_blank" rel="noopener noreferrer" href="https://pure.johnshopkins.edu/en/persons/matthew-newmeyer">Matthew Newmeyer</a>, a research associate at the Bloomberg School of Public Health and first author on the paper. "We're saying that these have a potential to be problematic and we need more information in order to make sure these biosolids are safe."Using biosolids can be beneficial, the researchers said. They are rich in nitrogen, phosphorus, and other nutrients that help plants grow. They require less energy to make than synthetic alternatives. And wastewater facilities can sell biosolids to generate revenue to offset treatment costs and reduce waste sent to landfills or incinerators.More than half of the 3.76 million tons of biosolids produced in the United States in 2022 fertilized agricultural lands, golf courses, and other landscaped areas, according to the EPA. While direct contact with biosolids is likely limited to occupational exposures, the broader population could be exposed to contaminants absorbed by crops grown in such fertilizers, the researchers said.The team plans to measure the identified compounds in the biosolids and vegetables grown in biosolid-amended soil to determine if their concentration levels warrant concern. The researchers are also investigating risks to farmers, landscapers, and composters who work with biosolids.Authors include: Keeve Nachman and Qinfan Lyu of Johns Hopkins University, and Jon Sobus and Antony Williams of the U.S. Environmental Protection Agency.This research was supported by U.S. EPA grant R840247 and U.S. Centers for Disease Control and Prevention grant T42 OH0008428.

Team aims to improve safety of fertilizers made from wastewater sludge

Article

Product

Events

Environment

Health

Scientific article

Science and research

Video

The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography (MDC) Workshop

Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

Our portfolio also includes pipettes and tips, digestors, PFA labware and other equipment for analytical laboratory and trace analysis.

ANALYTIKA

We are America’s first research university, founded in 1876 on the principle that by pursuing big ideas and sharing what we learn, we can make the world a better place. For more than 140 years, our faculty and students have worked side by side in pursuit of discoveries that improve lives.

Johns Hopkins University

Bruker

Thermo Fisher Scientific

Shimadzu Corporation

SCIEX

Waters Corporation

<h4>Virtual event: Pharma conclave series 2024</h4>
SCIEX offers the platform for the experts to take the stage and drive technological progress
Welcome to Pharma conclave series 2024 – where our customers’ expertise meets innovation, transforming your knowledge and empowering you to revolutionize your work processes. Join us in discovering techniques that will enhance your skills to accelerate your daily operations in the development of new drugs.
From the research of new markers to the drug development moving into non and GLP bioanalysis. Confidently plan your next lab expansion with the knowledge gained from industry leaders and pioneers.
<ul>
<li>May 16 Event 1: Pharma omics</li>
<li>September 17 Event 2: Impurities</li>
<li>October 23-24 Event 3: Pharma</li>
</ul>
10:00 a.m.–12:00 p.m. CET
<h3>Event 2: Impurities</h3>
Impurities in the pharmaceutical industry. What&#39;s next?
While the regulatory landscape is changing faster than ever, having the right information on impurities available to you at every stage of the drug development is vital to bring safe and effective therapies to the market. Whether you want to optimize your lab’s current capabilities or scale up to meet your future demands, this event creates a platform to share the customer’s expertise.
<blockquote>
Presenter: Bruno Manadas, PhD
</blockquote>
<blockquote>
Dr Manadas is a prominent Cell Biology researcher at CNC-UC since 2017. With expertise in biochemistry, psychology, and biotechnology, he&#39;s authored 130+ publications and led multiple projects. As head of CNC&#39;s Mass Spectrometry node and Associate Editor for Frontiers, he&#39;s contributed significantly to neuroscience and psychiatry. Bruno&#39;s research focuses on cell biology mechanisms, translational biomarker research, and MS-based approaches for studying protein oxidation. He played a pivotal role in establishing the hospital biobank and teaches at the Portuguese Catholic University.
</blockquote>
<blockquote>
Presenter: Dorte Bekker-Jensen
</blockquote>
<blockquote>
Dorte is heading the Applications Development team in Proteomics Research at Evosep. She has long-term experience within proteomics and has focused on technology development by developing simple and automated workflows for high-throughput applications.
</blockquote>
<blockquote>
Presenter: Stefan Ledinger
</blockquote>
<blockquote>
Stefan has 20 years of experience in the life sciences and diagnostic industries. For the last dozen years, he has been serving various functions within biocrates life sciences ag. Most recently, he has been responsible for the market development for metabolomics solutions in the pharmaceutical and biotech industries. He currently serves as Global Head of Sales. Stefan holds degrees in business administration and bioengineering, combining commercial know-how with a passion for science.
</blockquote>
<blockquote>
Presenter: Markus Langsdorf
</blockquote>
<blockquote>
Markus has 14 years of experience in life sciences industries. As he joined biocrates in 2010, he worked for 11 years as application support specialist for biocrates’ metabolomics profiling solutions. 3 years ago he changed his position withing the company to his new function as product manager. Markus studied chemistry and graduated with a PhD in Analytical Chemistry.
</blockquote>

Pharma conclave series 2024: Impurities

<h4>Live from the Lab hosted by NIBRT: Solutions for biotherapeutic analysis</h4>
By your side to accelerate your biopharmaceutical development journey
Join us for the second Live from the Lab of 2024, taking place on September 17th, an exciting biopharma hybrid event featuring the latest advancements in separation technology and mass spectrometry. Focusing on all stages of biotherapeutics development, from discovery and research, all the way to routine and QC analysis, this event will give you valuable insights to accelerate your biopharmaceutical development journey.
The following speakers will talk at this event at the NIBRT research facility which will be streamed live all over Europe:
<ul>
<li>Dr. Jonathan Bones, NIBRT</li>
<li>Prof. Mark Dickman, University of Sheffield</li>
<li>Dr. Dan Bach Kristensen, Symphogen</li>
<li>Dr. Mark Hilliard, Pfizer</li>
<li>Dr. Ken Cook, Thermo Fisher Scientific</li>
<li>Jon Bardsley, Thermo Fisher Scientific</li>
</ul>
Whether you are a researcher, scientist, or industry professional in our region, this biopharma event is not to be missed. Expand your knowledge, network with experts, and discover how the Thermo Scientific solutions will stand by your side to accelerate your biopharmaceutical development journey.
Mark your calendars for September 17th and join us for this impactful hybrid event foster collaboration within the scientific community.
Participation is free of charge, registration is required.
For any questions about this event or regarding your registration, please email CMDEvents@thermofisher.com.
<h4>How to attend?</h4>
3 ways of attending:
<h5>Online attendees (remote):</h5>
Unable to travel to a satellite? Not a problem! You can register to attend conveniently online from your desk or anywhere else through the live stream from NIBRT.
<ul>
<li><a href="https://assets.thermofisher.com/TFS-Assets/CMD/Flyers/fl-003119-pb-live-from-the-lab-ms-biotherapeutics-agenda-online-fl003119-em-en.pdf">Agenda</a></li>
</ul>
<h5>NIBRT Research Facility (in-person event):</h5>
Join the heart of the event where the main agenda will be hosted and live streamed across our region to our satellite events and our online audience. Attendance through VIP invitation only!
<h5>Join a ‘Satellite’ location (in-person event):</h5>
Across Europe, our in-person satellite events will be broadcasting the main agenda live streamed from NIBRT, Dublin and supplement the day with local speakers/lab tours pending on the satellite. Take this opportunity to network with fellow scientists and meet your Thermo Fisher representatives from technical, commercial, and service functions. Check out the closest location to you and their individual agenda!
<ul>
<li>Søborg, Denmark (AGC Biologics)</li>
<li>Dreieich, Germany (Thermo Fisher Scientific)</li>
<li>Segrate, Italy (MI) (Thermo Fisher Scientific S.P.A.)</li>
<li>Leiden, Netherlands (Janssen Biologics BV)</li>
<li>Ljubljana, Slovenia (Four Points by Sheraton Ljubljana Mons)</li>
<li>Reinach, Switzerland (Thermo Fisher Scientific)</li>
<li>Hemel Hempstead, UK (Thermo Fisher Scientific)</li>
</ul>

Thermo Fisher Scientific: Live from the Lab: Solutions for biotherapeutics

Live from the Lab: Solutions for biotherapeutics

An exciting biopharma hybrid event featuring the latest advancements in separation technology and mass spectrometry.

MALDI Top-Down Sequencing (MALDI-TDS) delivers N- and C-terminal sequence readout for intact proteins or protein subunits within minutes.
Leverage the novel neofleX™ MALDI-TDS workflow for verification of therapeutic antibodies, antigens and other protein expression products regarding sequence, terminal status and modifications and, thereby, enable instant decision making in strain development and production in biopharma or other branches of industry.
During this webinar, you will learn:
<ul>
<li>Overview of neofleX technology and its benefits to life sciences applications
</li>
<li>neofleX top-down workflow: Protein sequence verification with shortest time-to-result
</li>
<li>OmniScape™ software: From data to sequencing results with just a few mouse clicks
</li>
</ul>
Who should attend:
<ul>
<li>Characterization team leaders in biopharma companies and CROs
</li>
<li>Mass spectrometry core lab managers
</li>
<li>Researchers who are interested in fast protein characterization methods
</li>
<li>Anyone who needs to deliver instant sequence verification for protein expression products
</li>
<li>Anyone who would like to learn about the latest MALDI-TOF/TOF technology
</li>
</ul>
<blockquote>
Presenter: Jan Hendrik Kobarg, Ph.D. (Product Manager, MALDI-TOF, Bruker Daltonics, Bremen, Germany)
</blockquote>
<blockquote>
Jan Kobarg, Ph.D., is the product manager for the MALDI-TOF instrument portfolio at Bruker. The latest addition to the portfolio is the neofleX™ MALDI-TOF Benchtop instrument.
</blockquote>
<blockquote>
Presenter: Arndt Asperger, Ph.D. (Senior Applications Scientist, Bruker Daltonics, Bremen, Germany)
</blockquote>
<blockquote>
Arndt is analytical chemist by training and got his Ph.D. from Leipzig University. He joined Bruker in 2002 and has been working in various application related positions with a focus on pharma/biopharma.
</blockquote>

Bruker: LabCast: Simple and fast top-down protein characterization using neofleX benchtop MALDI-TOF/TOF

LabCast: Simple and fast top-down protein characterization using neofleX benchtop MALDI-TOF/TOF

Overview of neofleX technology and its benefits to life sciences applications.

LabCast: Simple and fast top-down protein characterization

The sample throughput of high-sensitivity liquid chromatography-mass spectrometry (LC-MS) based proteomics analysis is restricted by the pressure limitations of LC and column hardware, with some methods wasting as much as 50% of the method cycle time outside of MS acquisition.
Traditional routes for boosting throughput include shorter columns and gradients, higher flow rates, and using trap-and-elute workflows – all of which introduce trade-offs in sensitivity and proteome depth.
The Thermo Scientific™ Vanquish™ Neo tandem direct injection workflow leverages hardware innovations and software intelligence to eliminate method overhead while maintaining data quality across nano, capillary, and micro-flow LC-MS.
In this webinar experts from Evotec and Bayer will showcase how they implemented the tandem direct injection workflow for their proteomics work. Dr. Nagarjuna Nagaraj will present on how Evotec is using tandem direct injection with nano-LC columns packed in-house to boost sample throughput of their chemoproteomics screening pipeline, while Dr. Alexander Boychenko from Bayer will discuss how his lab is using a micro-flow tandem direct injection approach to analyze plasma samples for translational proteomics.
Learning Objectives
<ul>
<li>See how minimizing LC-MS method overhead can accelerate sample throughput while maintaining proteome depth
</li>
<li>Discover how labs are using tandem direct injection for chemoproteomics and translational proteomics applications
</li>
<li>Learn how to implement tandem direct injection in your proteomics workflow
</li>
</ul>
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Presenter: Dr. Nagarjuna Nagaraj (Group Leader High Sensitivity Proteomics, Evotec)
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<blockquote>
Dr. Nagarjuna Nagaraj is a proteomics group leader at Evotec focusing on high sensitivity and high throughput proteomics applications with more than 18 years of experience in proteomics and mass spectrometry. Nagarjuna obtained his PhD from the Matthias Mann lab focusing on sample preparation and MS data acquisition strategies for clinical applications. After a postdoc he directed the mass spectrometry core facility at the Max-Planck-Institute of Biochemistry working on a wide range of protein and peptide mass spectrometry projects such as bottom-up proteomics, structural mass spectrometry including HDX, native and crosslinking MS, intact protein and small molecule analysis.
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<blockquote>
Presenter: Dr. Alexander Boychenko (Head of R&amp;D Laboratory Precision Medicine Markers, Bayer)
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<blockquote>
Alexander Boychenko is leading Omics Research within the Translational Sciences team of the Pharmaceuticals division at Bayer Group. He is focused on implementing innovative analytical technologies and developing novel methodologies for proteomics, metabolomics, and ligand-binding assays (LBA) to comprehensively characterize human and animal model phenotypes, enabling disease understanding and novel biomarker discovery. He holds a Ph.D. in Analytical Chemistry from Kharkiv National University, Ukraine. During his post-doctoral work at the University of Groningen, The Netherlands, he combined LC-MS and immunoassays to discover and validate protein biomarkers in biofluids for cancer screening. Before joining Research and Early Development at Bayer AG, he developed and introduced new liquid chromatography-mass spectrometry products at Thermo Fisher Scientific. Alexander is a subject matter expert in LC-MS, biological data interpretation, and precision medicine. He utilizes his passion for applying technical expertise to develop new medicines.
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<blockquote>
Presenter: Dr. Alec Valenta (Product Marketing Manager, Thermo Fisher Scientific)
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<blockquote>
Alec is the product marketing manager for the Vanquish Neo UHPLC system and low-flow LC columns. Prior to joining Thermo Fisher Scientific he earned his PhD in analytical chemistry from the University of Michigan where he helped advance microdialysis sampling of neurochemicals and developed LC-MS methods to quantify small molecule neurotransmitters, neuropeptides, and metabolites in a variety of complex biological samples.
</blockquote>

Thermo Scientific: A Tandem LC Workflow for Maximizing Mass Spectrometer Utilization in Proteomics

A Tandem LC Workflow for Maximizing Mass Spectrometer Utilization in Proteomics

How experts from Evotec and Bayer implemented the tandem direct injection workflow for their proteomics work.

A Tandem LC Workflow for Maximizing Mass Spectrometer

With the timsTOF Pro, powered by the PASEF® acquisition modes, Bruker has largely contributed to take proteomics analysis to a new dimension, by removing the need to compromise speed for sensitivity or selectivity, while reaching unprecedented levels of robustness.
Introduced @ ASMS 2024, the timsTOF Ultra 2 is the pinnacle of timsTOF evolution, combining ultimate sensitivity, speed, selectivity and dynamic range with the field-proven legendary timsTOF robustness. During this live from the lab, you will witness through real-life examples how sensitive and versatile the timsTOF Ultra 2 can be.

Bruker: Taking 4D-Proteomics™ to the routinely exceptional with the timsTOF Ultra 2j

Taking 4D-Proteomics™ to the routinely exceptional with the timsTOF Ultra 2

Through real-life examples how sensitive and versatile the timsTOF Ultra 2 can be.

Taking 4D-Proteomics™ to the routinely exceptional

Fragmentation-based molecular annotations are the gold standard in high-confidence biomarker identification using mass spectrometry.
The new iprm-PASEF workflow integrates CCS-enabled MALDI Imaging of lipids with a targeted MS/MS imaging approach that allows spatial fragmentation and analysis of multiple targets in a single acquisition. The workflow includes a fully integrated pipeline within our software ecosystem to generate accurate identifications with spatial fidelity.
Key Learning Objectives:
<ul>
<li>Fragmentation based MALDI Imaging capabilities
</li>
<li>iprm-PASEF workflow for the timsTOF fleX
</li>
<li>Fragmentation based annotation pipeline using SCiLS™ Lab
</li>
</ul>
Who should attend:
<ul>
<li>Researchers interested in expanding their spatial biology toolkit
</li>
<li>Researchers focused on maximizing confidence of molecular annotations for MALDI Imaging
</li>
<li>Anyone who wants to expand their MALDI Imaging workflows
</li>
</ul>
<blockquote>
Presenter: Michael Becker, Ph.D. (Principal Scientist DMPK, Boehringer Ingelheim Pharma GmbH &amp; Co KG, Mainz, Germany)
</blockquote>
<blockquote>
Dr. Michael Becker is the head of the Mass Spectrometry Imaging lab at Boehringer Ingelheim. He received his Ph.D. in Neurobiology, and transitioned into the imaging field more than 15 years ago. He uses MSI to study drugs and drug-induced changes in tissue. To do so, he tries to push the sensitivity, reproducibility and specificity of the method.
</blockquote>
<blockquote>
Presenter: Arne Behrens, Ph.D. (Application Specialist in MALDI Imaging, Bruker Daltonics GmbH &amp; Co. KG, Bremen, Germany)
</blockquote>
<blockquote>
Dr. Arne Behrens is an Imaging Applications Scientist  at Bruker in Bremen with more than 6 years of experience on the timsTOF fleX platform. He received his Ph.D. in Analytical Chemistry and is an expert for CCS-enabled MALDI Imaging applications.
</blockquote>
<blockquote>
Presenter: Björn Wendik, Ph.D. (Business Development Manager, Bruker Daltonics GmbH &amp; Co. KG, Bremen, Germany)
</blockquote>
<blockquote>
Björn studied biology at the University of Würzburg and University of Freiburg with focus on developmental biology. In Freiburg he did his Ph.D. working on motoneuron development and pancreas formation. He became an expert on life cell imaging, timelapse studies and 3d-image software analyses. He continued his work as lecturer at the University of Freiburg where he also took care of parts of the Imaging core facility. When stepping into industry, he worked as a specialist for confocal microscopy and from there moved on into multispectral imaging, antibody based multi- and hiplexing and tissue analysis platforms. With this expertise, Björn started as a Business Development Manager for the MALDI Imaging at Bruker in July 2023.
</blockquote>

Bruker: Confidence in spatial identifications using iprm-PASEF on the timsTOF fleX

Confidence in spatial identifications using iprm-PASEF on the timsTOF fleX

The new iprm-PASEF workflow integrates CCS-enabled MALDI Imaging of lipids with a targeted MS/MS imaging approach.

Confidence in spatial identifications using iprm-PASEF

<div class="summary-section section" style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);box-sizing:border-box;color:rgb(51, 51, 51);font-family:&quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin-bottom:34px;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><h4><span style="font-family:-apple-system, BlinkMacSystemFont, &quot;Segoe UI&quot;, system-ui, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Web&quot;, sans-serif, &quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:18px;">Session #1 - Advancements in Targeted Quantitation of PFAS</h4>We are thrilled to invite you to our upcoming webinar focused on enhancing laboratory efficiency and accuracy in PFAS analysis. Join us to explore innovative solutions that streamline processes and improve detection capabilities.<h5 style="margin-left:0px;">1. Harnessing the Power of Mass Spectrometry and Automation to Reduce Sample Size, Sample Preparation Time and Increase Laboratory Efficiency of PFAS Analysis for EPA 1633</h5><ul><li>Presented by Kari Organtini</li></ul>EPA Method 1633 is widely used for analyzing PFAS in non-potable water, soils, biosolids, and tissues. This presentation will show how advanced mass spectrometry and automation can significantly reduce sample size, cut down preparation time, and boost overall laboratory efficiency.<h5 style="margin-left:0px;">2. Identification of short chain per and polyfluorinated alkyl substances (PFAS) using ion ratios with low mass product ions</h5><ul><li>Presented by Stuart Adams</li></ul>As long-chain PFAS are replaced by short and ultrashort-chain alternatives, their detection becomes more challenging. This talk will cover how modified tandem quadrupole mass spectrometry enhances sensitivity, enabling the identification of these difficult-to-detect PFAS compounds using low-mass product ions.<h5 style="margin-left:0px;">3. Evaluation of DESI mounted on Q-TOF and TQ mass spectrometers to image PFAS compounds in different matrices</h5><ul><li>Presented by Emmanuelle Claude</li></ul>Direct analysis with minimum sample preparation as well spatial dimension of PFAS in samples can add simplicity and localization information, to complement state of the art detection and quantification by UHPLC-MRM analysis. Results are presented to evaluate the level of detection of few tens of PFAS compounds that were spotted on porcine liver tissue section, after updating the DESI imaging workflow to minimize external contamination. Several mass spectrometers such as discovery workflow in full scan TOF mode on the MRT and Cyclic mass spectrometers as well as targeted workflow using MRM acquisition mode on the DESI XS Xevo TQ Absolute MS were compared. Finally the benefit of ion mobility separation for the MSI analysis of PFAS is described. 61% and 55% of the PFAS compounds were detected as low as 10 ng/mL spotted on tissue when analyzed by negative mode DESI in discovery full scan MS acquisition mode. The targeted MRM workflow is the most sensitive system with 77% of the PFAS compounds detected as low as 10 ng/mL spotted on tissue.Join us to learn how these technologies are transforming PFAS analysis, helping laboratories meet the growing demand for more efficient and accurate testing.<div class="speaker-fields-container" style="box-sizing:border-box;padding-top:5px;"><div class="section" style="box-sizing:border-box;margin-bottom:34px;"><div class="sp-begin" style="box-sizing:border-box;clear:both;color:rgb(0, 0, 0);font-size:14px;"><blockquote>Presenter: Dr. Stuart Adams (Principal Scientist, Market Development, Food and Environmental Applications, Europe, Waters Corporation)Stuart has been developing methods for the determination of contaminants in food and the environment for over 17 years and has been with Waters Corporation since 2018. Stuart's previous role was as a senior analytical chemist at Fera (the UK’s National Reference Laboratory) and moved to Waters to focus on application development in the European region. He now serves as the attached scientist to the European Market Development team responsible for the food and environmental application areas. In his role, he works with customers to understand their analytical challenges and helps address them with Waters technologies.Presenter: Kari Organtini, Ph.D. (Principal Scientist, Food &amp; Environmental, Waters Corporation)Kari Organtini is a senior scientist at WatersCorporation and has been with the company for five years. She received her PhD from Penn State University in 2015 studying the occurrence of dioxins and furans in fire debris and their implications to first responder health. At Waters, Kari is part of the food and environmental applications team. Kari has developed applications using both LC and GC techniques for a variety of applications ranging from pesticides to persistent organic pollutants during her career. She is currently the scientific lead for developing PFAS applications at Waters.Presenter: Emanuelle Claude (Consulting Scientist D&amp;C Imaging, Waters Corporation)Miss Emmanuelle Claude (Master in Fine Chemistry and Business and M.Phil in spectroscopy analysis in organic chemistry and biology) is currently a Consulting scientist in the Scientific Operations Department, Wilmslow, UK.She started at Waters Corporation in October 2000 as an Application Chemist in the Proteomics and Genomics Marketing group, developing automated Peptide Mass Fingerprint (PMF) MS methods using a MALDI-TOF mass spectrometer.Over the years she developed several methods in the proteomics analytical space using MALDI TOF and naturally moved in starting the development of Mass Spectrometry Imaging (MSI) at Waters corporation over 15 years ago.She has been involved with hardware and software R&amp;D to ensure that the solutions are fit-for-purpose for the MSI community and beyond. She has worked extensively with the main MSI leaders in Europe and the US such as Prof Heeren in the Netherlands, Prof Clench, Prof Takats and Bunch in the UK and Prof Caprioli in the US. She has been a Principal Scientist since 2014 and became a Consulting scientist in 2021 and is part of the MS imaging application team at Waters where data are generated for collaborations and marketing activities (i.e. application literature, customer presentation, papers, posters...), hardware and software requirements are defined for the R&amp;D teams. The team evaluates and develops new applications &amp; methods for imaging by both MALDI and DESI mass spectrometry, support sales with customers visit and demonstration laboratory worldwide.Presenter: Ken Rosnack (Principal Market Development Manager, Waters Corporation)Ken Rosnack is a Principal Market Development Manager in the Testing &amp; Lab Services Group for Waters Corporation. His primary focus is within regulated and routine LC-MS/MS environmental market where he is responsible for world-wide strategy implementation and performance. He maintains collaborations within regulatory agencies as well as with global industrial partners. Over his career, Ken has been primary author on numerous publications, been an invited speaker multi-nationally, and has presented at many conferences. He has been involved with MS for the past 40 years.</blockquote></div></div></div></div>

Waters Corporation: Advancements in Targeted Quantitation of PFAS

Advancements in Targeted Quantitation of PFAS

Learn how technologies are transforming PFAS analysis, helping laboratories meet the growing demand for more efficient and accurate testing.

<div class="summary-section section" style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);box-sizing:border-box;color:rgb(51, 51, 51);font-family:&quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin-bottom:34px;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><h4 style="margin-left:0px;"><span style="font-family:-apple-system, BlinkMacSystemFont, &quot;Segoe UI&quot;, system-ui, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Web&quot;, sans-serif, &quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:18px;">Session #2 - Innovative Approaches in HRMS and Software for PFAS Analysis</h4>We are excited to invite you to our upcoming webinar, where we will explore the latest advancements in PFAS analysis through innovative screening methods and technologies. Our expert speakers will cover various approaches to enhance the detection and identification of per- and polyfluoroalkyl substances (PFAS).<h5 style="margin-left:0px;">1. Nontarget Screening workflow (NTS) for the Analysis of Per and Polyfluoroalkyl Substances (PFAS) using High resolution mass spectrometry (HRMS)</h5><ul><li>Presented by Hania Khoury-Hollins</li></ul>This session will focus on using HRMS as an effective tool to detect both regulated and non-regulated PFAS. We’ll explore the UNIFI™ screening workflow and discuss the use of comprehensive PFAS libraries to improve detection capabilities.<h5 style="margin-left:0px;">2. Untargeted Screening for PFAS Chemicals Using Comprehensive Feature Detection</h5><ul><li>Presented by Jeff Goshawk</li></ul>Discover how advanced feature detection methods can identify a wide range of PFAS chemicals, including those not covered by traditional reference standards. This talk will highlight techniques to detect novel PFAS-like chemicals, providing a broader understanding of total organic fluorine content in samples.<h5 style="margin-left:0px;">3. Elevating Specificity and Identification Confidence for PFAS Liquid Chromatography and Cyclic Ion Mobility Mass Spectrometry</h5><ul><li>Presented by Michael McCullagh</li></ul>Learn how cyclic ion mobility (cIM) enhances the separation and identification of PFAS isomers. By using this method, we can achieve greater specificity and reduce analysis time, providing insights into PFAS exposure and its potential health impacts.Join us to learn how these cutting-edge approaches are revolutionizing PFAS detection and analysis, offering more accurate and efficient solutions for environmental monitoring and public health protection.<div class="speaker-fields-container" style="box-sizing:border-box;padding-top:5px;"><div class="section" style="box-sizing:border-box;margin-bottom:34px;"><div class="sp-begin" style="box-sizing:border-box;clear:both;color:rgb(0, 0, 0);font-size:14px;"><blockquote><div style="box-sizing:border-box;">Presenter: Hania Khoury-Hollins (Principal Scientist, Waters Corporation)</div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;">Hania Khoury-Hollins is a scientist and researcher at Waters Corporation. She holds a bachelor’s degree in science, which laid the foundation for her scientific pursuits. In 2001, Hania earned her master’s degree in Toxicology, deepening her understanding of the impact of chemicals on living organisms. In 2005 she successfully defended her Ph.D. in physical chemistry from University René Descartes - Paris V (France). After undertaking several different projects in academia Hania spent some time working at Agilent before joining Waters.</div>At Waters, her work revolves around developing cutting-edge analytical techniques and their applications with a focus on Liquid Chromatography coupled with High-Resolution Mass Spectrometry (LC-HRMS). Her expertise encompasses a diverse range of applications, including drug development, proteomics, metabolomics, and lipidomics. More recently, Hania has been developing applications strategies for per- and polyfluoroalkyl substances (PFAS).Presenter:&nbsp;Mike McCullagh (Consulting Scientist, Waters Corporation)Michael has worked at Waters Corporation for over 23 years. His main focus has been non-targeted analysis using time of flight mass spectrometry and ion mobility mass spectrometry. Michael has made contributions to various teams, including Food and Environmental, MS Evaluation, Life Science, Scientific Operations, the Advanced Mass Spectrometry Team and currently in Research, Development and Advanced Testing. Research has been performed across multiple application areas including, impurity profiling, pesticide screening, natural products, food analysis, metabolite identification and more recently non-targeted PFAS analysis. Having worn a number of different “hats”, the common thread has been the privileged opportunity to work with new technologies, new informatics solutions and to collaborate with industry and global collaborative partners, to forge a path to new discoveries and contribute to solutions to analytical challenges across multiple disciplines.<div style="box-sizing:border-box;">Presenter:&nbsp;Jeff Goshawk (Consulting Scientist, Waters Corporation)</div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;">Jeff is a Consulting Scientist at Waters Corporation and has been with the company for twenty-four years. Jeff started his career at Waters as a software developer working on MassLynx and its associated application managers. Jeff subsequently transitioned into the applications development group where he joined the toxicology team as a Principal Scientist. Jeff is now back in the software development world at Waters, and is currently working on the Pattern Analysis Application.</div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;">Presenter:&nbsp;Frank L. Dorman, PhD, FRSC (Principal Environmental Market Manager, Waters Corporation)</div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;">Frank Dorman is currently Senior Business Development Manager for Waters focusing on their global environmental business and, concurrently, Associate Professor (adjunct) in the Department of Biochemistry and Molecular Biology (BMB) at Penn State University in University Park, PA. In his role at Waters, Frank manages the research-focused environmental market, external collaborations and also interfaces with R&amp;D for new product development. Prior to Waters, Frank was employed full-time as a tenure-line Faculty member of Penn State and served as a member of the Graduate Faculty in: Biochemistry, Microbiology and Molecular Biology (BMMB), Chemistry (CHEM) and the Programs in Forensics Science (FRNSC), and Biogeochemistry (BGC). Frank is also a member of the Center for Molecular Toxicology and Carcinogenesis at Penn State. Frank’s scientific interests are in gas and liquid chromatography fundamental characterization, instrumentation and column development, as well and mass spectrometry and atomic spectroscopy as applied to trace analysis in complex sample matrices. This work is directed towards environmental forensics, traditional forensic chemistry and where environmental exposure events may contribute to human disease; an area sometimes referred to as “exposomics”.</div>Prior to joining the faculty at PSU, Frank was at Restek Corporation for 14 years as the Director of Technical Development, and R&amp;D Senior Chemist. During most of this same time, Frank was also an Adjunct Research Professor at Juniata College where he maintained an active undergraduate research program. Prior to that he was at Inchcape Testing Services for 5 years as a Senior Chemist, Organics Section Manager for Sample Preparation and Corporate Methods Development Chemist. As such, Frank has extensive experience in both the Industrial and Academic sectors giving him a relatively rare combination of skills and experience.</blockquote></div></div></div></div>

Waters Corporation: Innovative Approaches in HRMS and Software for PFAS Analysis

Innovative Approaches in HRMS and Software for PFAS Analysis

Learn how these cutting-edge approaches are revolutionizing PFAS detection and analysis, offering more accurate and efficient solutions.

<div class="summary-section section" style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);box-sizing:border-box;color:rgb(51, 51, 51);font-family:&quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin-bottom:34px;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;">This interactive session will bring together the MS community to discuss some of the most popular and exciting peer-reviewed publications in a friendly and open forum. Ahead of each meeting, we will send out a link to the discussion article, then during the session an expert will summarise the main findings and answer your questions.<h5 style="margin-left:0px;">Be prepared make sure you read&nbsp;<a style="box-sizing:border-box;color:rgb(66, 139, 202);text-decoration:none;user-select:auto;" target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acscentsci.0c00049" fr-original-style="">Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy</a></h5>We're going to be joined by Dr Rebecca Beveridge from the University of Strathclyde, a senior lecturer with a host of experience with development of native ion mobility mass spectrometry methods to study proteins and protein complexes&nbsp;This paper describes how Waters' SYNAPT MS can be utilized&nbsp;demonstrate the strength of native mass spectrometry to delineate the complex binding mechanisms of protein degraders, involving the formation of three-component protein−ligand complexes.<h5 style="margin-left:0px;">Reasons to Attend:</h5><ul style="box-sizing:border-box;margin-bottom:10px;margin-top:0px;"><li style="box-sizing:border-box;">Debate some of the most topical papers from all-time favourites to some of the latest releases &nbsp;</li><li style="box-sizing:border-box;">Focus on understanding the benefit of SYNAPT MS and how to get the most out of the system for native mass spectrometry and biomolecule analysis &nbsp;</li><li style="box-sizing:border-box;">Gain a greater understanding of applications and technologies by asking questions of the authors and/or expert panel &nbsp;</li><li style="box-sizing:border-box;">No pre-recorded content, authors will be LIVE and on camera to answer questions</li></ul>Abstract&nbsp;Protein degraders, also known as proteolysis targeting chimeras (PROTACs), are bifunctional small molecules that promote cellular degradation of a protein of interest (POI). PROTACs act as molecular mediators, bringing an E3 ligase and a POI into proximity, thus promoting ubiquitination and degradation of the targeted POI. Despite their great promise as next-generation pharmaceutical drugs, the development of new PROTACs is challenged by the complexity of the system, which involves binary and ternary interactions between components. Here, we demonstrate the strength of native mass spectrometry (nMS), a label-free technique, to provide novel insight into PROTAC-mediated protein interactions. We show that nMS can monitor the formation of ternary E3-PROTAC-POI complexes and detect various intermediate species in a single experiment. A unique benefit of the method is its ability to reveal preferentially formed E3-PROTAC-POI combinations in competition experiments with multiple substrate proteins, thereby positioning it as an ideal high-throughput screening strategy during the development of new PROTACs<div style="box-sizing:border-box;clear:both;">&nbsp;</div><div class="speaker-fields-container" style="box-sizing:border-box;padding-top:5px;"><div class="section" style="box-sizing:border-box;margin-bottom:34px;"><div class="sp-begin" style="box-sizing:border-box;clear:both;color:rgb(0, 0, 0);font-size:14px;"><blockquote><div style="box-sizing:border-box;">Presenter: Dr Rebecca Beveridge (Senior Lecturer, University of Strathclyde)</div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;">Rebecca is a Senior Lecturer and UKRI Future Leaders Fellow who joined the University of Strathclyde in June 2020 as a Chancellor's Fellow. She obtained a BSc in biochemistry and chemistry from the University of Leeds in 2011 and completed her PhD at the University of Manchester in 2015. Rebecca spent 4 years at the Institute for Molecular Pathology in Vienna, Austria as a postdoctoral researcher/ Lise Meitner Postdoctoral Fellow. Throughout her career, she has collected experience in a plethora of mass spectrometry methods to study protein structure such as native mass spectrometry, ion mobility, hydrogen-deuterium exchange, and crosslinking.</div>Rebecca’s current research is centered around the development of native ion mobility mass spectrometry methods to study proteins and protein complexes, particularly those that are challenging to study with conventional biochemistry methods.Such systems include intrinsically disordered proteins that exist in a wide range of different shapes, and protein complexes formed by protein-degrading molecules such as PROTACs, the complex binding modes of which are challenging to delineate.</blockquote></div></div></div></div>

Waters Corporation: Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy

Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy

Discuss some of the most popular and exciting peer-reviewed publications in a friendly and open forum.

Native Mass Spectrometry Can Effectively Predict PROTAC

Today, tomorrow, and forever – PFAS, the “forever chemical”, have emerged as one of the greatest public health concerns of our time, infiltrating our environment and food supply. Herein, join us on Digital Classrooms for an in-depth exploration of PFAS, tracing their origins in everyday consumer products and examining their potential health implications.Our experts, Dr Yap Siew Qi and Elton Goh, will guide you through this critical topic, exploring the regulatory landscape with insights into EFSA and FDA guidelines. They will also introduce Shimadzu's innovative LC-MS/MS solutions, featuring the latest LCMS-TQ RX series. Discover how their robustness, sensitivity, and accuracy can enable effective detection of PFAS in complex food and environmental samples.Let’s work together to overcome global PFAS challenges. Register now to stay informed on this pressing issue!<h5>Learning Objectives:</h5><ul><li>Understand the implications of PFAS presence in food and environment &nbsp;</li><li>Navigate the evolving regulatory landscape for PFAS &nbsp;</li><li>Discover the capabilities of Shimadzu LCMS-TQ RX to detect PFAS in food and environmental samples</li></ul><blockquote>Presenter: Goh Wan Yu Elton (Market Specialist Food, Shimadzu (Asia Pacific) Pte Ltd)Elton is a dedicated and experienced Food Market Specialist at Shimadzu, bringing over nine years of expertise in food safety and analytical chemistry to his role. His career began at the Singapore Food Regulatory Board, where he spent seven years honing his skills and developing a profound understanding of regulatory standards and testing protocols. With a passion for knowledge and innovation, Elton transitioned to the private sector, contributing significantly to the advancement of analytical techniques and the development of novel food safety solutions during his two-year tenure at a research and development centre.Now at Shimadzu, Elton continues to excel, leveraging his expertise to develop cutting-edge analytical methods for detecting and quantifying various compounds in food products. His commitment to food science is evident in his efforts to enhance safety standards, build consumer trust, and make meaningful contributions to the global food industry.Presenter:&nbsp;Yap Siew Qi (LCMS Product Specialist, Shimadzu (Asia Pacific) Pte Ltd)Yap Siew Qi is an experienced professional in analytical chemistry, with a strong focus on liquid chromatography-mass spectrometry (LCMS). Her career commenced as a Research Assistant at the NUS Life Sciences Institute, where she acquired substantial experience in scientific research and laboratory techniques. This role was pivotal in developing her comprehensive understanding of life sciences, setting the stage for her future contributions to analytical chemistry and instrumentation.In 2022, her journey continued at Shimadzu (Asia Pacific), where she joined as an Application Chemist, focusing on LC/LCMS. In this capacity, she refined her expertise in LCMS technology, delivering prompt application support and technical solutions for the customers. Her exceptional skills and knowledge in LCMS soon led to her advancement to the position of Product Specialist. In this role, she continues to provide specialized knowledge and support, demonstrating her dedication to the progression of analytical chemistry and her proficiency in applying innovative technology within the field.Presenter:&nbsp;Mr. Ramaswamy Parthiban (Assistant Vice President, TUV SUD South Asia)Mr. R Parthiban has a robust background in operations management and quality assurance within the testing, inspection, and certification industry. He currently serves as AVP at TUV SUD South Asia, a position he has held since March 2022. Prior to this, he was the National Head at Prime Certification &amp; Inspection from April 2020 to June 2021. His experience also includes a significant role as Director of Operations at ALS Testing Services India Pvt Ltd from July 2018 to March 2020, where he led strategic initiatives and operational excellence.Earlier in his career, Mr. Parthiban held leadership roles including VP Operations at Merieux NutriSciences and Laboratory Manager for Chemistry at Exova Bahrain/KSA. His extensive experience in the industry is complemented by his earlier positions as Senior Manager at Coca-Cola and Laboratory Manager at SGS India Private Ltd. He began his career as a Research Associate at the John F. Welch Technology Center and ITC R&amp;D Center, eventually progressing to an Executive role in Quality Assurance at Sanmar Speciality Chemicals Ltd. Mr. Parthiban's career is marked by his expertise in quality systems, operational management, and strategic leadership in both national and international contexts.</blockquote>

Shimadzu: Discover The Latest LC-MS/MS Innovations For PFAS Challenges

Discover The Latest LC-MS/MS Innovations For PFAS Challenges

Discover how their robustness, sensitivity, and accuracy can enable effective detection of PFAS in complex food and environmental samples.

LCMS webinars focusing on LC/MS/MS | LabRulez LCMS