In the week of March 23, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Aromatic profiling using GCMS and HRGCMS</h5><ul><li>Tu, 24.3.2026 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6020">Registration</a></li></ul>Discover how high-resolution GC–MS and LC–MS reveal the complex aroma chemistry of blue fenugreek. Learn how advanced separation strategies improve detection of volatile and precursor compounds.<h5>2. Waters Corporation: Bioanalysis simplified – A case study with Basile Khara</h5><ul><li>Tu, 24.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5921">Registration</a></li></ul>How OligoWorks™ SPE Microplate Kit simplifies oligonucleotide sample preparation.<h5>3. Merck: Innovate and Accelerate: Leveraging 3Rs for Superior Cell Line Characterization</h5><ul><li>Tu, 24.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6021">Registration</a></li></ul>In this webinar, we review the regulatory landscape and explore an approach to developing 3Rs roadmaps.<h5>4. Phenomenex: Characterizing Antibody-Oligonucleotide Conjugates (AOCs) Under Native and Reversed-Phase Conditions</h5><ul><li>We, 25.3.2026 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5964">Registration</a></li></ul>This webinar will showcase complementary LC-MS methods developed to characterize AOCs composed of a trastuzumab biosimilar conjugated with siRNA or ASO.<h5>5. Thermo Fisher Scientific: Why HPLC-CAD is ideal for quality assurance of APIs and excipients</h5><ul><li>We, 25.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6023">Registration</a></li></ul>Discover how HPLC-CAD enhances impurity profiling of APIs and excipients, enabling sensitive, near-universal detection beyond UV limits for robust pharmaceutical quality control workflows.<h5>6. SCIEX: Comprehensive characterization of monoclonal antibodies using SCIEX HRMS platforms</h5><ul><li>We, 25.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5959">Registration</a></li></ul>Explore comprehensive monoclonal antibody characterization using SCIEX HRMS, featuring Zeno trap sensitivity, EAD fragmentation, and real-world biotherapeutic case studies.<h5>7. Waters Corporation: Navigating Regulatory Guidance for LNP and Liposomal Drug Characterization Using FFF-MALS</h5><ul><li>We, 25.3.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5848">Registration</a></li></ul>Learn how FFF-MALS enables comprehensive characterization of lipid nanoparticles and liposomes, supporting regulatory-relevant CQAs such as size, morphology, and encapsulation efficiency.<h5>8. Metrohm: From Out-of-Spec Results to Audit-Ready: Controlling Titration in GxP Labs</h5><ul><li>We, 25.3.2026 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6022">Registration</a></li></ul>Learn how to resolve out-of-spec titration results with practical KF and potentiometric troubleshooting strategies, and discover how compliant software controls ensure audit-ready workflows.<h5>9. Thermo Fisher Scientific: Chromeleon Admin Console II: System management and automation</h5><ul><li>Th, 26.3.2026 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6029">Registration</a></li></ul>In this practical session, we’ll dive into more Administration Console capabilities that help you manage and standardize your setup at scale.<h5>10. Waters Corporation: Master the challenging EQS values for endocrine active compounds</h5><ul><li>Th, 26.3.2026 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5925">Registration</a></li></ul>Learn how a sensitive LC-MS/MS supports the detection of estrogens in different water types.<h5>11. Evosep Biosystems: Scalable Workflows for standardized proteomics</h5><ul><li>Th, 26.3.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5993">Registration</a></li></ul>Join us to learn how scalable proteomics workflows are moving from promise to practice.<h5>12. Waters Corporation: Rapid Analysis of GLP-1 Analogs Using Pre-Column Derivatization</h5><ul><li>Th, 26.3.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5922">Registration</a></li></ul>Discover a rapid, microwave-assisted UPLC amino acid analysis workflow for accurate GLP-1 analog characterization using AccQ·Tag Ultra chemistry and Empower CDS.<h5>13. Mettler-Toledo: Online HPLC Analysis with DirectInject-LC</h5><ul><li>Th, 26.3.2026 18:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5999">Registration</a></li></ul>Discover how DirectInject-LC transforms HPLC into an online PAT tool. Learn how to run experiments and gain near real-time reaction analysis insights.

Webinars LabRulezLCMS Week 13/2026

This study evaluates ion chromatography with electrical conductivity and UV absorbance detection for quantifying chloronitramide, a recently identified chloramine decomposition product, in tap water. Method performance showed strong agreement with HILIC–UHRMS results, enabling reliable detection across diverse water matrices.Chloronitramide was detected in both chloraminated and free chlorine systems, marking its first reported occurrence in the latter. The developed IC methods support large-scale monitoring of chloronitramide in drinking water, with UV detection providing reduced measurement bias and improved analytical reliability.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.estlett.5c01218">Chloronitramide Anion Quantitation in Tap Waters by Ion Chromatography with Electrical Conductivity and Ultraviolet Absorbance Detection</a></h4>Jason A. Thornhill, Juliana R. Laszakovits, Barrett E. Johnson, Justin R. Chimka, and Julian L. Fairey*Environ. Sci. Technol. Lett. 2026, 13, 2, 275–280<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.estlett.5c01218">https://doi.org/10.1021/acs.estlett.5c01218</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.<div>After ∼45 years since it was first detected in chloraminated water <a href="javascript:void(0);">(1)</a> and more than 30 years since its prior characterization efforts, <a href="javascript:void(0);">(2−5)</a> chloronitramide anion (Cl–N–NO2–) was identified as a decomposition product of inorganic chloramines. <a href="javascript:void(0);">(6)</a> In a limited survey of chloraminated tap waters in the United States, Cl–N–NO2– was found in all samples tested (n = 40) at a median concentration of 23 μg L–1 and first and third quartiles of 1.3 and 92 μg L–1, respectively. Although its toxicity is currently unknown, Cl–N–NO2– forms at levels comparable to some regulated disinfection byproducts (DBPs) but lower than others. For example, the Environmental Protection Agency (EPA) maximum contaminant levels (MCLs) for the mass-based sums of four trihalomethanes is 80 μg L–1 and five haloacetic acids is 60 μg L–1; <a href="javascript:void(0);">(7)</a> however, the chlorite MCL is over 1 order of magnitude greater, at 1 mg L–1. The Cl–N–NO2– formation pathway contrasts that of most other DBPs, which are formed by reactions between a disinfectant and source water precursors, such as natural organic matter (NOM) and/or bromide. <a href="javascript:void(0);">(8,9)</a> Cl–N–NO2– is formed by monochloramine (NH2Cl) or dichloramine (NHCl2) reacting with nitronium cation (NO2+), <a href="javascript:void(0);">(6)</a> a reactive nitrogen species formed during chloramine decomposition. <a href="javascript:void(0);">(10,11)</a> In this regard, Cl–N–NO2– is an intrinsic DBP, <a href="javascript:void(0);">(12)</a> like chlorate and perchlorate in hypochlorite feedstocks. <a href="javascript:void(0);">(13−16)</a> As chloramines are inherently unstable and autodecompose under typical conditions in drinking water systems, <a href="javascript:void(0);">(17−19)</a> Cl–N–NO2– is likely present in all waters where chloramines are used. This includes systems where chloramines are formed intentionally and free chlorine systems containing source water ammonia. <a href="javascript:void(0);">(20)</a> To facilitate Cl–N–NO2– occurrence studies and better understand its formation in tap water, analytical methods are needed for Cl–N–NO2– quantitation that leverage common instrumentation in drinking water laboratories.The discovery of Cl–N–NO2– was supported by its quantitation in chloraminated tap waters by hydrophilic interaction liquid chromatography–ultrahigh-resolution mass spectrometry (HILIC–UHRMS). <a href="javascript:void(0);">(6)</a> This method has a limit of detection (LOD) of 0.17 μg L–1 and a limit of quantitation (LOQ) of 0.58 μg L–1. However, the instrumentation required for HILIC–UHRMS (i.e., orbitrap mass spectrometers) is not widely accessible due to its high capital cost and operation and maintenance requirements, limiting collection of Cl–N–NO2– occurrence data. Cl–N–NO2– reference materials were previously isolated from mixtures containing common anions (e.g., chloride, nitrite, nitrate, sulfate, phosphate) at concentrations up to ∼100 mM using ion chromatography (IC) with electrical conductivity (EC) and ultraviolet absorbance (UV) detectors. <a href="javascript:void(0);">(6)</a> Given Cl–N–NO2– is an anion and has a molar absorptivity (ε) peak maxima at 243 nm of ε243 = 5,310 M–1 cm–1, <a href="javascript:void(0);">(6)</a> Cl–N–NO2– quantitation may be possible by IC-EC and/or IC-UV243, but the applicability of these methods at μg L–1 levels is unknown. IC methods could be a cost-effective alternative to MS-based methods and adopted at drinking water utilities and commercial water analysis laboratories, enabling widescale Cl–N–NO2– occurrence studies. The objective of this study is to assess IC-EC and IC-UV243 for Cl–N–NO2– quantitation in tap waters at μg L–1 levels. Cl–N–NO2– quantitation by IC-EC and IC-UV243 was compared to HILIC–UHRMS across an unprecedented range of Cl–N–NO2– concentrations in tap waters from U.S. residential homes.<h4>2. Materials and Methods</h4><h5>2.1. Ion Chromatography System</h5>A Metrohm 850 Professional IC equipped with an autosampler, suppressor, two electrical conductivity detectors, and an 887 Professional UV/vis detector was used to isolate Cl–N–NO2– standard reference materials and quantify Cl–N–NO2– in tap waters. Two Metrosep A Supp 7 separation columns were used, each 250 mm in length with a 4.0 mm diameter, one for Cl–N–NO2– isolation that had been used extensively (&gt;10,000 injections) and regenerated to maintain adequate anion separation and the second newly acquired for Cl–N–NO2– quantitation in drinking water matrices. Both IC columns consist of a PEEK housing packed with a poly(vinyl alcohol) carrier material with quaternary ammonium groups, 5 μm particle size, 15 MPa maximum pressure, 1.0 mL min–1 maximum flow rate, pH range 3–12, and temperature range of 20–60 °C. Na2CO3 eluent concentrate (Metrohm) was diluted 100× to 3.6 mM for Cl–N–NO2– isolation and 25× to 14.4 mM for Cl–N–NO2– quantitation.<h4>3. Results and Discussion</h4><h5>3.4. Tap Water Comparison of IC and HILIC–UHRMS</h5><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.estlett.5c01218#fig2">Figure 2</a> shows Cl–N–NO2– concentrations in the 12 tap waters measured by IC-EC and IC-UV243 peak area compared to the HILIC–UHRMS method developed in prior work. <a href="javascript:void(0);">(6)</a> <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acs.estlett.5c01218/suppl_file/ez5c01218_si_001.pdf">Figure s30</a> shows these data for peak height.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Environ_Sci_Technol_Lett_2026_13_2_275_280_Figure_2_Ion_chromatography_electrical_conductivity_IC_EC_Panels_A_and_B_and_ultraviolet_absorbance_at_243_nm_18517febbb.jpg" alt="Environ. Sci. Technol. Lett. 2026, 13, 2, 275–280: Figure 2. Ion chromatography-electrical conductivity (IC-EC, Panels A and B) and -ultraviolet absorbance at 243 nm (IC-UV243, Panels C and D) comparison testing with HILIC–UHRMS for Cl–N–NO2– quantitation in 12 waters which included eight chloraminated tap waters (TX-1, PA, TX-2, SC, CA, TX-3, OK, and MN), three chlorinated tap waters (AR, GA-1, and GA-2), and one synthetic groundwater (GW) with no added disinfectant. (A) IC-EC measured by peak area vs Cl–N–NO2– determined by HILIC–UHRMS, (B) IC-EC residuals by peak area, (C) IC-UV243 measured by peak area vs Cl–N–NO2– determined by HILIC–UHRMS, and (D) IC-UV243 residuals by peak area. The solid black line in Panels A and C is the 1:1 line and shown with the correlation coefficient, R2. The average residual ( 𝑟𝑖⎯⎯⎯ ; n = 12) in μg L–1 is shown in Panels B and D as a measure of the linear regression model bias and accuracy with values closer to zero indicating lesser overall bias." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Environ_Sci_Technol_Lett_2026_13_2_275_280_Figure_2_Ion_chromatography_electrical_conductivity_IC_EC_Panels_A_and_B_and_ultraviolet_absorbance_at_243_nm_18517febbb.jpg 214w," sizes="100vw" width="1750" height="1279">Cl–N–NO2– quantified using the IC methods tracked the 1:1 line across the range of Cl–N–NO2– concentrations in the tap waters from not detected to 315 μg L–1, indicating they were strongly correlated with the HILIC–UHRMS measurements. For IC-EC, the R2 (n = 12) was 0.991 (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.estlett.5c01218#fig2">Figure 2</a>A) and the average residual (𝑟𝑖⎯⎯⎯) was +3.2 μg L–1, indicating an overall positive bias. For IC-UV243, the R2 (n = 12) was 0.997 and the&nbsp;𝑟𝑖⎯⎯⎯ was 0.0 μg L–1, indicating no overall bias. Therefore, the accuracy and precision of Cl–N–NO2– quantitation by IC-UV243 exceeded that of IC-EC for the tap waters tested. This is the first report, to the best of our knowledge, of Cl–N–NO2– presence in chlorinated tap waters. Although the Cl–N–NO2– concentrations are lower compared to chloraminated tap waters, this finding suggests that Cl–N–NO2– exposure is more widespread and additional formation pathways such as breakpoint chlorination could be relevant, as previously speculated. <a href="javascript:void(0);">(6)</a> The Cl–N–NO2– concentration maximum observed in the chloraminated tap waters (315 μg L–1) is greater by a factor of about three compared to that in prior work, <a href="javascript:void(0);">(6)</a> illustrating a pressing need for additional occurrence studies to capture its full range in water systems.We demonstrated that IC-EC and IC-UV243 can be used to accurately quantify Cl–N–NO2– in tap waters with minor modifications to the IC system (i.e., 5 mL injection loop and 14.4 mM Na2CO3 eluent) using standards formulated in 1 mM borate buffer at pH 9. While the lowest LOD (5.8 μg L–1) and LOQ (8.2 μg L–1) are greater than those for HILIC-UHRMS (0.17 and 0.58 μg L–1, respectively), the IC methods are accurate within an environmentally relevant range, with Cl–N–NO2– at levels up to about 315 μg L–1. Spike recovery experiments indicate matrix effects were negligible for Cl–N–NO2– quantitation by IC-EC and IC-UV243 for concentrations &lt;50 μg L–1 (i.e., P&lt;50&nbsp;μg&nbsp;L–1 &gt; 0.05). IC-based quantitation methods were strongly correlated with HILIC–UHRMS (R2 ≥ 0.991) and unbiased for quantitation by IC-UV243 peak area. Cl–N–NO2– may continue to form in tap waters containing a chloramine residual, particularly at pH ≲ 8 where chloramines decompose more readily. <a href="javascript:void(0);">(29)</a> A quenching agent/procedure has not yet been identified for chloramines that does not impact Cl–N–NO2–. Thus, the time between sample collection and analysis should be minimized (&lt;1 day, if possible) to get the most accurate assessment of Cl–N–NO2– occurrence until if/when a suitable sample preservation procedure is developed. Nevertheless, the IC methods developed and validated here can be adopted by water utilities and testing laboratories for widespread Cl–N–NO2– monitoring campaigns.</div>

Chloronitramide Anion Quantitation in Tap Waters by Ion Chromatography with Electrical Conductivity and Ultraviolet Absorbance Detection

Visit the LabRulez booth at <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871">analytica 2026</a> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"><h3>Would you like to learn how the LabRulez portals work?</h3>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/">LabRulezLCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/">LabRulezGCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/">LabRulezICPMS</a><ul><li>A unique online solution for your marketing</li><li>A targeted audience from the analytical chemistry community</li><li>Modern technologies and a unique concept</li><li>Design optimized for most smart devices – PC, mobile, and tablet</li><li>Advanced statistical tools fully available to users</li></ul><h3>Services Offered</h3><h4>News + Company Updates</h4><ul><li>Publish news related to your instrumentation, applications, services, events, job openings, and more</li><li>News is shared both on our portals and across our social media channels</li></ul><h4>Library – All Documents in One Place</h4><ul><li>Applications, posters, presentations, technical articles, brochures, specifications</li><li>Fast and advanced search capabilities</li><li>Over 32,000 documents currently available in our database</li></ul><h4>Webinars</h4><ul><li>Upcoming and on-demand webinars from the field of analytical chemistry</li><li>More than 5,500 webinars covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4>Careers</h4><ul><li>Targeted job listings in analytical chemistry</li><li>Clear filtering by specialization or location</li><li>Increased visibility for job postings</li></ul><h4>Companies</h4><ul><li>Company profile with key information and contacts</li><li>Integration of all your activities on our portal: News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li>Connection to your Products listed on LabRulez portals</li></ul><h4>Products and Services</h4><ul><li>Comprehensive overview of instrumental techniques and services</li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4>Marketplace</h4><ul><li>Buying and selling pre-owned analytical equipment</li><li>We purchase analytical instrumentation of all brands and ages</li><li>Sell your equipment through LabRulez</li><li>Request and purchase complete systems, modules, or spare parts with warranty and service</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"><h3>What Will Be on Display at Our Booth?</h3>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar">LabRulezLCMS Marketplace</a></h4>Spare parts for LC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378">Vacuum turbo pumps for LC/MS</a></li></ul>Spare parts for HPLC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397">Degassers for HPLC/UHPLC</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve">Automatic valves for HPLC</a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377">HPLC lamps</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48">HPLC columns</a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar">LabRulezGCMS Marketplace</a></h4>Spare parts for GC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo">Turbo pumps for GC/MS</a></li></ul>Spare parts for GC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC">EPC modules</a></li></ul>Sample injection<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432">Autosampler 7693A for GC</a></li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7">GC columns </a>and selected accessories</li></ul>

LabRulez at analytica 2026

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Bruker

Thermo Fisher Scientific

Shimadzu Corporation

SCIEX

Waters Corporation

Measurements of drugs of abuse in blood in a forensic lab require highest reliablity with regard to identification and quantification of the compounds in question. After economical evaluation, the analytical setup of the forensic lab was completely rearranged, now processing up to 8000 blood samples each year including a multiple of different measurements.
Drug screening is no longer based on immunoassays lacking selectivity. It is now performed on LC/MS-Toxtyper systems directly providing quantification of five drugs as key compounds. Analysis of THC and further drugs such as neuroleptics and sedatives is carried out by LC/MS/MS.
Recently, a robotic system for sample preparation has been put into service transforming the laboratory process into a fully scalable application for high-throughput measurements.
<blockquote>
Presenter: Christian Vidal (Chemistry Department, State Criminal Investigation Office of Lower Saxony, Hannover, Germany)
</blockquote>

Pixabay/RenoBeranger: Drugs of abuse in blood - high-throughput measurements in a forensic lab

Drugs of abuse in blood - high-throughput measurements in a forensic lab

The ZenoTOF 7600 system was ranked the most innovative technology by The Analytical Scientist for its ability to help scientists address analytical challenges across many markets. Zeno trap coupled with electron activated dissociation (EAD) fragmentation technology unlocks sensitivity gains allowing you to uncover new information for certainty in your results to make better-informed decisions, faster.
Highlights of this technology:
<ul>
<li>Drive new limits of quantification achievable with accurate mass</li>
<li>Detect up to 20x more ions in every experiment</li>
<li>Deliver high depth of coverage on low abundance species, quickly and robustly with Zeno SWATH data-independent acquisition (DIA)</li>
</ul>
<blockquote>
Presenter: Bhavya Shukla (Sales Development Manager, SCIEX)
</blockquote>
<blockquote>
Bhavya Shukla, Sales Development Manager at SCIEX has more than 8 years of experience in the analytical industry. He pursued his post-graduation in chemical engineering from the Institute of Chemical Technology Mumbai. His major role is to support LCMS users by providing them optimal solutions through a keen understanding of their needs.
</blockquote>

SCIEX: Leveraging the power of Zeno trap and EAD

Leveraging the power of Zeno trap and EAD

Zeno trap coupled with electron activated dissociation (EAD) fragmentation technology unlocks sensitivity gains allowing you to uncover new information

Presentation Topics
<ul>
<li>Origins of the Digital Ion Trap
</li>
<li>Ion Trap v. Digital Ion Trap
</li>
<li>Shimadzu&#39;s Journey to the MALDI Digital Ion Trap
</li>
<li>Basic Proteomics
</li>
<li>Glycomics
</li>
<li>Antibody Drug Conjugates
</li>
<li>Summary and Acknowledgements
</li>
</ul>

Shimadzu: Proteomic Analysis Using a Miniature MALDI Digital Ion Trap Mass Spectrometer

Proteomic Analysis Using a Miniature MALDI Digital Ion Trap Mass Spectrometer

Proteomic Analysis Using a Miniature MALDI Digital Ion Trap

In this webinar you will discover how extractables and leachables (E&amp;L) testing can be streamlined using acquisition modes enhanced by QTRAP technology. If you are new to E&amp;L testing or want to learn how your own workflows can be improved when using nominal mass technology then this webinar is for you.
Key topics that will be covered in this webinar include:
<ul>
<li>Introduction to E&amp;L analysis using nominal mass instrumentation</li>
<li>How the QTRAP can enhance E&amp;L analysis</li>
<li>The importance of libraries and how they can be implemented to improve compound identification</li>
</ul>
<blockquote>
Presenter: Ferran Sanchez (Market Development Manager, Pharma/CRO (MS &amp; CE), EMEAI, SCIEX)
</blockquote>
<blockquote>
Ferran obtained his PhD in Pharmaceutical Sciences at the University of Barcelona in 2005 and has been involved with mass spectrometry ever since. He has worked for SCIEX for 18 years holding different positions in sales, marketing and business development covering the EMEAI region. During this time, Ferran has been working closely with customers in the pharmaceutical industry to deepen his understanding of the market and user needs for delivering the right solutions at the right time.
</blockquote>
<blockquote>
Presenter: Jack Steed, Sr. (Technical Specialist, SCIEX)
</blockquote>
<blockquote>
Jack joined SCIEX in 2019 as a technical specialist, his main responsibilities include the creation and proliferation of technical marketing content such as application notes and presentations as well as having a strong focus on the pharma market and small molecule analysis. Prior to joining SCIEX, Jack was employed by a CRO working mainly in small molecule method development and validation, with an emphasis on LC and LC-MS analysis.
</blockquote>

SCIEX: Extractables and leachables: the complete workflow using QTRAP LC-MS/MS technology

Extractables and leachables: the complete workflow using QTRAP LC-MS/MS technology

Discover how extractables and leachables (E&L) testing can be streamlined using acquisition modes enhanced by QTRAP technology.

Extractables and leachables: QTRAP LC-MS/MS workflow

Rebroadcast of the Live from the Lab: Solutions for Multi-Omics Research from June 13, 2024
The new Stellar MS - Instrumentation that scales analytical throughput reliably and practically
How can you bridge the gap between discovery and the clinical research? 
With the new Thermo Scientific Stellar MS, it’s now easier than ever to go from discovery to validation with unrivaled quantitation at scale.
Key learning points
<ul>
<li>Meet the most advanced ion trap platform, the new Stellar MS system with acquisition rates of 100Hz+, MS3, and HCD/Resonance CID.</li>
<li>Hear how PRM Conductor Software helps bridge discovery to targeted gap, eliminates/reduces scripting+Microsoft® Excel, and automates refinement/method creation.</li>
<li>Learn how intelligent acquisition provides adaptive RT for higher throughput and robust operation, and dynamic AGC for best quantitation.</li>
</ul>
Can&#39;t attend the rebroadcast? No problem! Register anyway and you will automatically receive the link to the recording. 
<blockquote>
Presenter: Hamish Stewart (Senior Staff Scientist, Thermo Fisher Scientific)
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<blockquote>
Hamish Stewart is a Senior Staff Scientist at Thermo Fisher Scientific Bremen. He is the lead scientist for the Orbitrap Astral and a developer of Orbitrap instrumentation, responsible for research on future commercial mass spectrometers, novel related concepts and technologies.
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Previously, he obtained his PhD in Physical Chemistry from the University of Nottingham and then worked for Shimadzu Research Laboratory (Europe) Ltd.
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He is the holder of 65 patents and is the winner of The George N Hatsopoulos Technical Innovation Award.
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The new Stellar MS - Instrumentation that scales analytical throughput reliably and practically

With the new Thermo Scientific Stellar MS, it’s now easier than ever to go from discovery to validation with unrivaled quantitation at scale.

The new Thermo Scientific Stellar MS

Join us to explore the versatile power of the QTRAP LC-MS/MS system in food analysis and contaminant detection, including phytochemical profiling, targeted/untargeted analysis, trace contaminant detection, food authenticity, and nutraceutical development.<h5>Key highlights:</h5><ul><li>QTRAP LC-MS/MS system in enabling comprehensive phytochemical analysis in food and fruits</li><li>Validated sMRM quantitation of essential health-promoting phytomarkers</li><li>Untargeted and targeted procedures to define the extensive phytochemistry of food</li><li>Capability to identify contaminants such as pesticid and, drug contaminants at trace levels</li></ul><blockquote>Presenter: Dr. Pratibha Srivastava (Agharkar Research Institute)</blockquote>

SCIEX: QTRAP LC-MS/MS system: a versatile platform for food analysis and contaminant detection

QTRAP LC-MS/MS system: a versatile platform for food analysis and contaminant detection

Join us to explore the versatile power of the QTRAP LC-MS/MS system in food analysis and contaminant detection.

QTRAP LC-MS/MS for food analysis and contaminant detection

<div>The Waters Xevo CDMS delivers game-changing improvements in the measurement and characterization of high mass and highly heterogeneous compounds, paving the way for breakthroughs in fields such as gene therapy and structural biophysics.Join us for this webinar to explore how the Waters Xevo CDMS is revolutionizing the analysis of complex biomolecules.Learn how cutting-edge innovations are transforming research-grade technology into accessible, high-performance tools - enabling simplified, compliant workflows and deeper insights into rAAVs, VLPs, mRNA/LNPs, and more.<ul><li>Gain insights on Waters Xevo CDMS product, from the nanoESI emitter, to ELIT. Learn the development journey of the research grade CDMS technology from Indiana University into a commercial product that enables the democratization of the novel technology.</li><li>Learn application space of the Waters Xevo CDMS, hearing application examples based on collaboration with Key Opinion Leaders from the Pharma and Biotech industry and from various research institutes.</li><li>Hear from Pfizer scientist to examine how ELIT CDMS has evolved through commercialization, address key considerations for introducing Xevo CDMS into an industrial setting and highlight user experiences across multiple modalities with Xevo CDMS.</li></ul><blockquote>Presenter: Lauren Barnes, Ph.D. (Senior Scientist, Pfizer)Dr. Lauren Barnes is a Senior Scientist at Pfizer within the Biotherapeutics and Pharmaceutical Sciences division at Pfizer. She joined Pfizer September 2022 as a mass spectrometrist within the Analytical Research &amp; Development (ARD) organization performing heightened characterization on biotherapeutic molecules, including proteins and gene therapies. In this role, she has expanded her expertise to include mass photometry, leveraging her background in the analysis of large, intact biomolecular species to develop methods for species characterization with this emerging technique. Lauren has contributed to collaborative efforts involving CDMS, both during her graduate research and in her professional role at Pfizer.Lauren received her Ph.D. in Analytical Chemistry from Indiana University Bloomington in 2022. Her graduate research focused on the analysis of intact viral gene therapy systems using charge detection mass spectrometry (CDMS) in the lab of Dr. Martin Jarrold.Presenter: Jakub Ujma, Ph.D. (Principal Consulting Technical Product Lead, Waters Corporation)Jakub works at Waters Corporation as a Principal Consulting Technical Product Lead in mass spectrometry R&amp;D. His work has focused on Charge Detection Mass Spectrometry (CDMS), with applications in the analysis of large biomolecules such as protein complexes and virus particles. Jakub leads the development of the Waters Xevo™ CDMS system, which utilizes an electrostatic linear ion trap to enable unambiguous mass measurement of megadalton-sized molecules. In addition to CDMS, Jakub also contributed to a number of projects involving ion mobility and time-of-flight (ToF) mass spectrometry, such as hardware design and performance characterization. He has co-authored several research papers and regularly participates in scientific meetings and discussions within the mass spectrometry community.Jakub received his PhD in Chemistry from Manchester University with a focus on ion mobility techniques for studying protein structure.Presenter: Anisha Haris, Ph.D. (Senior Applications Scientist, Waters Corporation)Anisha is a Senior Applications Scientist in the Charge Detection Mass Spectrometry (CDMS) Program at Waters Corporation. Her work focuses on supporting the evaluation, development, and commercialization of charge detection mass spectrometry (CDMS) for the precise characterization of large, complex, and heterogeneous biomolecules - including protein complexes, virus-like particles, and viral vectors. By bridging cutting-edge instrumentation with real-world applications, Anisha supports the expansion of CDMS through close collaboration with researchers and industry partners in biopharmaceutical development, structural biology, and virology.Anisha received her Ph.D. from the University of Warwick. Her dissertation was focused on “Advanced Applications of Mass Spectrometry for Isomer Differentiation and Analysis of Biomolecules”.</blockquote></div>

Waters Corporation: Unveiling the Waters Xevo CDMS: Biomolecule Characterization Redefined

Unveiling the Waters Xevo CDMS: Biomolecule Characterization Redefined

Join us for this webinar to explore how the Waters Xevo CDMS is revolutionizing the analysis of complex biomolecules.

Waters Xevo CDMS Biomolecule Characterization

Immunoassays dominate the drug screen assay market as the most widely used method for routine urine toxicology screens. However, this method of analysis lacks specificity and suffers from cross-reactivity with irrelevant, similarly structured compounds. Furthermore, not all immunoassays are sensitive to drug metabolites, leading to false negatives. These limitations lead to the need for confirmation testing by LC-MS/MS, which has longer turnaround times. The Toxtyper is an automated LC-MSn coupled with a method-specific library search engine and compound identification algorithm. Its push-button interface is designed for implementation in the lab without the need for toxicology trained staff.
This webinar will be focused on the Toxtyper drugs-of-abuse (DOA) LC-MSn method and how it compares with the currently used immunoassays (CEDIA, EMIT and DRI) for urine toxicology routine panels in terms of sensitivity, number of compounds identified, speed, and sample preparation. The comparative study conducted by Dr. Adina Badea, PhD, DABCC, demonstrated that the Toxtyper provides consistent results with commonly used immunoassay screens, within a competitive timeframe. Furthermore, the added information and specificity provided by the LC-MSn system can have a significant impact in optimization of patient care.
<h3>Key Learning Objectives:</h3>
<ul>
<li>Comparison between the Toxtyper LC-MS and conventional immunoassays</li>
<li>Avantages of using the Toxtyper system to optimize patient care</li>
<li>Using the Toxtyper to elucidate unusual exposures in the emergency medicine setting</li>
</ul>
<h3>Who Should Attend:</h3>
<ul>
<li>Toxicologists</li>
<li>Medical Examiners</li>
<li>Toxicology Lab Supervisors</li>
</ul>
For Research Use Only. Not for use in clinical diagnostic procedures.
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Presenter: Adina Badea (Director of Toxicology at Lifespan / Rhode Island Hospital)
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Dr. Adina Badea, PhD, DABCC, received her clinical chemistry and toxicology training from UCSF, where she worked under the supervision of Dr. Alan Wu and Dr. Kara Lynch on developing methods and finding new solutions to current challenges in clinical toxicology testing. Currently she is Director of Toxicology at Rhode Island Hospital and Assistant Professor of Pathology and Laboratory Medicine at The Warren Alpert Medical School of Brown University, where she focuses on expanding the capabilities of the clinical toxicology lab using high resolution mass spectrometry and investigating emerging matrices.
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Bruker Daltonics: Moving Away From Immunoassays: Adapting LC-MS for Routine Urine Toxicology Screens

LCMS webinars focusing on LC/IT - page 1