We are pleased to announce that a maintenance release is now available for KnowItAll 2025.Maintenance releases are an important way to introduce improvements and bug fixes between major releases to make sure users get the most out of KnowItAll solutions.Late 2024, we announced the KnowItAll 2025 major release featuring the new LC Expert tool, KnowItAll Data Control, KnowItAll Drug Classification Models, and various advances for spectral analysis workflows. This is the first update available after that release.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Know_It_All_LC_Expert_Streamline_component_identification_with_the_power_of_the_new_Know_It_All_LC_Expert_s_automated_workflow_84a090a7c2.jpg" alt="Wiley: NEW! KnowItAll LC Expert: Streamline component identification with the power of the new KnowItAll LC Expert’s automated workflow." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Know_It_All_LC_Expert_Streamline_component_identification_with_the_power_of_the_new_Know_It_All_LC_Expert_s_automated_workflow_84a090a7c2.jpg 245w," sizes="100vw" width="1735" height="960"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Know_It_All_drug_classification_models_25277cc5e0.jpg" alt="Wiley: NEW! KnowItAll drug classification models." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Know_It_All_drug_classification_models_25277cc5e0.jpg 245w," sizes="100vw" width="603" height="324">We encourage users to ensure they are using the most recent version of the software for best performance.<blockquote>Current users can <a target="_blank" rel="noopener noreferrer" href="https://get.knowitall.com/Download?_gl=1*18h0vjr*_gcl_au*Mjk3ODY0Mzg1LjE3MTMyNzcyMDEuMTkwNDkyNDI4NS4xNzEzMzY3NDc0LjE3MTMzNjc0Nzk.">download the most recent version here</a>.</blockquote><h4>Learn more about KnowItAll 2025:&nbsp;&nbsp;</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/whats-new-in-knowitall-2025/">What's New&nbsp;</a> &nbsp;&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/knowitall-version-history/">Version History</a></li></ul><h4>About KnowItAll</h4>KnowItAll Software offers solutions to analyze and manage multiple types of spectral and chemical data in multiple file and instrument formats. KnowItAll's integrated toolsets eliminate the need for multiple software packages and increase overall lab efficiency and staff proficiency. Combined with Wiley’s comprehensive, high-quality spectral reference libraries, it provides an unparalleled solution for fast, reliable spectral analysis.<h4>About Wiley</h4>Wiley (NYSE: WLY) is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at <a target="_blank" rel="noopener noreferrer" href="https://www.wiley.com/en-ie">Wiley.com</a>.&nbsp;

KnowItAll 2025 Maintenance Release 2025.1 Available

SIELC has developed the first and only HPLC software that is accessible via the cloud - <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1250">HPLC.cloud</a>.<h4>&nbsp;Special Features:</h4><ul><li>Cloud Integration: Real-time data streaming and storage on HPLC.cloud ensure your experiment data is always backed up and accessible.</li><li>Remote Access: Control and monitor your system from anywhere — lab, office, or on the go — using a PC, tablet, or phone.</li><li>Data Security: All your results are stored in a centralized, secure location — so no data is ever lost.</li><li>Sync Capabilities: Chromatograms are synced with HPLC.cloud every second, providing real-time experiment updates.</li></ul><h4>Key Functionality:</h4><ul><li>Real-time Chromatogram Streaming: Watch live data as it’s being collected.</li><li>Sequence Building and Recording: Build, record, and store experiment sequences.</li><li>Method Storage: Save and reuse methods for consistency and efficiency.</li><li>Data Accessibility: Store all your sample and result data securely in the cloud, accessible anytime.</li><li>Remote Control: Start, stop, or modify analyses from any internet-connected device.</li><li>Comprehensive Data Analysis: Calibrate, analyze, and quantify directly within the cloud interface.</li><li>Mobile and PC Access: Use on PC, tablet, or smartphone for maximum flexibility.</li><li>Online Data Search: Easily search and access your data from anywhere.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SIELC_SIELC_Software_HPLC_cloud_1_441d304d5d.jpg" alt="SIELC: SIELC Software – HPLC.cloud" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SIELC_SIELC_Software_HPLC_cloud_1_441d304d5d.jpg 225w," sizes="100vw" width="801" height="554">No software installation. No USBs. No data loss.

How to Use HPLC Cloud - A Complete Guide

News from LabRulezLCMS Library - Week 20, 2025

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Bioanalytic started its operations in 1998. The company was born from a passion for science and the need to provide innovative solutions in the laboratory equipment market, from a small business to a dynamically developing company with an established position.

Bioanalytic

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Bruker

Thermo Fisher Scientific

Shimadzu Corporation

SCIEX

Measurements of drugs of abuse in blood in a forensic lab require highest reliablity with regard to identification and quantification of the compounds in question. After economical evaluation, the analytical setup of the forensic lab was completely rearranged, now processing up to 8000 blood samples each year including a multiple of different measurements.
Drug screening is no longer based on immunoassays lacking selectivity. It is now performed on LC/MS-Toxtyper systems directly providing quantification of five drugs as key compounds. Analysis of THC and further drugs such as neuroleptics and sedatives is carried out by LC/MS/MS.
Recently, a robotic system for sample preparation has been put into service transforming the laboratory process into a fully scalable application for high-throughput measurements.
<blockquote>
Presenter: Christian Vidal (Chemistry Department, State Criminal Investigation Office of Lower Saxony, Hannover, Germany)
</blockquote>

Pixabay/RenoBeranger: Drugs of abuse in blood - high-throughput measurements in a forensic lab

Drugs of abuse in blood - high-throughput measurements in a forensic lab

The ZenoTOF 7600 system was ranked the most innovative technology by The Analytical Scientist for its ability to help scientists address analytical challenges across many markets. Zeno trap coupled with electron activated dissociation (EAD) fragmentation technology unlocks sensitivity gains allowing you to uncover new information for certainty in your results to make better-informed decisions, faster.
Highlights of this technology:
<ul>
<li>Drive new limits of quantification achievable with accurate mass</li>
<li>Detect up to 20x more ions in every experiment</li>
<li>Deliver high depth of coverage on low abundance species, quickly and robustly with Zeno SWATH data-independent acquisition (DIA)</li>
</ul>
<blockquote>
Presenter: Bhavya Shukla (Sales Development Manager, SCIEX)
</blockquote>
<blockquote>
Bhavya Shukla, Sales Development Manager at SCIEX has more than 8 years of experience in the analytical industry. He pursued his post-graduation in chemical engineering from the Institute of Chemical Technology Mumbai. His major role is to support LCMS users by providing them optimal solutions through a keen understanding of their needs.
</blockquote>

SCIEX: Leveraging the power of Zeno trap and EAD

Leveraging the power of Zeno trap and EAD

Zeno trap coupled with electron activated dissociation (EAD) fragmentation technology unlocks sensitivity gains allowing you to uncover new information

Presentation Topics
<ul>
<li>Origins of the Digital Ion Trap
</li>
<li>Ion Trap v. Digital Ion Trap
</li>
<li>Shimadzu&#39;s Journey to the MALDI Digital Ion Trap
</li>
<li>Basic Proteomics
</li>
<li>Glycomics
</li>
<li>Antibody Drug Conjugates
</li>
<li>Summary and Acknowledgements
</li>
</ul>

Shimadzu: Proteomic Analysis Using a Miniature MALDI Digital Ion Trap Mass Spectrometer

Proteomic Analysis Using a Miniature MALDI Digital Ion Trap Mass Spectrometer

Proteomic Analysis Using a Miniature MALDI Digital Ion Trap

In this webinar you will discover how extractables and leachables (E&amp;L) testing can be streamlined using acquisition modes enhanced by QTRAP technology. If you are new to E&amp;L testing or want to learn how your own workflows can be improved when using nominal mass technology then this webinar is for you.
Key topics that will be covered in this webinar include:
<ul>
<li>Introduction to E&amp;L analysis using nominal mass instrumentation</li>
<li>How the QTRAP can enhance E&amp;L analysis</li>
<li>The importance of libraries and how they can be implemented to improve compound identification</li>
</ul>
<blockquote>
Presenter: Ferran Sanchez (Market Development Manager, Pharma/CRO (MS &amp; CE), EMEAI, SCIEX)
</blockquote>
<blockquote>
Ferran obtained his PhD in Pharmaceutical Sciences at the University of Barcelona in 2005 and has been involved with mass spectrometry ever since. He has worked for SCIEX for 18 years holding different positions in sales, marketing and business development covering the EMEAI region. During this time, Ferran has been working closely with customers in the pharmaceutical industry to deepen his understanding of the market and user needs for delivering the right solutions at the right time.
</blockquote>
<blockquote>
Presenter: Jack Steed, Sr. (Technical Specialist, SCIEX)
</blockquote>
<blockquote>
Jack joined SCIEX in 2019 as a technical specialist, his main responsibilities include the creation and proliferation of technical marketing content such as application notes and presentations as well as having a strong focus on the pharma market and small molecule analysis. Prior to joining SCIEX, Jack was employed by a CRO working mainly in small molecule method development and validation, with an emphasis on LC and LC-MS analysis.
</blockquote>

SCIEX: Extractables and leachables: the complete workflow using QTRAP LC-MS/MS technology

Extractables and leachables: the complete workflow using QTRAP LC-MS/MS technology

Discover how extractables and leachables (E&L) testing can be streamlined using acquisition modes enhanced by QTRAP technology.

Extractables and leachables: QTRAP LC-MS/MS workflow

Rebroadcast of the Live from the Lab: Solutions for Multi-Omics Research from June 13, 2024
The new Stellar MS - Instrumentation that scales analytical throughput reliably and practically
How can you bridge the gap between discovery and the clinical research? 
With the new Thermo Scientific Stellar MS, it’s now easier than ever to go from discovery to validation with unrivaled quantitation at scale.
Key learning points
<ul>
<li>Meet the most advanced ion trap platform, the new Stellar MS system with acquisition rates of 100Hz+, MS3, and HCD/Resonance CID.</li>
<li>Hear how PRM Conductor Software helps bridge discovery to targeted gap, eliminates/reduces scripting+Microsoft® Excel, and automates refinement/method creation.</li>
<li>Learn how intelligent acquisition provides adaptive RT for higher throughput and robust operation, and dynamic AGC for best quantitation.</li>
</ul>
Can&#39;t attend the rebroadcast? No problem! Register anyway and you will automatically receive the link to the recording. 
<blockquote>
Presenter: Hamish Stewart (Senior Staff Scientist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Hamish Stewart is a Senior Staff Scientist at Thermo Fisher Scientific Bremen. He is the lead scientist for the Orbitrap Astral and a developer of Orbitrap instrumentation, responsible for research on future commercial mass spectrometers, novel related concepts and technologies.
</blockquote>
<blockquote>
Previously, he obtained his PhD in Physical Chemistry from the University of Nottingham and then worked for Shimadzu Research Laboratory (Europe) Ltd.
</blockquote>
<blockquote>
He is the holder of 65 patents and is the winner of The George N Hatsopoulos Technical Innovation Award.
</blockquote>

The new Stellar MS - Instrumentation that scales analytical throughput reliably and practically

With the new Thermo Scientific Stellar MS, it’s now easier than ever to go from discovery to validation with unrivaled quantitation at scale.

The new Thermo Scientific Stellar MS

Immunoassays dominate the drug screen assay market as the most widely used method for routine urine toxicology screens. However, this method of analysis lacks specificity and suffers from cross-reactivity with irrelevant, similarly structured compounds. Furthermore, not all immunoassays are sensitive to drug metabolites, leading to false negatives. These limitations lead to the need for confirmation testing by LC-MS/MS, which has longer turnaround times. The Toxtyper is an automated LC-MSn coupled with a method-specific library search engine and compound identification algorithm. Its push-button interface is designed for implementation in the lab without the need for toxicology trained staff.
This webinar will be focused on the Toxtyper drugs-of-abuse (DOA) LC-MSn method and how it compares with the currently used immunoassays (CEDIA, EMIT and DRI) for urine toxicology routine panels in terms of sensitivity, number of compounds identified, speed, and sample preparation. The comparative study conducted by Dr. Adina Badea, PhD, DABCC, demonstrated that the Toxtyper provides consistent results with commonly used immunoassay screens, within a competitive timeframe. Furthermore, the added information and specificity provided by the LC-MSn system can have a significant impact in optimization of patient care.
<h3>Key Learning Objectives:</h3>
<ul>
<li>Comparison between the Toxtyper LC-MS and conventional immunoassays</li>
<li>Avantages of using the Toxtyper system to optimize patient care</li>
<li>Using the Toxtyper to elucidate unusual exposures in the emergency medicine setting</li>
</ul>
<h3>Who Should Attend:</h3>
<ul>
<li>Toxicologists</li>
<li>Medical Examiners</li>
<li>Toxicology Lab Supervisors</li>
</ul>
For Research Use Only. Not for use in clinical diagnostic procedures.
<blockquote>
Presenter: Adina Badea (Director of Toxicology at Lifespan / Rhode Island Hospital)
</blockquote>
<blockquote>
Dr. Adina Badea, PhD, DABCC, received her clinical chemistry and toxicology training from UCSF, where she worked under the supervision of Dr. Alan Wu and Dr. Kara Lynch on developing methods and finding new solutions to current challenges in clinical toxicology testing. Currently she is Director of Toxicology at Rhode Island Hospital and Assistant Professor of Pathology and Laboratory Medicine at The Warren Alpert Medical School of Brown University, where she focuses on expanding the capabilities of the clinical toxicology lab using high resolution mass spectrometry and investigating emerging matrices.
</blockquote>

Bruker Daltonics: Moving Away From Immunoassays: Adapting LC-MS for Routine Urine Toxicology Screens

LCMS webinars focusing on LC/IT | LabRulez LCMS