News from LabRulezLCMS Library Week 27, 2024

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 1st July 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!

👉 SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES

👉 Need info about different analytical techniques? Peek into LabRulezGCMS or LabRulezICPMS libraries.

1. Thermo Fisher Scientific: Screening of PFAS compounds in wastewater using adsorbable organic fluorine with combustion ion chromatography (CIC)

• Application note

• Results from U.S. EPA draft Method 1621 Collaboration Study

• Keywords: EPA Method 1621, AOF, CIC, PFOA, PFHxS, GAC, Dionex, IonPac AS24 column, PFAS, (per- and polyfluoroalkyl substances), combustion ion chromatography (CIC), adsorbable organic fluorine (AOF), granular activated carbon (GAC)

Conclusion: This application note demonstrated our results from the multi-laboratory collaboration study of EPA draft Method 1621. This method shows that CIC is an excellent tool to measure AOF andscreen for PFAS in wastewater. Along with its ease of use, RFIC provides more accurate results as fluoride is well separated from the water dip, ensuring optimized automated peak integration. The method is sensitive, with MBs of 1 ng/mL and MDLs of 2.5 ng/mL, and accurate, with recoveries of 80–120%. Together, these data highlight the power of CIC in eliminating the sample matrix and measuring only the adsorbable organically bound fluorine content in samples, successfully achieving the goals outlined in EPA draft Method 1621.

2. Metrohm: Halogens and sulfur in solid samples according to EN 17813

• Application note
• Rapid analysis with combustion ion chromatography (CIC)

Conclusion: Combustion ion chromatography is a straightforward analytical technique to determine halogens and sulfur in environmental and solid matrices. The ceramic setup is especially suitable for CIC analysis of sample matrices with high amounts of alkali metals and/or alkaline earth metals. With the ceramic setup, the robustness of the analysis and the lifetime of consumables is drastically improved. The ease-of-use is further advanced by the possibility to inject different sample volumes – depending on the analyte concentration in the samples – to guarantee that these fit into the calibration range.

Overall, users of this whole validated procedure profit from easy and standardized handling, the precise determination of the analytes, automatic eluent roduction, calibration, and results calculation, low maintenance, and a single-manufacturer setup.

3. Waters Corporation: Cyclic™ Ion Mobility Unravels Sites of Chemically Induced Deamidation

• Application note

Abstract: Acid deamidation can mimic the action of tissue transglutaminase in deamidation of specific peptide glutamine residues, and possibly increase the immunotoxicity of the deamidated gluten food ingredient and convey an increased risk to those with coeliac disease. Peptides with multiple deamidation sites may co-elute under the same chromatographic peak and therefore other methods of site determination are required such as ion mobility mass spectrometry, increasing confidence in profiling these post-translational modifications (PTMs).

4. Waters Corporation: Sample Preparation and Analysis Workflow to Address the PFAS Primary National Drinking Water Regulation

• Application note

Abstract: The newly announced PFAS National Primary Drinking Water Regulation has set enforceable levels of six PFAS compounds in drinking water for the first time in the United States. Regulatory levels of individual compounds range from 4–10 ng/L (or ppt). The Waters™ PFAS Solution for sample preparation through sample analysis is presented to make implementation of the new PFAS regulations straightforward and accurately reach far below the lowest regulated Maximum Contamination Level of 4 ng/L.

5. Agilent Technologies: Determination of Catecholamines by Agilent Ultivo LC/TQ with an InfinityLab Poroshell 120 Aq‑C18 Column

• Application note - Clinical Research

Abstract: In this application note, a quantification method was established for catecholamines (3-MT, DA, E, NE, MN, and NMN) using the Agilent Ultivo liquid chromatography/triple quadrupole mass spectrometer (LC/TQ) system with a newly developed Agilent InfinityLab Poroshell 120 Aq-C18 column. The Poroshell 120 Aq-C18 column shows good performance with baseline separation of these six catecholamine compounds. The validation test results give a wide linearity range of 5 to 500 pg/mL in bovine serum albumin (BSA) matrices with excellent accuracy.

6. Shimadzu: Oligonucleotide Characterization for Quality Control on the Shimadzu Single Quad Mass Spectrometer LCMS-2050

• Application News

User Benefits:

• The Shimadzu LCMS-2050 single quadrupole mass spectrometer and SPD-M30A photodiode array detector offer a straightforward workflow for quantitating oligonucleotides, streamlining the analysis process.
• Confident mass confirmation can be obtained over a wide mass range of nucleotide oligomers.
• The Shimadzu LCMS-2050 enables the detection and identification of lower levels of impurities commonly found in synthetic oligomers.

7. Shimadzu: Ion Chromatography Solutions for Environmental Analysis

• Guide

• Overview of Environment Analysis

• Relevance of Ion Chromatography in Environmental Analysis

• Overview of Ion Chromatography

• Introduction of Ion Exchange Chromatography

• Shimadzu’s Ion Chromatography Solutions

• LabSolutions Software

• Lineup of Columns