<p>Dear colleagues and guests,</p>
<p>On behalf of the organizing committee and organizing institutions, it is a great pleasure to welcome you to <a href="http://ms-prague2021.uochb.cas.cz/index.php"><strong>the Prague meeting on historical perspectives of mass spectrometry</strong></a>. The conference is held on the inauguration of <a href="https://www.ms-museum.org/"><strong>the Czech Mass Spectrometry Museum</strong></a> and celebrates the <strong>70th anniversary of mass spectrometry</strong> in our country.</p>
<p><a href="http://ms-prague2021.uochb.cas.cz/registration.php"><strong>REGISTRATION</strong></a></p>
<p><a href="http://ms-prague2021.uochb.cas.cz/index.php"><strong>Prague Meeting on Historical Perspectives of Mass Spectrometry</strong></a></p>
<h3><strong>Confirmed Speakers</strong></h3>
<ul>
<li><a href="http://www.biosciences-labs.bham.ac.uk/cooper/"><strong>Prof. Helen J. COOPER</strong></a> (University of Birmingham, Birmingham, UK)</li>
<li><a href="https://www.hecklab.com/"><strong>Prof. Albert J. R. HECK</strong></a> (Utrecht University, Utrecht, The Netherlands)</li>
<li><a href="https://holcapek.upce.cz/"><strong>Prof. Michal HOLČAPEK</strong></a> (University of Pardubice, Pardubice, Czech Republic)</li>
<li><a href="https://orcid.org/0000-0003-3158-0637"><strong>Prof. Karel LEMR</strong></a> (Palacky University Olomouc, Olomouc, Czech Republic)</li>
<li><a href="https://faculty.skoltech.ru/people/evgenynikolaev"><strong>Prof. Evgeny NIKOLAEV</strong></a> (Skolkovo Institute of Science and Technology, Moscow, Russia)</li>
<li><a href="https://www.jh-inst.cas.cz/jh_employee/polasek"><strong>Dr. Miroslav POLÁŠEK</strong></a> (Heyrovský Institute of Physical Chemistry of the CAS, Prague, Czech Republic)</li>
<li><a href="https://bart.chemi.muni.cz/index.php/en/"><strong>Prof. Jan PREISLER</strong></a> (Masaryk University, Brno, Czech Republic)</li>
<li><a href="https://www.chem.tu-berlin.de/helmut.schwarz/"><strong>Prof. Helmut SCHWARZ</strong></a> (Technische Universität Berlin, Berlin, Germany)</li>
<li><a href="https://www.ice.mpg.de/ext/?id=438"><strong>Dr. Aleš SVATOŠ</strong></a> (Max Planck Institute for Chemical Ecology, Jena, Germany)</li>
<li><a href="http://www.jh-inst.cas.cz/~spanel/"><strong>Prof. Patrik ŠPANĚL</strong></a> (Heyrovský Institute of Physical Chemistry of the CAS, Prague, Czech Republic)</li>
<li><a href="https://sites.google.com/a/uw.edu/turecek-group/"><strong>Prof. František TUREČEK</strong></a> (University of Washington, Seattle, WA, USA)</li>
</ul>
<p>The origins of mass spectrometry in the Czech Republic date back to the <strong>1950s</strong> when <strong>the first mass spectrometer was built</strong>. Despite the post-war shortage and considerable international isolation of socialist Czechoslovakia, the device was successfully completed and used in the newly founded <strong>Czechoslovak Academy of Sciences</strong>. Later, commercial instruments started to appear. Mass spectrometry became increasingly important and the community started to grow. Since 1985, summer courses <strong>&quot;School of Mass Spectrometry&quot;</strong> have been organized regularly. The number of participants in this popular annual one-week event is now <strong>over two hundred</strong>. <strong>National scientific conferences on mass spectrometry</strong> have been organized biennially since 2011. Mass spectrometry has become a very important and widely used technique for research and industry.</p>
<p><a href="https://www.ms-museum.org/"><strong>The Czech Mass Spectrometry Museum</strong></a> has been established at <strong>the Institute of Organic Chemistry and Biochemistry of the CAS</strong> in Prague. The museum aims to collect and display <strong>artifacts related to mass spectrometry</strong>, especially those associated with the local geographical region. The technical museum mostly shows the key <strong>components of mass spectrometers</strong> used in the past and in contemporary laboratory practice. It also collects and displays <strong>historical documents</strong>, <strong>photographs</strong>, <strong>books</strong>, etc. The museum&#39;s mission is expressed in two words: <strong>education</strong> and <strong>inspiration</strong>. It demonstrates technologies hidden behind the cover and inside the vacuum systems, thus allowing a better understanding of how the mass spectrometers actually work. Displayed technical solutions, prototypes, ideas, and stories can be inspiring for students, scientists, as well as instrument designers.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/8619b6eab01a4ec18b531bf1a7d20dff/obrazek.png" alt="IOCB Prague: The Czech Mass Spectrometry Museum"/></p>
<p>The Prague Meeting on Historical Perspectives of Mass Spectrometry is a <strong>two-day conference</strong> devoted to history, status and future perspectives of mass spectrometry. The event will bring an exciting program combining <strong>presentations</strong> from honorable <strong>Czech</strong> and <strong>international scientists</strong>, <strong>representatives of producing companies</strong> mapping the historical development of their instruments, and <strong>young colleagues</strong> early in their careers. The early evening poster session will be conveniently followed by a social evening with dinner. The organizing committee will make any possible effort to make sure that your participation will be a scientifically rewarding and pleasurable experience.</p>
<h5><strong>Josef Cvačka</strong></h5>
<p><em>Chair of the PMHPMS</em></p>
<p><a href="https://ms.group.uochb.cz/en"><strong>Mass Spectrometry Research-Service Group</strong></a></p>
<p><a href="https://www.uochb.cz/en"><strong>Institute of Organic Chemistry and Biochemistry of the CAS</strong></a></p>


Prague Meeting on Historical Perspectives of Mass Spectrometry - Early registration!

<h3><strong>Conference Program</strong></h3>
<h3><strong>13th October 2021 (Wednesday)</strong></h3>
<h5><strong>7:30 - 8:20 REGISTRATION</strong></h5>
<h5><strong>8:20 - 8:40 OPENING OF THE CONFERENCE</strong></h5>
<h4><strong>SESSION I (in NLT)</strong></h4>
<p>(Chair: František Tureček (University of Washington, United States))</p>
<h5><strong>8:40 - 9:30 Computational and Gas-phase Studies in Service of Catalysis Research: Identification of the &quot;Aristocratic Atoms&quot;</strong></h5>
<ul>
<li><em>Helmut Schwarz (Technische Universität Berlin, Germany)</em><h5><strong>9:30 - 10:00 Mass Spectrometry at the J. Heyrovský Institute of Physical Chemistry</strong></h5>
</li>
<li><em>Miroslav Polášek (Heyrovský Institute of Physical Chemistry of the CAS, Czech Republic)</em><h5><strong>10:00 - 10:30 Gas Phase Ion-molecule Reactions in Czechia over 60 Years</strong></h5>
</li>
<li><em>Patrik Španěl (Heyrovský Institute of Physical Chemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>COFFEE BREAK</strong></h5>
<h4><strong>SESSION II (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=michal+holcapek">Michal Holčapek</a> (<a href="https://lcms.cz/companies/15">University of Pardubice</a>, Czech Republic))</p>
<h5><strong>11:00 - 11:30 Past, Present and Future of Orbitrap Mass Spectrometry (virtual presentation)</strong></h5>
<ul>
<li><em>Alexander Makarov (Thermo Fisher Scientific, Germany)</em></li>
</ul>
<h5><strong>11:30 - 12:00 Development of Novel Ion-less Matrices for Profiling and Imaging Mass Spectrometry</strong></h5>
<ul>
<li><em>Aleš Svatoš (Max Planck Institute for Chemical Ecology, Germany)</em></li>
</ul>
<h5><strong>12:00 - 12:30 Mass Spectrometry at the Institute of Organic Chemistry and Biochemistry &amp; Museum Opening</strong></h5>
<ul>
<li><em>Josef Cvačka (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>LUNCH BREAK</strong></h5>
<h4><strong>SESSION III (in NLT)</strong></h4>
<p>(Chair: Miroslav Polášek (Heyrovský Inst. of Physical Chemistry of the <a href="https://lcms.cz/companies/10">CAS</a>, Czech Republic))</p>
<h5><strong>14:00 - 14:50 High-resolution Native Mass Spectrometry</strong></h5>
<ul>
<li><em>Albert J. R. Heck (Utrecht University, The Netherlands)</em></li>
</ul>
<h5><strong>14:50 - 15:20 Noncanonical Ionized DNA Nucleobases and Nucleosides. A Dark Matter of DNA Ionization?</strong></h5>
<ul>
<li><em>František Tureček (University of Washington, United States)</em></li>
</ul>
<h5><strong>15:20 - 15:50 Mass Spectrometry at the University of Pardubice: Focus on Lipidomics</strong></h5>
<ul>
<li><em>Michal Holčapek (University of Pardubice, Czech Republic)</em></li>
</ul>
<h5><strong>15:50 - 16:20 Forty Year Evolution of High Throughput Mass Spectrometry: A Perspective (virtual presentation)</strong></h5>
<ul>
<li><em>Tom Covey (SCIEX, Canada)</em></li>
</ul>
<h5><strong>BREAK</strong></h5>
<h4><strong>POSTER SESSION &amp; DINNER (in OWTP)</strong></h4>
<h5><strong>17:30 - 19:00 POSTER SESSION</strong></h5>
<h5><strong>19:00 - 23:00 SOCIAL EVENT - Conference dinner, concert performance, guided underground tours</strong></h5>
<h3><strong>14th October 2021 (Thursday)</strong></h3>
<h4><strong>SESSION IV (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=jan+preisler">Jan Preisler</a> (<a href="https://lcms.cz/companies/12">Masaryk University</a>, Czech Republic))</p>
<h5><strong>8:40 - 9:30 FT ICR Mass Spectrometry. Is There Room for Further Improvements? (virtual presentation)</strong></h5>
<ul>
<li><em>Evgeny Nikolaev (Skolkovo Institute of Science and Technology, Russia)</em></li>
</ul>
<h5><strong>9:30 - 10:00 Mass Spectrometry: from Metabolites to Art</strong></h5>
<ul>
<li><em>Karel Lemr (Palacký University Olomouc, Czech Republic)</em></li>
</ul>
<h5><strong>10:00 - 10:30 Historical Perspectives on Bruker’s Involvement in Mass Spectrometry and the Development of Modern Q-TOF Mass Spectrometry</strong></h5>
<ul>
<li><em>Gary H. Kruppa (Bruker, Czech Republic)</em></li>
</ul>
<h5><strong>COFFEE BREAK</strong></h5>
<h4><strong>SESSION V – YOUNG SCIENTISTS (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=karel+lemr">Karel Lemr</a> (<a href="https://lcms.cz/companies/17">Palacký University Olomouc</a>, Czech Republic))</p>
<h5><strong>11:00 - 11:15 Identification of Novel Fatty Acids in Vernix Caseosa using UV Photodissociation Mass Spectrometry in Combination with Fixed-charge Photo-labile Derivatives</strong></h5>
<ul>
<li><em>Lukáš Cudlman (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>11:15 - 11:30 Mass Spectrometry-based Chemical Proteomics in Protein Post-translational Modifications Analysis</strong></h5>
<ul>
<li><em>Pavel Kielkowski (Ludwig-Maximilians-Universität München, Germany)</em></li>
</ul>
<h5><strong>11:30 - 11:45 Mapping of Regional and Subregional Unbound Drug Transport Across Blood-Brain Barrier Enabled by Quantitative Mass Spectrometry Imaging</strong></h5>
<ul>
<li><em>Dominika Luptáková (Uppsala University, Sweden)</em></li>
</ul>
<h5><strong>11:45 - 12:00 Visualization of Polyamines and Amino Acids Alterations in Neonatal Brain Hypoxic-Ischemic Injury in Rats by Mass Spectrometry Imaging</strong></h5>
<ul>
<li><em>Hynek Mácha (Institute of Microbiology of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>12:00 - 12:15 Temperature-Controlled Electrospray: A Window into Solution Thermochemistry of Non-Canonical Nucleic Acid Complexes</strong></h5>
<ul>
<li><em>Adam Pruška (ETH Zurich, Switzerland)</em></li>
</ul>
<h5><strong>12:15 - 12:30 Freeing Aspergillus fumigatus of Polymycovirus Infection renders it More Resistant to Competition with Pseudomonas aeruginosa due to Altered Iron-acquiring Tactics</strong></h5>
<ul>
<li><em>Rutuja Patil (Institute of Microbiology of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>LUNCH BREAK</strong></h5>
<h4><strong>SESSION VI (in NLT)</strong></h4>
<p>(Chair: Aleš Svatoš (Max Planck Institute for Chemical Ecology, Germany))</p>
<h5><strong>14:00 - 14:50 Native Ambient Mass Spectrometry: Mass Spectrometry Imaging of Intact Proteins and Protein Complexes (virtual presentation)</strong></h5>
<ul>
<li><em>Helen J. Cooper (University of Birmingham, United Kingdom)</em></li>
</ul>
<h5><strong>14:50 - 15:20 A (Time of) Flight from Ames to Brno: Laser Desorption Mass Spectrometry at Masaryk University</strong></h5>
<ul>
<li><em>Jan Preisler (Masaryk University, Czech Republic)</em></li>
</ul>
<h5><strong>15:20 - 15:50 The History of Time-of-Flight Mass Spectrometry at: VG - Micromass - Waters (virtual presentation)</strong></h5>
<ul>
<li><em>Mike Morris (Waters Corporation, Manchester, United Kingdom)</em></li>
</ul>
<h5><strong>15:50 - 16:20 Mass Spectrometry Innovation at Agilent Technologies (virtual presentation)</strong></h5>
<ul>
<li><em>George Stafford (Agilent Technologies, United States)</em></li>
</ul>
<h5><strong>16:20 - 16:30 CONFERENCE CLOSING</strong></h5>
<h4><strong>IOCB ChemBioDrug Workshop (in NLT</strong>)</h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=josef+cvacka"> Josef Cvačka</a> (<a href="https://lcms.cz/companies/62">IOCB</a>, Czech Republic))</p>
<h5><strong>17:00 - 17:05 OPENING</strong></h5>
<h5><strong>17:05 - 17:25 Orbitrap Fusion Lumos: A Versatile Mass Spectrometer for Biomolecules</strong></h5>
<ul>
<li><em>Martin Hubálek (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>17:25 - 17:45 Protein Structure and Interactions Studied by Cross-Linking Mass Spectrometry</strong></h5>
<ul>
<li><em>Petra Junková (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>17:45 - 18:05 Protein Structure and Interactions Studied by Hydrogen Deuterium Exchange Mass Spectrometry</strong></h5>
<ul>
<li><em>Jakub Sýs (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>18:05 - 18:30 HPLC/ESI-MS2 – Based Lipidomic Analysis and MALDI Imaging of Lipids</strong></h5>
<ul>
<li><em>Vladimír Vrkoslav, Štěpán Strnad (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>18:30 - 19:00 Discussion / User Meeting</strong></h5>
<h5><strong>WORKSHOP CLOSING</strong></h5>
<p>Program je k dispozici také jako pdf na webu <a href="http://ms-prague2021.uochb.cas.cz/program.php">Prague Meeting on Historical Perspectives of Mass Spectrometry</a></p>


Conference Program Prague Meeting on Historical Perspectives of Mass Spectrometry

<p><strong>Dear friends and fans of mass spectrometry,</strong></p>
<p><strong>The history of a method for studying of matter known as mass spectrometry dates back more than a century. The foundations have mostly been laid by physics studying discharges in gases. After about five decades mass spectrometry entered the domain of chemistry and evolved into an excellent tool for studying the structure of chemical compounds. Recently we are witnessing its expansion into the field of cellular, molecular, and structural biology. The technology of mass spectrometry developed immensely over the time. Let us take a tour into the history and learn about the past technologies. Let us explore the state-of-art mass spectrometry.</strong></p>
<p>A technical museum focused on unique and significant part of science, the Czech Museum of Mass Spectrometry will display and explain laboratory instrumentation that encompasses physics, chemistry, engineering and informatics and combines them into a device that contributes to many parts of our daily life.</p>
<p>Czech and English speaking visitors will have an opportunity to learn about the principles and applications of mass spectrometry, its history, and important scientists including Nobel price winners, while experiencing a remarkable collection of mass spectrometers. Founded by mass spectrometry enthusiasts Jaroslav Pol (Thermo Scientific) and Josef Cvacka (Institute of Organic Chemistry and Biochemistry) and sponsored by Frantisek Turecek (University of Washington, Seattle), the Czech Museum of Mass Spectrometry is now being assembled and will open in Prague in 2017. Donations of mass spectrometry artifacts are gratefully appreciated; those willing to contribute please contact the curators.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d3e7627196634c0a8fa129f95fef6edd/obrazek.png" alt="The Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Mass spectrometry</strong></h3>
<p>Study of matter through the formation of gas-phase ions that are characterized using mass spectrometers by their mass, charge, structure, and/or physico-chemical properties.</p>
<h3><strong>Mass Analyzers</strong></h3>
<h5><strong>Fourier Transform Ion Cyclotron Resonance</strong></h5>
<p>Mass spectrometer based on the principle of ion cyclotron resonance in which an ion in a magnetic field moves in a circular orbit at the cyclotron frequency that is characteristic of its m/z value. Ions are coherently excited to a larger radius orbit using a pulse of radio frequency electric field, and their image charge is detected on receiver plates as a time domain signal. Fourier transformation of the time domain signal results in a frequency domain signal that is converted to a mass spectrum based on the inverse relationship between cyclotron frequency and m/z.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/1628c6d87adf47538f70c2d7ce971db9/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Ion Trap</strong></h5>
<p>Device for spatially confining ions using electric and magnetic fields alone or in combination.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/bcc0887a778f4df29f488bcd87ce8718/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Linear Ion Trap</strong></h5>
<p>Two-dimensional Paul ion trap in which ions are confined in the axial dimension by means of a static electric potential.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/6d35a6cdb4ee4baa95ad2d831b20db19/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Orbitrap</strong></h5>
<p>Ion trapping device that consists of an outer barrel-like electrode and a coaxial inner spindle-like elec- trode that form an electrostatic </p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/4c8de0a71fef446fa44829e9d37c8b62/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Sector</strong></h5>
<p>Device that produces a magnetic field perpendicular to a charged particle beam that deflects the beam to an extent that is proportional to the ratio of particle momentum and charge.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/240ae6e09cb443508bf7dce8309b2928/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Time of Flight</strong></h5>
<p>Mass spectrometer that separates ions by m/z in a field-free region after acceleration through a fixed accelerating potential. Ions of the same initial translational energy and different m/z require different times to traverse a given distance in the field-free region.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/0d0eaa3a8aa544d1abcca833a9e6e9ae/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Triple Quadrupole</strong></h5>
<p>Tandem mass spectrometer comprising two transmission quadrupole mass spectrometers in series, with a (non-selecting) RF-only quadrupole (or other multipole) between them to act as a collision cell.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/b6e4bd36ccb44cd8a93e84353b28a357/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h3><strong>Ion Sources</strong></h3>
<h5><strong>Atmospheric pressure chemical ionization</strong></h5>
<p>Atmospheric pressure chemical ionization (APCI) is chemical ionization of a sample that is a gas or nebulized liquid, using an atmospheric pressure corona discharge or beta emitter such as 63Ni.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d562c1ce1a9f43c78d8a93a2c6c43932/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Atmospheric pressure photoionization</strong></h5>
<p>Atmospheric pressure photoionization (APPI) is direct ionization of molecules at atmospheric pressure by electron detachment induced by photons forming M+•, or atmospheric pressure chemical ionization in which the reactant ions are generated by photoionization of suitable dopant species and subsequent ion/molecule reactions of their molecular ions.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/828a17ec377a4313bdd59f9275192e87/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Desorption electrospray ionization</strong></h5>
<p>Desorption electrospray ionization (DESI) is formation of gas-phase ions from a solid or liquid sample at atmospheric pressure through the inter- action of electrosprayed droplets with the sample surface.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/86624af57b96403586bd27b3bafccec3/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Electrospray ionization</strong></h5>
<p>Electrospray ionization (ESI) is spray ionization process in which either cations or anions in solution are transferred to the gas phase via formation and desolvation at atmospheric pressure of a stream of highly charged droplets that result from applying a potential difference between the tip of the electrospray needle containing the solution and a counter electrode.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/673ec39a73b64561805cf60670486635/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Fast atom bombardment ionization</strong></h5>
<p>Fast atom bombardment ionization (FAB) is ionization of molecules initiated by a beam of neutral atoms with translational energies in the keV range. Labile molecules susceptible to dissociation are dissolved in an involatile liquid matrix that absorbs the energy of the bombarding atoms to form a selvedge region above the liquid surface in which ionization of the molecules occurs.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/afda171085f54f6e856bc930cf873fca/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Matrix-assisted laser desorption/ionization</strong></h5>
<p>Matrix-assisted laser desorption/ionization (MALDI) is formation of gas-phase ions from molecules present in a solid or liquid matrix that is irradiated with a laser. The matrix is a material that absorbs the laser energy and promotes ionization.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/39f899169e27496f938621f0d25a0f12/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Secondary ion mass spectrometry</strong></h5>
<p>Secondary ion mass spectrometry (SIMS) is technique in which a focused beam of primary ions produces secondary ions by sputtering from a solid surface. The secondary ions are analyzed by mass spectrometry.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/fd584fd784ab4c5197b461de5c42c5ee/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>


The Czech Museum of Mass Spectrometry

<h3><strong>HOW TO WEIGH A MOLECULE?</strong></h3>
<p>Imagine that you want <strong>to weigh a water molecule</strong>. You cannot just place it on a weighing pan because it certainly would not work. You need a much more sophisticated device called <strong>a mass spectrometer</strong>.</p>
<p><strong>The first such instrument was constructed by J. J. Thomson in 1912</strong>. Since then, mass spectrometry has developed into a fascinating field with many practical applications.</p>
<p><a href="https://lcms.labrulez.com/library?categoryItems=12&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=newborn+screening"><strong>Newborn screeningg</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=3&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=doping"><strong>doping tests of athletes</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=1&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=contaminants"><strong>analysis of pollutants</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=5&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=drug"><strong>testing of new drugs</strong></a> or <strong>space exploration</strong> are only a few <strong>examples of the application of mass spectrometry</strong>. Yet there are many more.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_Mass_Spectrometer_d6267dd11d/Czech-Museum-of-MS-Mass-Spectrometer.jpg" alt="Czech Museum of MS: Mass Spectrometer"/></p>
<h3><strong>MASS SPECTROMETER</strong></h3>
<p><strong>A mass spectrometer</strong> is a remarkable instrument that <strong>provides information about the mass and structure of molecules</strong>. In essence, it is a very accurate scale for electrically charged molecules. However, such a scale does not resemble the traditional ones known from kitchens and pharmacies. It is an ingenious device that <strong>uses electric and magnetic fields to manipulate, separate and detect charged molecules</strong>. Some instruments also make it possible to break charged molecules into pieces, which is useful for deducing the molecular structure.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_gridless_two_stage_reflectron_from_the_MALDI_TOF_system_Biflex_II_manufactured_by_Bruker_Daltonics_690d1900fb/Czech-Museum-of-MS-A-gridless-two-stage-reflectron-from-the-MALDI-TOF-system-Biflex-II-manufactured-by-Bruker-Daltonics.jpg" alt="Czech Museum of MS: A gridless two-stage reflectron from the MALDI-TOF system Biflex II manufactured by Bruker Daltonics"/></p>
<h3><strong>OUR MISSION</strong></h3>
<p>The museum aims <strong>to collect</strong> and <strong>display artifacts in mass spectrometry</strong>, especially those <strong>associated with our geographical region</strong>. Students professionals and the general public can look a the key components of spectrometers and understand <strong>how mass spectrometers work</strong>. The technical solutions and stories behind the exhibits can inspire young scientists as wall as experienced designers of scientific instruments.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_Mass_Spectrometry_history_in_Czech_Republic_fce8ca9112/Czech-Museum-of-MS-Mass-Spectrometry-history-in-Czech-Republic.jpg" alt="Czech Museum of MS: Mass Spectrometry history in Czech Republic"/></p>
<h3><strong>EXHIBITION</strong></h3>
<p>The exhibition shows instrument components tha are often <strong>hidden in inaccessible vacuum chambers of mass spectrometers</strong>. You can take a closer look at them, understand their function, and at the same time admire their technical perfection and beauty. Use your smartphone to learn more about the exhibit you are currently viewing. <strong>The posters on the walls will teach you about mass spectrometry and its history</strong>.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_grid_cell_of_LTQ_FT_Ultra_Thermo_Electron_Corporation_7e8ae7d076/Czech-Museum-of-MS-A-grid-cell-of-LTQ-FT-Ultra-(Thermo-Electron-Corporation).jpg" alt="Czech Museum of MS: A grid cell of LTQ FT Ultra (Thermo Electron Corporation)"/></p>
<h3><strong>DONATE AN EXHIBIT</strong></h3>
<p>The museum accepts <strong>donations</strong> to its collection, especially <strong>instruments</strong> or <strong>parts of them</strong> (even broken, damaged or worn), <strong>documents</strong>, and <strong>photographs related to mass spectrometry and its history</strong>. All donations are highly appreciated.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_EI_source_from_the_single_quadrupole_mass_spectrometer_TRIO_1000_manufactured_by_VG_Masslab_Altrincham_UK_9824bf2fd9/Czech-Museum-of-MS-EI-source-from-the-single-quadrupole-mass-spectrometer-TRIO-1000-manufactured-by-VG-Masslab-(Altrincham-UK).jpg" alt="Czech Museum of MS: EI source from the single quadrupole mass spectrometer TRIO 1000 manufactured by VG Masslab (Altrincham, UK)"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_triple_stage_quadrupole_LC_MS_mass_spectrometer_TSQ_Vantage_manufactured_by_Thermo_Scientific_fbf31e162f/Czech-Museum-of-MS-A-triple-stage-quadrupole-LC-MS-mass-spectrometer-TSQ-Vantage-manufactured-by-Thermo-Scientific.jpg" alt="Czech Museum of MS: A triple stage quadrupole LC-MS mass spectrometer TSQ Vantage manufactured by Thermo Scientific"/></p>
<h3><strong>FIND US HERE</strong></h3>
<h5><a href="https://www.uochb.cz/en"><strong>Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences</strong></a></h5>
<ul>
<li>Building A, 2nd floor</li>
<li>Flemingovo náměstí 542/2</li>
<li>160 00 Praha 6</li>
<li>Czech Republic</li>
</ul>
<h3><strong>HOURS AND ADMISSION</strong></h3>
<p>The museum is <strong>open daily from 8 am to 6 pm.</strong> A guide is required to move around the building.</p>
<p><strong>Please call in advance</strong> to check the guide‘s availability.</p>
<ul>
<li><strong>Inquiries:</strong> Josef Cvačka</li>
<li>+420 731 447 868</li>
<li>josef.cvacka@uochb.cas.cz</li>
</ul>
<p><strong>The admission is free for all visitors.</strong></p>
<p><strong>The Czech Academy of Sciences has contributed financially to the promotion of the museum.</strong></p>


Czech Museum of Mass Spectrometry

<p><strong>The origins of mass spectrometry in Czechia date back to the 1950s when a group of young scientists in the newly founded Czechoslovak Academy of Sciences started to build the first mass spectrometer in the country. Over the years, mass spectrometry gradually developed and gained in importance. The conference will explore the history, status and perspectives of mass spectrometry. It will mark the opening of the Czech Mass Spectrometry Museum and contribute to celebrations of 70th anniversary of mass spectrometry in our region.</strong></p>
<h3><strong>Organizing institutions</strong></h3>
<p><a href="https://gcms.cz/companies/22">ÚOCHB/IOCB PRAGUE</a></p>
<p><a href="https://gcms.cz/companies/21">Czech Society for Mass Spectrometry/Česká společnost pro hmotnostní spektrometrii</a></p>
<p><a href="https://gcms.cz/companies/7">Ioannes Marcus Marci Spectroscopic Society/Spektroskopická společnost Jana Marka Marci</a></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/03cce7b42575402eb5c91750579dec76/obrazek.png" alt="ÚOCHB/IOCB PRAGUE - Czech Society for Mass Spectrometry/Česká společnost pro hmotnostní spektrometrii -  Ioannes Marcus Marci Spectroscopic Society/Spektroskopická společnost Jana Marka Marci"/></p>
<h3><strong>Conference program</strong></h3>
<p>Available on <a href="http://ms-prague2020.uochb.cas.cz/program.php">Prague Meeting on Historical Perspectives of Mass Spectrometry website</a></p>
<h3><strong>Venue</strong></h3>
<p>The conference will take place in three localities in Prague districts Dejvice and Bubeneč: National Library of Technology (lectures), Institute of Organic Chemistry and Biochemistry of the CAS (vernissage tours), and Old Wastewater Treatment Plant (poster session &amp; dinner).</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/0827c374acec4191b3ff1610c02ae928/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Prague Meeting on Historical Perspectives of Mass Spectrometry"/></p>
<h3><strong>Czech Museum of Mass Spectrometry</strong></h3>
<p>The museum aims to collect and display artifacts related to mass spectrometry, especially those associated with our geographical region. The technical museum shows key components of mass spectrometers used in the past and in contemporary laboratory practice, and it also displays historical documents, photographs, books, etc. The museum&#39;s mission is expressed in two words: education and inspiration. It demonstrates technologies hidden behind the cover and inside the vacuum systems, thus allowing a better understanding how the mass spectrometers actually work. Displayed technical solutions, prototypes, ideas, and stories can be inspiring for students, scientists, and designers of instruments.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/8619b6eab01a4ec18b531bf1a7d20dff/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Exhibition</strong></h3>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/3bc183e590444d81a74ce5538a9b5b59/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Website</strong></h3>
<p>The <a href="http://www.ms-museum.org/">website</a> will store the museum database with a detailed description of exhibits and bring topics from MS history.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/c4771b1119d84181929ea3cd97c56e76/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Donations</strong></h3>
<p>The Czech Museum of Mass Spectrometry welcomes donations to its collection: instruments or their parts (broken, damaged, unused), and documents, photographs or books related to MS history. </p>


Prague Meeting on Historical Perspectives of Mass Spectrometry and  the Czech Mass Spectrometry Museum

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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