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Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography
Scientific article | Various

Impact of mobile and stationary phases on siRNA duplex stability in liquid chromatography

This study investigates how mobile phases and chromatographic conditions affect siRNA duplex stability, using DSC and chromatography to measure melting temperatures.
Mo, 10.3.2025
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Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography
Scientific article | Various

Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography

This study identifies ion release from borosilicate glass bottles as a cause of poor HILIC retention time repeatability and proposes PFA bottles as a solution.
Mo, 3.3.2025
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Synthesis and absolute configuration of cyclic synthetic cathinones derived from α-tetralone
Scientific article | Various

Synthesis and absolute configuration of cyclic synthetic cathinones derived from α-tetralone

The goal of this study is to design, synthesize, and characterize novel cyclic α-tetralone-based synthetic cathinones and determine their absolute configurations.
Tu, 28.1.2025
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Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms
Scientific article | Various

Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms

The goal of this study is to integrate and analyze large-scale lipoprotein and lipidomics data for understanding molecular epidemiology and cardiometabolic risk.
Tu, 21.1.2025
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Evaluation of ion pairing reversed-phase liquid chromatography for the separation of large RNA molecules
Scientific article | Various

Evaluation of ion pairing reversed-phase liquid chromatography for the separation of large RNA molecules

The goal of this study is to optimize IP-RPLC for separating and characterizing large RNA molecules, enhancing RNA quality attribute analysis for therapeutic development.
Tu, 21.1.2025
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Understanding the fundamentals of the on-off retention mechanism of oligonucleotides and their application to high throughput analysis
Scientific article | Various

Understanding the fundamentals of the on-off retention mechanism of oligonucleotides and their application to high throughput analysis

The goal of this study is to investigate oligonucleotide elution behavior in IP-RPLC under various mobile phase conditions and develop ultra-fast separation methods for therapeutic oligonucleotides.
Tu, 14.1.2025
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LabRulez portals in 2024 and our plans for 2025
Article | Various

LabRulez portals in 2024 and our plans for 2025

Dear LabRulez portal users, customers and friends, as the year draws to a close, we would like to thank you for your trust, support and cooperation.
We, 1.1.2025
LabRulez
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Merry Christmas and a Happy New Year 2025
Article | Various

Merry Christmas and a Happy New Year 2025

It has been an honor to be part of your projects and to push the boundaries of science, technology and especially chromatography together.
Fr, 20.12.2024
Watrex Praha
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LabRulez portals in 2023 (How was it?)
Article | Various

LabRulez portals in 2023 (How was it?)

What do statistics or AI chatbot BING say about LabRulez portals in 2023? Thank you for your trust and we look forward to 2024.
Fr, 12.1.2024
LabRulez
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Merry Christmas and best wishes for 2023
Article | Various

Merry Christmas and best wishes for 2023

Merry Christmas and best wishes for 2023. Be part of the LabRulez in 2023.
Tu, 27.12.2022
LabRulez
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