James Little - Mass Spec Interpretation Services
James Little - Mass Spec Interpretation Services

My name is James Little and my private consulting company is Mass Spec Interpretation Services. I contract for NIST, Wiley, and Sapec. Previously, I was a Research Fellow specializing in mass spectrometry at Eastman Chemical Company in Kingsport, TN and retired in early 2016 after >37 years of service. For 2017-2019, I did NMR as a limited service employee specializing in end group determinations for Eastman.

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures. All the technical information on my web page was approved as technical session handouts, conference presentations, workshops, journal publications, courses, etc. for distribution outside Eastman. Other postings on this site are my own and do not necessarily represent Eastman’s positions, strategies or opinions. I also include a “little” information about my sailing experiences.

In 2017, I purchased a used Model S85 Tesla and starting to participate in electric vehicle events. In addition, I am a member of the choir at St. Paul’s Episcopal Church, play competitive duplicate bridge, and race sailboats on Watauga Lake.

 

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Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (Elemental Composition with Freestyle)
Article | Video

Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (Elemental Composition with Freestyle)

This course shows how to identify unknowns in LCMS analysis employing the NIST MSMS search software. Part 5 discusses the the determination of molecular formulae with Thermo Freestyle software.
James Little/Mass Spec Interpretation Services
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Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (Setting Up NIST Search and Freestyle Parameters)
Article | Video

Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (Setting Up NIST Search and Freestyle Parameters)

This course shows how to identify unknowns in LCMS analysis employing the NIST MSMS search software. Part 3 discusses basic settings for Thermo Freestyle software and the NIST 2023 Search.
James Little/Mass Spec Interpretation Services
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News from LabRulezLCMS Library - Week 42, 2024
Article | Application

News from LabRulezLCMS Library - Week 42, 2024

We bring you posters, presentations, applications, and other documents by Thermo Fisher Scientific, Agilent Technologies, Shimadzu, Waters Corporation, and James Little Mass Spec Interpretation Services!
LabRulez
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News from LabRulezLCMS Library - Week 41, 2024
Article | Application

News from LabRulezLCMS Library - Week 41, 2024

This week we bring to you applications by Shimadzu, Thermo Fisher Scientific, Agilent Technologies, and presentation by James Little Mass Spec Interpretation Services!
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Library

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Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (NIST Search Type Demonstration)

Presentations
| 2024 | James Little/Mass Spec Interpretation Services
Instrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap, Software
Manufacturer
Thermo Fisher Scientific
Industries

Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (Elemental Composition with Freestyle)

Presentations
| 2024 | James Little/Mass Spec Interpretation Services
Instrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap, Software
Manufacturer
Thermo Fisher Scientific
Industries

Additional Tips for Processing MSMS Data Files in Agilent MassHunter for NIST MSMS Search

Presentations
| 2024 | James Little/Mass Spec Interpretation Services
Instrumentation
LC/MS, LC/MS/MS, Software
Manufacturer
Agilent Technologies
Industries

LCMS Unknown Identification with NIST Search Using MSMS Libraries

Presentations
| 2024 | James Little/Mass Spec Interpretation Services
Instrumentation
Software, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies, Wiley
Industries
 

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