James Little - Mass Spec Interpretation Services
James Little - Mass Spec Interpretation Services

My name is James Little and my private consulting company is Mass Spec Interpretation Services. I contract for NIST, Wiley, and Sapec. Previously, I was a Research Fellow specializing in mass spectrometry at Eastman Chemical Company in Kingsport, TN and retired in early 2016 after >37 years of service. For 2017-2019, I did NMR as a limited service employee specializing in end group determinations for Eastman.

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures. All the technical information on my web page was approved as technical session handouts, conference presentations, workshops, journal publications, courses, etc. for distribution outside Eastman. Other postings on this site are my own and do not necessarily represent Eastman’s positions, strategies or opinions. I also include a “little” information about my sailing experiences.

In 2017, I purchased a used Model S85 Tesla and starting to participate in electric vehicle events. In addition, I am a member of the choir at St. Paul’s Episcopal Church, play competitive duplicate bridge, and race sailboats on Watauga Lake.

 

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Configuring and Navigating Chromatogram Window NIST26
Article | Academy

Configuring and Navigating Chromatogram Window NIST26

Learn how to configure, customize, and navigate the new NIST 26 Chromatogram Window. This practical guide covers layouts, zooming, filtering, structure display, and efficient data review workflows.
James Little/Mass Spec Interpretation Services
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Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (Elemental Composition with Freestyle)
Article | Video

Data Processing Using Thermo Freestyle Software with NIST MSMS Search for Compound Identifications (Elemental Composition with Freestyle)

This course shows how to identify unknowns in LCMS analysis employing the NIST MSMS search software. Part 5 discusses the the determination of molecular formulae with Thermo Freestyle software.
James Little/Mass Spec Interpretation Services
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Wrote about us

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News from LabRulezLCMS Library - Week 42, 2024
Article | Application

News from LabRulezLCMS Library - Week 42, 2024

We bring you posters, presentations, applications, and other documents by Thermo Fisher Scientific, Agilent Technologies, Shimadzu, Waters Corporation, and James Little Mass Spec Interpretation Services!
LabRulez
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News from LabRulezLCMS Library - Week 41, 2024
Article | Application

News from LabRulezLCMS Library - Week 41, 2024

This week we bring to you applications by Shimadzu, Thermo Fisher Scientific, Agilent Technologies, and presentation by James Little Mass Spec Interpretation Services!
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Library

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Processing MS/MS Data in NIST26 Chromatogram Window

Presentations
| 2026 | James Little/Mass Spec Interpretation Services
Instrumentation
Software, LC/MS, LC/MS/MS
Manufacturer
Wiley
Industries
Other

Manual and Automated Hybrid Searches in NIST26

Presentations
| 2026 | James Little/Mass Spec Interpretation Services
Instrumentation
Software, LC/MS, LC/MS/MS
Manufacturer
Wiley
Industries
Other

Theoretical and Practical Understanding of XICs (Extracted Ion Chromatograms)

Presentations
| 2026 | James Little/Mass Spec Interpretation Services
Instrumentation
Software, LC/MS, LC/MS/MS
Manufacturer
Wiley
Industries
Other

Creating and Using Free Public and User Libraries in NIST26 Chromatogram and Lib Search

Presentations
| 2026 | James Little/Mass Spec Interpretation Services
Instrumentation
Software, LC/MS, LC/MS/MS
Manufacturer
Wiley
Industries
Other
 

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Comprehensive and Robust Analysis of Ultrashort- to Long-Chain PFAS, PAE, OPE, and PAH

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Other projects
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